GDIB_HUMAN
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GDIB_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 52.5000 | 4 | no |
GO:0000166 | nucleotide binding | 51.2500 | 4 | no |
GO:0017076 | purine nucleotide binding | 51.2500 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
GO:0016462 | pyrophosphatase activity | 36.2500 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 36.2500 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 36.2500 | 6 | no |
GO:0003924 | GTPase activity | 30.0000 | 7 | no |
GO:0005525 | GTP binding | 30.0000 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 30.0000 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 30.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 22.5000 | 6 | no |
GO:0005524 | ATP binding | 21.2500 | 5 | no |
GO:0019900 | kinase binding | 21.2500 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.2500 | 5 | no |
GO:0003723 | RNA binding | 17.5000 | 4 | yes |
GO:0031267 | small GTPase binding | 6.2500 | 5 | yes |
GO:0051020 | GTPase binding | 6.2500 | 4 | yes |
GO:0005096 | GTPase activator activity | 5.0000 | 4 | yes |
GO:0030695 | GTPase regulator activity | 5.0000 | 4 | yes |
GO:0005092 | GDP-dissociation inhibitor activity | 2.5000 | 5 | yes |
GO:0005093 | Rab GDP-dissociation inhibitor activity | 2.5000 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GDIB_HUMAN |
---|---|---|---|---|
GO:0008104 | protein localization | 60.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 53.7500 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 48.7500 | 4 | yes |
GO:0006996 | organelle organization | 46.2500 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 46.2500 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 45.0000 | 4 | no |
GO:0071702 | organic substance transport | 43.7500 | 4 | yes |
GO:0071705 | nitrogen compound transport | 43.7500 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 42.5000 | 4 | no |
GO:0015031 | protein transport | 41.2500 | 4 | yes |
GO:0010646 | regulation of cell communication | 41.2500 | 4 | no |
GO:0051049 | regulation of transport | 40.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 36.2500 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 36.2500 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.0000 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.0000 | 5 | no |
GO:0060341 | regulation of cellular localization | 33.7500 | 4 | yes |
GO:0009966 | regulation of signal transduction | 33.7500 | 4 | no |
GO:0010468 | regulation of gene expression | 33.7500 | 6 | no |
GO:0009892 | negative regulation of metabolic process | 32.5000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 31.2500 | 5 | no |
GO:0022607 | cellular component assembly | 31.2500 | 4 | no |
GO:0032880 | regulation of protein localization | 30.0000 | 5 | yes |
GO:0033043 | regulation of organelle organization | 30.0000 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 28.7500 | 4 | yes |
GO:0071310 | cellular response to organic substance | 28.7500 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 27.5000 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 26.2500 | 5 | yes |
GO:0006886 | intracellular protein transport | 26.2500 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.2500 | 5 | no |
GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0030030 | cell projection organization | 25.0000 | 4 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
GO:0072657 | protein localization to membrane | 25.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 23.7500 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.7500 | 6 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.7500 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 23.7500 | 6 | no |
GO:0036211 | protein modification process | 23.7500 | 4 | no |
GO:0043412 | macromolecule modification | 23.7500 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 23.7500 | 5 | no |
GO:0031344 | regulation of cell projection organization | 22.5000 | 5 | yes |
GO:0009894 | regulation of catabolic process | 22.5000 | 4 | no |
GO:0031399 | regulation of protein modification process | 22.5000 | 6 | no |
GO:0043067 | regulation of programmed cell death | 22.5000 | 4 | no |
GO:0051050 | positive regulation of transport | 22.5000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 22.5000 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.5000 | 6 | no |
GO:0033365 | protein localization to organelle | 22.5000 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 22.5000 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 22.5000 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 22.5000 | 6 | no |
GO:0010648 | negative regulation of cell communication | 21.2500 | 5 | no |
GO:0023057 | negative regulation of signaling | 21.2500 | 4 | no |
GO:0042981 | regulation of apoptotic process | 21.2500 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 21.2500 | 4 | no |
GO:0080134 | regulation of response to stress | 21.2500 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.0000 | 6 | yes |
GO:0141124 | intracellular signaling cassette | 17.5000 | 4 | yes |
GO:0010639 | negative regulation of organelle organization | 12.5000 | 6 | yes |
GO:1902115 | regulation of organelle assembly | 12.5000 | 5 | yes |
GO:0007264 | small GTPase-mediated signal transduction | 10.0000 | 5 | yes |
GO:0060491 | regulation of cell projection assembly | 8.7500 | 5 | yes |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 8.7500 | 6 | yes |
GO:0031345 | negative regulation of cell projection organization | 6.2500 | 6 | yes |
GO:1903828 | negative regulation of protein localization | 6.2500 | 5 | yes |
GO:1902017 | regulation of cilium assembly | 5.0000 | 6 | yes |
GO:1903564 | regulation of protein localization to cilium | 2.5000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RAB2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NREP_HUMAN | [view interactions] | Low throughput | no | yes |
TRI39_HUMAN | [view interactions] | Low throughput | no | no |
RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | Low throughput | no | yes |
RAB1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DZIP1_HUMAN | [view interactions] | Low throughput | no | yes |
