Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RASL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed). Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RASL1_HUMAN
GO:0005096 GTPase activator activity 44.4444 4 yes
GO:0030695 GTPase regulator activity 44.4444 4 yes
GO:0043169 cation binding 44.4444 4 yes
GO:0046872 metal ion binding 44.4444 5 yes
GO:0019900 kinase binding 44.4444 4 no
GO:0043168 anion binding 44.4444 4 no
GO:0000166 nucleotide binding 33.3333 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 33.3333 6 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0004674 protein serine/threonine kinase activity 22.2222 4 no
GO:0016301 kinase activity 22.2222 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RASL1_HUMAN
GO:0048523 negative regulation of cellular process 77.7778 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0010646 regulation of cell communication 55.5556 4 yes
GO:0051128 regulation of cellular component organization 55.5556 4 yes
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 44.4444 4 yes
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0008104 protein localization 44.4444 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010038 response to metal ion 33.3333 4 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:1902531 regulation of intracellular signal transduction 33.3333 5 yes
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 yes
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0006996 organelle organization 33.3333 4 no
GO:0007612 learning 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0050890 cognition 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0001558 regulation of cell growth 22.2222 4 yes
GO:0022604 regulation of cell morphogenesis 22.2222 5 yes
GO:0030307 positive regulation of cell growth 22.2222 5 yes
GO:0045927 positive regulation of growth 22.2222 4 yes
GO:0046578 regulation of Ras protein signal transduction 22.2222 7 yes
GO:0046580 negative regulation of Ras protein signal transduction 22.2222 8 yes
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 22.2222 7 yes
GO:0051592 response to calcium ion 22.2222 5 yes
GO:0071241 cellular response to inorganic substance 22.2222 4 yes
GO:0071248 cellular response to metal ion 22.2222 5 yes
GO:0006417 regulation of translation 22.2222 6 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0007268 chemical synaptic transmission 22.2222 7 no
GO:0009889 regulation of biosynthetic process 22.2222 4 no
GO:0010468 regulation of gene expression 22.2222 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0010608 post-transcriptional regulation of gene expression 22.2222 7 no
GO:0016310 phosphorylation 22.2222 5 no
GO:0031326 regulation of cellular biosynthetic process 22.2222 5 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 no
GO:0099536 synaptic signaling 22.2222 4 no
GO:0099537 trans-synaptic signaling 22.2222 5 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 22.2222 5 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043113 receptor clustering 22.2222 5 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0048168 regulation of neuronal synaptic plasticity 22.2222 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 22.2222 5 no
GO:0048812 neuron projection morphogenesis 22.2222 5 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 4 no
GO:0006915 apoptotic process 22.2222 4 no
GO:0008306 associative learning 22.2222 5 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0043524 negative regulation of neuron apoptotic process 22.2222 7 no
GO:0050808 synapse organization 22.2222 5 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009895 negative regulation of catabolic process 22.2222 5 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0006811 monoatomic ion transport 22.2222 4 no
GO:0006812 monoatomic cation transport 22.2222 5 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0030001 metal ion transport 22.2222 6 no
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0036293 response to decreased oxygen levels 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
APLP1_HUMAN [view interactions] High throughput no yes
APLP2_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
SH23A_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
PNCB_HUMAN [view interactions] High throughput no no
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGB_HUMAN [view interactions] High throughput no yes
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes