Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDPK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDPK1_HUMAN
GO:0017076 purine nucleotide binding 42.2222 4 yes
GO:0030554 adenyl nucleotide binding 41.1111 5 yes
GO:0032555 purine ribonucleotide binding 41.1111 4 yes
GO:0032559 adenyl ribonucleotide binding 40.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 yes
GO:0005524 ATP binding 38.8889 5 yes
GO:0016301 kinase activity 26.6667 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 26.6667 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 25.5556 4 yes
GO:0003723 RNA binding 25.5556 4 no
GO:0004674 protein serine/threonine kinase activity 24.4444 4 yes
GO:0046872 metal ion binding 24.4444 4 no
GO:0106310 protein serine kinase activity 23.3333 4 yes
GO:0031625 ubiquitin protein ligase binding 23.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 23.3333 4 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0043274 phospholipase binding 4.4444 4 yes
GO:0016004 phospholipase activator activity 3.3333 5 yes
GO:0060229 lipase activator activity 3.3333 4 yes
GO:0004676 3-phosphoinositide-dependent protein kinase activity 2.2222 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDPK1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 72.2222 4 yes
GO:0080090 regulation of primary metabolic process 68.8889 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 67.7778 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0048522 positive regulation of cellular process 62.2222 4 yes
GO:0010646 regulation of cell communication 61.1111 4 yes
GO:0009966 regulation of signal transduction 60.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 yes
GO:0010468 regulation of gene expression 54.4444 5 no
GO:0051246 regulation of protein metabolic process 52.2222 5 yes
GO:0009893 positive regulation of metabolic process 52.2222 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.8889 5 yes
GO:0031325 positive regulation of cellular metabolic process 46.6667 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 45.5556 5 yes
GO:0009889 regulation of biosynthetic process 45.5556 4 no
GO:0051128 regulation of cellular component organization 45.5556 4 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 43.3333 5 no
GO:0009892 negative regulation of metabolic process 42.2222 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.1111 5 no
GO:0031399 regulation of protein modification process 41.1111 6 yes
GO:0071310 cellular response to organic substance 40.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 yes
GO:0006796 phosphate-containing compound metabolic process 38.8889 4 yes
GO:0051174 regulation of phosphorus metabolic process 37.7778 5 yes
GO:0048584 positive regulation of response to stimulus 37.7778 4 no
GO:0019220 regulation of phosphate metabolic process 37.7778 6 yes
GO:0036211 protein modification process 37.7778 4 yes
GO:0043412 macromolecule modification 37.7778 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 36.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 36.6667 6 yes
GO:1902531 regulation of intracellular signal transduction 36.6667 5 yes
GO:0010647 positive regulation of cell communication 35.5556 5 no
GO:0023056 positive regulation of signaling 35.5556 4 no
GO:0009967 positive regulation of signal transduction 34.4444 5 no
GO:0010941 regulation of cell death 34.4444 4 yes
GO:0031324 negative regulation of cellular metabolic process 34.4444 5 yes
GO:0051049 regulation of transport 34.4444 4 yes
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 5 yes
GO:0008104 protein localization 32.2222 4 no
GO:0045595 regulation of cell differentiation 32.2222 4 no
GO:0042325 regulation of phosphorylation 32.2222 7 yes
GO:0060341 regulation of cellular localization 31.1111 4 yes
GO:0010243 response to organonitrogen compound 31.1111 4 yes
GO:0010648 negative regulation of cell communication 31.1111 5 yes
GO:0023057 negative regulation of signaling 31.1111 4 yes
GO:0042981 regulation of apoptotic process 31.1111 6 yes
GO:0048585 negative regulation of response to stimulus 31.1111 4 yes
GO:1901701 cellular response to oxygen-containing compound 30.0000 4 yes
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0006996 organelle organization 30.0000 4 yes
GO:0009968 negative regulation of signal transduction 30.0000 5 yes
GO:0032880 regulation of protein localization 30.0000 5 yes
GO:0060548 negative regulation of cell death 28.8889 5 yes
GO:0006355 regulation of DNA-templated transcription 28.8889 6 no
GO:1903506 regulation of nucleic acid-templated transcription 28.8889 7 no
GO:2001141 regulation of RNA biosynthetic process 28.8889 6 no
GO:0001932 regulation of protein phosphorylation 28.8889 7 yes
GO:0016310 phosphorylation 28.8889 5 yes
GO:0031401 positive regulation of protein modification process 28.8889 7 yes
GO:0042127 regulation of cell population proliferation 28.8889 4 yes
GO:0051094 positive regulation of developmental process 28.8889 4 yes
GO:0022607 cellular component assembly 27.7778 4 no
GO:0044087 regulation of cellular component biogenesis 27.7778 4 no
GO:0018193 peptidyl-amino acid modification 27.7778 5 yes
GO:0043085 positive regulation of catalytic activity 27.7778 4 yes
GO:0051240 positive regulation of multicellular organismal process 26.6667 4 yes
GO:0051248 negative regulation of protein metabolic process 26.6667 6 yes
GO:0051338 regulation of transferase activity 26.6667 4 yes
GO:0009891 positive regulation of biosynthetic process 26.6667 5 no
GO:0006468 protein phosphorylation 26.6667 5 yes
GO:0043066 negative regulation of apoptotic process 26.6667 7 yes
GO:0043069 negative regulation of programmed cell death 26.6667 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.5556 6 no
GO:0031329 regulation of cellular catabolic process 25.5556 5 no
GO:2000026 regulation of multicellular organismal development 24.4444 4 yes
GO:2000145 regulation of cell motility 24.4444 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 24.4444 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.4444 6 no
GO:0071702 organic substance transport 24.4444 4 no
GO:0033043 regulation of organelle organization 24.4444 5 no
GO:0051726 regulation of cell cycle 24.4444 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.4444 6 yes
GO:0018209 peptidyl-serine modification 24.4444 6 yes
GO:0045937 positive regulation of phosphate metabolic process 24.4444 7 yes
GO:0051336 regulation of hydrolase activity 23.3333 4 yes
GO:0051130 positive regulation of cellular component organization 23.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.3333 6 no
GO:0018105 peptidyl-serine phosphorylation 23.3333 6 yes
GO:0030334 regulation of cell migration 23.3333 5 yes
GO:0042327 positive regulation of phosphorylation 23.3333 8 yes
GO:1901699 cellular response to nitrogen compound 22.2222 4 yes
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 yes
GO:0071417 cellular response to organonitrogen compound 21.1111 4 yes
GO:2000147 positive regulation of cell motility 21.1111 5 yes
GO:0006915 apoptotic process 21.1111 4 no
GO:0010628 positive regulation of gene expression 21.1111 6 no
GO:0008284 positive regulation of cell population proliferation 21.1111 5 yes
GO:0030335 positive regulation of cell migration 21.1111 6 yes
GO:0031400 negative regulation of protein modification process 21.1111 7 yes
GO:0040017 positive regulation of locomotion 21.1111 4 yes
GO:0043549 regulation of kinase activity 21.1111 5 yes
GO:0051347 positive regulation of transferase activity 20.0000 5 yes
GO:1901652 response to peptide 20.0000 4 yes
GO:1903829 positive regulation of protein localization 20.0000 5 yes
GO:0045859 regulation of protein kinase activity 20.0000 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 18.8889 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 18.8889 4 yes
GO:0032870 cellular response to hormone stimulus 18.8889 4 yes
GO:0045936 negative regulation of phosphate metabolic process 18.8889 7 yes
GO:0002684 positive regulation of immune system process 17.7778 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 17.7778 4 yes
GO:0043086 negative regulation of catalytic activity 17.7778 4 yes
GO:0043434 response to peptide hormone 17.7778 4 yes
GO:0050776 regulation of immune response 17.7778 4 yes
GO:0051050 positive regulation of transport 17.7778 4 yes
GO:0051345 positive regulation of hydrolase activity 16.6667 5 yes
GO:0007010 cytoskeleton organization 16.6667 5 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 16.6667 5 yes
GO:0034762 regulation of transmembrane transport 16.6667 4 yes
GO:1901653 cellular response to peptide 15.5556 5 yes
GO:0010632 regulation of epithelial cell migration 15.5556 4 yes
GO:0032868 response to insulin 15.5556 5 yes
GO:0033674 positive regulation of kinase activity 15.5556 6 yes
GO:0045860 positive regulation of protein kinase activity 14.4444 7 yes
GO:0051348 negative regulation of transferase activity 13.3333 5 yes
GO:0060627 regulation of vesicle-mediated transport 13.3333 4 yes
GO:0070848 response to growth factor 13.3333 4 yes
GO:0071375 cellular response to peptide hormone stimulus 13.3333 5 yes
GO:0010634 positive regulation of epithelial cell migration 13.3333 5 yes
GO:0032869 cellular response to insulin stimulus 12.2222 6 yes
GO:0042326 negative regulation of phosphorylation 12.2222 8 yes
GO:0050865 regulation of cell activation 12.2222 4 yes
GO:0071363 cellular response to growth factor stimulus 11.1111 5 yes
GO:0090287 regulation of cellular response to growth factor stimulus 11.1111 4 yes
GO:1905475 regulation of protein localization to membrane 11.1111 6 yes
GO:0001933 negative regulation of protein phosphorylation 11.1111 8 yes
GO:0010594 regulation of endothelial cell migration 11.1111 5 yes
GO:0018107 peptidyl-threonine phosphorylation 11.1111 6 yes
GO:0018210 peptidyl-threonine modification 11.1111 6 yes
GO:0043269 regulation of ion transport 11.1111 5 yes
GO:1901342 regulation of vasculature development 10.0000 5 yes
GO:0006469 negative regulation of protein kinase activity 10.0000 7 yes
GO:0010595 positive regulation of endothelial cell migration 10.0000 6 yes
GO:0033673 negative regulation of kinase activity 10.0000 6 yes
GO:0045765 regulation of angiogenesis 10.0000 5 yes
GO:0050678 regulation of epithelial cell proliferation 10.0000 5 yes
GO:1904018 positive regulation of vasculature development 8.8889 5 yes
GO:1904062 regulation of cation transmembrane transport 8.8889 6 yes
GO:1904375 regulation of protein localization to cell periphery 8.8889 6 yes
GO:0002694 regulation of leukocyte activation 8.8889 4 yes
GO:0010959 regulation of metal ion transport 8.8889 6 yes
GO:0032147 activation of protein kinase activity 8.8889 8 yes
GO:0034765 regulation of ion transmembrane transport 8.8889 5 yes
GO:0038127 ERBB signaling pathway 8.8889 6 yes
GO:0045766 positive regulation of angiogenesis 8.8889 6 yes
GO:0046777 protein autophosphorylation 8.8889 6 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 7.7778 5 yes
GO:1903530 regulation of secretion by cell 7.7778 4 yes
GO:0001936 regulation of endothelial cell proliferation 7.7778 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 7.7778 7 yes
GO:0007173 epidermal growth factor receptor signaling pathway 7.7778 7 yes
GO:0043535 regulation of blood vessel endothelial cell migration 7.7778 6 yes
GO:0050679 positive regulation of epithelial cell proliferation 7.7778 6 yes
GO:0051046 regulation of secretion 7.7778 5 yes
GO:0051282 regulation of sequestering of calcium ion 6.6667 4 yes
GO:0051924 regulation of calcium ion transport 6.6667 7 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 6.6667 6 yes
GO:1903169 regulation of calcium ion transmembrane transport 6.6667 7 yes
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 6.6667 5 yes
GO:1905477 positive regulation of protein localization to membrane 6.6667 6 yes
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 6.6667 6 yes
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 6.6667 7 yes
GO:0034764 positive regulation of transmembrane transport 6.6667 5 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 6.6667 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 6.6667 7 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 5.5556 5 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 5.5556 5 yes
GO:1903076 regulation of protein localization to plasma membrane 5.5556 7 yes
GO:1903078 positive regulation of protein localization to plasma membrane 5.5556 7 yes
GO:1903305 regulation of regulated secretory pathway 5.5556 6 yes
GO:1904377 positive regulation of protein localization to cell periphery 5.5556 6 yes
GO:0002064 epithelial cell development 5.5556 4 yes
GO:0017157 regulation of exocytosis 5.5556 5 yes
GO:0032148 activation of protein kinase B activity 5.5556 9 yes
GO:0060191 regulation of lipase activity 4.4444 5 yes
GO:0060193 positive regulation of lipase activity 4.4444 6 yes
GO:0071364 cellular response to epidermal growth factor stimulus 4.4444 4 yes
GO:0002697 regulation of immune effector process 4.4444 4 yes
GO:0010517 regulation of phospholipase activity 4.4444 6 yes
GO:0010518 positive regulation of phospholipase activity 4.4444 7 yes
GO:0019722 calcium-mediated signaling 4.4444 5 yes
GO:0019932 second-messenger-mediated signaling 4.4444 4 yes
GO:0097191 extrinsic apoptotic signaling pathway 3.3333 4 yes
GO:1903670 regulation of sprouting angiogenesis 3.3333 6 yes
GO:1903672 positive regulation of sprouting angiogenesis 3.3333 7 yes
GO:1904035 regulation of epithelial cell apoptotic process 3.3333 7 yes
GO:1905562 regulation of vascular endothelial cell proliferation 3.3333 7 yes
GO:1905564 positive regulation of vascular endothelial cell proliferation 3.3333 8 yes
GO:2000351 regulation of endothelial cell apoptotic process 3.3333 8 yes
GO:0002066 columnar/cuboidal epithelial cell development 3.3333 5 yes
GO:0002699 positive regulation of immune effector process 3.3333 5 yes
GO:0002703 regulation of leukocyte mediated immunity 3.3333 5 yes
GO:0006972 hyperosmotic response 3.3333 4 yes
GO:0010656 negative regulation of muscle cell apoptotic process 3.3333 8 yes
GO:0010660 regulation of muscle cell apoptotic process 3.3333 7 yes
GO:0034121 regulation of toll-like receptor signaling pathway 3.3333 6 yes
GO:0043270 positive regulation of ion transport 3.3333 5 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2.2222 6 yes
GO:0051928 positive regulation of calcium ion transport 2.2222 6 yes
GO:1904036 negative regulation of epithelial cell apoptotic process 2.2222 8 yes
GO:1904064 positive regulation of cation transmembrane transport 2.2222 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 2.2222 7 yes
GO:2000352 negative regulation of endothelial cell apoptotic process 2.2222 9 yes
GO:0002068 glandular epithelial cell development 2.2222 6 yes
GO:0002886 regulation of myeloid leukocyte mediated immunity 2.2222 6 yes
GO:0003323 type B pancreatic cell development 2.2222 7 yes
GO:0010662 regulation of striated muscle cell apoptotic process 2.2222 8 yes
GO:0010664 negative regulation of striated muscle cell apoptotic process 2.2222 9 yes
GO:0010665 regulation of cardiac muscle cell apoptotic process 2.2222 9 yes
GO:0010667 negative regulation of cardiac muscle cell apoptotic process 2.2222 10 yes
GO:0033003 regulation of mast cell activation 2.2222 5 yes
GO:0033006 regulation of mast cell activation involved in immune response 2.2222 5 yes
GO:0034122 negative regulation of toll-like receptor signaling pathway 2.2222 6 yes
GO:0034767 positive regulation of ion transmembrane transport 2.2222 6 yes
GO:0043300 regulation of leukocyte degranulation 2.2222 5 yes
GO:0043304 regulation of mast cell degranulation 2.2222 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in PDPK1_HUMAN
DOID:9351 diabetes mellitus 2.2222 6 no
DOID:9352 type 2 diabetes mellitus 2.2222 7 no
DOID:0050686 organ system cancer 2.2222 3 no
DOID:6457 Cowden syndrome 2.2222 3 no
DOID:0081062 diabetes 2.2222 5 no
DOID:2978 carbohydrate metabolic disorder 2.2222 3 no
DOID:4194 glucose metabolism disease 2.2222 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SPOP_HUMAN [view interactions] Low throughput no no
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
MK08_HUMAN [view interactions] Low throughput no yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
CAR11_HUMAN [view interactions] Low throughput no no
PDPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
2ABB_HUMAN [view interactions] Low throughput no yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCI_HUMAN [view entry] [view interactions] Low throughput yes yes
KC1D_HUMAN [view entry] [view interactions] Low throughput yes yes
KC1E_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
ULK1_HUMAN [view interactions] Low throughput no no
CBLB_HUMAN [view interactions] Low throughput no yes
B2CL1_HUMAN [view interactions] Low throughput no yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
SGK1_HUMAN [view interactions] Low throughput no yes
ADA17_HUMAN [view interactions] Low throughput no yes
WDR5_HUMAN [view interactions] Low throughput no no
KS6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
PKN2_HUMAN [view interactions] Low throughput no yes
PKN1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF2_HUMAN [view entry] [view interactions] Low throughput yes no
ILK_HUMAN [view interactions] Low throughput no no
KPCT_HUMAN [view interactions] Low throughput no no
STRAP_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K7_HUMAN [view interactions] Low throughput no yes
PK3C3_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
SENP3_HUMAN [view interactions] Low throughput no yes
MLP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
WIPI2_HUMAN [view interactions] Low throughput no yes
ATG5_HUMAN [view interactions] Low throughput no no
COX2_HUMAN [view entry] [view interactions] Low throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
FAXC_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
RBBP5_HUMAN [view interactions] High throughput no yes
NRBP_HUMAN [view interactions] High throughput no yes
CASP3_HUMAN [view interactions] High throughput no yes
CDSN_HUMAN [view interactions] High throughput no no
ATG10_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
FAK2_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
APOA1_HUMAN [view interactions] High throughput no no
ZMY11_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
ATPB_HUMAN [view interactions] High throughput no yes
TOM70_HUMAN [view interactions] High throughput no yes
RL29_HUMAN [view entry] [view interactions] High throughput yes yes
TOP2A_HUMAN [view interactions] High throughput no no
VATL_HUMAN [view interactions] High throughput no no
PAF1_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
CYTC_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
DDX42_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
BLMH_HUMAN [view interactions] High throughput no yes
KTBL1_HUMAN [view interactions] High throughput no no
PXL2B_HUMAN [view interactions] High throughput no yes
WDCP_HUMAN [view interactions] High throughput no yes
DDIT4_HUMAN [view interactions] High throughput no yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
LC7L2_HUMAN [view interactions] High throughput no yes
PEA15_HUMAN [view entry] [view interactions] High throughput yes no
PHAX_HUMAN [view interactions] High throughput no yes
PNO1_HUMAN [view interactions] High throughput no no
PDIP2_HUMAN [view interactions] High throughput no no
MTMR5_HUMAN [view entry] [view interactions] High throughput yes no
SNF5_HUMAN [view interactions] High throughput no yes
SOCS3_HUMAN [view interactions] High throughput no yes
TELT_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC6_HUMAN [view interactions] High throughput no yes
NIPA_HUMAN [view interactions] High throughput no yes
ZN133_HUMAN [view interactions] High throughput no yes
PA2G4_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
TBL2_HUMAN [view interactions] High throughput no no
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
RPOM_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
PDPK2_HUMAN [view interactions] High throughput no no
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
GPC4_HUMAN [view entry] [view interactions] High throughput yes yes
FGF2_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CD44_HUMAN [view interactions] High throughput no yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
SDC1_HUMAN [view interactions] High throughput no no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
RPB1_HUMAN [view interactions] High throughput no no
SDC4_HUMAN [view interactions] High throughput no yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
GTF2I_HUMAN [view interactions] High throughput no yes
PGBM_HUMAN [view interactions] High throughput no no
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
DHX9_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
CAF1B_HUMAN [view interactions] High throughput no no
MTA1_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
CHD4_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
TBC15_HUMAN [view interactions] High throughput no yes
PRP31_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
GSLG1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
SNX18_HUMAN [view interactions] High throughput no no
S29A1_HUMAN [view entry] [view interactions] High throughput yes yes
TCF25_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
DDX24_HUMAN [view interactions] High throughput no yes
GRPE1_HUMAN [view interactions] High throughput no yes
T161A_HUMAN [view interactions] High throughput no yes
ACOT9_HUMAN [view interactions] High throughput no yes
TMED7_HUMAN [view interactions] High throughput no yes
TF3C5_HUMAN [view interactions] High throughput no yes
ARPC5_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
CAMP3_HUMAN [view interactions] High throughput no no
IMP2L_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TEFF1_HUMAN [view interactions] High throughput no no
GPC6_HUMAN [view entry] [view interactions] High throughput yes yes
NRX3A_HUMAN [view entry] [view interactions] High throughput yes yes
CQ080_HUMAN [view interactions] High throughput no yes
HS2ST_HUMAN [view interactions] High throughput no yes
EGFLA_HUMAN [view interactions] High throughput no no
TGBR3_HUMAN [view interactions] High throughput no yes
GPC3_HUMAN [view interactions] High throughput no no
SDC2_HUMAN [view interactions] High throughput no yes
TPP2_HUMAN [view interactions] High throughput no yes
FETUA_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
IGHG1_HUMAN [view interactions] High throughput no no
SRPK1_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
APBB3_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
PININ_HUMAN [view interactions] High throughput no yes
PRS23_HUMAN [view interactions] High throughput no no
CDAN1_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
PTPRC_HUMAN [view interactions] High throughput no no
PTPRK_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
PTPRB_HUMAN [view interactions] High throughput no yes
PTPRJ_HUMAN [view interactions] High throughput no yes
PTPRO_HUMAN [view entry] [view interactions] High throughput yes no
PTN12_HUMAN [view interactions] High throughput no yes
PTN22_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
TANK_HUMAN [view interactions] High throughput no yes
ZDH17_HUMAN [view interactions] High throughput no yes
KAIN_HUMAN [view interactions] High throughput no no
CBPA4_HUMAN [view interactions] High throughput no no
F199X_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD5_HUMAN [view interactions] High throughput no no
SCRN2_HUMAN [view interactions] High throughput no yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
TSC2_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
PI3R6_HUMAN [view interactions] Computational no yes
SGK3_HUMAN [view interactions] Computational no yes
IKKB_HUMAN [view interactions] Computational no yes
P85B_HUMAN [view interactions] Computational no yes
KS6A2_HUMAN [view interactions] Computational no yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
IRS1_HUMAN [view entry] [view interactions] Computational yes yes
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
ITA2B_HUMAN [view interactions] Computational no no
OGT1_HUMAN [view entry] [view interactions] Computational yes yes
TGFR2_HUMAN [view interactions] Computational no no
TGFR1_HUMAN [view interactions] Computational no no
PKN3_HUMAN [view interactions] Computational no yes
KS6A1_HUMAN [view interactions] Computational no yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
NEMO_HUMAN [view interactions] Computational no yes
SMAD7_HUMAN [view interactions] Computational no yes
ITB3_HUMAN [view entry] [view interactions] Computational yes no
PK3CB_HUMAN [view interactions] Computational no yes
PK3CD_HUMAN [view interactions] Computational no no
IKKA_HUMAN [view interactions] Computational no yes
UB2V1_HUMAN [view entry] [view interactions] Computational yes no
TGFB3_HUMAN [view interactions] Computational no no
GRB14_HUMAN [view interactions] Computational no yes
GNDS_HUMAN [view interactions] Computational no yes
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
P55G_HUMAN [view interactions] Computational no yes
RICTR_HUMAN [view interactions] Computational no yes
SGK2_HUMAN [view interactions] Computational no yes
PI3R5_HUMAN [view interactions] Computational no no
KS6B2_HUMAN [view interactions] Computational no yes
TRAF6_HUMAN [view interactions] Computational no yes
P85A_HUMAN [view interactions] Computational no yes
PK3CG_HUMAN [view interactions] Computational no yes
AKTS1_HUMAN [view interactions] Computational no yes
RIPK2_HUMAN [view interactions] Computational no yes
UBE2N_HUMAN [view entry] [view interactions] Computational yes yes
INSR_HUMAN [view interactions] Computational no yes
INS_HUMAN [view interactions] Computational no no
KS6A6_HUMAN [view interactions] Computational no yes
HS90A_HUMAN [view entry] [view interactions] Computational yes yes