KS6A3_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed, PubMed, PubMed, PubMed). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at Ser-10, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed, PubMed). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity (PubMed). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed, PubMed). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed, PubMed). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression . In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 . Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 . Phosphorylates SOS1 at Ser-1134 and Ser-1161 that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation . Phosphorylates EPHA2 at Ser-897, the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KS6A3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 40.5797 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 39.1304 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.6812 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 34.7826 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | yes |
| GO:0005524 | ATP binding | 31.8841 | 5 | yes |
| GO:0003723 | RNA binding | 27.5362 | 4 | no |
| GO:0046872 | metal ion binding | 24.6377 | 4 | yes |
| GO:0019900 | kinase binding | 21.7391 | 4 | yes |
| GO:0019901 | protein kinase binding | 21.7391 | 5 | yes |
| GO:0016301 | kinase activity | 20.2899 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.8406 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 15.9420 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 14.4928 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 13.0435 | 4 | yes |
| GO:0000287 | magnesium ion binding | 5.7971 | 5 | yes |
| GO:0004711 | ribosomal protein S6 kinase activity | 2.8986 | 5 | yes |
| GO:0004866 | endopeptidase inhibitor activity | 2.8986 | 5 | yes |
| GO:0004869 | cysteine-type endopeptidase inhibitor activity | 2.8986 | 6 | yes |
| GO:0030414 | peptidase inhibitor activity | 2.8986 | 4 | yes |
| GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | 2.8986 | 4 | yes |
| GO:0061135 | endopeptidase regulator activity | 2.8986 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KS6A3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 75.3623 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 62.3188 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 62.3188 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 59.4203 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 59.4203 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 57.9710 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 56.5217 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.6232 | 5 | yes |
| GO:0010468 | regulation of gene expression | 50.7246 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 49.2754 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 49.2754 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 49.2754 | 5 | yes |
| GO:0010646 | regulation of cell communication | 46.3768 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 46.3768 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 44.9275 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.9275 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.4783 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 42.0290 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.5797 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.5797 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 39.1304 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.1304 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 37.6812 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 36.2319 | 6 | no |
| GO:0023056 | positive regulation of signaling | 34.7826 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.7826 | 4 | no |
| GO:0010941 | regulation of cell death | 34.7826 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 31.8841 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.8841 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 31.8841 | 4 | yes |
| GO:0071702 | organic substance transport | 30.4348 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.4348 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.4348 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 30.4348 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.9855 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 28.9855 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.9855 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.9855 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.9855 | 4 | no |
| GO:0033043 | regulation of organelle organization | 28.9855 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.9855 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 28.9855 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 28.9855 | 5 | yes |
| GO:0060548 | negative regulation of cell death | 28.9855 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 27.5362 | 4 | no |
| GO:0009894 | regulation of catabolic process | 27.5362 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.5362 | 6 | yes |
| GO:0051094 | positive regulation of developmental process | 27.5362 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 27.5362 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.5362 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 27.5362 | 6 | yes |
| GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.0870 | 5 | yes |
| GO:0036211 | protein modification process | 26.0870 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 26.0870 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 26.0870 | 6 | yes |
| GO:0043412 | macromolecule modification | 26.0870 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 26.0870 | 7 | no |
| GO:0060341 | regulation of cellular localization | 24.6377 | 4 | no |
| GO:0015031 | protein transport | 24.6377 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.6377 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.6377 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.6377 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.6377 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 23.1884 | 7 | no |
| GO:0043933 | protein-containing complex organization | 23.1884 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.1884 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.1884 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.1884 | 5 | no |
| GO:0051338 | regulation of transferase activity | 23.1884 | 4 | no |
| GO:0051726 | regulation of cell cycle | 23.1884 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.1884 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.1884 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 23.1884 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.1884 | 7 | yes |
| GO:0045595 | regulation of cell differentiation | 23.1884 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 21.7391 | 5 | no |
| GO:0051345 | positive regulation of hydrolase activity | 21.7391 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 21.7391 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.7391 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.7391 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0016310 | phosphorylation | 21.7391 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 21.7391 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 20.2899 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.2899 | 7 | no |
| GO:0010629 | negative regulation of gene expression | 20.2899 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.2899 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 20.2899 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.2899 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.2899 | 6 | no |
| GO:0043086 | negative regulation of catalytic activity | 20.2899 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 20.2899 | 6 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.2899 | 6 | no |
| GO:0006468 | protein phosphorylation | 18.8406 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 17.3913 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 17.3913 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 15.9420 | 7 | yes |
| GO:0050776 | regulation of immune response | 15.9420 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 15.9420 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 15.9420 | 8 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 14.4928 | 8 | yes |
| GO:0052547 | regulation of peptidase activity | 14.4928 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 14.4928 | 6 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 13.0435 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 13.0435 | 6 | yes |
| GO:0001558 | regulation of cell growth | 11.5942 | 4 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 11.5942 | 6 | yes |
| GO:0033993 | response to lipid | 11.5942 | 4 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 11.5942 | 7 | yes |
| GO:0006417 | regulation of translation | 10.1449 | 6 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 10.1449 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 10.1449 | 5 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 10.1449 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 8.6957 | 6 | yes |
| GO:0030307 | positive regulation of cell growth | 8.6957 | 5 | yes |
| GO:0045861 | negative regulation of proteolysis | 8.6957 | 7 | yes |
| GO:0045927 | positive regulation of growth | 8.6957 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 8.6957 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 8.6957 | 4 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 7.2464 | 8 | yes |
| GO:0043620 | regulation of DNA-templated transcription in response to stress | 7.2464 | 4 | yes |
| GO:0010466 | negative regulation of peptidase activity | 5.7971 | 6 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 5.7971 | 7 | yes |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5.7971 | 8 | yes |
| GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 5.7971 | 8 | yes |
| GO:0002237 | response to molecule of bacterial origin | 4.3478 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 4.3478 | 4 | yes |
| GO:0001501 | skeletal system development | 2.8986 | 4 | yes |
| GO:0002221 | pattern recognition receptor signaling pathway | 2.8986 | 4 | yes |
| GO:0002224 | toll-like receptor signaling pathway | 2.8986 | 5 | yes |
| GO:0007417 | central nervous system development | 2.8986 | 4 | yes |
| GO:0043555 | regulation of translation in response to stress | 2.8986 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KS6A3_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 4.3478 | 3 | no |
| DOID:1059 | intellectual disability | 4.3478 | 4 | no |
| DOID:0050888 | syndromic intellectual disability | 2.8986 | 5 | no |
| DOID:0060309 | syndromic X-linked intellectual disability | 2.8986 | 6 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 2.8986 | 6 | no |
| DOID:440 | neuromuscular disease | 2.8986 | 5 | no |
| DOID:574 | peripheral nervous system disease | 2.8986 | 3 | no |
| DOID:870 | neuropathy | 2.8986 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MAGI1_HUMAN | [view interactions] | Low throughput | no | no |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PEA15_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| NFAC1_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FOXN2_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| YBOX1_HUMAN | [view interactions] | Low throughput | no | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBX5_HUMAN | [view interactions] | Low throughput | no | yes |
| HMGN1_HUMAN | [view interactions] | Low throughput | no | yes |
| ILKAP_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| CTND1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ATM_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| BARX1_HUMAN | [view interactions] | High throughput | no | no |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MASP1_HUMAN | [view interactions] | High throughput | no | no |
| SPSY_HUMAN | [view interactions] | High throughput | no | no |
| SETD3_HUMAN | [view interactions] | High throughput | no | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| GLCM_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| SPRE2_HUMAN | [view interactions] | High throughput | no | yes |
| TM139_HUMAN | [view interactions] | High throughput | no | no |
| IIGP5_HUMAN | [view interactions] | High throughput | no | no |
| TRM9B_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RA1L2_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| H13_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK23_HUMAN | [view interactions] | High throughput | no | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| H90B2_HUMAN | [view interactions] | High throughput | no | no |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| H3C_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A1C_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A3_HUMAN | [view interactions] | High throughput | no | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| CR025_HUMAN | [view interactions] | High throughput | no | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM5_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| STRAB_HUMAN | [view interactions] | High throughput | no | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| AMHR2_HUMAN | [view interactions] | High throughput | no | no |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| ADA18_HUMAN | [view interactions] | High throughput | no | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT4_HUMAN | [view interactions] | High throughput | no | no |
| EFCE2_HUMAN | [view interactions] | High throughput | no | no |
| ECE2_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| DFFA_HUMAN | [view interactions] | High throughput | no | yes |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| RASL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GUAD_HUMAN | [view interactions] | High throughput | no | yes |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| DOCK4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FRS2_HUMAN | [view interactions] | High throughput | no | no |
| ERD22_HUMAN | [view interactions] | High throughput | no | yes |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UTP18_HUMAN | [view interactions] | High throughput | no | yes |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| UB2D3_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A4_HUMAN | [view interactions] | Computational | no | yes |
| KS6A6_HUMAN | [view interactions] | Computational | no | yes |
| SRF_HUMAN | [view interactions] | Computational | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KS6A5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CEBPB_HUMAN | [view interactions] | Computational | no | no |
| ATF4_HUMAN | [view interactions] | Computational | no | no |
| TSC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BUB1_HUMAN | [view interactions] | Computational | no | no |
| CREB1_HUMAN | [view interactions] | Computational | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MEFV_HUMAN | [view interactions] | Computational | no | no |
| TIA1_HUMAN | [view interactions] | Computational | no | no |
| MK07_HUMAN | [view interactions] | Computational | no | yes |
| PMYT1_HUMAN | [view interactions] | Computational | no | no |