Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RASL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed). Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RASL1_HUMAN
GO:0030695 GTPase regulator activity 44.4444 4 yes
GO:0046872 metal ion binding 44.4444 4 yes
GO:0019900 kinase binding 44.4444 4 no
GO:0019901 protein kinase binding 44.4444 5 no
GO:0005096 GTPase activator activity 33.3333 4 yes
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0003924 GTPase activity 22.2222 7 no
GO:0005525 GTP binding 22.2222 5 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no
GO:0019001 guanyl nucleotide binding 22.2222 5 no
GO:0032561 guanyl ribonucleotide binding 22.2222 5 no
GO:0005524 ATP binding 22.2222 5 no
GO:0030554 adenyl nucleotide binding 22.2222 5 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in RASL1_HUMAN
GO:0048523 negative regulation of cellular process 88.8889 4 yes
GO:0048522 positive regulation of cellular process 77.7778 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0051336 regulation of hydrolase activity 66.6667 4 yes
GO:0009966 regulation of signal transduction 55.5556 4 yes
GO:0043087 regulation of GTPase activity 55.5556 5 yes
GO:0009893 positive regulation of metabolic process 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 no
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0051246 regulation of protein metabolic process 55.5556 5 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0010941 regulation of cell death 55.5556 4 no
GO:0060548 negative regulation of cell death 55.5556 5 no
GO:1902531 regulation of intracellular signal transduction 44.4444 5 yes
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0008104 protein localization 44.4444 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0031344 regulation of cell projection organization 44.4444 5 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0043085 positive regulation of catalytic activity 44.4444 4 no
GO:0043549 regulation of kinase activity 44.4444 5 no
GO:0045859 regulation of protein kinase activity 44.4444 6 no
GO:0051049 regulation of transport 44.4444 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0051338 regulation of transferase activity 44.4444 4 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 no
GO:0042981 regulation of apoptotic process 44.4444 6 no
GO:0043066 negative regulation of apoptotic process 44.4444 7 no
GO:0043067 regulation of programmed cell death 44.4444 5 no
GO:0043069 negative regulation of programmed cell death 44.4444 6 no
GO:1901214 regulation of neuron death 44.4444 5 no
GO:1901215 negative regulation of neuron death 44.4444 6 no
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010038 response to metal ion 33.3333 4 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 yes
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0006996 organelle organization 33.3333 4 no
GO:0007612 learning 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0048168 regulation of neuronal synaptic plasticity 33.3333 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0050890 cognition 33.3333 4 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0032970 regulation of actin filament-based process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0016192 vesicle-mediated transport 33.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0043086 negative regulation of catalytic activity 33.3333 4 no
GO:0043523 regulation of neuron apoptotic process 33.3333 6 no
GO:0043524 negative regulation of neuron apoptotic process 33.3333 7 no
GO:0051346 negative regulation of hydrolase activity 33.3333 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0001558 regulation of cell growth 22.2222 4 yes
GO:0022604 regulation of cell morphogenesis 22.2222 5 yes
GO:0030307 positive regulation of cell growth 22.2222 5 yes
GO:0045927 positive regulation of growth 22.2222 4 yes
GO:0046578 regulation of Ras protein signal transduction 22.2222 7 yes
GO:0046580 negative regulation of Ras protein signal transduction 22.2222 8 yes
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 22.2222 7 yes
GO:0051592 response to calcium ion 22.2222 5 yes
GO:0071241 cellular response to inorganic substance 22.2222 4 yes
GO:0071248 cellular response to metal ion 22.2222 5 yes
GO:0007268 chemical synaptic transmission 22.2222 6 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0032412 regulation of ion transmembrane transporter activity 22.2222 5 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of ion transmembrane transport 22.2222 5 no
GO:0043113 receptor clustering 22.2222 5 no
GO:0043269 regulation of ion transport 22.2222 5 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0098916 anterograde trans-synaptic signaling 22.2222 5 no
GO:0099537 trans-synaptic signaling 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1904062 regulation of cation transmembrane transport 22.2222 6 no
GO:1905475 regulation of protein localization to membrane 22.2222 6 no
GO:1905477 positive regulation of protein localization to membrane 22.2222 6 no
GO:0006811 ion transport 22.2222 4 no
GO:0006812 cation transport 22.2222 5 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0030001 metal ion transport 22.2222 6 no
GO:0036293 response to decreased oxygen levels 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0006897 endocytosis 22.2222 5 no
GO:0007264 small GTPase mediated signal transduction 22.2222 4 no
GO:0007265 Ras protein signal transduction 22.2222 5 no
GO:0008285 negative regulation of cell population proliferation 22.2222 5 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010629 negative regulation of gene expression 22.2222 6 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0034260 negative regulation of GTPase activity 22.2222 4 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043547 positive regulation of GTPase activity 22.2222 6 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0044089 positive regulation of cellular component biogenesis 22.2222 5 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0050776 regulation of immune response 22.2222 4 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0051345 positive regulation of hydrolase activity 22.2222 5 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0051495 positive regulation of cytoskeleton organization 22.2222 7 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.2222 8 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009895 negative regulation of catabolic process 22.2222 5 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0006417 regulation of translation 22.2222 6 no
GO:0010608 post-transcriptional regulation of gene expression 22.2222 6 no
GO:0034248 regulation of cellular amide metabolic process 22.2222 5 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:2000112 regulation of cellular macromolecule biosynthetic process 22.2222 6 no
GO:0008306 associative learning 22.2222 5 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0010977 negative regulation of neuron projection development 22.2222 7 no
GO:0031345 negative regulation of cell projection organization 22.2222 6 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0050808 synapse organization 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
APLP1_HUMAN [view interactions] High throughput no yes
APLP2_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
SH23A_HUMAN [view interactions] High throughput no no
PNCB_HUMAN [view interactions] High throughput no no
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGB_HUMAN [view interactions] High throughput no yes
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no