RAB6B_HUMAN
Evidence for PS localization
Functions
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB6B_HUMAN |
|---|---|---|---|---|
| GO:0003924 | GTPase activity | 24.3243 | 7 | yes |
| GO:0005525 | GTP binding | 24.3243 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 24.3243 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.3243 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 24.3243 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.3243 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 24.3243 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 24.3243 | 4 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 24.3243 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.3243 | 4 | yes |
| GO:0046872 | metal ion binding | 21.6216 | 4 | no |
| GO:0017022 | myosin binding | 8.1081 | 4 | yes |
| GO:0031489 | myosin V binding | 8.1081 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB6B_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 56.7568 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.0541 | 4 | no |
| GO:0015031 | protein transport | 45.9459 | 4 | yes |
| GO:0071702 | organic substance transport | 45.9459 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 45.9459 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.9459 | 4 | no |
| GO:0006996 | organelle organization | 40.5405 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 37.8378 | 4 | yes |
| GO:0010646 | regulation of cell communication | 37.8378 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.8378 | 4 | no |
| GO:0051049 | regulation of transport | 35.1351 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.1351 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.1351 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.1351 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.1351 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.4324 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.4324 | 5 | no |
| GO:0033043 | regulation of organelle organization | 32.4324 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.4324 | 4 | no |
| GO:0022607 | cellular component assembly | 29.7297 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.7297 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.7297 | 6 | no |
| GO:0006886 | intracellular protein transport | 27.0270 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.0270 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.3243 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.3243 | 4 | no |
| GO:0009966 | regulation of signal transduction | 24.3243 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3243 | 5 | no |
| GO:0051050 | positive regulation of transport | 24.3243 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.6216 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.6216 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.6216 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.6216 | 6 | no |
| GO:0031399 | regulation of protein modification process | 21.6216 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.6216 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 21.6216 | 4 | no |
| GO:0016482 | cytosolic transport | 16.2162 | 4 | yes |
| GO:0048193 | Golgi vesicle transport | 16.2162 | 5 | yes |
| GO:0016197 | endosomal transport | 13.5135 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 13.5135 | 5 | yes |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 5.4054 | 6 | yes |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 5.4054 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RAB6B_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 10.8108 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 10.8108 | 5 | no |
| DOID:114 | heart disease | 10.8108 | 3 | no |
| DOID:2843 | long QT syndrome | 5.4054 | 6 | no |
| DOID:12930 | dilated cardiomyopathy | 5.4054 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| KI20A_HUMAN | [view interactions] | Low throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| CNGA3_HUMAN | [view interactions] | High throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6C_HUMAN | [view interactions] | High throughput | no | no |
| PGTA_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| TARB1_HUMAN | [view interactions] | High throughput | no | no |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE2_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICL1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPY_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMM1_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| IRS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| SPEF2_HUMAN | [view interactions] | High throughput | no | no |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| RAB3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2B2_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| ACVR1_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1B_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| ZN131_HUMAN | [view interactions] | High throughput | no | yes |
| RAB41_HUMAN | [view interactions] | High throughput | no | no |
| MTMR5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| VASH1_HUMAN | [view interactions] | High throughput | no | yes |
| CC117_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDC2_HUMAN | [view interactions] | High throughput | no | no |
| LYPD1_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| I5P2_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| AVR2B_HUMAN | [view interactions] | High throughput | no | no |
| O10H2_HUMAN | [view interactions] | High throughput | no | no |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL7_HUMAN | [view interactions] | High throughput | no | yes |
| FWCH2_HUMAN | [view interactions] | High throughput | no | no |
| AQP9_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGH_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGE_HUMAN | [view interactions] | High throughput | no | no |
| RXFP1_HUMAN | [view interactions] | High throughput | no | yes |
| RB33B_HUMAN | [view interactions] | High throughput | no | no |
| S12A6_HUMAN | [view interactions] | High throughput | no | yes |
| SHPK_HUMAN | [view interactions] | High throughput | no | no |
| PCDAC_HUMAN | [view interactions] | High throughput | no | yes |
| S12A4_HUMAN | [view interactions] | High throughput | no | yes |
| TM11A_HUMAN | [view interactions] | High throughput | no | no |
| PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| CALR3_HUMAN | [view interactions] | High throughput | no | no |
| VP13B_HUMAN | [view interactions] | High throughput | no | no |
| RING1_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS3_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB3GP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VPS52_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB43_HUMAN | [view interactions] | Computational | no | yes |
| RGP1_HUMAN | [view interactions] | Computational | no | yes |
| RIC1_HUMAN | [view interactions] | Computational | no | no |
| STX16_HUMAN | [view interactions] | Computational | no | yes |
| TMF1_HUMAN | [view interactions] | Computational | no | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARL1_HUMAN | [view interactions] | Computational | no | yes |