MACD1_HUMAN
Evidence for PS localization
Functions
Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed, PubMed). Inactive towards proteins bearing poly-ADP-ribose (PubMed, PubMed). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed). Plays a role in estrogen signaling (PubMed, PubMed, PubMed). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed, PubMed). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed). Enhances ESR1-mediated transcription activity (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MACD1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 53.3333 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 53.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 46.6667 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 46.6667 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 40.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 40.0000 | 6 | no |
| GO:0036211 | protein modification process | 40.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0010941 | regulation of cell death | 40.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 40.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 40.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 40.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 26.6667 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0043603 | cellular amide metabolic process | 26.6667 | 4 | no |
| GO:0072521 | purine-containing compound metabolic process | 26.6667 | 4 | yes |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0015031 | protein transport | 26.6667 | 4 | no |
| GO:0071702 | organic substance transport | 26.6667 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.6667 | 4 | no |
| GO:0016070 | RNA metabolic process | 26.6667 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 26.6667 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.6667 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.6667 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0018130 | heterocycle biosynthetic process | 26.6667 | 4 | no |
| GO:0019438 | aromatic compound biosynthetic process | 26.6667 | 4 | no |
| GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.6667 | 6 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 26.6667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0006974 | cellular response to DNA damage stimulus | 13.3333 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MACD1_HUMAN |
|---|---|---|---|---|
| DOID:0080000 | muscular disease | 13.3333 | 3 | no |
| DOID:423 | myopathy | 13.3333 | 5 | no |
| DOID:66 | muscle tissue disease | 13.3333 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| K1C18_HUMAN | [view interactions] | Low throughput | no | no |
| PARP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UXT_HUMAN | [view interactions] | Low throughput | no | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| H37_HUMAN | [view interactions] | High throughput | no | no |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| XPC_HUMAN | [view interactions] | High throughput | no | yes |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| DNLI3_HUMAN | [view interactions] | High throughput | no | yes |
| CETN2_HUMAN | [view interactions] | High throughput | no | yes |
| HBE_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| IKKB_HUMAN | [view interactions] | High throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TP4A1_HUMAN | [view interactions] | High throughput | no | no |
| PTN6_HUMAN | [view interactions] | High throughput | no | no |
| PTN7_HUMAN | [view interactions] | High throughput | no | no |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| HTAI2_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| MTDC_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPHL_HUMAN | [view interactions] | High throughput | no | no |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK2_HUMAN | [view interactions] | High throughput | no | yes |
| PARG_HUMAN | [view interactions] | Computational | no | yes |
| ADPRS_HUMAN | [view interactions] | Computational | no | yes |
| OARD1_HUMAN | [view interactions] | Computational | no | yes |