SHAN2_HUMAN
Evidence for PS localization
Functions
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003502 | LIG_IBAR_NPY_1 | LIG | 608 | 610 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SHAN2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.4902 | 4 | no |
| GO:0019900 | kinase binding | 23.5294 | 4 | no |
| GO:0017124 | SH3 domain binding | 15.6863 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 13.7255 | 4 | yes |
| GO:0030159 | signaling receptor complex adaptor activity | 11.7647 | 4 | yes |
| GO:0030160 | synaptic receptor adaptor activity | 7.8431 | 5 | yes |
| GO:0035255 | ionotropic glutamate receptor binding | 7.8431 | 5 | yes |
| GO:0098879 | structural constituent of postsynaptic specialization | 3.9216 | 4 | yes |
| GO:0098919 | structural constituent of postsynaptic density | 3.9216 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SHAN2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 64.7059 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 60.7843 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 56.8627 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.9804 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 49.0196 | 4 | yes |
| GO:0022607 | cellular component assembly | 47.0588 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 45.0980 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 45.0980 | 4 | yes |
| GO:0008104 | protein localization | 45.0980 | 4 | no |
| GO:0051049 | regulation of transport | 41.1765 | 4 | no |
| GO:0034330 | cell junction organization | 37.2549 | 4 | yes |
| GO:0044057 | regulation of system process | 37.2549 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.2941 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.2941 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.2941 | 4 | no |
| GO:0030030 | cell projection organization | 35.2941 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:0050808 | synapse organization | 31.3725 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 31.3725 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.3725 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 31.3725 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 31.3725 | 6 | no |
| GO:0031644 | regulation of nervous system process | 31.3725 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 31.3725 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 31.3725 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.4118 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.4118 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 29.4118 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 29.4118 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.4118 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 29.4118 | 5 | no |
| GO:0006996 | organelle organization | 29.4118 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.4510 | 4 | no |
| GO:0043269 | regulation of ion transport | 27.4510 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.4510 | 4 | no |
| GO:0034329 | cell junction assembly | 25.4902 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 25.4902 | 5 | yes |
| GO:0050890 | cognition | 25.4902 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.4902 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.4902 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 25.4902 | 4 | no |
| GO:0007612 | learning | 23.5294 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.5294 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 23.5294 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.5294 | 5 | no |
| GO:0099601 | regulation of neurotransmitter receptor activity | 23.5294 | 4 | no |
| GO:0072657 | protein localization to membrane | 23.5294 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 23.5294 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.5686 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 21.5686 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.5686 | 4 | no |
| GO:0051960 | regulation of nervous system development | 21.5686 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 21.5686 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.5686 | 5 | no |
| GO:0007416 | synapse assembly | 19.6078 | 6 | yes |
| GO:0007420 | brain development | 15.6863 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 15.6863 | 5 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 11.7647 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 9.8039 | 4 | yes |
| GO:0008306 | associative learning | 7.8431 | 5 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 5.8824 | 5 | yes |
| GO:0008344 | adult locomotory behavior | 3.9216 | 4 | yes |
| GO:0031667 | response to nutrient levels | 3.9216 | 4 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 3.9216 | 5 | yes |
| GO:0060291 | long-term synaptic potentiation | 3.9216 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BI2L1_HUMAN | [view interactions] | Low throughput | no | yes |
| SL9A3_HUMAN | [view interactions] | Low throughput | no | yes |
| SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AGRL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CFTR_HUMAN | [view interactions] | Low throughput | no | no |
| NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLGP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RET_HUMAN | [view interactions] | Low throughput | no | yes |
| GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NLK_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RIPR3_HUMAN | [view interactions] | High throughput | no | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG12_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGNX_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NLGN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HOME2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NLGN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HOME3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NRX2A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NRX3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |