GPC6_HUMAN
Evidence for PS localization
Functions
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases . Enhances migration and invasion of cancer cells through WNT5A signaling. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPC6_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 30.0000 | 4 | no |
| GO:0071936 | coreceptor activity involved in Wnt signaling pathway | 10.0000 | 4 | yes |
| GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway | 10.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPC6_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 45.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 35.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | no |
| GO:0036211 | protein modification process | 30.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 30.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 25.0000 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:1904375 | regulation of protein localization to cell periphery | 20.0000 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 20.0000 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 15.0000 | 4 | yes |
| GO:0051963 | regulation of synapse assembly | 15.0000 | 6 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 15.0000 | 4 | yes |
| GO:0099560 | synaptic membrane adhesion | 15.0000 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 15.0000 | 5 | yes |
| GO:0099174 | regulation of presynapse organization | 10.0000 | 6 | yes |
| GO:1902473 | regulation of protein localization to synapse | 10.0000 | 6 | yes |
| GO:1902683 | regulation of receptor localization to synapse | 10.0000 | 4 | yes |
| GO:1905606 | regulation of presynapse assembly | 10.0000 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GPC6_HUMAN |
|---|---|---|---|---|
| DOID:1697 | ichthyosis | 10.0000 | 4 | no |
| DOID:37 | skin disease | 10.0000 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| GP183_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| GPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP158_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| OGFD3_HUMAN | [view interactions] | High throughput | no | no |
| ZACN_HUMAN | [view interactions] | High throughput | no | no |
| CHST8_HUMAN | [view interactions] | High throughput | no | no |
| PLTP_HUMAN | [view interactions] | High throughput | no | no |
| SCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLX4_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| HEPS_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| MLX_HUMAN | [view interactions] | High throughput | no | yes |
| LRIQ1_HUMAN | [view interactions] | High throughput | no | no |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| SDC2_HUMAN | [view interactions] | Computational | no | yes |
| LRP10_HUMAN | [view interactions] | Computational | no | no |
| NDST1_HUMAN | [view interactions] | Computational | no | yes |
| B3GT6_HUMAN | [view interactions] | Computational | no | no |
| HS3SB_HUMAN | [view interactions] | Computational | no | no |
| HPSE2_HUMAN | [view interactions] | Computational | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PGS1_HUMAN | [view interactions] | Computational | no | no |
| CSPG4_HUMAN | [view interactions] | Computational | no | yes |
| LRP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PGCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS3S4_HUMAN | [view interactions] | Computational | no | no |
| LRP8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GLCE_HUMAN | [view interactions] | Computational | no | yes |
| NDST2_HUMAN | [view interactions] | Computational | no | no |
| H6ST3_HUMAN | [view interactions] | Computational | no | no |
| HS2ST_HUMAN | [view interactions] | Computational | no | yes |
| H6ST2_HUMAN | [view interactions] | Computational | no | no |
| CSPG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NDST4_HUMAN | [view interactions] | Computational | no | no |
| CSPG5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| B3GA2_HUMAN | [view interactions] | Computational | no | no |
| EXT2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WNT1_HUMAN | [view interactions] | Computational | no | no |
| PGBM_HUMAN | [view interactions] | Computational | no | no |
| LRP12_HUMAN | [view interactions] | Computational | no | yes |
| HS3S5_HUMAN | [view interactions] | Computational | no | yes |
| XYLT2_HUMAN | [view interactions] | Computational | no | no |
| HS3S6_HUMAN | [view interactions] | Computational | no | no |
| XYLT1_HUMAN | [view interactions] | Computational | no | yes |
| HS3S1_HUMAN | [view interactions] | Computational | no | yes |
| B3GA1_HUMAN | [view interactions] | Computational | no | yes |
| NDST3_HUMAN | [view interactions] | Computational | no | yes |
| EXT1_HUMAN | [view interactions] | Computational | no | yes |
| B4GT7_HUMAN | [view interactions] | Computational | no | yes |
| PGS2_HUMAN | [view interactions] | Computational | no | no |
| HS3S2_HUMAN | [view interactions] | Computational | no | yes |
| HPSE_HUMAN | [view interactions] | Computational | no | no |
| HS3SA_HUMAN | [view interactions] | Computational | no | yes |
| H6ST1_HUMAN | [view interactions] | Computational | no | no |
| NCAN_HUMAN | [view entry] [view interactions] | Computational | yes | no |