RAB6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RABX5_HUMAN | [view interactions] | Low throughput | no | no |
BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
H2AY_HUMAN | [view interactions] | High throughput | no | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPT1_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLUC_HUMAN | [view interactions] | High throughput | no | no |
NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
TFE3_HUMAN | [view interactions] | High throughput | no | yes |
MRP6_HUMAN | [view interactions] | High throughput | no | no |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC2_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
FA20C_HUMAN | [view interactions] | High throughput | no | no |
APR_HUMAN | [view interactions] | High throughput | no | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
RB33A_HUMAN | [view interactions] | High throughput | no | no |
RAB43_HUMAN | [view interactions] | High throughput | no | yes |
RAB2B_HUMAN | [view interactions] | High throughput | no | no |
RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB32_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BAG1_HUMAN | [view interactions] | High throughput | no | yes |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
TOM70_HUMAN | [view interactions] | High throughput | no | yes |
SGTA_HUMAN | [view interactions] | High throughput | no | yes |
RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN1_HUMAN | [view interactions] | High throughput | no | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB22A_HUMAN | [view interactions] | High throughput | no | yes |
RAB23_HUMAN | [view interactions] | High throughput | no | yes |
IF4H_HUMAN | [view interactions] | High throughput | no | yes |
RRS1_HUMAN | [view interactions] | High throughput | no | yes |
RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
ASXL1_HUMAN | [view interactions] | High throughput | no | no |
ASXL2_HUMAN | [view interactions] | High throughput | no | no |
ASXL3_HUMAN | [view interactions] | High throughput | no | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
RN149_HUMAN | [view interactions] | High throughput | no | no |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
ATG12_HUMAN | [view interactions] | High throughput | no | yes |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
ATG10_HUMAN | [view interactions] | High throughput | no | yes |
ATG3_HUMAN | [view interactions] | High throughput | no | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUT_HUMAN | [view interactions] | High throughput | no | yes |
CLIC3_HUMAN | [view interactions] | High throughput | no | no |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDIR3_HUMAN | [view interactions] | High throughput | no | no |
WDFY2_HUMAN | [view interactions] | High throughput | no | no |
PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
PPCE_HUMAN | [view interactions] | High throughput | no | yes |
RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STMN1_HUMAN | [view interactions] | High throughput | no | yes |
TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TXND5_HUMAN | [view interactions] | High throughput | no | yes |
PAPS2_HUMAN | [view interactions] | High throughput | no | yes |
ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PACS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN598_HUMAN | [view interactions] | High throughput | no | no |
CPNE1_HUMAN | [view interactions] | High throughput | no | no |
MGME1_HUMAN | [view interactions] | High throughput | no | yes |
GATA_HUMAN | [view interactions] | High throughput | no | yes |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
NECD_HUMAN | [view interactions] | High throughput | no | no |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB25_HUMAN | [view interactions] | High throughput | no | no |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
MK13_HUMAN | [view interactions] | High throughput | no | yes |
RAB24_HUMAN | [view interactions] | High throughput | no | no |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
HAKAI_HUMAN | [view interactions] | High throughput | no | yes |
RASFA_HUMAN | [view interactions] | High throughput | no | no |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SKA3_HUMAN | [view interactions] | High throughput | no | no |
SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
RAB12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PAAT_HUMAN | [view interactions] | High throughput | no | yes |
RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB31_HUMAN | [view interactions] | High throughput | no | yes |
RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAGL_HUMAN | [view interactions] | High throughput | no | no |
CNR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEK10_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
BACE1_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
M3K7_HUMAN | [view interactions] | High throughput | no | yes |
MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NEK7_HUMAN | [view interactions] | High throughput | no | yes |
KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
IF6_HUMAN | [view interactions] | High throughput | no | yes |
PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF1B_HUMAN | [view interactions] | High throughput | no | no |
VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP6_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNR14_HUMAN | [view interactions] | High throughput | no | no |
SGK1_HUMAN | [view interactions] | High throughput | no | yes |
SOMA_HUMAN | [view interactions] | High throughput | no | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
GLRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
TIFAB_HUMAN | [view interactions] | High throughput | no | no |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EPHA6_HUMAN | [view interactions] | High throughput | no | no |
MERTK_HUMAN | [view interactions] | High throughput | no | yes |
SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
ISG15_HUMAN | [view interactions] | High throughput | no | no |
SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |