Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GDIB_HUMAN

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GDIB_HUMAN
GO:0017076 purine nucleotide binding 50.0000 4 no
GO:0032555 purine ribonucleotide binding 48.6486 4 no
GO:0035639 purine ribonucleoside triphosphate binding 48.6486 4 no
GO:0016462 pyrophosphatase activity 39.1892 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 39.1892 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 39.1892 6 no
GO:0003924 GTPase activity 32.4324 7 no
GO:0005525 GTP binding 32.4324 5 no
GO:0019001 guanyl nucleotide binding 32.4324 5 no
GO:0032561 guanyl ribonucleotide binding 32.4324 5 no
GO:0019003 GDP binding 21.6216 4 no
GO:0003723 RNA binding 17.5676 4 yes
GO:0030695 GTPase regulator activity 16.2162 4 yes
GO:0031267 small GTPase binding 10.8108 5 yes
GO:0051020 GTPase binding 10.8108 4 yes
GO:0005096 GTPase activator activity 9.4595 4 yes
GO:0005092 GDP-dissociation inhibitor activity 2.7027 5 yes
GO:0005093 Rab GDP-dissociation inhibitor activity 2.7027 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GDIB_HUMAN
GO:0008104 protein localization 64.8649 4 yes
GO:0048522 positive regulation of cellular process 55.4054 4 no
GO:0071702 organic substance transport 48.6486 4 yes
GO:0015031 protein transport 47.2973 4 yes
GO:0071705 nitrogen compound transport 47.2973 4 yes
GO:0016192 vesicle-mediated transport 44.5946 4 yes
GO:0051049 regulation of transport 44.5946 4 no
GO:0060255 regulation of macromolecule metabolic process 43.2432 4 no
GO:0051128 regulation of cellular component organization 41.8919 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 40.5405 4 no
GO:0080090 regulation of primary metabolic process 40.5405 4 no
GO:0048523 negative regulation of cellular process 39.1892 4 yes
GO:0010646 regulation of cell communication 39.1892 4 no
GO:0031323 regulation of cellular metabolic process 39.1892 4 no
GO:0009893 positive regulation of metabolic process 37.8378 4 no
GO:0006996 organelle organization 36.4865 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.1351 5 no
GO:0051246 regulation of protein metabolic process 33.7838 5 no
GO:0009966 regulation of signal transduction 32.4324 4 no
GO:0006886 intracellular protein transport 32.4324 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.0811 5 no
GO:0060341 regulation of cellular localization 29.7297 4 yes
GO:0031325 positive regulation of cellular metabolic process 29.7297 5 no
GO:0071310 cellular response to organic substance 29.7297 4 no
GO:0032880 regulation of protein localization 27.0270 5 yes
GO:0060627 regulation of vesicle-mediated transport 27.0270 4 no
GO:0044087 regulation of cellular component biogenesis 25.6757 4 yes
GO:0009892 negative regulation of metabolic process 25.6757 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.6757 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.6757 5 no
GO:0051247 positive regulation of protein metabolic process 25.6757 6 no
GO:0031399 regulation of protein modification process 25.6757 6 no
GO:0022607 cellular component assembly 25.6757 4 no
GO:0010468 regulation of gene expression 24.3243 5 no
GO:0072657 protein localization to membrane 24.3243 4 no
GO:0033043 regulation of organelle organization 22.9730 5 yes
GO:0009889 regulation of biosynthetic process 22.9730 4 no
GO:0010556 regulation of macromolecule biosynthetic process 22.9730 5 no
GO:0051050 positive regulation of transport 22.9730 4 no
GO:1902531 regulation of intracellular signal transduction 22.9730 5 no
GO:0033365 protein localization to organelle 22.9730 5 no
GO:0030030 cell projection organization 22.9730 4 no
GO:0051129 negative regulation of cellular component organization 21.6216 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.6216 5 no
GO:0031324 negative regulation of cellular metabolic process 21.6216 5 no
GO:0031326 regulation of cellular biosynthetic process 21.6216 5 no
GO:0009894 regulation of catabolic process 20.2703 4 no
GO:0051240 positive regulation of multicellular organismal process 20.2703 4 no
GO:0031344 regulation of cell projection organization 18.9189 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 16.2162 6 yes
GO:0007264 small GTPase mediated signal transduction 12.1622 4 yes
GO:1902115 regulation of organelle assembly 12.1622 5 yes
GO:0010639 negative regulation of organelle organization 9.4595 6 yes
GO:0031345 negative regulation of cell projection organization 6.7568 6 yes
GO:0060491 regulation of cell projection assembly 5.4054 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 5.4054 6 yes
GO:1903828 negative regulation of protein localization 5.4054 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in GDIB_HUMAN
DOID:0050539 Charcot-Marie-Tooth disease type 2 4.0541 7 no
DOID:10595 Charcot-Marie-Tooth disease 4.0541 6 no
DOID:440 neuromuscular disease 4.0541 5 no
DOID:574 peripheral nervous system disease 4.0541 3 no
DOID:870 neuropathy 4.0541 4 no
DOID:0050686 organ system cancer 2.7027 3 no
DOID:0050700 cardiomyopathy 2.7027 4 no
DOID:0060036 intrinsic cardiomyopathy 2.7027 5 no
DOID:0080000 muscular disease 2.7027 3 no
DOID:114 heart disease 2.7027 3 no
DOID:12930 dilated cardiomyopathy 2.7027 6 no
DOID:423 myopathy 2.7027 5 no
DOID:66 muscle tissue disease 2.7027 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRI39_HUMAN [view interactions] Low throughput no no
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB10_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB1A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB9A_HUMAN [view interactions] Low throughput no yes
DZIP1_HUMAN [view interactions] Low throughput no yes
RAB6A_HUMAN [view entry] [view interactions] Low throughput yes yes
RABX5_HUMAN [view interactions] Low throughput no no
RAB2A_HUMAN [view entry] [view interactions] Low throughput yes yes
NREP_HUMAN [view interactions] Low throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
RB33A_HUMAN [view interactions] High throughput no no
RAB43_HUMAN [view interactions] High throughput no yes
RAB2B_HUMAN [view interactions] High throughput no no
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
RAB32_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
BAG1_HUMAN [view interactions] High throughput no yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC8_HUMAN [view interactions] High throughput no yes
TOM70_HUMAN [view interactions] High throughput no yes
SGTA_HUMAN [view interactions] High throughput no yes
RAB13_HUMAN [view entry] [view interactions] High throughput yes yes
CSN1_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RB22A_HUMAN [view interactions] High throughput no yes
RAB23_HUMAN [view interactions] High throughput no yes
IF4H_HUMAN [view interactions] High throughput no yes
RRS1_HUMAN [view interactions] High throughput no yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
ATG12_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
DUT_HUMAN [view interactions] High throughput no yes
CLIC3_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
GDIR3_HUMAN [view interactions] High throughput no no
WDFY2_HUMAN [view interactions] High throughput no no
PLIN3_HUMAN [view interactions] High throughput no yes
PPCE_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
TXND5_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
TBB5_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
MK13_HUMAN [view interactions] High throughput no yes
RAB24_HUMAN [view interactions] High throughput no no
IQCB1_HUMAN [view interactions] High throughput no no
HAKAI_HUMAN [view interactions] High throughput no yes
RASFA_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
SKA3_HUMAN [view interactions] High throughput no no
SMAD3_HUMAN [view interactions] High throughput no yes
RAB12_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
PAAT_HUMAN [view interactions] High throughput no yes
RAB6B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB31_HUMAN [view interactions] High throughput no yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TAGL_HUMAN [view interactions] High throughput no no
CNR2_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
BACE1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
NCBP3_HUMAN [view interactions] High throughput no yes
NCBP2_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MYLK_HUMAN [view interactions] High throughput no no
NEK7_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
ATG5_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
EIF1B_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
ARP6_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view interactions] High throughput no yes
TNR14_HUMAN [view interactions] High throughput no no
SGK1_HUMAN [view interactions] High throughput no yes
SOMA_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
GLRA2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
TIFAB_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
EPHA6_HUMAN [view interactions] High throughput no no
MERTK_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
SMUF1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HUWE1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
U2AF2_HUMAN [view interactions] High throughput no yes
H2AY_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
PPT1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
NHLC2_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
MRP6_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
TPC6B_HUMAN [view interactions] Computational no yes
DEN5A_HUMAN [view interactions] Computational no yes
DEN2C_HUMAN [view interactions] Computational no no
ALS2_HUMAN [view entry] [view interactions] Computational yes yes
ANR27_HUMAN [view interactions] Computational no yes
TPC2L_HUMAN [view interactions] Computational no yes
DEN1B_HUMAN [view interactions] Computational no yes
RAB3I_HUMAN [view interactions] Computational no no
HPS1_HUMAN [view interactions] Computational no yes
DEN5B_HUMAN [view interactions] Computational no yes
DEN2B_HUMAN [view interactions] Computational no yes
RIN3_HUMAN [view interactions] Computational no yes
TPPC5_HUMAN [view interactions] Computational no yes
HPS4_HUMAN [view interactions] Computational no yes
TPC2A_HUMAN [view interactions] Computational no yes
TPC2B_HUMAN [view interactions] Computational no no
MON1A_HUMAN [view interactions] Computational no no
RIN1_HUMAN [view entry] [view interactions] Computational yes yes
RAE1_HUMAN [view interactions] Computational no yes
DEN2D_HUMAN [view interactions] Computational no yes
DEN1C_HUMAN [view interactions] Computational no no
RINL_HUMAN [view interactions] Computational no no
DEN4C_HUMAN [view interactions] Computational no yes
R3GEF_HUMAN [view interactions] Computational no yes
MADD_HUMAN [view entry] [view interactions] Computational yes yes
RAB9B_HUMAN [view interactions] Computational no yes
RBGPR_HUMAN [view entry] [view interactions] Computational yes yes
TPC11_HUMAN [view interactions] Computational no no
DEN6A_HUMAN [view interactions] Computational no yes
1433E_HUMAN [view entry] [view interactions] Computational yes yes
DEN4B_HUMAN [view interactions] Computational no yes
RAE2_HUMAN [view interactions] Computational no yes
CCZ1_HUMAN [view interactions] Computational no yes
CCZ1B_HUMAN [view interactions] Computational no yes
MTMRD_HUMAN [view entry] [view interactions] Computational yes yes
RAB7B_HUMAN [view interactions] Computational no no
TPPC1_HUMAN [view interactions] Computational no yes
TPC12_HUMAN [view interactions] Computational no yes
AL2CL_HUMAN [view interactions] Computational no yes
RB3GP_HUMAN [view entry] [view interactions] Computational yes yes
TPC13_HUMAN [view interactions] Computational no yes
DEN2A_HUMAN [view interactions] Computational no no
TPC6A_HUMAN [view interactions] Computational no yes
RIN2_HUMAN [view interactions] Computational no yes
GAPD1_HUMAN [view entry] [view interactions] Computational yes yes
TPPC8_HUMAN [view interactions] Computational no yes
RIC1_HUMAN [view interactions] Computational no no
RGP1_HUMAN [view interactions] Computational no yes
DEN6B_HUMAN [view interactions] Computational no no
TPC10_HUMAN [view interactions] Computational no no
DEND3_HUMAN [view interactions] Computational no no
DEN1A_HUMAN [view interactions] Computational no no
MON1B_HUMAN [view interactions] Computational no yes
TPPC4_HUMAN [view entry] [view interactions] Computational yes yes
MTMR5_HUMAN [view entry] [view interactions] Computational yes no