Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GDIB_HUMAN

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GDIB_HUMAN
GO:0043168 anion binding 52.5000 4 no
GO:0000166 nucleotide binding 51.2500 4 no
GO:0017076 purine nucleotide binding 51.2500 5 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0016462 pyrophosphatase activity 36.2500 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 36.2500 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 36.2500 6 no
GO:0003924 GTPase activity 30.0000 7 no
GO:0005525 GTP binding 30.0000 5 no
GO:0019001 guanyl nucleotide binding 30.0000 6 no
GO:0032561 guanyl ribonucleotide binding 30.0000 5 no
GO:0030554 adenyl nucleotide binding 22.5000 6 no
GO:0005524 ATP binding 21.2500 5 no
GO:0019900 kinase binding 21.2500 4 no
GO:0032559 adenyl ribonucleotide binding 21.2500 5 no
GO:0003723 RNA binding 17.5000 4 yes
GO:0031267 small GTPase binding 6.2500 5 yes
GO:0051020 GTPase binding 6.2500 4 yes
GO:0005096 GTPase activator activity 5.0000 4 yes
GO:0030695 GTPase regulator activity 5.0000 4 yes
GO:0005092 GDP-dissociation inhibitor activity 2.5000 5 yes
GO:0005093 Rab GDP-dissociation inhibitor activity 2.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GDIB_HUMAN
GO:0008104 protein localization 60.0000 4 yes
GO:0048522 positive regulation of cellular process 53.7500 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0051128 regulation of cellular component organization 48.7500 4 yes
GO:0006996 organelle organization 46.2500 4 no
GO:0031323 regulation of cellular metabolic process 46.2500 4 no
GO:0060255 regulation of macromolecule metabolic process 45.0000 4 no
GO:0071702 organic substance transport 43.7500 4 yes
GO:0071705 nitrogen compound transport 43.7500 4 yes
GO:0080090 regulation of primary metabolic process 42.5000 4 no
GO:0015031 protein transport 41.2500 4 yes
GO:0010646 regulation of cell communication 41.2500 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009889 regulation of biosynthetic process 36.2500 4 no
GO:0031326 regulation of cellular biosynthetic process 36.2500 5 no
GO:0010556 regulation of macromolecule biosynthetic process 35.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 35.0000 5 no
GO:0060341 regulation of cellular localization 33.7500 4 yes
GO:0009966 regulation of signal transduction 33.7500 4 no
GO:0010468 regulation of gene expression 33.7500 6 no
GO:0009892 negative regulation of metabolic process 32.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0032880 regulation of protein localization 30.0000 5 yes
GO:0033043 regulation of organelle organization 30.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 30.0000 5 no
GO:0051246 regulation of protein metabolic process 30.0000 5 no
GO:0044087 regulation of cellular component biogenesis 28.7500 4 yes
GO:0071310 cellular response to organic substance 28.7500 4 no
GO:0051240 positive regulation of multicellular organismal process 27.5000 4 no
GO:0051129 negative regulation of cellular component organization 26.2500 5 yes
GO:0006886 intracellular protein transport 26.2500 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.2500 5 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 23.7500 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.7500 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.7500 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.7500 6 no
GO:0036211 protein modification process 23.7500 4 no
GO:0043412 macromolecule modification 23.7500 4 no
GO:0051252 regulation of RNA metabolic process 23.7500 5 no
GO:0031344 regulation of cell projection organization 22.5000 5 yes
GO:0009894 regulation of catabolic process 22.5000 4 no
GO:0031399 regulation of protein modification process 22.5000 6 no
GO:0043067 regulation of programmed cell death 22.5000 4 no
GO:0051050 positive regulation of transport 22.5000 4 no
GO:0051094 positive regulation of developmental process 22.5000 4 no
GO:0051247 positive regulation of protein metabolic process 22.5000 6 no
GO:0033365 protein localization to organelle 22.5000 5 no
GO:0048584 positive regulation of response to stimulus 22.5000 4 no
GO:0006355 regulation of DNA-templated transcription 22.5000 7 no
GO:2001141 regulation of RNA biosynthetic process 22.5000 6 no
GO:0010648 negative regulation of cell communication 21.2500 5 no
GO:0023057 negative regulation of signaling 21.2500 4 no
GO:0042981 regulation of apoptotic process 21.2500 5 no
GO:0048585 negative regulation of response to stimulus 21.2500 4 no
GO:0080134 regulation of response to stress 21.2500 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.0000 6 yes
GO:0141124 intracellular signaling cassette 17.5000 4 yes
GO:0010639 negative regulation of organelle organization 12.5000 6 yes
GO:1902115 regulation of organelle assembly 12.5000 5 yes
GO:0007264 small GTPase-mediated signal transduction 10.0000 5 yes
GO:0060491 regulation of cell projection assembly 8.7500 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 8.7500 6 yes
GO:0031345 negative regulation of cell projection organization 6.2500 6 yes
GO:1903828 negative regulation of protein localization 6.2500 5 yes
GO:1902017 regulation of cilium assembly 5.0000 6 yes
GO:1903564 regulation of protein localization to cilium 2.5000 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAB2A_HUMAN [view entry] [view interactions] Low throughput yes yes
NREP_HUMAN [view interactions] Low throughput no yes
TRI39_HUMAN [view interactions] Low throughput no no
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB10_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB9A_HUMAN [view interactions] Low throughput no yes
RAB1A_HUMAN [view entry] [view interactions] Low throughput yes yes
DZIP1_HUMAN [view interactions] Low throughput no yes
RAB6A_HUMAN [view entry] [view interactions] Low throughput yes yes
RABX5_HUMAN [view interactions] Low throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HUWE1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
U2AF2_HUMAN [view interactions] High throughput no yes
H2AY_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
PPT1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
NHLC2_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
MRP6_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
RB33A_HUMAN [view interactions] High throughput no no
RAB43_HUMAN [view interactions] High throughput no yes
RAB2B_HUMAN [view interactions] High throughput no no
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
RAB32_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
BAG1_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC8_HUMAN [view interactions] High throughput no yes
TOM70_HUMAN [view interactions] High throughput no yes
SGTA_HUMAN [view interactions] High throughput no yes
RAB13_HUMAN [view entry] [view interactions] High throughput yes yes
CSN1_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RB22A_HUMAN [view interactions] High throughput no yes
RAB23_HUMAN [view interactions] High throughput no yes
IF4H_HUMAN [view interactions] High throughput no yes
RRS1_HUMAN [view interactions] High throughput no yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
ASXL3_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
ATG12_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
DUT_HUMAN [view interactions] High throughput no yes
CLIC3_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
GDIR3_HUMAN [view interactions] High throughput no no
WDFY2_HUMAN [view interactions] High throughput no no
PLIN3_HUMAN [view interactions] High throughput no yes
PPCE_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
TXND5_HUMAN [view interactions] High throughput no yes
PAPS2_HUMAN [view interactions] High throughput no yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
KCY_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
PACS1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN598_HUMAN [view interactions] High throughput no no
CPNE1_HUMAN [view interactions] High throughput no no
MGME1_HUMAN [view interactions] High throughput no yes
GATA_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
TBB5_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
PCDH7_HUMAN [view entry] [view interactions] High throughput yes no
RAB25_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
MK13_HUMAN [view interactions] High throughput no yes
RAB24_HUMAN [view interactions] High throughput no no
IQCB1_HUMAN [view interactions] High throughput no no
HAKAI_HUMAN [view interactions] High throughput no yes
RASFA_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
SKA3_HUMAN [view interactions] High throughput no no
SMAD3_HUMAN [view interactions] High throughput no yes
RAB12_HUMAN [view entry] [view interactions] High throughput yes no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
PAAT_HUMAN [view interactions] High throughput no yes
RAB6B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
RAB31_HUMAN [view interactions] High throughput no yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TAGL_HUMAN [view interactions] High throughput no no
CNR2_HUMAN [view entry] [view interactions] High throughput yes yes
NEK10_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
BACE1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
NCBP3_HUMAN [view interactions] High throughput no yes
NCBP2_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MYLK_HUMAN [view entry] [view interactions] High throughput yes no
NEK7_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
EIF1B_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
ARP6_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
TNR14_HUMAN [view interactions] High throughput no no
SGK1_HUMAN [view interactions] High throughput no yes
SOMA_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
GLRA2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
TIFAB_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
EPHA6_HUMAN [view interactions] High throughput no no
MERTK_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
SMUF1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes