RASL1_HUMAN
Evidence for PS localization
Functions
Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed). Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
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Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Close ✖
RASL1_HUMAN has binary interactions with 8 proteins
Isoforms
Interacting regions
Canonical [RASL1_HUMAN]
Isoform [O95294-2] alignment
Isoform [O95294-3] alignment
Isoform [O95294-4] alignment
LOADING 89%
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RASL1_HUMAN |
---|---|---|---|---|
GO:0005096 | GTPase activator activity | 44.4444 | 4 | yes |
GO:0030695 | GTPase regulator activity | 44.4444 | 4 | yes |
GO:0043169 | cation binding | 44.4444 | 4 | yes |
GO:0046872 | metal ion binding | 44.4444 | 5 | yes |
GO:0019900 | kinase binding | 44.4444 | 4 | no |
GO:0043168 | anion binding | 44.4444 | 4 | no |
GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
GO:0005524 | ATP binding | 33.3333 | 5 | no |
GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 33.3333 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
GO:0004674 | protein serine/threonine kinase activity | 22.2222 | 4 | no |
GO:0016301 | kinase activity | 22.2222 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 22.2222 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RASL1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 77.7778 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
GO:0010646 | regulation of cell communication | 55.5556 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 55.5556 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 55.5556 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 55.5556 | 4 | no |
GO:0009966 | regulation of signal transduction | 44.4444 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 44.4444 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 44.4444 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
GO:0008104 | protein localization | 44.4444 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | yes |
GO:0010038 | response to metal ion | 33.3333 | 4 | yes |
GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | yes |
GO:0023057 | negative regulation of signaling | 33.3333 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 33.3333 | 6 | yes |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APLP1_HUMAN | [view interactions] | High throughput | no | yes |
APLP2_HUMAN | [view interactions] | High throughput | no | yes |
BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLUC_HUMAN | [view interactions] | High throughput | no | no |
KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PNCB_HUMAN | [view interactions] | High throughput | no | no |
RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH23A_HUMAN | [view interactions] | High throughput | no | no |
STING_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |