Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDE4D_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
190 Ser Ala Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
225 Pro Thr Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
226 Phe Ser Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
587 Thr Pro Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
227 Ala Ser Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
228 Gln Glu Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
301 Ser Thr Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
304 Ala Val Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
329 Val Ala Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
590 Glu Ala Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
673 Gly Asp Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -
678 Ile Thr Acrodysostosis2,withorwithouthormoneresistance(ACRDYS2) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDE4D_HUMAN
GO:0017076 purine nucleotide binding 48.7805 4 yes
GO:0032555 purine ribonucleotide binding 48.7805 4 yes
GO:0046872 metal ion binding 48.7805 4 yes
GO:0030554 adenyl nucleotide binding 43.9024 5 yes
GO:0032559 adenyl ribonucleotide binding 43.9024 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 41.4634 4 no
GO:0005524 ATP binding 36.5854 5 no
GO:0016301 kinase activity 26.8293 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 24.3902 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 24.3902 4 no
GO:0019900 kinase binding 21.9512 4 no
GO:0019901 protein kinase binding 21.9512 5 no
GO:0001664 G protein-coupled receptor binding 17.0732 4 yes
GO:0042578 phosphoric ester hydrolase activity 14.6341 4 yes
GO:0031690 adrenergic receptor binding 9.7561 5 yes
GO:0051117 ATPase binding 9.7561 4 yes
GO:0004112 cyclic-nucleotide phosphodiesterase activity 7.3171 6 yes
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity 7.3171 7 yes
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity 7.3171 8 yes
GO:0008081 phosphoric diester hydrolase activity 7.3171 5 yes
GO:0030551 cyclic nucleotide binding 7.3171 4 yes
GO:0030552 cAMP binding 7.3171 4 yes
GO:0031698 beta-2 adrenergic receptor binding 4.8780 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDE4D_HUMAN
GO:0010646 regulation of cell communication 75.6098 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.8537 4 yes
GO:0009966 regulation of signal transduction 63.4146 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 60.9756 4 yes
GO:0080090 regulation of primary metabolic process 60.9756 4 yes
GO:0048522 positive regulation of cellular process 60.9756 4 no
GO:0010468 regulation of gene expression 60.9756 5 yes
GO:0031323 regulation of cellular metabolic process 60.9756 4 yes
GO:0048523 negative regulation of cellular process 56.0976 4 yes
GO:0051049 regulation of transport 53.6585 4 yes
GO:0051128 regulation of cellular component organization 53.6585 4 no
GO:0006796 phosphate-containing compound metabolic process 53.6585 4 yes
GO:0009893 positive regulation of metabolic process 53.6585 4 yes
GO:1902531 regulation of intracellular signal transduction 51.2195 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.7805 5 yes
GO:0051246 regulation of protein metabolic process 46.3415 5 yes
GO:0009889 regulation of biosynthetic process 46.3415 4 no
GO:0050804 modulation of chemical synaptic transmission 46.3415 5 no
GO:0099177 regulation of trans-synaptic signaling 46.3415 4 no
GO:0051240 positive regulation of multicellular organismal process 43.9024 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 43.9024 5 no
GO:0031326 regulation of cellular biosynthetic process 43.9024 5 no
GO:0010647 positive regulation of cell communication 43.9024 5 no
GO:0023056 positive regulation of signaling 43.9024 4 no
GO:0048584 positive regulation of response to stimulus 43.9024 4 yes
GO:0031325 positive regulation of cellular metabolic process 41.4634 5 no
GO:0036211 protein modification process 41.4634 4 no
GO:0043412 macromolecule modification 41.4634 4 no
GO:0048585 negative regulation of response to stimulus 41.4634 4 yes
GO:0071310 cellular response to organic substance 39.0244 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 39.0244 5 no
GO:0051130 positive regulation of cellular component organization 39.0244 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.0244 5 no
GO:0010648 negative regulation of cell communication 39.0244 5 yes
GO:0023057 negative regulation of signaling 39.0244 4 yes
GO:1901701 cellular response to oxygen-containing compound 36.5854 4 yes
GO:0006355 regulation of DNA-templated transcription 36.5854 6 no
GO:0051050 positive regulation of transport 36.5854 4 no
GO:0051252 regulation of RNA metabolic process 36.5854 5 no
GO:1903506 regulation of nucleic acid-templated transcription 36.5854 7 no
GO:2001141 regulation of RNA biosynthetic process 36.5854 6 no
GO:0009892 negative regulation of metabolic process 36.5854 4 yes
GO:0009968 negative regulation of signal transduction 36.5854 5 yes
GO:0010243 response to organonitrogen compound 36.5854 4 yes
GO:0031399 regulation of protein modification process 36.5854 6 yes
GO:0051174 regulation of phosphorus metabolic process 34.1463 5 yes
GO:0051241 negative regulation of multicellular organismal process 34.1463 4 yes
GO:0022607 cellular component assembly 34.1463 4 no
GO:0016192 vesicle-mediated transport 34.1463 4 no
GO:0016310 phosphorylation 34.1463 5 no
GO:0010605 negative regulation of macromolecule metabolic process 34.1463 5 yes
GO:0019220 regulation of phosphate metabolic process 34.1463 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 31.7073 5 yes
GO:0060627 regulation of vesicle-mediated transport 31.7073 4 no
GO:0006996 organelle organization 31.7073 4 no
GO:0009967 positive regulation of signal transduction 31.7073 5 no
GO:0006468 protein phosphorylation 31.7073 5 no
GO:0043408 regulation of MAPK cascade 31.7073 6 no
GO:0051247 positive regulation of protein metabolic process 31.7073 6 no
GO:0001932 regulation of protein phosphorylation 31.7073 7 yes
GO:0042325 regulation of phosphorylation 31.7073 7 yes
GO:0050776 regulation of immune response 29.2683 4 yes
GO:0071417 cellular response to organonitrogen compound 29.2683 4 yes
GO:1901699 cellular response to nitrogen compound 29.2683 4 yes
GO:0009891 positive regulation of biosynthetic process 29.2683 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 29.2683 6 no
GO:0045595 regulation of cell differentiation 29.2683 4 no
GO:0080134 regulation of response to stress 29.2683 4 no
GO:0033043 regulation of organelle organization 29.2683 5 no
GO:0010941 regulation of cell death 29.2683 4 no
GO:0043085 positive regulation of catalytic activity 29.2683 4 no
GO:0051336 regulation of hydrolase activity 29.2683 4 no
GO:0010628 positive regulation of gene expression 29.2683 6 yes
GO:0031324 negative regulation of cellular metabolic process 29.2683 5 yes
GO:0043269 regulation of ion transport 29.2683 5 yes
GO:0044057 regulation of system process 29.2683 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 26.8293 6 no
GO:0031344 regulation of cell projection organization 26.8293 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.8293 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.8293 6 no
GO:0051094 positive regulation of developmental process 26.8293 4 no
GO:1902533 positive regulation of intracellular signal transduction 26.8293 6 no
GO:0001934 positive regulation of protein phosphorylation 26.8293 8 no
GO:0010562 positive regulation of phosphorus metabolic process 26.8293 6 no
GO:0031401 positive regulation of protein modification process 26.8293 7 no
GO:0042327 positive regulation of phosphorylation 26.8293 8 no
GO:0042981 regulation of apoptotic process 26.8293 6 no
GO:0043067 regulation of programmed cell death 26.8293 5 no
GO:0045937 positive regulation of phosphate metabolic process 26.8293 7 no
GO:0001817 regulation of cytokine production 26.8293 4 yes
GO:0010959 regulation of metal ion transport 26.8293 6 yes
GO:0014070 response to organic cyclic compound 26.8293 4 yes
GO:0051248 negative regulation of protein metabolic process 24.3902 6 yes
GO:0051924 regulation of calcium ion transport 24.3902 7 yes
GO:0071407 cellular response to organic cyclic compound 24.3902 5 yes
GO:1904062 regulation of cation transmembrane transport 24.3902 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 24.3902 7 no
GO:0060341 regulation of cellular localization 24.3902 4 no
GO:0044087 regulation of cellular component biogenesis 24.3902 4 no
GO:0030162 regulation of proteolysis 24.3902 6 no
GO:0006897 endocytosis 24.3902 5 no
GO:0010942 positive regulation of cell death 24.3902 5 no
GO:0002684 positive regulation of immune system process 24.3902 4 yes
GO:0034762 regulation of transmembrane transport 24.3902 4 yes
GO:0034765 regulation of ion transmembrane transport 24.3902 5 yes
GO:0050778 positive regulation of immune response 21.9512 5 yes
GO:1902532 negative regulation of intracellular signal transduction 21.9512 6 yes
GO:1903522 regulation of blood circulation 21.9512 5 yes
GO:0008104 protein localization 21.9512 4 no
GO:0030334 regulation of cell migration 21.9512 5 no
GO:0032880 regulation of protein localization 21.9512 5 no
GO:0045893 positive regulation of DNA-templated transcription 21.9512 7 no
GO:0051223 regulation of protein transport 21.9512 5 no
GO:0051254 positive regulation of RNA metabolic process 21.9512 6 no
GO:0070201 regulation of establishment of protein localization 21.9512 6 no
GO:1902680 positive regulation of RNA biosynthetic process 21.9512 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 21.9512 8 no
GO:2000145 regulation of cell motility 21.9512 4 no
GO:0007010 cytoskeleton organization 21.9512 5 no
GO:0043393 regulation of protein binding 21.9512 4 no
GO:0045597 positive regulation of cell differentiation 21.9512 5 no
GO:0050890 cognition 21.9512 4 no
GO:0043933 protein-containing complex organization 21.9512 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.9512 4 no
GO:0030030 cell projection organization 21.9512 4 no
GO:0051338 regulation of transferase activity 21.9512 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 21.9512 7 no
GO:0080135 regulation of cellular response to stress 21.9512 4 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 21.9512 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 21.9512 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 21.9512 4 yes
GO:0019932 second-messenger-mediated signaling 21.9512 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 19.5122 5 yes
GO:0090257 regulation of muscle system process 19.5122 5 yes
GO:1903169 regulation of calcium ion transmembrane transport 19.5122 7 yes
GO:0001819 positive regulation of cytokine production 19.5122 5 yes
GO:0031400 negative regulation of protein modification process 19.5122 7 yes
GO:0032970 regulation of actin filament-based process 19.5122 4 yes
GO:0050852 T cell receptor signaling pathway 17.0732 6 yes
GO:0071867 response to monoamine 17.0732 5 yes
GO:0071868 cellular response to monoamine stimulus 17.0732 5 yes
GO:0071869 response to catecholamine 17.0732 4 yes
GO:0071870 cellular response to catecholamine stimulus 17.0732 5 yes
GO:0072521 purine-containing compound metabolic process 17.0732 4 yes
GO:1901565 organonitrogen compound catabolic process 17.0732 4 yes
GO:0006163 purine nucleotide metabolic process 17.0732 5 yes
GO:0006753 nucleoside phosphate metabolic process 17.0732 4 yes
GO:0006937 regulation of muscle contraction 17.0732 6 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 17.0732 5 yes
GO:0008016 regulation of heart contraction 17.0732 6 yes
GO:0009117 nucleotide metabolic process 17.0732 5 yes
GO:0009150 purine ribonucleotide metabolic process 17.0732 6 yes
GO:0009259 ribonucleotide metabolic process 17.0732 5 yes
GO:0019693 ribose phosphate metabolic process 17.0732 4 yes
GO:0055117 regulation of cardiac muscle contraction 14.6341 7 yes
GO:2001257 regulation of cation channel activity 14.6341 6 yes
GO:0006942 regulation of striated muscle contraction 14.6341 7 yes
GO:0010563 negative regulation of phosphorus metabolic process 14.6341 6 yes
GO:0022898 regulation of transmembrane transporter activity 14.6341 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 14.6341 5 yes
GO:0032649 regulation of interferon-gamma production 14.6341 5 yes
GO:0032729 positive regulation of interferon-gamma production 14.6341 6 yes
GO:0045936 negative regulation of phosphate metabolic process 14.6341 7 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 12.1951 5 yes
GO:0051282 regulation of sequestering of calcium ion 12.1951 4 yes
GO:0071871 response to epinephrine 12.1951 5 yes
GO:1903523 negative regulation of blood circulation 12.1951 5 yes
GO:0001933 negative regulation of protein phosphorylation 12.1951 8 yes
GO:0009187 cyclic nucleotide metabolic process 12.1951 6 yes
GO:0042326 negative regulation of phosphorylation 12.1951 8 yes
GO:0046058 cAMP metabolic process 12.1951 7 yes
GO:0071872 cellular response to epinephrine stimulus 9.7561 6 yes
GO:0071875 adrenergic receptor signaling pathway 9.7561 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 9.7561 5 yes
GO:0086004 regulation of cardiac muscle cell contraction 9.7561 6 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 9.7561 6 yes
GO:1901136 carbohydrate derivative catabolic process 9.7561 4 yes
GO:1903115 regulation of actin filament-based movement 9.7561 5 yes
GO:1903524 positive regulation of blood circulation 9.7561 5 yes
GO:0010460 positive regulation of heart rate 9.7561 4 yes
GO:0032663 regulation of interleukin-2 production 9.7561 5 yes
GO:0032743 positive regulation of interleukin-2 production 9.7561 6 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 9.7561 8 yes
GO:0045822 negative regulation of heart contraction 9.7561 6 yes
GO:0045823 positive regulation of heart contraction 9.7561 6 yes
GO:0051591 response to cAMP 7.3171 4 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 7.3171 6 yes
GO:0071320 cellular response to cAMP 7.3171 5 yes
GO:0072523 purine-containing compound catabolic process 7.3171 5 yes
GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 7.3171 4 yes
GO:1901077 regulation of relaxation of muscle 7.3171 6 yes
GO:1901078 negative regulation of relaxation of muscle 7.3171 5 yes
GO:1901292 nucleoside phosphate catabolic process 7.3171 5 yes
GO:1901361 organic cyclic compound catabolic process 7.3171 4 yes
GO:1901897 regulation of relaxation of cardiac muscle 7.3171 7 yes
GO:1901898 negative regulation of relaxation of cardiac muscle 7.3171 6 yes
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine 7.3171 5 yes
GO:0002064 epithelial cell development 7.3171 4 yes
GO:0006195 purine nucleotide catabolic process 7.3171 6 yes
GO:0006198 cAMP catabolic process 7.3171 7 yes
GO:0009154 purine ribonucleotide catabolic process 7.3171 6 yes
GO:0009166 nucleotide catabolic process 7.3171 6 yes
GO:0009214 cyclic nucleotide catabolic process 7.3171 7 yes
GO:0009261 ribonucleotide catabolic process 7.3171 5 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 7.3171 6 yes
GO:0014074 response to purine-containing compound 7.3171 5 yes
GO:0019439 aromatic compound catabolic process 7.3171 4 yes
GO:0019933 cAMP-mediated signaling 7.3171 6 yes
GO:0019935 cyclic-nucleotide-mediated signaling 7.3171 5 yes
GO:0034655 nucleobase-containing compound catabolic process 7.3171 4 yes
GO:0044270 cellular nitrogen compound catabolic process 7.3171 4 yes
GO:0046434 organophosphate catabolic process 7.3171 4 yes
GO:0046683 response to organophosphorus 7.3171 4 yes
GO:0046700 heterocycle catabolic process 7.3171 4 yes
GO:0061028 establishment of endothelial barrier 4.8780 6 yes
GO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 4.8780 5 yes
GO:0086024 adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate 4.8780 6 yes
GO:0140200 adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate 4.8780 6 yes
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 4.8780 6 yes
GO:0001885 endothelial cell development 4.8780 5 yes
GO:0010649 regulation of cell communication by electrical coupling 4.8780 5 yes
GO:0032674 regulation of interleukin-5 production 4.8780 5 yes
GO:0032754 positive regulation of interleukin-5 production 4.8780 6 yes
GO:0033137 negative regulation of peptidyl-serine phosphorylation 4.8780 9 yes
GO:0043949 regulation of cAMP-mediated signaling 4.8780 6 yes
GO:0043951 negative regulation of cAMP-mediated signaling 4.8780 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in PDE4D_HUMAN
DOID:0080001 bone disease 4.8780 4 yes
DOID:0080006 bone development disease 4.8780 5 yes
DOID:14669 acrodysostosis 4.8780 7 yes
DOID:1934 dysostosis 4.8780 6 yes
DOID:65 connective tissue disease 4.8780 3 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ADRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
AKA12_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
RYR1_HUMAN [view interactions] Low throughput no no
MYOME_HUMAN [view interactions] Low throughput no no
RACK1_HUMAN [view interactions] Low throughput no yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKAP6_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view interactions] Low throughput no yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
CANB1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
PAQRB_HUMAN [view interactions] Low throughput no no
CUL1_HUMAN [view interactions] Low throughput no yes
FBX2_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
KC1A_HUMAN [view interactions] Low throughput no yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
PIAS4_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
LMX1B_HUMAN [view interactions] High throughput no no
COIL_HUMAN [view interactions] High throughput no yes
MAGA6_HUMAN [view interactions] High throughput no no
GOG8F_HUMAN [view interactions] High throughput no no
GOG8D_HUMAN [view interactions] High throughput no no
TRAF1_HUMAN [view interactions] High throughput no no
BUB1_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
ZDH17_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB1_HUMAN [view interactions] High throughput no no
IP3KB_HUMAN [view interactions] High throughput no no
F262_HUMAN [view interactions] High throughput no no
PTN13_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
SMAP1_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
SMO_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PLK1_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
OXSR1_HUMAN [view interactions] High throughput no yes
ABCF3_HUMAN [view entry] [view interactions] High throughput yes yes
CLPB_HUMAN [view interactions] High throughput no yes
PDXD1_HUMAN [view interactions] High throughput no no
PDE4A_HUMAN [view interactions] High throughput no no
PGAM2_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
FBX7_HUMAN [view interactions] High throughput no yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
HDGR2_HUMAN [view interactions] High throughput no yes
ADCY6_HUMAN [view interactions] Computational no yes
ADRB2_HUMAN [view entry] [view interactions] Computational yes no
ADCY5_HUMAN [view interactions] Computational no no
PUR8_HUMAN [view interactions] Computational no yes
KAD3_HUMAN [view entry] [view interactions] Computational yes yes
ADCY9_HUMAN [view interactions] Computational no yes
ADCYA_HUMAN [view interactions] Computational no yes
ADCY4_HUMAN [view interactions] Computational no yes
DCK_HUMAN [view interactions] Computational no no
AT2A2_HUMAN [view entry] [view interactions] Computational yes yes
ADCY2_HUMAN [view interactions] Computational no yes
RHEB_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
APT_HUMAN [view interactions] Computational no yes
ADCY1_HUMAN [view entry] [view interactions] Computational yes no
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
DISC1_HUMAN [view entry] [view interactions] Computational yes no
AL7A1_HUMAN [view entry] [view interactions] Computational yes no
ADCY7_HUMAN [view interactions] Computational no yes