PSA_HUMAN
Evidence for PS localization
Functions
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PSA_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | no |
| GO:0005524 | ATP binding | 27.5000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 27.5000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.5000 | 5 | no |
| GO:0003723 | RNA binding | 22.5000 | 4 | no |
| GO:0019900 | kinase binding | 22.5000 | 4 | no |
| GO:0046872 | metal ion binding | 12.5000 | 4 | yes |
| GO:0008235 | metalloexopeptidase activity | 5.0000 | 5 | yes |
| GO:0008237 | metallopeptidase activity | 5.0000 | 4 | yes |
| GO:0008238 | exopeptidase activity | 5.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PSA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 55.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0051049 | regulation of transport | 35.0000 | 4 | yes |
| GO:0008104 | protein localization | 35.0000 | 4 | no |
| GO:0036211 | protein modification process | 32.5000 | 4 | yes |
| GO:0043412 | macromolecule modification | 32.5000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.5000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.5000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.5000 | 5 | no |
| GO:0032880 | regulation of protein localization | 30.0000 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 30.0000 | 4 | yes |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.0000 | 4 | no |
| GO:0071702 | organic substance transport | 30.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.5000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.5000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.5000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.5000 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 25.0000 | 5 | yes |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.5000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 22.5000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.5000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.5000 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.5000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.5000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.5000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.5000 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.5000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 22.5000 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 17.5000 | 6 | yes |
| GO:0051223 | regulation of protein transport | 15.0000 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 15.0000 | 5 | yes |
| GO:0032446 | protein modification by small protein conjugation | 12.5000 | 6 | yes |
| GO:0051222 | positive regulation of protein transport | 12.5000 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 12.5000 | 6 | yes |
| GO:0006508 | proteolysis | 12.5000 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 10.0000 | 4 | yes |
| GO:0033157 | regulation of intracellular protein transport | 7.5000 | 6 | yes |
| GO:0043603 | cellular amide metabolic process | 7.5000 | 4 | yes |
| GO:0090316 | positive regulation of intracellular protein transport | 7.5000 | 6 | yes |
| GO:0006518 | peptide metabolic process | 7.5000 | 4 | yes |
| GO:0016567 | protein ubiquitination | 7.5000 | 7 | yes |
| GO:0032386 | regulation of intracellular transport | 7.5000 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 7.5000 | 5 | yes |
| GO:1903533 | regulation of protein targeting | 5.0000 | 7 | yes |
| GO:1903747 | regulation of establishment of protein localization to mitochondrion | 5.0000 | 7 | yes |
| GO:0000209 | protein polyubiquitination | 5.0000 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CDK20_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| CMKMT_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| F204A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A1_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| PAQR9_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| TCAL8_HUMAN | [view interactions] | High throughput | no | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC8B_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC8C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC8D_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CG_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| GBP1_HUMAN | [view interactions] | High throughput | no | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| ZN622_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| HYES_HUMAN | [view interactions] | High throughput | no | no |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRC_HUMAN | [view interactions] | High throughput | no | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| LRC8E_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIMP2_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| NBPFC_HUMAN | [view interactions] | Computational | no | yes |
| NBPF1_HUMAN | [view interactions] | Computational | no | yes |
| GRIN2_HUMAN | [view interactions] | Computational | no | yes |
| UDB17_HUMAN | [view interactions] | Computational | no | no |
| CDK5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HYDIN_HUMAN | [view interactions] | Computational | no | no |