CBLB_HUMAN
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA . [View more on UniProt]
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No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003309 | DOC_MAPK_DCC_7 | DOC | 491 | 499 | - |
ELMI003726 | LIG_SH2_CRK | LIG | 665 | 669 | - |
ELMI003727 | LIG_SH2_CRK | LIG | 709 | 713 | - |
ELMI003707 | LIG_SH2_STAP1 | LIG | 802 | 806 | - |
ELMI004428 | LIG_SH3_CIN85_PxpxPR_1 | LIG | 906 | 911 | - |
ELMI003309 | DOC_MAPK_DCC_7 | DOC | 491 | 499 | - |
ELMI003726 | LIG_SH2_CRK | LIG | 665 | 669 | - |
ELMI003727 | LIG_SH2_CRK | LIG | 709 | 713 | - |
ELMI003707 | LIG_SH2_STAP1 | LIG | 802 | 806 | - |
ELMI004428 | LIG_SH3_CIN85_PxpxPR_1 | LIG | 906 | 911 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CBLB_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 32.8767 | 4 | no |
GO:0019900 | kinase binding | 31.5068 | 4 | yes |
GO:0019901 | protein kinase binding | 30.1370 | 5 | yes |
GO:0043169 | cation binding | 27.3973 | 4 | yes |
GO:0046872 | metal ion binding | 27.3973 | 5 | yes |
GO:0043168 | anion binding | 26.0274 | 4 | no |
GO:0000166 | nucleotide binding | 23.2877 | 4 | no |
GO:0017076 | purine nucleotide binding | 23.2877 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 23.2877 | 6 | no |
GO:0045309 | protein phosphorylated amino acid binding | 21.9178 | 4 | yes |
GO:0005524 | ATP binding | 21.9178 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 21.9178 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.9178 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 21.9178 | 4 | no |
GO:0001784 | phosphotyrosine residue binding | 20.5479 | 5 | yes |
GO:0046914 | transition metal ion binding | 13.6986 | 6 | yes |
GO:0017124 | SH3 domain binding | 12.3288 | 4 | yes |
GO:0030971 | receptor tyrosine kinase binding | 12.3288 | 4 | yes |
GO:1990782 | protein tyrosine kinase binding | 12.3288 | 6 | yes |
GO:0004842 | ubiquitin-protein transferase activity | 10.9589 | 4 | yes |
GO:0008270 | zinc ion binding | 10.9589 | 7 | yes |
GO:0016755 | aminoacyltransferase activity | 10.9589 | 4 | yes |
GO:0061630 | ubiquitin protein ligase activity | 9.5890 | 5 | yes |
GO:0061659 | ubiquitin-like protein ligase activity | 9.5890 | 4 | yes |
GO:0005509 | calcium ion binding | 6.8493 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CBLB_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 63.0137 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 60.2740 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 58.9041 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 56.1644 | 4 | no |
GO:0048523 | negative regulation of cellular process | 52.0548 | 4 | yes |
GO:0010646 | regulation of cell communication | 50.6849 | 4 | yes |
GO:0009966 | regulation of signal transduction | 49.3151 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 49.3151 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 47.9452 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 47.9452 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 47.9452 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 47.9452 | 5 | no |
GO:0010468 | regulation of gene expression | 45.2055 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 43.8356 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 42.4658 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 39.7260 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 39.7260 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 38.3562 | 5 | no |
GO:0010647 | positive regulation of cell communication | 38.3562 | 5 | no |
GO:0023056 | positive regulation of signaling | 38.3562 | 4 | no |
GO:0036211 | protein modification process | 36.9863 | 4 | yes |
GO:0043412 | macromolecule modification | 36.9863 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 36.9863 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.6164 | 5 | no |
GO:0002684 | positive regulation of immune system process | 32.8767 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 32.8767 | 6 | yes |
GO:0009892 | negative regulation of metabolic process | 32.8767 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 32.8767 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 32.8767 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 31.5068 | 5 | no |
