PSA_HUMAN
Evidence for PS localization
Functions
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PSA_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 38.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 38.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 36.0000 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 36.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.0000 | 4 | no |
| GO:0043168 | anion binding | 36.0000 | 4 | no |
| GO:0005524 | ATP binding | 34.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 34.0000 | 5 | no |
| GO:0003723 | RNA binding | 26.0000 | 4 | no |
| GO:0019900 | kinase binding | 24.0000 | 4 | no |
| GO:0043169 | cation binding | 22.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 22.0000 | 5 | yes |
| GO:0016301 | kinase activity | 22.0000 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 22.0000 | 4 | no |
| GO:0008270 | zinc ion binding | 6.0000 | 7 | yes |
| GO:0046914 | transition metal ion binding | 6.0000 | 6 | yes |
| GO:0008235 | metalloexopeptidase activity | 4.0000 | 5 | yes |
| GO:0008237 | metallopeptidase activity | 4.0000 | 4 | yes |
| GO:0008238 | exopeptidase activity | 4.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PSA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 58.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 38.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 36.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 34.0000 | 4 | no |
| GO:0008104 | protein localization | 34.0000 | 4 | no |
| GO:0036211 | protein modification process | 32.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 32.0000 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 32.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 32.0000 | 4 | no |
| GO:0006996 | organelle organization | 32.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0071702 | organic substance transport | 30.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 28.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.0000 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 28.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 28.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.0000 | 6 | no |
| GO:0080134 | regulation of response to stress | 28.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.0000 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.0000 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 26.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.0000 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.0000 | 6 | no |
| GO:0032880 | regulation of protein localization | 24.0000 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 24.0000 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 24.0000 | 8 | no |
| GO:0009968 | negative regulation of signal transduction | 24.0000 | 5 | no |
| GO:0030162 | regulation of proteolysis | 24.0000 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 24.0000 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0000 | 5 | no |
| GO:0030030 | cell projection organization | 22.0000 | 4 | no |
| GO:0001558 | regulation of cell growth | 22.0000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.0000 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.0000 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.0000 | 4 | no |
| GO:0015031 | protein transport | 22.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.0000 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 22.0000 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 22.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.0000 | 5 | no |
| GO:0043687 | post-translational protein modification | 18.0000 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 18.0000 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 18.0000 | 5 | yes |
| GO:0006508 | proteolysis | 16.0000 | 4 | yes |
| GO:0032446 | protein modification by small protein conjugation | 16.0000 | 7 | yes |
| GO:0070201 | regulation of establishment of protein localization | 14.0000 | 6 | yes |
| GO:0016567 | protein ubiquitination | 12.0000 | 8 | yes |
| GO:0000209 | protein polyubiquitination | 8.0000 | 9 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 8.0000 | 6 | yes |
| GO:1903747 | regulation of establishment of protein localization to mitochondrion | 6.0000 | 7 | yes |
| GO:1903214 | regulation of protein targeting to mitochondrion | 4.0000 | 8 | yes |
| GO:1903533 | regulation of protein targeting | 4.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CDK20_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CG_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| GBP1_HUMAN | [view interactions] | High throughput | no | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| ZN622_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| HYES_HUMAN | [view interactions] | High throughput | no | no |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRC_HUMAN | [view interactions] | High throughput | no | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPB_HUMAN | [view interactions] | High throughput | no | no |
| PCP_HUMAN | [view interactions] | High throughput | no | yes |
| SELB_HUMAN | [view interactions] | High throughput | no | no |
| SSH3_HUMAN | [view interactions] | High throughput | no | yes |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| TBC23_HUMAN | [view interactions] | High throughput | no | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| TCAF1_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| LRC8E_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIMP2_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| CMKMT_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| F204A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A1_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| PAQR9_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| TCAL8_HUMAN | [view interactions] | High throughput | no | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC8B_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC8C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC8D_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |