SHAN1_HUMAN
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003087 | DOC_MAPK_JIP1_4 | DOC | 2016 | 2022 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SHAN1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 21.2766 | 4 | no |
GO:0019900 | kinase binding | 21.2766 | 4 | no |
GO:0001664 | G protein-coupled receptor binding | 19.1489 | 4 | yes |
GO:0035254 | glutamate receptor binding | 17.0213 | 4 | yes |
GO:0017124 | SH3 domain binding | 14.8936 | 4 | yes |
GO:0030159 | signaling receptor complex adaptor activity | 14.8936 | 4 | yes |
GO:0030160 | synaptic receptor adaptor activity | 10.6383 | 5 | yes |
GO:0035255 | ionotropic glutamate receptor binding | 10.6383 | 5 | yes |
GO:0031877 | somatostatin receptor binding | 4.2553 | 6 | yes |
GO:0071532 | ankyrin repeat binding | 4.2553 | 4 | yes |
GO:0071855 | neuropeptide receptor binding | 4.2553 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SHAN1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.2128 | 4 | yes |
GO:0010646 | regulation of cell communication | 68.0851 | 4 | yes |
GO:0009966 | regulation of signal transduction | 63.8298 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 55.3191 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 51.0638 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 51.0638 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 51.0638 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 44.6809 | 5 | yes |
GO:0023056 | positive regulation of signaling | 44.6809 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 40.4255 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 40.4255 | 4 | no |
GO:0008104 | protein localization | 40.4255 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 38.2979 | 5 | yes |
GO:0022607 | cellular component assembly | 38.2979 | 4 | yes |
GO:0050890 | cognition | 38.2979 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 38.2979 | 4 | yes |
GO:0034330 | cell junction organization | 36.1702 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 36.1702 | 6 | no |
GO:0098916 | anterograde trans-synaptic signaling | 36.1702 | 5 | no |
GO:0099537 | trans-synaptic signaling | 36.1702 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 36.1702 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.1702 | 4 | no |
GO:0031644 | regulation of nervous system process | 34.0426 | 5 | yes |
GO:0044057 | regulation of system process | 34.0426 | 4 | yes |
GO:0050808 | synapse organization | 34.0426 | 5 | yes |
GO:0031344 | regulation of cell projection organization | 34.0426 | 5 | no |
GO:0030030 | cell projection organization | 31.9149 | 4 | yes |
GO:0044087 | regulation of cellular component biogenesis | 31.9149 | 4 | yes |
GO:0051049 | regulation of transport | 31.9149 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 31.9149 | 5 | no |
GO:0007612 | learning | 31.9149 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.7872 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 29.7872 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 29.7872 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 29.7872 | 4 | no |
GO:0043269 | regulation of ion transport | 27.6596 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 27.6596 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.6596 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.6596 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 27.6596 | 5 | no |
GO:0050807 | regulation of synapse organization | 25.5319 | 5 | no |
GO:0072657 | protein localization to membrane | 25.5319 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.5319 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 25.5319 | 4 | no |
GO:0031175 | neuron projection development | 23.4043 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 23.4043 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 23.4043 | 5 | yes |
GO:0035418 | protein localization to synapse | 23.4043 | 6 | yes |
GO:0051129 | negative regulation of cellular component organization | 23.4043 | 5 | yes |
GO:0098815 | modulation of excitatory postsynaptic potential | 23.4043 | 4 | yes |
GO:0099601 | regulation of neurotransmitter receptor activity | 23.4043 | 4 | yes |
GO:1902414 | protein localization to cell junction | 23.4043 | 5 | yes |
GO:0006996 | organelle organization | 23.4043 | 4 | no |
GO:0010468 | regulation of gene expression | 23.4043 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 23.4043 | 4 | no |
GO:0045595 | regulation of cell differentiation | 23.4043 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 23.4043 | 4 | no |
GO:0010648 | negative regulation of cell communication | 23.4043 | 5 | no |
GO:0023057 | negative regulation of signaling | 23.4043 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 23.4043 | 4 | no |
GO:0022898 | regulation of transmembrane transporter activity | 21.2766 | 4 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 21.2766 | 5 | yes |
GO:0033043 | regulation of organelle organization | 21.2766 | 5 | yes |
GO:1904062 | regulation of cation transmembrane transport | 21.2766 | 6 | yes |
GO:2000463 | positive regulation of excitatory postsynaptic potential | 21.2766 | 5 | yes |
GO:0043113 | receptor clustering | 21.2766 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 21.2766 | 6 | no |
GO:0051240 | positive regulation of multicellular organismal process | 21.2766 | 4 | no |
GO:0051960 | regulation of nervous system development | 21.2766 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 21.2766 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 19.1489 | 6 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 19.1489 | 5 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 17.0213 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 17.0213 | 4 | yes |
GO:0032990 | cell part morphogenesis | 17.0213 | 4 | yes |
GO:0048812 | neuron projection morphogenesis | 17.0213 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 17.0213 | 5 | yes |
GO:0110053 | regulation of actin filament organization | 17.0213 | 6 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 17.0213 | 6 | yes |
GO:2001257 | regulation of cation channel activity | 17.0213 | 6 | yes |
GO:0008306 | associative learning | 14.8936 | 5 | yes |
GO:0010639 | negative regulation of organelle organization | 12.7660 | 6 | yes |
GO:0043933 | protein-containing complex organization | 12.7660 | 4 | yes |
GO:0060998 | regulation of dendritic spine development | 12.7660 | 4 | yes |
GO:0060999 | positive regulation of dendritic spine development | 12.7660 | 5 | yes |
GO:0065003 | protein-containing complex assembly | 12.7660 | 5 | yes |
GO:2000311 | regulation of AMPA receptor activity | 12.7660 | 5 | yes |
GO:0050885 | neuromuscular process controlling balance | 10.6383 | 5 | yes |
GO:0050905 | neuromuscular process | 10.6383 | 4 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 10.6383 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 10.6383 | 6 | yes |
GO:0007613 | memory | 10.6383 | 4 | yes |
GO:0032231 | regulation of actin filament bundle assembly | 8.5106 | 5 | yes |
GO:0060997 | dendritic spine morphogenesis | 8.5106 | 6 | yes |
GO:0097061 | dendritic spine organization | 8.5106 | 5 | yes |
GO:0099173 | postsynapse organization | 8.5106 | 4 | yes |
GO:0106027 | neuron projection organization | 8.5106 | 6 | yes |
GO:0007616 | long-term memory | 8.5106 | 5 | yes |
GO:0032232 | negative regulation of actin filament bundle assembly | 6.3830 | 6 | yes |
GO:0042048 | olfactory behavior | 4.2553 | 4 | yes |
GO:0046958 | nonassociative learning | 4.2553 | 5 | yes |
GO:0046959 | habituation | 4.2553 | 6 | yes |
GO:0050893 | sensory processing | 4.2553 | 5 | yes |
GO:0050894 | determination of affect | 4.2553 | 6 | yes |
GO:0060013 | righting reflex | 4.2553 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BI2L1_HUMAN | [view interactions] | Low throughput | no | yes |
DLGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KS6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KS6A2_HUMAN | [view interactions] | Low throughput | no | yes |
SHRPN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACE2_HUMAN | [view interactions] | Low throughput | no | no |
GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AGRL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HOME3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AGRL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AGRB2_HUMAN | [view interactions] | Low throughput | no | no |
CAC1D_HUMAN | [view interactions] | Low throughput | no | yes |
GKAP1_HUMAN | [view interactions] | Low throughput | no | no |
CRCM_HUMAN | [view interactions] | Low throughput | no | no |
DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CSMD2_HUMAN | [view interactions] | Low throughput | no | no |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
NEK4_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TB10C_HUMAN | [view interactions] | High throughput | no | no |
WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
S26A6_HUMAN | [view interactions] | High throughput | no | yes |
MELT_HUMAN | [view interactions] | High throughput | no | yes |
TM219_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
NLGN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
BRCA2_HUMAN | [view interactions] | High throughput | no | no |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
HOME2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NLGNX_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DLGP3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NMDZ1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NRX1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NRX3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NLGN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SHAN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NRX2A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DLG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |