Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHAN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003087 DOC_MAPK_JIP1_4 DOC 2016 2022 -
ELMI003087 DOC_MAPK_JIP1_4 DOC 2016 2022 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SHAN1_HUMAN
GO:0019900 kinase binding 21.4286 4 no
GO:0043169 cation binding 21.4286 4 no
GO:0046872 metal ion binding 21.4286 5 no
GO:0035254 glutamate receptor binding 19.0476 4 yes
GO:0001664 G protein-coupled receptor binding 16.6667 4 yes
GO:0017124 SH3 domain binding 16.6667 4 yes
GO:0030159 signaling receptor complex adaptor activity 14.2857 4 yes
GO:0035255 ionotropic glutamate receptor binding 11.9048 5 yes
GO:0030160 synaptic receptor adaptor activity 9.5238 5 yes
GO:0098879 structural constituent of postsynaptic specialization 7.1429 4 yes
GO:0098919 structural constituent of postsynaptic density 7.1429 5 yes
GO:0031877 somatostatin receptor binding 4.7619 6 yes
GO:0071532 ankyrin repeat binding 4.7619 4 yes
GO:0071855 neuropeptide receptor binding 4.7619 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SHAN1_HUMAN
GO:0048522 positive regulation of cellular process 69.0476 4 yes
GO:0010646 regulation of cell communication 61.9048 4 yes
GO:0051128 regulation of cellular component organization 61.9048 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0009966 regulation of signal transduction 47.6190 4 yes
GO:0008104 protein localization 45.2381 4 yes
GO:0050804 modulation of chemical synaptic transmission 45.2381 5 yes
GO:0099177 regulation of trans-synaptic signaling 45.2381 4 yes
GO:0022607 cellular component assembly 42.8571 4 yes
GO:0010647 positive regulation of cell communication 38.0952 5 yes
GO:0023056 positive regulation of signaling 38.0952 4 yes
GO:0060255 regulation of macromolecule metabolic process 38.0952 4 no
GO:0051094 positive regulation of developmental process 35.7143 4 yes
GO:0031344 regulation of cell projection organization 35.7143 5 no
GO:0030030 cell projection organization 33.3333 4 yes
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009967 positive regulation of signal transduction 30.9524 5 yes
GO:0034330 cell junction organization 30.9524 4 yes
GO:0050890 cognition 30.9524 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.9524 6 no
GO:0051130 positive regulation of cellular component organization 30.9524 5 no
GO:0050808 synapse organization 28.5714 5 yes
GO:0051049 regulation of transport 28.5714 4 yes
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 yes
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0007268 chemical synaptic transmission 26.1905 7 no
GO:0098916 anterograde trans-synaptic signaling 26.1905 6 no
GO:0099536 synaptic signaling 26.1905 4 no
GO:0099537 trans-synaptic signaling 26.1905 5 no
GO:0022603 regulation of anatomical structure morphogenesis 26.1905 4 no
GO:0048585 negative regulation of response to stimulus 26.1905 4 no
GO:0007612 learning 23.8095 4 yes
GO:0031175 neuron projection development 23.8095 6 yes
GO:0033043 regulation of organelle organization 23.8095 5 yes
GO:0035418 protein localization to synapse 23.8095 6 yes
GO:0048812 neuron projection morphogenesis 23.8095 5 yes
GO:0051129 negative regulation of cellular component organization 23.8095 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.8095 4 yes
GO:1902414 protein localization to cell junction 23.8095 5 yes
GO:1902903 regulation of supramolecular fiber organization 23.8095 5 yes
GO:0009892 negative regulation of metabolic process 23.8095 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 no
GO:0031325 positive regulation of cellular metabolic process 23.8095 5 no
GO:0045595 regulation of cell differentiation 23.8095 4 no
GO:0010975 regulation of neuron projection development 23.8095 7 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:2000026 regulation of multicellular organismal development 23.8095 4 no
GO:0044057 regulation of system process 21.4286 4 yes
GO:0051493 regulation of cytoskeleton organization 21.4286 6 yes
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:0051960 regulation of nervous system development 21.4286 5 no
GO:0022898 regulation of transmembrane transporter activity 19.0476 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 19.0476 5 yes
GO:0032956 regulation of actin cytoskeleton organization 19.0476 5 yes
GO:0032970 regulation of actin filament-based process 19.0476 4 yes
GO:0034762 regulation of transmembrane transport 19.0476 4 yes
GO:0110053 regulation of actin filament organization 19.0476 6 yes
GO:0007613 memory 16.6667 4 yes
GO:0008306 associative learning 16.6667 5 yes
GO:0031644 regulation of nervous system process 16.6667 5 yes
GO:0043933 protein-containing complex organization 16.6667 4 yes
GO:0065003 protein-containing complex assembly 16.6667 5 yes
GO:0098815 modulation of excitatory postsynaptic potential 16.6667 4 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 16.6667 5 yes
GO:0060998 regulation of dendritic spine development 14.2857 4 yes
GO:0060999 positive regulation of dendritic spine development 14.2857 5 yes
GO:0099601 regulation of neurotransmitter receptor activity 14.2857 4 yes
GO:0007616 long-term memory 11.9048 5 yes
GO:0010639 negative regulation of organelle organization 11.9048 6 yes
GO:0051494 negative regulation of cytoskeleton organization 11.9048 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 11.9048 6 yes
GO:2000311 regulation of AMPA receptor activity 11.9048 5 yes
GO:0032231 regulation of actin filament bundle assembly 9.5238 5 yes
GO:0050885 neuromuscular process controlling balance 9.5238 5 yes
GO:0050905 neuromuscular process 9.5238 4 yes
GO:0060997 dendritic spine morphogenesis 9.5238 6 yes
GO:0097061 dendritic spine organization 9.5238 5 yes
GO:0099173 postsynapse organization 9.5238 4 yes
GO:0106027 neuron projection organization 9.5238 6 yes
GO:0032232 negative regulation of actin filament bundle assembly 7.1429 6 yes
GO:0042048 olfactory behavior 4.7619 4 yes
GO:0046958 nonassociative learning 4.7619 5 yes
GO:0046959 habituation 4.7619 6 yes
GO:0050893 sensory processing 4.7619 5 yes
GO:0050894 determination of affect 4.7619 6 yes
GO:0060013 righting reflex 4.7619 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
ACE2_HUMAN [view interactions] Low throughput no no
GKAP1_HUMAN [view interactions] Low throughput no no
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRL1_HUMAN [view interactions] Low throughput no no
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRL2_HUMAN [view entry] [view interactions] Low throughput yes no
AGRB2_HUMAN [view interactions] Low throughput no no
CAC1D_HUMAN [view entry] [view interactions] Low throughput yes yes
CRCM_HUMAN [view interactions] Low throughput no no
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
KLOT_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
CSMD2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
BI2L1_HUMAN [view interactions] Low throughput no yes
DLGP2_HUMAN [view entry] [view interactions] Low throughput yes no
KS6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6A2_HUMAN [view interactions] Low throughput no yes
SHRPN_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] Low throughput yes no
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
SSR2_HUMAN [view interactions] Low throughput no yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
ANM2_HUMAN [view interactions] High throughput no yes
TB10C_HUMAN [view interactions] High throughput no no
TM219_HUMAN [view interactions] High throughput no yes
S26A6_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
MELT_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
NLGN1_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
BRCA2_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
NEK4_HUMAN [view interactions] High throughput no yes