Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MACD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed, PubMed). Inactive towards proteins bearing poly-ADP-ribose (PubMed, PubMed). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed). Plays a role in estrogen signaling (PubMed, PubMed, PubMed). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed, PubMed). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed). Enhances ESR1-mediated transcription activity (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MACD1_HUMAN
GO:0000166 nucleotide binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0043169 cation binding 27.7778 4 no
GO:0046872 metal ion binding 27.7778 5 no
GO:0017076 purine nucleotide binding 27.7778 5 no
GO:0030554 adenyl nucleotide binding 27.7778 6 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0003723 RNA binding 22.2222 4 no
GO:0005524 ATP binding 22.2222 5 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0045296 cadherin binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in MACD1_HUMAN
GO:0031323 regulation of cellular metabolic process 61.1111 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 55.5556 5 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0048522 positive regulation of cellular process 44.4444 4 no
GO:2001141 regulation of RNA biosynthetic process 44.4444 6 no
GO:0006796 phosphate-containing compound metabolic process 44.4444 4 no
GO:0006355 regulation of DNA-templated transcription 44.4444 7 no
GO:0008104 protein localization 38.8889 4 no
GO:0009966 regulation of signal transduction 38.8889 4 no
GO:0042981 regulation of apoptotic process 38.8889 5 no
GO:0043067 regulation of programmed cell death 38.8889 4 no
GO:0048523 negative regulation of cellular process 38.8889 4 no
GO:0036211 protein modification process 38.8889 4 yes
GO:0043412 macromolecule modification 38.8889 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0009890 negative regulation of biosynthetic process 27.7778 5 no
GO:0009891 positive regulation of biosynthetic process 27.7778 5 no
GO:0009967 positive regulation of signal transduction 27.7778 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0010604 positive regulation of macromolecule metabolic process 27.7778 5 no
GO:0010647 positive regulation of cell communication 27.7778 5 no
GO:0022607 cellular component assembly 27.7778 4 no
GO:0023056 positive regulation of signaling 27.7778 4 no
GO:0031327 negative regulation of cellular biosynthetic process 27.7778 6 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0048584 positive regulation of response to stimulus 27.7778 4 no
GO:0051049 regulation of transport 27.7778 4 no
GO:0051246 regulation of protein metabolic process 27.7778 5 no
GO:0060341 regulation of cellular localization 27.7778 4 no
GO:0080134 regulation of response to stress 27.7778 4 no
GO:1901565 organonitrogen compound catabolic process 27.7778 4 no
GO:0016070 RNA metabolic process 27.7778 5 no
GO:0090304 nucleic acid metabolic process 27.7778 4 no
GO:0045595 regulation of cell differentiation 27.7778 4 no
GO:0015031 protein transport 27.7778 4 no
GO:0072521 purine-containing compound metabolic process 27.7778 4 yes
GO:0006996 organelle organization 22.2222 4 no
GO:0009057 macromolecule catabolic process 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0030163 protein catabolic process 22.2222 4 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 8 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0006163 purine nucleotide metabolic process 22.2222 5 no
GO:0006753 nucleoside phosphate metabolic process 22.2222 4 no
GO:0009117 nucleotide metabolic process 22.2222 5 no
GO:0009150 purine ribonucleotide metabolic process 22.2222 6 no
GO:0009259 ribonucleotide metabolic process 22.2222 5 no
GO:0019693 ribose phosphate metabolic process 22.2222 4 no
GO:0032870 cellular response to hormone stimulus 22.2222 4 no
GO:0033993 response to lipid 22.2222 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 22.2222 4 no
GO:1901362 organic cyclic compound biosynthetic process 22.2222 4 no
GO:0006974 DNA damage response 11.1111 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ESR1_HUMAN [view interactions] Low throughput no no
K1C18_HUMAN [view interactions] Low throughput no no
PARP1_HUMAN [view entry] [view interactions] Low throughput yes yes
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
UXT_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
HBE_HUMAN [view interactions] High throughput no no
H2AX_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CETN2_HUMAN [view interactions] High throughput no yes
DNLI3_HUMAN [view interactions] High throughput no yes
HBA_HUMAN [view interactions] High throughput no no
XPC_HUMAN [view interactions] High throughput no yes
SSRP1_HUMAN [view interactions] High throughput no yes
H37_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
NDUF4_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
XRCC6_HUMAN [view interactions] High throughput no yes
XRCC5_HUMAN [view interactions] High throughput no yes
IKKB_HUMAN [view interactions] High throughput no yes
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
E2AK2_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPU_HUMAN [view interactions] High throughput no yes
CSTF3_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
TP4A1_HUMAN [view interactions] High throughput no no
PTN6_HUMAN [view interactions] High throughput no no
PTN7_HUMAN [view interactions] High throughput no no
PARP2_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
HTAI2_HUMAN [view interactions] High throughput no yes
ATPF1_HUMAN [view interactions] High throughput no yes
LRC15_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
FAHD1_HUMAN [view interactions] High throughput no yes
MTDC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
BPHL_HUMAN [view interactions] High throughput no no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
PDK2_HUMAN [view interactions] High throughput no yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP2_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes