Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCRB_HUMAN

GO
G2C
SynGO

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KCRB_HUMAN
GO:0003723 RNA binding 27.7778 4 no
GO:0046872 metal ion binding 27.7778 4 no
GO:0019900 kinase binding 21.1111 4 no
GO:0017076 purine nucleotide binding 20.0000 4 yes
GO:0032555 purine ribonucleotide binding 18.8889 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 18.8889 4 yes
GO:0030554 adenyl nucleotide binding 16.6667 5 yes
GO:0044389 ubiquitin-like protein ligase binding 16.6667 4 yes
GO:0005524 ATP binding 15.5556 5 yes
GO:0031625 ubiquitin protein ligase binding 15.5556 5 yes
GO:0032559 adenyl ribonucleotide binding 15.5556 5 yes
GO:0016301 kinase activity 7.7778 4 yes
GO:0004111 creatine kinase activity 2.2222 5 yes
GO:0016775 phosphotransferase activity, nitrogenous group as acceptor 2.2222 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCRB_HUMAN
GO:0048522 positive regulation of cellular process 57.7778 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 47.7778 4 no
GO:0080090 regulation of primary metabolic process 47.7778 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.6667 4 no
GO:0048523 negative regulation of cellular process 43.3333 4 no
GO:0009966 regulation of signal transduction 38.8889 4 no
GO:0010646 regulation of cell communication 38.8889 4 no
GO:0051128 regulation of cellular component organization 36.6667 4 no
GO:0006996 organelle organization 35.5556 4 no
GO:0051246 regulation of protein metabolic process 34.4444 5 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0009892 negative regulation of metabolic process 32.2222 4 no
GO:0010468 regulation of gene expression 32.2222 5 no
GO:0010604 positive regulation of macromolecule metabolic process 32.2222 5 no
GO:0008104 protein localization 31.1111 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.1111 5 no
GO:0022607 cellular component assembly 30.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.8889 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.8889 5 no
GO:0031324 negative regulation of cellular metabolic process 28.8889 5 no
GO:0031325 positive regulation of cellular metabolic process 28.8889 5 no
GO:0010941 regulation of cell death 28.8889 4 no
GO:0043412 macromolecule modification 28.8889 4 no
GO:1902531 regulation of intracellular signal transduction 28.8889 5 no
GO:0009889 regulation of biosynthetic process 27.7778 4 no
GO:0010556 regulation of macromolecule biosynthetic process 27.7778 5 no
GO:0031326 regulation of cellular biosynthetic process 27.7778 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.7778 5 no
GO:0043067 regulation of programmed cell death 27.7778 5 no
GO:0036211 protein modification process 27.7778 4 no
GO:0042981 regulation of apoptotic process 26.6667 6 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0051049 regulation of transport 25.5556 4 no
GO:0006796 phosphate-containing compound metabolic process 24.4444 4 yes
GO:0051247 positive regulation of protein metabolic process 24.4444 6 no
GO:0051252 regulation of RNA metabolic process 23.3333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 23.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 23.3333 6 no
GO:0019220 regulation of phosphate metabolic process 23.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 23.3333 5 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0043933 protein-containing complex organization 21.1111 4 no
GO:0071702 organic substance transport 21.1111 4 no
GO:0048878 chemical homeostasis 12.2222 4 yes
GO:0021762 substantia nigra development 8.8889 4 yes
GO:0050801 ion homeostasis 8.8889 5 yes
GO:0090407 organophosphate biosynthetic process 8.8889 4 yes
GO:0098771 inorganic ion homeostasis 8.8889 6 yes
GO:0006873 cellular ion homeostasis 7.7778 4 yes
GO:1901566 organonitrogen compound biosynthetic process 6.6667 4 yes
GO:0006599 phosphagen metabolic process 2.2222 4 yes
GO:0006603 phosphocreatine metabolic process 2.2222 5 yes
GO:0030002 cellular anion homeostasis 2.2222 5 yes
GO:0030320 cellular monovalent inorganic anion homeostasis 2.2222 6 yes
GO:0030644 cellular chloride ion homeostasis 2.2222 7 yes
GO:0042396 phosphagen biosynthetic process 2.2222 5 yes
GO:0042398 cellular modified amino acid biosynthetic process 2.2222 4 yes
GO:0046314 phosphocreatine biosynthetic process 2.2222 6 yes
GO:0055064 chloride ion homeostasis 2.2222 8 yes
GO:0055081 anion homeostasis 2.2222 6 yes
GO:0055083 monovalent inorganic anion homeostasis 2.2222 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCRB_HUMAN
DOID:0050700 cardiomyopathy 3.3333 4 no
DOID:0060036 intrinsic cardiomyopathy 3.3333 5 no
DOID:114 heart disease 3.3333 3 no
DOID:574 peripheral nervous system disease 3.3333 3 no
DOID:870 neuropathy 3.3333 4 no
DOID:0080000 muscular disease 2.2222 3 no
DOID:423 myopathy 2.2222 5 no
DOID:66 muscle tissue disease 2.2222 4 no
DOID:65 connective tissue disease 2.2222 3 no
DOID:0050686 organ system cancer 2.2222 3 no
DOID:12930 dilated cardiomyopathy 2.2222 6 no
DOID:1289 neurodegenerative disease 2.2222 4 no
DOID:331 central nervous system disease 2.2222 3 no
DOID:10595 Charcot-Marie-Tooth disease 2.2222 6 no
DOID:440 neuromuscular disease 2.2222 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
PGAM2_HUMAN [view entry] [view interactions] Low throughput yes no
HSP7C_HUMAN [view entry] [view interactions] Low throughput yes yes
KLC1_HUMAN [view entry] [view interactions] Low throughput yes no
GOGA2_HUMAN [view entry] [view interactions] Low throughput yes yes
MT3_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP38_HUMAN [view interactions] Low throughput no no
ARI2_HUMAN [view interactions] Low throughput no no
ELOB_HUMAN [view interactions] Low throughput no no
ELOC_HUMAN [view interactions] Low throughput no no
KCRB_HUMAN [view entry] [view interactions] Low throughput yes no
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ASB9_HUMAN [view interactions] Low throughput no no
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG24_HUMAN [view interactions] High throughput no yes
SOS2_HUMAN [view interactions] High throughput no yes
RHGBB_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
SOAT1_HUMAN [view interactions] High throughput no no
SODC_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
PPTC7_HUMAN [view interactions] High throughput no yes
PHOP1_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
LACC1_HUMAN [view interactions] High throughput no yes
PAX8_HUMAN [view interactions] High throughput no yes
KLF16_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
MIPT3_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
SERP2_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ARI3A_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1A_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
TERF1_HUMAN [view interactions] High throughput no no
TINF2_HUMAN [view interactions] High throughput no no
ACD_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
CNTRL_HUMAN [view interactions] High throughput no yes
SPICE_HUMAN [view interactions] High throughput no yes
CNTRB_HUMAN [view interactions] High throughput no yes
CE120_HUMAN [view interactions] High throughput no no
POC1A_HUMAN [view interactions] High throughput no yes
B9D2_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
DDR2_HUMAN [view interactions] High throughput no no
FHI1A_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
HDAC5_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ASB12_HUMAN [view interactions] High throughput no no
ASB16_HUMAN [view interactions] High throughput no no
HUWE1_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
INADL_HUMAN [view interactions] High throughput no no
TADBP_HUMAN [view interactions] High throughput no yes
ARMC8_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
LZTR1_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
K1C17_HUMAN [view interactions] High throughput no no
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
TFE3_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
S15A3_HUMAN [view interactions] High throughput no yes
DUS19_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
NFX1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
NGB_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
DOCK8_HUMAN [view interactions] High throughput no yes
DOCK7_HUMAN [view entry] [view interactions] High throughput yes no
RHGBA_HUMAN [view interactions] High throughput no yes
RHG17_HUMAN [view interactions] High throughput no no
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
MYO9A_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG5_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
CDC27_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
PTMA_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
RC3H2_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
BAG1_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
NCLN_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
ITA2B_HUMAN [view interactions] High throughput no no
UBE3A_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
PA24A_HUMAN [view entry] [view interactions] High throughput yes yes
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
DFFA_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
ERP44_HUMAN [view interactions] High throughput no yes
FTO_HUMAN [view interactions] High throughput no yes
HMGB2_HUMAN [view interactions] High throughput no yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGB_HUMAN [view interactions] High throughput no yes
NHRF1_HUMAN [view interactions] High throughput no no
TBCB_HUMAN [view entry] [view interactions] High throughput yes yes
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
ISOC1_HUMAN [view interactions] High throughput no no
SIAS_HUMAN [view interactions] High throughput no yes
PSA_HUMAN [view entry] [view interactions] High throughput yes yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
PUR4_HUMAN [view interactions] High throughput no yes
SCLY_HUMAN [view interactions] High throughput no yes
TGM2_HUMAN [view interactions] High throughput no no
UBFD1_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ABCB7_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
ICAL_HUMAN [view interactions] High throughput no yes
MYH7B_HUMAN [view interactions] High throughput no no
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
DDX10_HUMAN [view interactions] High throughput no yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
LSM8_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
DCA15_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
MK11_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANC2_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MLH1_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
TAB1_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
MK13_HUMAN [view interactions] High throughput no yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
USPL1_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRAP_HUMAN [view interactions] High throughput no no
RAD52_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
RC3H1_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
KCRM_HUMAN [view interactions] High throughput no no
RRP1B_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
GAMT_HUMAN [view interactions] Computational no no