KS6A3_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed, PubMed, PubMed, PubMed). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at Ser-10, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed, PubMed). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity (PubMed). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed, PubMed). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed, PubMed). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression . In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 . Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 . Phosphorylates SOS1 at Ser-1134 and Ser-1161 that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation . Phosphorylates EPHA2 at Ser-897, the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KS6A3_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 42.3529 | 4 | yes |
| GO:0000166 | nucleotide binding | 40.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 40.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 38.8235 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.6471 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.4706 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 35.2941 | 5 | yes |
| GO:0005524 | ATP binding | 34.1176 | 5 | yes |
| GO:0043169 | cation binding | 29.4118 | 4 | yes |
| GO:0046872 | metal ion binding | 28.2353 | 5 | yes |
| GO:0003723 | RNA binding | 25.8824 | 4 | no |
| GO:0016301 | kinase activity | 24.7059 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 23.5294 | 4 | yes |
| GO:0019900 | kinase binding | 21.1765 | 4 | yes |
| GO:0019901 | protein kinase binding | 21.1765 | 5 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 20.0000 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 17.6471 | 4 | yes |
| GO:0000287 | magnesium ion binding | 5.8824 | 6 | yes |
| GO:0004711 | ribosomal protein S6 kinase activity | 4.7059 | 5 | yes |
| GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | 3.5294 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KS6A3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 74.1176 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 65.8824 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 64.7059 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 62.3529 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.1765 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 56.4706 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 56.4706 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 55.2941 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 55.2941 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 55.2941 | 5 | yes |
| GO:0010468 | regulation of gene expression | 51.7647 | 6 | yes |
| GO:0010646 | regulation of cell communication | 51.7647 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.5882 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 49.4118 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 49.4118 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 47.0588 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 44.7059 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 42.3529 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.3529 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 41.1765 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 41.1765 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 41.1765 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 40.0000 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 38.8235 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 37.6471 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 37.6471 | 5 | no |
| GO:0051049 | regulation of transport | 36.4706 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 36.4706 | 5 | yes |
| GO:0008104 | protein localization | 36.4706 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 35.2941 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 35.2941 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 35.2941 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.1176 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.9412 | 7 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 32.9412 | 4 | yes |
| GO:0036211 | protein modification process | 32.9412 | 4 | yes |
| GO:0043412 | macromolecule modification | 32.9412 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 32.9412 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 31.7647 | 5 | yes |
| GO:0071702 | organic substance transport | 30.5882 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 30.5882 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 30.5882 | 6 | no |
| GO:0060341 | regulation of cellular localization | 29.4118 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 29.4118 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 29.4118 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 29.4118 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 29.4118 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 29.4118 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 29.4118 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 28.2353 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.2353 | 4 | no |
| GO:0006996 | organelle organization | 28.2353 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 28.2353 | 5 | no |
| GO:0022607 | cellular component assembly | 28.2353 | 4 | no |
| GO:0023057 | negative regulation of signaling | 28.2353 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 27.0588 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.0588 | 5 | no |
| GO:0071705 | nitrogen compound transport | 27.0588 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.0588 | 5 | no |
| GO:0009894 | regulation of catabolic process | 27.0588 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.0588 | 4 | no |
| GO:0030162 | regulation of proteolysis | 27.0588 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 27.0588 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 27.0588 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 27.0588 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.0588 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.8824 | 8 | yes |
| GO:0016310 | phosphorylation | 25.8824 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 24.7059 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.7059 | 5 | no |
| GO:0032880 | regulation of protein localization | 24.7059 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.7059 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.7059 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.5294 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0015031 | protein transport | 23.5294 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.3529 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 22.3529 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.3529 | 6 | no |
| GO:0006468 | protein phosphorylation | 22.3529 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 22.3529 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 21.1765 | 7 | no |
| GO:0065003 | protein-containing complex assembly | 21.1765 | 5 | no |
| GO:2000145 | regulation of cell motility | 21.1765 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.1765 | 7 | no |
| GO:0010629 | negative regulation of gene expression | 21.1765 | 7 | no |
| GO:0018193 | peptidyl-amino acid modification | 20.0000 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 20.0000 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 20.0000 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.0000 | 8 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.0000 | 7 | yes |
| GO:0032101 | regulation of response to external stimulus | 18.8235 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 17.6471 | 4 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 16.4706 | 9 | yes |
| GO:0052547 | regulation of peptidase activity | 16.4706 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 16.4706 | 6 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 15.2941 | 5 | yes |
| GO:0033993 | response to lipid | 15.2941 | 4 | yes |
| GO:0001558 | regulation of cell growth | 14.1176 | 4 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 14.1176 | 7 | yes |
| GO:0031347 | regulation of defense response | 14.1176 | 5 | yes |
| GO:0045861 | negative regulation of proteolysis | 14.1176 | 7 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 12.9412 | 4 | yes |
| GO:0006417 | regulation of translation | 12.9412 | 6 | yes |
| GO:0045927 | positive regulation of growth | 12.9412 | 4 | yes |
| GO:0050776 | regulation of immune response | 12.9412 | 4 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 12.9412 | 7 | yes |
| GO:0045088 | regulation of innate immune response | 11.7647 | 5 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 10.5882 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 10.5882 | 6 | yes |
| GO:0030307 | positive regulation of cell growth | 10.5882 | 5 | yes |
| GO:0031349 | positive regulation of defense response | 10.5882 | 5 | yes |
| GO:0050778 | positive regulation of immune response | 10.5882 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 10.5882 | 5 | yes |
| GO:0002833 | positive regulation of response to biotic stimulus | 9.4118 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 9.4118 | 7 | yes |
| GO:0010466 | negative regulation of peptidase activity | 9.4118 | 6 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 9.4118 | 7 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 9.4118 | 8 | yes |
| GO:0045089 | positive regulation of innate immune response | 9.4118 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 9.4118 | 6 | yes |
| GO:0099536 | synaptic signaling | 9.4118 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 9.4118 | 5 | yes |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 8.2353 | 7 | yes |
| GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 8.2353 | 8 | yes |
| GO:0002237 | response to molecule of bacterial origin | 5.8824 | 4 | yes |
| GO:0002758 | innate immune response-activating signaling pathway | 5.8824 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 5.8824 | 4 | yes |
| GO:0001501 | skeletal system development | 3.5294 | 4 | yes |
| GO:0002221 | pattern recognition receptor signaling pathway | 3.5294 | 5 | yes |
| GO:0002224 | toll-like receptor signaling pathway | 3.5294 | 6 | yes |
| GO:0007417 | central nervous system development | 3.5294 | 4 | yes |
| GO:0043555 | regulation of translation in response to stress | 3.5294 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| YBOX1_HUMAN | [view interactions] | Low throughput | no | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBX5_HUMAN | [view interactions] | Low throughput | no | yes |
| HMGN1_HUMAN | [view interactions] | Low throughput | no | yes |
| ILKAP_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| CTND1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ATM_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LST8_HUMAN | [view interactions] | Low throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | Low throughput | no | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MAGI1_HUMAN | [view interactions] | Low throughput | no | no |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPRE2_HUMAN | [view interactions] | Low throughput | no | yes |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PEA15_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| NFAC1_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FOXN2_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SGK3_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| DFFA_HUMAN | [view interactions] | High throughput | no | yes |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| RASL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| DPCD_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBSK_HUMAN | [view interactions] | High throughput | no | yes |
| ES8L2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| DOCK4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FRS2_HUMAN | [view interactions] | High throughput | no | no |
| ERD22_HUMAN | [view interactions] | High throughput | no | yes |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UTP18_HUMAN | [view interactions] | High throughput | no | yes |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| UB2D3_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| BARX1_HUMAN | [view interactions] | High throughput | no | no |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MASP1_HUMAN | [view interactions] | High throughput | no | no |
| SPSY_HUMAN | [view interactions] | High throughput | no | no |
| SETD3_HUMAN | [view interactions] | High throughput | no | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| GBA1_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| IIGP5_HUMAN | [view interactions] | High throughput | no | no |
| TM139_HUMAN | [view interactions] | High throughput | no | no |
| TRM9B_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| H2A3_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1C_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| H3C_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| H90B2_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| CSK23_HUMAN | [view interactions] | High throughput | no | no |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H13_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| RA1L2_HUMAN | [view interactions] | High throughput | no | no |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARK2N_HUMAN | [view interactions] | High throughput | no | yes |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM5_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| STRAB_HUMAN | [view interactions] | High throughput | no | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| AMHR2_HUMAN | [view interactions] | High throughput | no | no |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| ADA18_HUMAN | [view interactions] | High throughput | no | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT4_HUMAN | [view interactions] | High throughput | no | no |
| EFCE2_HUMAN | [view interactions] | High throughput | no | no |
| ECE2_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBP6_HUMAN | [view interactions] | High throughput | no | yes |
| WASC4_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| KS6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A4_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| SGK2_HUMAN | [view interactions] | High throughput | no | yes |