GPC6_HUMAN
Evidence for PS localization
Functions
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases . Enhances migration and invasion of cancer cells through WNT5A signaling. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPC6_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 38.4615 | 4 | no |
| GO:0000166 | nucleotide binding | 30.7692 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.7692 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 30.7692 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 30.7692 | 5 | no |
| GO:0004674 | protein serine/threonine kinase activity | 23.0769 | 4 | no |
| GO:0005524 | ATP binding | 23.0769 | 5 | no |
| GO:0016301 | kinase activity | 23.0769 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 23.0769 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.0769 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPC6_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 69.2308 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 61.5385 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.1538 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 38.4615 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.4615 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 38.4615 | 4 | no |
| GO:0050807 | regulation of synapse organization | 38.4615 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 38.4615 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.7692 | 4 | no |
| GO:0006996 | organelle organization | 30.7692 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.7692 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 30.7692 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 23.0769 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 23.0769 | 6 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 23.0769 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.0769 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.0769 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.0769 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 23.0769 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0022407 | regulation of cell-cell adhesion | 23.0769 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 23.0769 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.0769 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0031347 | regulation of defense response | 23.0769 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 23.0769 | 4 | no |
| GO:0032868 | response to insulin | 23.0769 | 5 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0043434 | response to peptide hormone | 23.0769 | 4 | no |
| GO:0045088 | regulation of innate immune response | 23.0769 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 23.0769 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.0769 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.0769 | 4 | no |
| GO:0050776 | regulation of immune response | 23.0769 | 4 | no |
| GO:0051049 | regulation of transport | 23.0769 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.0769 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0080134 | regulation of response to stress | 23.0769 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 23.0769 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0099536 | synaptic signaling | 23.0769 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 23.0769 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
| GO:0051960 | regulation of nervous system development | 23.0769 | 5 | no |
| GO:0051963 | regulation of synapse assembly | 23.0769 | 6 | no |
| GO:1901888 | regulation of cell junction assembly | 23.0769 | 5 | no |
| GO:0008104 | protein localization | 23.0769 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0042176 | regulation of protein catabolic process | 23.0769 | 5 | no |
| GO:1902473 | regulation of protein localization to synapse | 15.3846 | 6 | yes |
| GO:1902683 | regulation of receptor localization to synapse | 15.3846 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GP183_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| GPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGLYR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| OGFD3_HUMAN | [view interactions] | High throughput | no | no |
| ZACN_HUMAN | [view interactions] | High throughput | no | no |
| CHST8_HUMAN | [view interactions] | High throughput | no | no |
| PLTP_HUMAN | [view interactions] | High throughput | no | no |
| SCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLX4_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| HEPS_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| MLX_HUMAN | [view interactions] | High throughput | no | yes |
| LRIQ1_HUMAN | [view interactions] | High throughput | no | no |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |