Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DLGP3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004042 LIG_DLG_GKlike_1 LIG 393 401 -
ELMI004042 LIG_DLG_GKlike_1 LIG 393 401 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DLGP3_HUMAN
GO:0019900 kinase binding 42.1053 4 no
GO:0019901 protein kinase binding 28.9474 5 no
GO:0016301 kinase activity 23.6842 4 no
GO:0043168 anion binding 21.0526 4 no
GO:0043169 cation binding 21.0526 4 no
GO:0046872 metal ion binding 21.0526 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in DLGP3_HUMAN
GO:0010646 regulation of cell communication 71.0526 4 yes
GO:0048522 positive regulation of cellular process 71.0526 4 no
GO:0048523 negative regulation of cellular process 68.4211 4 no
GO:0031323 regulation of cellular metabolic process 60.5263 4 no
GO:0060255 regulation of macromolecule metabolic process 60.5263 4 no
GO:0051128 regulation of cellular component organization 57.8947 4 no
GO:0080090 regulation of primary metabolic process 55.2632 4 no
GO:0009893 positive regulation of metabolic process 47.3684 4 no
GO:0009966 regulation of signal transduction 47.3684 4 no
GO:0050804 modulation of chemical synaptic transmission 44.7368 5 yes
GO:0099177 regulation of trans-synaptic signaling 44.7368 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.7368 5 no
GO:0051246 regulation of protein metabolic process 44.7368 5 no
GO:0031325 positive regulation of cellular metabolic process 42.1053 5 no
GO:0031399 regulation of protein modification process 42.1053 6 no
GO:0006996 organelle organization 39.4737 4 no
GO:0022607 cellular component assembly 39.4737 4 no
GO:0008104 protein localization 36.8421 4 no
GO:0051247 positive regulation of protein metabolic process 36.8421 6 no
GO:0051049 regulation of transport 36.8421 4 no
GO:0019220 regulation of phosphate metabolic process 36.8421 6 no
GO:0051174 regulation of phosphorus metabolic process 36.8421 5 no
GO:0031401 positive regulation of protein modification process 34.2105 7 no
GO:0010647 positive regulation of cell communication 34.2105 5 no
GO:0010648 negative regulation of cell communication 34.2105 5 no
GO:0022603 regulation of anatomical structure morphogenesis 34.2105 4 no
GO:0023056 positive regulation of signaling 34.2105 4 no
GO:0023057 negative regulation of signaling 34.2105 4 no
GO:0031344 regulation of cell projection organization 34.2105 5 no
GO:0048585 negative regulation of response to stimulus 34.2105 4 no
GO:1902531 regulation of intracellular signal transduction 34.2105 5 no
GO:0009889 regulation of biosynthetic process 31.5789 4 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0031326 regulation of cellular biosynthetic process 31.5789 5 no
GO:0001932 regulation of protein phosphorylation 31.5789 7 no
GO:0042325 regulation of phosphorylation 31.5789 7 no
GO:0048584 positive regulation of response to stimulus 31.5789 4 no
GO:0050890 cognition 31.5789 4 no
GO:0051130 positive regulation of cellular component organization 31.5789 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.5789 6 no
GO:0141124 intracellular signaling cassette 31.5789 4 no
GO:0007010 cytoskeleton organization 28.9474 5 no
GO:0031324 negative regulation of cellular metabolic process 28.9474 5 no
GO:0010562 positive regulation of phosphorus metabolic process 28.9474 6 no
GO:0042127 regulation of cell population proliferation 28.9474 4 no
GO:0043085 positive regulation of catalytic activity 28.9474 4 no
GO:0045937 positive regulation of phosphate metabolic process 28.9474 7 no
GO:0009968 negative regulation of signal transduction 28.9474 5 no
GO:0010468 regulation of gene expression 28.9474 6 no
GO:0010605 negative regulation of macromolecule metabolic process 28.9474 5 no
GO:0001934 positive regulation of protein phosphorylation 26.3158 8 no
GO:0042327 positive regulation of phosphorylation 26.3158 8 no
GO:0033043 regulation of organelle organization 26.3158 5 no
GO:0034330 cell junction organization 23.6842 4 yes
GO:0043933 protein-containing complex organization 23.6842 4 no
GO:0072657 protein localization to membrane 23.6842 4 no
GO:0009967 positive regulation of signal transduction 23.6842 5 no
GO:0010975 regulation of neuron projection development 23.6842 7 no
GO:0030030 cell projection organization 23.6842 4 no
GO:0034762 regulation of transmembrane transport 23.6842 4 no
GO:0043269 regulation of monoatomic ion transport 23.6842 5 no
GO:0044087 regulation of cellular component biogenesis 23.6842 4 no
GO:0051050 positive regulation of transport 23.6842 4 no
GO:1902532 negative regulation of intracellular signal transduction 23.6842 6 no
GO:0036211 protein modification process 21.0526 4 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0065003 protein-containing complex assembly 21.0526 5 no
GO:0007268 chemical synaptic transmission 21.0526 7 no
GO:0098916 anterograde trans-synaptic signaling 21.0526 6 no
GO:0099536 synaptic signaling 21.0526 4 no
GO:0099537 trans-synaptic signaling 21.0526 5 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0045859 regulation of protein kinase activity 21.0526 6 no
GO:0051338 regulation of transferase activity 21.0526 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.0526 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.0526 5 no
GO:0007612 learning 21.0526 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.0526 5 no
GO:0043408 regulation of MAPK cascade 21.0526 6 no
GO:0044057 regulation of system process 21.0526 4 no
GO:0051094 positive regulation of developmental process 21.0526 4 no
GO:0051248 negative regulation of protein metabolic process 21.0526 6 no
GO:0051726 regulation of cell cycle 21.0526 4 no
GO:0071363 cellular response to growth factor stimulus 21.0526 4 no
GO:0050808 synapse organization 15.7895 5 yes
GO:0099563 modification of synaptic structure 5.2632 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS12_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP3_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
MAGA6_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
KRA13_HUMAN [view interactions] High throughput no no
KRA52_HUMAN [view interactions] High throughput no no
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL4B_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1B_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MPIP1_HUMAN [view interactions] High throughput no no
DUS14_HUMAN [view interactions] High throughput no yes
DUS5_HUMAN [view interactions] High throughput no no
PTN3_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
HAPR1_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes