Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PACS1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
203 Arg Trp Schuurs-Hoeijmakerssyndrome(SHMS) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PACS1_HUMAN
GO:0019900 kinase binding 33.3333 4 no
GO:0043169 cation binding 30.3030 4 no
GO:0046872 metal ion binding 30.3030 5 no
GO:0019901 protein kinase binding 30.3030 5 no
GO:0000166 nucleotide binding 21.2121 4 no
GO:0017076 purine nucleotide binding 21.2121 5 no
GO:0032555 purine ribonucleotide binding 21.2121 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.2121 4 no
GO:0043168 anion binding 21.2121 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PACS1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 75.7576 4 no
GO:0031323 regulation of cellular metabolic process 69.6970 4 no
GO:0048522 positive regulation of cellular process 69.6970 4 no
GO:0080090 regulation of primary metabolic process 69.6970 4 no
GO:0048523 negative regulation of cellular process 60.6061 4 no
GO:0010646 regulation of cell communication 57.5758 4 no
GO:0051246 regulation of protein metabolic process 54.5455 5 no
GO:0009893 positive regulation of metabolic process 51.5152 4 no
GO:0009966 regulation of signal transduction 51.5152 4 no
GO:0009889 regulation of biosynthetic process 48.4848 4 no
GO:0009892 negative regulation of metabolic process 48.4848 4 no
GO:0010556 regulation of macromolecule biosynthetic process 48.4848 5 no
GO:0010604 positive regulation of macromolecule metabolic process 48.4848 5 no
GO:0010605 negative regulation of macromolecule metabolic process 48.4848 5 no
GO:0031326 regulation of cellular biosynthetic process 48.4848 5 no
GO:0051128 regulation of cellular component organization 48.4848 4 no
GO:0031325 positive regulation of cellular metabolic process 45.4545 5 no
GO:0051049 regulation of transport 45.4545 4 no
GO:0010468 regulation of gene expression 42.4242 6 no
GO:0031324 negative regulation of cellular metabolic process 42.4242 5 no
GO:0048584 positive regulation of response to stimulus 42.4242 4 no
GO:0019220 regulation of phosphate metabolic process 42.4242 6 no
GO:0031399 regulation of protein modification process 42.4242 6 no
GO:0051174 regulation of phosphorus metabolic process 42.4242 5 no
GO:0051247 positive regulation of protein metabolic process 39.3939 6 no
GO:1902531 regulation of intracellular signal transduction 39.3939 5 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:0023056 positive regulation of signaling 36.3636 4 no
GO:0001932 regulation of protein phosphorylation 36.3636 7 no
GO:0042325 regulation of phosphorylation 36.3636 7 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0006996 organelle organization 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0008104 protein localization 30.3030 4 yes
GO:0001934 positive regulation of protein phosphorylation 30.3030 8 no
GO:0042327 positive regulation of phosphorylation 30.3030 8 no
GO:0051338 regulation of transferase activity 30.3030 4 no
GO:0051050 positive regulation of transport 30.3030 4 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0051336 regulation of hydrolase activity 27.2727 4 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0032101 regulation of response to external stimulus 27.2727 4 no
GO:0043085 positive regulation of catalytic activity 27.2727 4 no
GO:0043549 regulation of kinase activity 27.2727 5 no
GO:0045859 regulation of protein kinase activity 27.2727 6 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0071705 nitrogen compound transport 27.2727 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:0042127 regulation of cell population proliferation 24.2424 4 no
GO:0042981 regulation of apoptotic process 24.2424 5 no
GO:0043067 regulation of programmed cell death 24.2424 4 no
GO:0010563 negative regulation of phosphorus metabolic process 24.2424 6 no
GO:0010959 regulation of metal ion transport 24.2424 6 no
GO:0031400 negative regulation of protein modification process 24.2424 7 no
GO:0032103 positive regulation of response to external stimulus 24.2424 5 no
GO:0034762 regulation of transmembrane transport 24.2424 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 24.2424 5 no
GO:0043269 regulation of monoatomic ion transport 24.2424 5 no
GO:0045595 regulation of cell differentiation 24.2424 4 no
GO:0045936 negative regulation of phosphate metabolic process 24.2424 7 no
GO:0051130 positive regulation of cellular component organization 24.2424 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 24.2424 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 24.2424 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.2424 5 no
GO:0060341 regulation of cellular localization 24.2424 4 no
GO:0006468 protein phosphorylation 21.2121 5 no
GO:0008284 positive regulation of cell population proliferation 21.2121 5 no
GO:0009890 negative regulation of biosynthetic process 21.2121 5 no
GO:0009894 regulation of catabolic process 21.2121 4 no
GO:0009968 negative regulation of signal transduction 21.2121 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.2121 6 no
GO:0010648 negative regulation of cell communication 21.2121 5 no
GO:0016310 phosphorylation 21.2121 5 no
GO:0023057 negative regulation of signaling 21.2121 4 no
GO:0031327 negative regulation of cellular biosynthetic process 21.2121 6 no
GO:0048585 negative regulation of response to stimulus 21.2121 4 no
GO:0051726 regulation of cell cycle 21.2121 4 no
GO:0001933 negative regulation of protein phosphorylation 21.2121 8 no
GO:0002684 positive regulation of immune system process 21.2121 4 no
GO:0042326 negative regulation of phosphorylation 21.2121 8 no
GO:0051345 positive regulation of hydrolase activity 21.2121 5 no
GO:0051924 regulation of calcium ion transport 21.2121 7 no
GO:0060627 regulation of vesicle-mediated transport 21.2121 4 no
GO:1903169 regulation of calcium ion transmembrane transport 21.2121 7 no
GO:0015031 protein transport 21.2121 4 no
GO:0043933 protein-containing complex organization 21.2121 4 no
GO:0006355 regulation of DNA-templated transcription 21.2121 7 no
GO:0051252 regulation of RNA metabolic process 21.2121 5 no
GO:2001141 regulation of RNA biosynthetic process 21.2121 6 no
GO:0044087 regulation of cellular component biogenesis 21.2121 4 no
GO:0032880 regulation of protein localization 21.2121 5 no
GO:0010038 response to metal ion 21.2121 4 no
GO:0022898 regulation of transmembrane transporter activity 21.2121 4 no
GO:0051347 positive regulation of transferase activity 21.2121 5 no
GO:0033365 protein localization to organelle 15.1515 5 yes
GO:0072657 protein localization to membrane 9.0909 4 yes
GO:0072659 protein localization to plasma membrane 6.0606 5 yes
GO:1990778 protein localization to cell periphery 6.0606 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GGA3_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
WDR37_HUMAN [view entry] [view interactions] Low throughput yes yes
MPRI_HUMAN [view interactions] Low throughput no yes
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
FURIN_HUMAN [view interactions] Low throughput no yes
VAMP4_HUMAN [view entry] [view interactions] Low throughput yes yes
SORL_HUMAN [view interactions] Low throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
MD13L_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
PP1R7_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FP100_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
IQCF1_HUMAN [view interactions] High throughput no no
SNX24_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
CEBPA_HUMAN [view interactions] High throughput no yes
CEBPB_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
LEAP2_HUMAN [view interactions] High throughput no no
SPXN2_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
ATG4A_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
SGF29_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RHG24_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
PP2AB_HUMAN [view interactions] High throughput no yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MUC18_HUMAN [view interactions] High throughput no yes