MINK1_HUMAN
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MINK1_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 40.7407 | 4 | yes |
GO:0017076 | purine nucleotide binding | 40.7407 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 40.7407 | 4 | yes |
GO:0043168 | anion binding | 40.7407 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 38.2716 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 24.6914 | 6 | yes |
GO:0032559 | adenyl ribonucleotide binding | 24.6914 | 5 | yes |
GO:0019900 | kinase binding | 24.6914 | 4 | no |
GO:0005524 | ATP binding | 22.2222 | 5 | yes |
GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
GO:0003723 | RNA binding | 20.9877 | 4 | no |
GO:0016301 | kinase activity | 18.5185 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.5185 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 11.1111 | 4 | yes |
GO:0106310 | protein serine kinase activity | 9.8765 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MINK1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 62.9630 | 4 | yes |
GO:0010646 | regulation of cell communication | 56.7901 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 55.5556 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 53.0864 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 53.0864 | 4 | no |
GO:0051128 | regulation of cellular component organization | 50.6173 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 48.1481 | 4 | no |
GO:0009966 | regulation of signal transduction | 48.1481 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 41.9753 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 40.7407 | 4 | no |
GO:0006996 | organelle organization | 39.5062 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 39.5062 | 5 | no |
GO:0008104 | protein localization | 38.2716 | 4 | no |
GO:0022607 | cellular component assembly | 38.2716 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 34.5679 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
GO:0030030 | cell projection organization | 33.3333 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 32.0988 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 32.0988 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 32.0988 | 5 | no |
GO:0031399 | regulation of protein modification process | 32.0988 | 6 | no |
GO:0010468 | regulation of gene expression | 30.8642 | 6 | no |
GO:0051247 | positive regulation of protein metabolic process | 30.8642 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 29.6296 | 5 | no |
GO:0010647 | positive regulation of cell communication | 29.6296 | 5 | yes |
GO:0023056 | positive regulation of signaling | 29.6296 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 29.6296 | 5 | no |
GO:0042325 | regulation of phosphorylation | 29.6296 | 7 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.3951 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 28.3951 | 7 | no |
GO:0031324 | negative regulation of cellular metabolic process | 27.1605 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 27.1605 | 5 | yes |
GO:0051049 | regulation of transport | 27.1605 | 4 | yes |
GO:0044087 | regulation of cellular component biogenesis | 25.9259 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 24.6914 | 5 | no |
GO:0007010 | cytoskeleton organization | 24.6914 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 24.6914 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 23.4568 | 5 | no |
GO:0060341 | regulation of cellular localization | 23.4568 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 23.4568 | 8 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 23.4568 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 23.4568 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 23.4568 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 23.4568 | 7 | no |
GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
GO:0042981 | regulation of apoptotic process | 22.2222 | 5 | no |
GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
GO:0043412 | macromolecule modification | 22.2222 | 4 | yes |
GO:0141124 | intracellular signaling cassette | 22.2222 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | yes |
GO:0045595 | regulation of cell differentiation | 20.9877 | 4 | no |
GO:0033043 | regulation of organelle organization | 20.9877 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 20.9877 | 4 | yes |
GO:0036211 | protein modification process | 20.9877 | 4 | yes |
GO:0016310 | phosphorylation | 19.7531 | 5 | yes |
GO:0030334 | regulation of cell migration | 19.7531 | 5 | yes |
GO:0043408 | regulation of MAPK cascade | 19.7531 | 6 | yes |
GO:2000145 | regulation of cell motility | 19.7531 | 4 | yes |
GO:0030155 | regulation of cell adhesion | 18.5185 | 4 | yes |
GO:0006468 | protein phosphorylation | 17.2840 | 5 | yes |
GO:0022407 | regulation of cell-cell adhesion | 12.3457 | 5 | yes |
GO:0048812 | neuron projection morphogenesis | 12.3457 | 5 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 12.3457 | 4 | yes |
GO:0000165 | MAPK cascade | 11.1111 | 5 | yes |
GO:0043410 | positive regulation of MAPK cascade | 11.1111 | 7 | yes |
GO:0046777 | protein autophosphorylation | 11.1111 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 9.8765 | 4 | yes |
GO:0010810 | regulation of cell-substrate adhesion | 8.6420 | 5 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 7.4074 | 4 | yes |
GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 7.4074 | 5 | yes |
GO:0046328 | regulation of JNK cascade | 7.4074 | 7 | yes |
GO:0099536 | synaptic signaling | 7.4074 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 7.4074 | 5 | yes |
GO:0001952 | regulation of cell-matrix adhesion | 6.1728 | 6 | yes |
GO:0007268 | chemical synaptic transmission | 6.1728 | 7 | yes |
GO:0046330 | positive regulation of JNK cascade | 6.1728 | 8 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 6.1728 | 6 | yes |
GO:0048813 | dendrite morphogenesis | 4.9383 | 6 | yes |
GO:0007420 | brain development | 3.7037 | 4 | yes |
GO:0099601 | regulation of neurotransmitter receptor activity | 3.7037 | 4 | yes |
GO:1900744 | regulation of p38MAPK cascade | 3.7037 | 7 | yes |
GO:0007254 | JNK cascade | 2.4691 | 6 | yes |
GO:1900745 | positive regulation of p38MAPK cascade | 2.4691 | 8 | yes |
GO:2000311 | regulation of AMPA receptor activity | 2.4691 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RAP2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IER5_HUMAN | [view interactions] | Low throughput | no | yes |
HSF1_HUMAN | [view interactions] | Low throughput | no | yes |
NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
LATS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
M4K4_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
GRHL1_HUMAN | [view interactions] | High throughput | no | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI54_HUMAN | [view interactions] | High throughput | no | no |
CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
GPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR5_HUMAN | [view interactions] | High throughput | no | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
STRP1_HUMAN | [view interactions] | High throughput | no | yes |
CAVN1_HUMAN | [view interactions] | High throughput | no | no |
CNKR3_HUMAN | [view interactions] | High throughput | no | yes |
GLT13_HUMAN | [view interactions] | High throughput | no | no |
CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TB182_HUMAN | [view interactions] | High throughput | no | yes |
CPVL_HUMAN | [view interactions] | High throughput | no | no |
WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
CT2NL_HUMAN | [view interactions] | High throughput | no | yes |
CNOT7_HUMAN | [view interactions] | High throughput | no | no |
CNO11_HUMAN | [view interactions] | High throughput | no | yes |
NUDC_HUMAN | [view interactions] | High throughput | no | yes |
KLH20_HUMAN | [view interactions] | High throughput | no | yes |
SGT1_HUMAN | [view interactions] | High throughput | no | no |
PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGLN_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EPHA5_HUMAN | [view interactions] | High throughput | no | no |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TX264_HUMAN | [view interactions] | High throughput | no | no |
NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATM_HUMAN | [view interactions] | High throughput | no | yes |
NANO2_HUMAN | [view interactions] | High throughput | no | no |
PR15A_HUMAN | [view interactions] | High throughput | no | yes |
SEN15_HUMAN | [view interactions] | High throughput | no | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
INS_HUMAN | [view interactions] | High throughput | no | no |
ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDA1_HUMAN | [view interactions] | High throughput | no | yes |
OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRX1_HUMAN | [view interactions] | High throughput | no | no |
RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL36_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGOP2_HUMAN | [view interactions] | High throughput | no | yes |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
CG050_HUMAN | [view interactions] | High throughput | no | yes |
AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EBP2_HUMAN | [view interactions] | High throughput | no | yes |
PPBI_HUMAN | [view interactions] | High throughput | no | no |
SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
RL37A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
U2AF1_HUMAN | [view interactions] | High throughput | no | yes |
HNRC3_HUMAN | [view interactions] | High throughput | no | no |
RCC2_HUMAN | [view interactions] | High throughput | no | no |
RL34_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RSMB_HUMAN | [view interactions] | High throughput | no | yes |
FACOS_HUMAN | [view interactions] | High throughput | no | no |
CNO6L_HUMAN | [view interactions] | High throughput | no | no |
V1BR_HUMAN | [view interactions] | High throughput | no | no |
EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
RPGF1_HUMAN | [view interactions] | High throughput | no | yes |
BAKOR_HUMAN | [view interactions] | High throughput | no | yes |
SL9A8_HUMAN | [view interactions] | High throughput | no | yes |
INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEBP_HUMAN | [view interactions] | High throughput | no | yes |
T3JAM_HUMAN | [view interactions] | High throughput | no | no |
ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
RIOK2_HUMAN | [view interactions] | High throughput | no | yes |
SH24A_HUMAN | [view interactions] | High throughput | no | no |
ABT1_HUMAN | [view interactions] | High throughput | no | no |
FNTB_HUMAN | [view interactions] | High throughput | no | no |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
CNO10_HUMAN | [view interactions] | High throughput | no | yes |
GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
ALKB5_HUMAN | [view interactions] | High throughput | no | yes |
ERC6L_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
PKNX1_HUMAN | [view interactions] | High throughput | no | yes |
HEMH_HUMAN | [view interactions] | High throughput | no | yes |
NFYA_HUMAN | [view interactions] | High throughput | no | yes |
TCP4_HUMAN | [view interactions] | High throughput | no | yes |
STK26_HUMAN | [view interactions] | High throughput | no | no |
PARPT_HUMAN | [view interactions] | High throughput | no | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
NED4L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOP2_HUMAN | [view interactions] | High throughput | no | yes |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRD15_HUMAN | [view interactions] | High throughput | no | no |
GTPB3_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTPRK_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
E41LA_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
AR13B_HUMAN | [view interactions] | High throughput | no | yes |
ARL14_HUMAN | [view interactions] | High throughput | no | no |
ARL15_HUMAN | [view interactions] | High throughput | no | yes |
CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTK7_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOB3B_HUMAN | [view interactions] | High throughput | no | no |
MOB3C_HUMAN | [view interactions] | High throughput | no | no |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |