Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MINK1_HUMAN

Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MINK1_HUMAN
GO:0000166 nucleotide binding 40.7407 4 yes
GO:0017076 purine nucleotide binding 40.7407 5 yes
GO:0032555 purine ribonucleotide binding 40.7407 4 yes
GO:0043168 anion binding 40.7407 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.2716 4 yes
GO:0030554 adenyl nucleotide binding 24.6914 6 yes
GO:0032559 adenyl ribonucleotide binding 24.6914 5 yes
GO:0019900 kinase binding 24.6914 4 no
GO:0005524 ATP binding 22.2222 5 yes
GO:0019901 protein kinase binding 22.2222 5 no
GO:0003723 RNA binding 20.9877 4 no
GO:0016301 kinase activity 18.5185 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 18.5185 4 yes
GO:0004674 protein serine/threonine kinase activity 11.1111 4 yes
GO:0106310 protein serine kinase activity 9.8765 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MINK1_HUMAN
GO:0048522 positive regulation of cellular process 62.9630 4 yes
GO:0010646 regulation of cell communication 56.7901 4 yes
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 53.0864 4 no
GO:0031323 regulation of cellular metabolic process 53.0864 4 no
GO:0051128 regulation of cellular component organization 50.6173 4 no
GO:0080090 regulation of primary metabolic process 48.1481 4 no
GO:0009966 regulation of signal transduction 48.1481 4 yes
GO:0051246 regulation of protein metabolic process 41.9753 5 no
GO:0009893 positive regulation of metabolic process 40.7407 4 no
GO:0006996 organelle organization 39.5062 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 39.5062 5 no
GO:0008104 protein localization 38.2716 4 no
GO:0022607 cellular component assembly 38.2716 4 no
GO:0031325 positive regulation of cellular metabolic process 34.5679 5 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:1902531 regulation of intracellular signal transduction 33.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0009892 negative regulation of metabolic process 32.0988 4 no
GO:0010556 regulation of macromolecule biosynthetic process 32.0988 5 no
GO:0031326 regulation of cellular biosynthetic process 32.0988 5 no
GO:0031399 regulation of protein modification process 32.0988 6 no
GO:0010468 regulation of gene expression 30.8642 6 no
GO:0051247 positive regulation of protein metabolic process 30.8642 6 no
GO:0010605 negative regulation of macromolecule metabolic process 29.6296 5 no
GO:0010647 positive regulation of cell communication 29.6296 5 yes
GO:0023056 positive regulation of signaling 29.6296 4 yes
GO:0031344 regulation of cell projection organization 29.6296 5 no
GO:0042325 regulation of phosphorylation 29.6296 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.3951 6 no
GO:0001932 regulation of protein phosphorylation 28.3951 7 no
GO:0031324 negative regulation of cellular metabolic process 27.1605 5 no
GO:0009967 positive regulation of signal transduction 27.1605 5 yes
GO:0051049 regulation of transport 27.1605 4 yes
GO:0044087 regulation of cellular component biogenesis 25.9259 4 no
GO:0120036 plasma membrane bounded cell projection organization 24.6914 5 no
GO:0007010 cytoskeleton organization 24.6914 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 24.6914 4 no
GO:0051130 positive regulation of cellular component organization 23.4568 5 no
GO:0060341 regulation of cellular localization 23.4568 4 no
GO:0001934 positive regulation of protein phosphorylation 23.4568 8 no
GO:0010562 positive regulation of phosphorus metabolic process 23.4568 6 no
GO:0031401 positive regulation of protein modification process 23.4568 7 no
GO:0042327 positive regulation of phosphorylation 23.4568 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.4568 7 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0043412 macromolecule modification 22.2222 4 yes
GO:0141124 intracellular signaling cassette 22.2222 4 yes
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 yes
GO:0045595 regulation of cell differentiation 20.9877 4 no
GO:0033043 regulation of organelle organization 20.9877 5 no
GO:0006796 phosphate-containing compound metabolic process 20.9877 4 yes
GO:0036211 protein modification process 20.9877 4 yes
GO:0016310 phosphorylation 19.7531 5 yes
GO:0030334 regulation of cell migration 19.7531 5 yes
GO:0043408 regulation of MAPK cascade 19.7531 6 yes
GO:2000145 regulation of cell motility 19.7531 4 yes
GO:0030155 regulation of cell adhesion 18.5185 4 yes
GO:0006468 protein phosphorylation 17.2840 5 yes
GO:0022407 regulation of cell-cell adhesion 12.3457 5 yes
GO:0048812 neuron projection morphogenesis 12.3457 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 12.3457 4 yes
GO:0000165 MAPK cascade 11.1111 5 yes
GO:0043410 positive regulation of MAPK cascade 11.1111 7 yes
GO:0046777 protein autophosphorylation 11.1111 6 yes
GO:0034762 regulation of transmembrane transport 9.8765 4 yes
GO:0010810 regulation of cell-substrate adhesion 8.6420 5 yes
GO:0022898 regulation of transmembrane transporter activity 7.4074 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 7.4074 5 yes
GO:0046328 regulation of JNK cascade 7.4074 7 yes
GO:0099536 synaptic signaling 7.4074 4 yes
GO:0099537 trans-synaptic signaling 7.4074 5 yes
GO:0001952 regulation of cell-matrix adhesion 6.1728 6 yes
GO:0007268 chemical synaptic transmission 6.1728 7 yes
GO:0046330 positive regulation of JNK cascade 6.1728 8 yes
GO:0098916 anterograde trans-synaptic signaling 6.1728 6 yes
GO:0048813 dendrite morphogenesis 4.9383 6 yes
GO:0007420 brain development 3.7037 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 3.7037 4 yes
GO:1900744 regulation of p38MAPK cascade 3.7037 7 yes
GO:0007254 JNK cascade 2.4691 6 yes
GO:1900745 positive regulation of p38MAPK cascade 2.4691 8 yes
GO:2000311 regulation of AMPA receptor activity 2.4691 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAP2A_HUMAN [view entry] [view interactions] Low throughput yes yes
IER5_HUMAN [view interactions] Low throughput no yes
HSF1_HUMAN [view interactions] Low throughput no yes
NCK1_HUMAN [view interactions] Low throughput no yes
LATS1_HUMAN [view entry] [view interactions] Low throughput yes yes
M4K4_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
GRHL1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
TRI54_HUMAN [view interactions] High throughput no no
CNOT1_HUMAN [view interactions] High throughput no yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT3_HUMAN [view interactions] High throughput no yes
GPC4_HUMAN [view entry] [view interactions] High throughput yes yes
UBR5_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
CAV1_HUMAN [view interactions] High throughput no no
STRN3_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
STRP1_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
CNKR3_HUMAN [view interactions] High throughput no yes
GLT13_HUMAN [view interactions] High throughput no no
CNOT9_HUMAN [view interactions] High throughput no yes
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
TB182_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT2_HUMAN [view interactions] High throughput no yes
CT2NL_HUMAN [view interactions] High throughput no yes
CNOT7_HUMAN [view interactions] High throughput no no
CNO11_HUMAN [view interactions] High throughput no yes
NUDC_HUMAN [view interactions] High throughput no yes
KLH20_HUMAN [view interactions] High throughput no yes
SGT1_HUMAN [view interactions] High throughput no no
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
GPC6_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
MYOME_HUMAN [view interactions] High throughput no no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
EGLN_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
EPHA5_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
KCNK3_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
TX264_HUMAN [view interactions] High throughput no no
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
ATM_HUMAN [view interactions] High throughput no yes
NANO2_HUMAN [view interactions] High throughput no no
PR15A_HUMAN [view interactions] High throughput no yes
SEN15_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
ZRAB2_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
DDA1_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
DCAF1_HUMAN [view interactions] High throughput no yes
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
BRX1_HUMAN [view interactions] High throughput no no
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
RL36_HUMAN [view entry] [view interactions] High throughput yes yes
FGOP2_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
GTF2I_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH10_HUMAN [view interactions] High throughput no yes
AP3M1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC9_HUMAN [view interactions] High throughput no yes
CG050_HUMAN [view interactions] High throughput no yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
RL30_HUMAN [view entry] [view interactions] High throughput yes yes
EBP2_HUMAN [view interactions] High throughput no yes
PPBI_HUMAN [view interactions] High throughput no no
SRRM2_HUMAN [view interactions] High throughput no yes
RL37A_HUMAN [view entry] [view interactions] High throughput yes yes
U2AF1_HUMAN [view interactions] High throughput no yes
HNRC3_HUMAN [view interactions] High throughput no no
RCC2_HUMAN [view interactions] High throughput no no
RL34_HUMAN [view entry] [view interactions] High throughput yes yes
RSMB_HUMAN [view interactions] High throughput no yes
FACOS_HUMAN [view interactions] High throughput no no
CNO6L_HUMAN [view interactions] High throughput no no
V1BR_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
RPGF1_HUMAN [view interactions] High throughput no yes
BAKOR_HUMAN [view interactions] High throughput no yes
SL9A8_HUMAN [view interactions] High throughput no yes
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
T3JAM_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
RIOK2_HUMAN [view interactions] High throughput no yes
SH24A_HUMAN [view interactions] High throughput no no
ABT1_HUMAN [view interactions] High throughput no no
FNTB_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
CNO10_HUMAN [view interactions] High throughput no yes
GTPB1_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
ALKB5_HUMAN [view interactions] High throughput no yes
ERC6L_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
PKNX1_HUMAN [view interactions] High throughput no yes
HEMH_HUMAN [view interactions] High throughput no yes
NFYA_HUMAN [view interactions] High throughput no yes
TCP4_HUMAN [view interactions] High throughput no yes
STK26_HUMAN [view interactions] High throughput no no
PARPT_HUMAN [view interactions] High throughput no no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
NOP2_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
PRD15_HUMAN [view interactions] High throughput no no
GTPB3_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
PTPRK_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
E41LA_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
ARL4C_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
ARL15_HUMAN [view interactions] High throughput no yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
MOB3B_HUMAN [view interactions] High throughput no no
MOB3C_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes