Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PACS1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
203 Arg Trp Schuurs-Hoeijmakerssyndrome(SHMS) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PACS1_HUMAN
GO:0019900 kinase binding 34.4828 4 no
GO:0046872 metal ion binding 31.0345 4 no
GO:0019901 protein kinase binding 31.0345 5 no
GO:0019887 protein kinase regulator activity 20.6897 4 no
GO:0017076 purine nucleotide binding 20.6897 4 no
GO:0032555 purine ribonucleotide binding 20.6897 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.6897 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PACS1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 82.7586 4 no
GO:0080090 regulation of primary metabolic process 82.7586 4 no
GO:0051171 regulation of nitrogen compound metabolic process 79.3103 4 no
GO:0031323 regulation of cellular metabolic process 75.8621 4 no
GO:0048522 positive regulation of cellular process 68.9655 4 no
GO:0051246 regulation of protein metabolic process 62.0690 5 no
GO:0009893 positive regulation of metabolic process 58.6207 4 no
GO:0010646 regulation of cell communication 58.6207 4 no
GO:0048523 negative regulation of cellular process 58.6207 4 no
GO:0010604 positive regulation of macromolecule metabolic process 55.1724 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 55.1724 5 no
GO:0009966 regulation of signal transduction 51.7241 4 no
GO:0031325 positive regulation of cellular metabolic process 51.7241 5 no
GO:0009892 negative regulation of metabolic process 48.2759 4 no
GO:0010605 negative regulation of macromolecule metabolic process 48.2759 5 no
GO:0019220 regulation of phosphate metabolic process 48.2759 6 no
GO:0031399 regulation of protein modification process 48.2759 6 no
GO:0051174 regulation of phosphorus metabolic process 48.2759 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 44.8276 5 no
GO:0051247 positive regulation of protein metabolic process 44.8276 6 no
GO:0001932 regulation of protein phosphorylation 41.3793 7 no
GO:0010468 regulation of gene expression 41.3793 5 no
GO:0042325 regulation of phosphorylation 41.3793 7 no
GO:0051128 regulation of cellular component organization 41.3793 4 no
GO:0051049 regulation of transport 41.3793 4 no
GO:0008104 protein localization 37.9310 4 yes
GO:0009889 regulation of biosynthetic process 37.9310 4 no
GO:0010562 positive regulation of phosphorus metabolic process 37.9310 6 no
GO:0031324 negative regulation of cellular metabolic process 37.9310 5 no
GO:0031401 positive regulation of protein modification process 37.9310 7 no
GO:0045937 positive regulation of phosphate metabolic process 37.9310 7 no
GO:0051248 negative regulation of protein metabolic process 37.9310 6 no
GO:0006996 organelle organization 37.9310 4 no
GO:0071702 organic substance transport 37.9310 4 no
GO:0071705 nitrogen compound transport 37.9310 4 no
GO:0001934 positive regulation of protein phosphorylation 34.4828 8 no
GO:0006796 phosphate-containing compound metabolic process 34.4828 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.4828 5 no
GO:0031326 regulation of cellular biosynthetic process 34.4828 5 no
GO:0042327 positive regulation of phosphorylation 34.4828 8 no
GO:1902531 regulation of intracellular signal transduction 34.4828 5 no
GO:0010647 positive regulation of cell communication 34.4828 5 no
GO:0023056 positive regulation of signaling 34.4828 4 no
GO:0048584 positive regulation of response to stimulus 34.4828 4 no
GO:0016192 vesicle-mediated transport 34.4828 4 no
GO:0036211 protein modification process 31.0345 4 no
GO:0043412 macromolecule modification 31.0345 4 no
GO:0051338 regulation of transferase activity 31.0345 4 no
GO:0051336 regulation of hydrolase activity 31.0345 4 no
GO:0015031 protein transport 31.0345 4 no
GO:0010563 negative regulation of phosphorus metabolic process 27.5862 6 no
GO:0031400 negative regulation of protein modification process 27.5862 7 no
GO:0043085 positive regulation of catalytic activity 27.5862 4 no
GO:0043549 regulation of kinase activity 27.5862 5 no
GO:0045595 regulation of cell differentiation 27.5862 4 no
GO:0045859 regulation of protein kinase activity 27.5862 6 no
GO:0045936 negative regulation of phosphate metabolic process 27.5862 7 no
GO:0006886 intracellular protein transport 27.5862 4 no
GO:0010959 regulation of metal ion transport 27.5862 6 no
GO:0034762 regulation of transmembrane transport 27.5862 4 no
