WDR37_HUMAN
Evidence for PS localization
Functions
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 119 | Ser | Phe | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
| 125 | Thr | Ile | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
| 129 | Ser | Cys | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
| 130 | Thr | Ile | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
| 115 | Thr | Ile | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
| 119 | Ser | Tyr | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
| 220 | Asp | Gly | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
| 260 | Asp | Asn | Neurooculocardiogenitourinarysyndrome(NOCGUS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in WDR37_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 34.2857 | 4 | no |
| GO:0000166 | nucleotide binding | 31.4286 | 4 | no |
| GO:0003723 | RNA binding | 31.4286 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.4286 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 31.4286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.4286 | 4 | no |
| GO:0043168 | anion binding | 31.4286 | 4 | no |
| GO:0019901 | protein kinase binding | 31.4286 | 5 | no |
| GO:0005524 | ATP binding | 28.5714 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 28.5714 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.5714 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.5714 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 28.5714 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.5714 | 5 | no |
| GO:0016887 | ATP hydrolysis activity | 25.7143 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in WDR37_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 82.8571 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 80.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 74.2857 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 68.5714 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 54.2857 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 54.2857 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 54.2857 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 54.2857 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 54.2857 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 54.2857 | 4 | no |
| GO:0060341 | regulation of cellular localization | 48.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.7143 | 5 | no |
| GO:0032880 | regulation of protein localization | 45.7143 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 45.7143 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 45.7143 | 5 | no |
| GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 42.8571 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 40.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 40.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.0000 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 37.1429 | 5 | no |
| GO:0010468 | regulation of gene expression | 37.1429 | 6 | no |
| GO:0051049 | regulation of transport | 37.1429 | 4 | no |
| GO:0051338 | regulation of transferase activity | 34.2857 | 4 | no |
| GO:0008104 | protein localization | 34.2857 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 31.4286 | 7 | no |
| GO:0022607 | cellular component assembly | 31.4286 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 31.4286 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 31.4286 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 31.4286 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.5714 | 7 | no |
| GO:0031400 | negative regulation of protein modification process | 28.5714 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0033043 | regulation of organelle organization | 28.5714 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.7143 | 7 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.7143 | 6 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.7143 | 7 | no |
| GO:0051050 | positive regulation of transport | 25.7143 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.7143 | 6 | no |
| GO:0051347 | positive regulation of transferase activity | 25.7143 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.7143 | 6 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 25.7143 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.7143 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.7143 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.7143 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 25.7143 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.7143 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.8571 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.8571 | 4 | no |
| GO:0043549 | regulation of kinase activity | 22.8571 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.8571 | 8 | no |
| GO:0051726 | regulation of cell cycle | 22.8571 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 22.8571 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.8571 | 5 | no |
| GO:0050821 | protein stabilization | 22.8571 | 4 | no |
| GO:1900180 | regulation of protein localization to nucleus | 22.8571 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.8571 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.8571 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.8571 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WDR37_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACS2_HUMAN | [view interactions] | Low throughput | no | no |
| COCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| IF4G3_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIPB_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| ST65G_HUMAN | [view interactions] | High throughput | no | yes |
| TADA1_HUMAN | [view interactions] | High throughput | no | yes |
| TAD2B_HUMAN | [view interactions] | High throughput | no | yes |
| TAF5L_HUMAN | [view interactions] | High throughput | no | no |
| TAF6L_HUMAN | [view interactions] | High throughput | no | yes |
| ZZZ3_HUMAN | [view interactions] | High throughput | no | yes |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| YETS2_HUMAN | [view interactions] | High throughput | no | no |
| TADA3_HUMAN | [view interactions] | High throughput | no | yes |
| KAT2A_HUMAN | [view interactions] | High throughput | no | no |
| SUPT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRRAP_HUMAN | [view interactions] | High throughput | no | no |
| TAF9B_HUMAN | [view interactions] | High throughput | no | no |
| SP20H_HUMAN | [view interactions] | High throughput | no | yes |
| CSR2B_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG4A_HUMAN | [view interactions] | High throughput | no | yes |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEAP2_HUMAN | [view interactions] | High throughput | no | no |
| SPXN2_HUMAN | [view interactions] | High throughput | no | no |
| RS4Y1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SETD2_HUMAN | [view interactions] | High throughput | no | yes |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| LRC46_HUMAN | [view interactions] | High throughput | no | no |
| TOM70_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD13L_HUMAN | [view interactions] | High throughput | no | no |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB38_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCF1_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPB_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| TAD2A_HUMAN | [view interactions] | High throughput | no | no |