PGAM2_HUMAN
Evidence for PS localization
Functions
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 89 | Glu | Ala | Glycogenstoragedisease10(GSD10) | - |
| 90 | Arg | Trp | Glycogenstoragedisease10(GSD10) | - |
| 97 | Gly | Asp | Glycogenstoragedisease10(GSD10) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PGAM2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 25.5814 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 25.5814 | 4 | no |
| GO:0003723 | RNA binding | 23.2558 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.2558 | 4 | no |
| GO:0004082 | bisphosphoglycerate mutase activity | 6.9767 | 5 | yes |
| GO:0004619 | phosphoglycerate mutase activity | 6.9767 | 5 | yes |
| GO:0016868 | intramolecular transferase activity, phosphotransferases | 6.9767 | 4 | yes |
| GO:0046538 | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity | 4.6512 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PGAM2_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 51.1628 | 4 | yes |
| GO:0016310 | phosphorylation | 39.5349 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 37.2093 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 37.2093 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 37.2093 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 37.2093 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 37.2093 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 37.2093 | 4 | yes |
| GO:0006090 | pyruvate metabolic process | 34.8837 | 7 | yes |
| GO:0006163 | purine nucleotide metabolic process | 34.8837 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 34.8837 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 34.8837 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 34.8837 | 4 | yes |
| GO:0006165 | nucleoside diphosphate phosphorylation | 32.5581 | 6 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 32.5581 | 5 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 32.5581 | 6 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 32.5581 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 32.5581 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 32.5581 | 7 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 32.5581 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 32.5581 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 32.5581 | 7 | yes |
| GO:0016052 | carbohydrate catabolic process | 32.5581 | 4 | yes |
| GO:0046031 | ADP metabolic process | 32.5581 | 7 | yes |
| GO:0046034 | ATP metabolic process | 32.5581 | 7 | yes |
| GO:0046939 | nucleotide phosphorylation | 32.5581 | 6 | yes |
| GO:0006096 | glycolytic process | 30.2326 | 5 | yes |
| GO:0006757 | ATP generation from ADP | 30.2326 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 27.9070 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.5814 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 25.5814 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 25.5814 | 4 | no |
| GO:0019318 | hexose metabolic process | 23.2558 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.2558 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.2558 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.2558 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 23.2558 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 20.9302 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.9302 | 5 | no |
| GO:0006006 | glucose metabolic process | 18.6047 | 5 | yes |
| GO:0016051 | carbohydrate biosynthetic process | 13.9535 | 4 | yes |
| GO:0046364 | monosaccharide biosynthetic process | 13.9535 | 4 | yes |
| GO:0006094 | gluconeogenesis | 11.6279 | 6 | yes |
| GO:0010038 | response to metal ion | 11.6279 | 4 | yes |
| GO:0019319 | hexose biosynthetic process | 11.6279 | 5 | yes |
| GO:0006936 | muscle contraction | 9.3023 | 4 | yes |
| GO:0006941 | striated muscle contraction | 6.9767 | 5 | yes |
| GO:0007219 | Notch signaling pathway | 4.6512 | 4 | yes |
| GO:0046689 | response to mercury ion | 4.6512 | 5 | yes |
| GO:0048232 | male gamete generation | 4.6512 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PGAM2_HUMAN |
|---|---|---|---|---|
| DOID:2978 | carbohydrate metabolic disorder | 4.6512 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PGK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ENOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LDHA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| PMGE_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLVS2_HUMAN | [view interactions] | High throughput | no | no |
| KATL1_HUMAN | [view interactions] | High throughput | no | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPAR6_HUMAN | [view interactions] | High throughput | no | no |
| ST1A1_HUMAN | [view interactions] | High throughput | no | no |
| VEGFB_HUMAN | [view interactions] | High throughput | no | no |
| SOX5_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN444_HUMAN | [view interactions] | High throughput | no | no |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| ORNT2_HUMAN | [view interactions] | High throughput | no | no |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| DEN10_HUMAN | [view interactions] | High throughput | no | no |
| PXMP4_HUMAN | [view interactions] | High throughput | no | yes |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| GNT2A_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| RIPP1_HUMAN | [view interactions] | High throughput | no | no |
| PLPP3_HUMAN | [view interactions] | High throughput | no | no |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| KCNN4_HUMAN | [view interactions] | High throughput | no | no |
| STK36_HUMAN | [view interactions] | High throughput | no | yes |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| DNJC4_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNNC2_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASH1_HUMAN | [view interactions] | High throughput | no | yes |
| KLK2_HUMAN | [view interactions] | High throughput | no | no |
| LRIQ3_HUMAN | [view interactions] | High throughput | no | no |
| BIRC7_HUMAN | [view interactions] | High throughput | no | no |
| PDE4D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| CCM2_HUMAN | [view interactions] | High throughput | no | yes |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| NTF2_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| KAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCRM_HUMAN | [view interactions] | High throughput | no | no |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMPX_HUMAN | [view interactions] | High throughput | no | no |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRVA_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM4_HUMAN | [view interactions] | High throughput | no | no |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MINP1_HUMAN | [view interactions] | Computational | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GLCTK_HUMAN | [view interactions] | Computational | no | yes |
| KPYM_HUMAN | [view interactions] | Computational | no | yes |
| ENOG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TALDO_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DEOC_HUMAN | [view interactions] | Computational | no | no |
| A0A2U3TZM8_HUMAN | [view interactions] | Computational | no | no |
| PGK2_HUMAN | [view interactions] | Computational | no | no |
| ENO4_HUMAN | [view interactions] | Computational | no | no |
| G6PE_HUMAN | [view interactions] | Computational | no | yes |