GO:0034765 regulation of ion transmembrane transport 27.5862 5 no
GO:0043269 regulation of ion transport 27.5862 5 no
GO:1904062 regulation of cation transmembrane transport 27.5862 6 no
GO:0010941 regulation of cell death 27.5862 4 no
GO:0042981 regulation of apoptotic process 27.5862 6 no
GO:0043067 regulation of programmed cell death 27.5862 5 no
GO:0001933 negative regulation of protein phosphorylation 24.1379 8 no
GO:0010038 response to metal ion 24.1379 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.1379 5 no
GO:0042326 negative regulation of phosphorylation 24.1379 8 no
GO:0051347 positive regulation of transferase activity 24.1379 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 24.1379 7 no
GO:0009967 positive regulation of signal transduction 24.1379 5 no
GO:0022607 cellular component assembly 24.1379 4 no
GO:0035303 regulation of dephosphorylation 24.1379 7 no
GO:0035304 regulation of protein dephosphorylation 24.1379 7 no
GO:0051050 positive regulation of transport 24.1379 4 no
GO:0050804 modulation of chemical synaptic transmission 24.1379 5 no
GO:0099177 regulation of trans-synaptic signaling 24.1379 4 no
GO:0022898 regulation of transmembrane transporter activity 24.1379 4 no
GO:0051924 regulation of calcium ion transport 24.1379 7 no
GO:1903169 regulation of calcium ion transmembrane transport 24.1379 7 no
GO:0009894 regulation of catabolic process 24.1379 4 no
GO:0033365 protein localization to organelle 20.6897 5 yes
GO:0006355 regulation of DNA-templated transcription 20.6897 6 no
GO:0033674 positive regulation of kinase activity 20.6897 6 no
GO:0051252 regulation of RNA metabolic process 20.6897 5 no
GO:0051726 regulation of cell cycle 20.6897 4 no
GO:1903506 regulation of nucleic acid-templated transcription 20.6897 7 no
GO:2001141 regulation of RNA biosynthetic process 20.6897 6 no
GO:0006468 protein phosphorylation 20.6897 5 no
GO:0016310 phosphorylation 20.6897 5 no
GO:0042127 regulation of cell population proliferation 20.6897 4 no
GO:0048193 Golgi vesicle transport 20.6897 5 no
GO:0060627 regulation of vesicle-mediated transport 20.6897 4 no
GO:0031344 regulation of cell projection organization 20.6897 5 no
GO:0061024 membrane organization 20.6897 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:0032412 regulation of ion transmembrane transporter activity 20.6897 5 no
GO:0051051 negative regulation of transport 20.6897 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 20.6897 5 no
GO:0051282 regulation of sequestering of calcium ion 20.6897 4 no
GO:0051345 positive regulation of hydrolase activity 20.6897 5 no
GO:0072657 protein localization to membrane 13.7931 4 yes
GO:0072659 protein localization to plasma membrane 6.8966 5 yes
GO:1990778 protein localization to cell periphery 6.8966 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PACS1_HUMAN
DOID:0060038 specific developmental disorder 6.8966 3 yes
DOID:0060307 autosomal dominant intellectual developmental disorder 6.8966 5 yes
DOID:1059 intellectual disability 6.8966 4 yes
DOID:0050700 cardiomyopathy 6.8966 4 no
DOID:0060036 intrinsic cardiomyopathy 6.8966 5 no
DOID:114 heart disease 6.8966 3 no
DOID:2843 long QT syndrome 6.8966 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GGA3_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
MPRI_HUMAN [view interactions] Low throughput no yes
FURIN_HUMAN [view interactions] Low throughput no yes
VAMP4_HUMAN [view interactions] Low throughput no yes
SORL_HUMAN [view interactions] Low throughput no yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR37_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
PP1R7_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
FP100_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
IQCF1_HUMAN [view interactions] High throughput no no
SNX24_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
CEBPA_HUMAN [view interactions] High throughput no yes
CEBPB_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
LEAP2_HUMAN [view interactions] High throughput no no
SPXN2_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
ATG4A_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
SGF29_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
OTUD4_HUMAN [view interactions] High throughput no yes
PP2AB_HUMAN [view interactions] High throughput no yes
PKD2_HUMAN [view interactions] Computational no yes