GO:0080134 | regulation of response to stress | 31.5068 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 31.5068 | 7 | no |
GO:0022607 | cellular component assembly | 31.5068 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 31.5068 | 6 | no |
GO:0031399 | regulation of protein modification process | 30.1370 | 6 | yes |
GO:0050776 | regulation of immune response | 30.1370 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 30.1370 | 4 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 30.1370 | 4 | no |
GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 30.1370 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 30.1370 | 5 | no |
GO:0042981 | regulation of apoptotic process | 30.1370 | 5 | no |
GO:0043067 | regulation of programmed cell death | 30.1370 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 27.3973 | 4 | yes |
GO:0006996 | organelle organization | 27.3973 | 4 | no |
GO:0030155 | regulation of cell adhesion | 26.0274 | 4 | yes |
GO:0031401 | positive regulation of protein modification process | 26.0274 | 7 | yes |
GO:0051049 | regulation of transport | 26.0274 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 26.0274 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.0274 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 26.0274 | 6 | no |
GO:0048585 | negative regulation of response to stimulus | 24.6575 | 4 | yes |
GO:0050778 | positive regulation of immune response | 24.6575 | 5 | yes |
GO:0071310 | cellular response to organic substance | 24.6575 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 24.6575 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.6575 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 24.6575 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 23.2877 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 23.2877 | 6 | no |
GO:0042325 | regulation of phosphorylation | 23.2877 | 7 | no |
GO:0051130 | positive regulation of cellular component organization | 23.2877 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 23.2877 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.2877 | 4 | no |
GO:0008104 | protein localization | 21.9178 | 4 | yes |
GO:0009894 | regulation of catabolic process | 21.9178 | 4 | yes |
GO:0010648 | negative regulation of cell communication | 21.9178 | 5 | yes |
GO:0023057 | negative regulation of signaling | 21.9178 | 4 | yes |
GO:0030030 | cell projection organization | 21.9178 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 21.9178 | 4 | no |
GO:0045785 | positive regulation of cell adhesion | 21.9178 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 21.9178 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.9178 | 4 | no |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 20.5479 | 4 | yes |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 20.5479 | 4 | yes |
GO:0022407 | regulation of cell-cell adhesion | 20.5479 | 5 | yes |
GO:0008284 | positive regulation of cell population proliferation | 20.5479 | 5 | no |
GO:0051094 | positive regulation of developmental process | 20.5479 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 20.5479 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 20.5479 | 8 | no |
GO:0043933 | protein-containing complex organization | 20.5479 | 4 | no |
GO:0009059 | macromolecule biosynthetic process | 20.5479 | 4 | no |
GO:0002694 | regulation of leukocyte activation | 19.1781 | 4 | yes |
GO:0009057 | macromolecule catabolic process | 19.1781 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 19.1781 | 5 | yes |
GO:0043687 | post-translational protein modification | 19.1781 | 5 | yes |
GO:0050865 | regulation of cell activation | 19.1781 | 4 | yes |
GO:0051249 | regulation of lymphocyte activation | 19.1781 | 5 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 19.1781 | 6 | yes |
GO:0032446 | protein modification by small protein conjugation | 17.8082 | 7 | yes |
GO:0050863 | regulation of T cell activation | 17.8082 | 6 | yes |
GO:1903037 | regulation of leukocyte cell-cell adhesion | 17.8082 | 6 | yes |
GO:0002683 | negative regulation of immune system process | 16.4384 | 4 | yes |
GO:0016567 | protein ubiquitination | 16.4384 | 8 | yes |
GO:0033365 | protein localization to organelle | 15.0685 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 15.0685 | 4 | yes |
GO:0009896 | positive regulation of catabolic process | 13.6986 | 5 | yes |
GO:0030163 | protein catabolic process | 13.6986 | 4 | yes |
GO:0050851 | antigen receptor-mediated signaling pathway | 13.6986 | 5 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 13.6986 | 4 | yes |
GO:0071702 | organic substance transport | 13.6986 | 4 | yes |
GO:0071705 | nitrogen compound transport | 13.6986 | 4 | yes |
GO:0031396 | regulation of protein ubiquitination | 12.3288 | 9 | yes |
GO:1901873 | regulation of post-translational protein modification | 12.3288 | 7 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 12.3288 | 8 | yes |
GO:0008285 | negative regulation of cell population proliferation | 10.9589 | 5 | yes |
GO:0015031 | protein transport | 10.9589 | 4 | yes |
GO:0042176 | regulation of protein catabolic process | 10.9589 | 5 | yes |
GO:0050852 | T cell receptor signaling pathway | 10.9589 | 6 | yes |
GO:0006886 | intracellular protein transport | 9.5890 | 4 | yes |
GO:0042110 | T cell activation | 9.5890 | 4 | yes |
GO:0007162 | negative regulation of cell adhesion | 8.2192 | 5 | yes |
GO:0031398 | positive regulation of protein ubiquitination | 8.2192 | 10 | yes |
GO:0070663 | regulation of leukocyte proliferation | 8.2192 | 5 | yes |
GO:0072594 | establishment of protein localization to organelle | 8.2192 | 4 | yes |
GO:1901875 | positive regulation of post-translational protein modification | 8.2192 | 8 | yes |
GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 8.2192 | 9 | yes |
GO:0006913 | nucleocytoplasmic transport | 6.8493 | 5 | yes |
GO:0032944 | regulation of mononuclear cell proliferation | 6.8493 | 6 | yes |
GO:0034504 | protein localization to nucleus | 6.8493 | 6 | yes |
GO:0045732 | positive regulation of protein catabolic process | 6.8493 | 6 | yes |
GO:0050670 | regulation of lymphocyte proliferation | 6.8493 | 6 | yes |
GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 6.8493 | 5 | yes |
GO:0051169 | nuclear transport | 6.8493 | 4 | yes |
GO:0006606 | protein import into nucleus | 5.4795 | 5 | yes |
GO:0022408 | negative regulation of cell-cell adhesion | 5.4795 | 6 | yes |
GO:0032943 | mononuclear cell proliferation | 5.4795 | 4 | yes |
GO:0042098 | T cell proliferation | 5.4795 | 5 | yes |
GO:0042129 | regulation of T cell proliferation | 5.4795 | 7 | yes |
GO:0046631 | alpha-beta T cell activation | 5.4795 | 5 | yes |
GO:0046651 | lymphocyte proliferation | 5.4795 | 4 | yes |
GO:0050856 | regulation of T cell receptor signaling pathway | 5.4795 | 6 | yes |
GO:0051170 | import into nucleus | 5.4795 | 6 | yes |
GO:0002695 | negative regulation of leukocyte activation | 4.1096 | 5 | yes |
GO:0010640 | regulation of platelet-derived growth factor receptor signaling pathway | 4.1096 | 5 | yes |
GO:0032945 | negative regulation of mononuclear cell proliferation | 4.1096 | 7 | yes |
GO:0050672 | negative regulation of lymphocyte proliferation | 4.1096 | 7 | yes |
GO:0050866 | negative regulation of cell activation | 4.1096 | 5 | yes |
GO:0051250 | negative regulation of lymphocyte activation | 4.1096 | 6 | yes |
GO:0070664 | negative regulation of leukocyte proliferation | 4.1096 | 6 | yes |
GO:0002643 | regulation of tolerance induction | 2.7397 | 4 | yes |
GO:0002645 | positive regulation of tolerance induction | 2.7397 | 5 | yes |
GO:0002664 | regulation of T cell tolerance induction | 2.7397 | 5 | yes |
GO:0002666 | positive regulation of T cell tolerance induction | 2.7397 | 6 | yes |
GO:0002667 | regulation of T cell anergy | 2.7397 | 6 | yes |
GO:0002669 | positive regulation of T cell anergy | 2.7397 | 7 | yes |
GO:0002870 | T cell anergy | 2.7397 | 4 | yes |
GO:0002911 | regulation of lymphocyte anergy | 2.7397 | 5 | yes |
GO:0002913 | positive regulation of lymphocyte anergy | 2.7397 | 6 | yes |
GO:0006607 | NLS-bearing protein import into nucleus | 2.7397 | 6 | yes |
GO:0035710 | CD4-positive, alpha-beta T cell activation | 2.7397 | 6 | yes |
GO:0035739 | CD4-positive, alpha-beta T cell proliferation | 2.7397 | 7 | yes |
GO:0042130 | negative regulation of T cell proliferation | 2.7397 | 8 | yes |
GO:0046633 | alpha-beta T cell proliferation | 2.7397 | 6 | yes |
GO:0046634 | regulation of alpha-beta T cell activation | 2.7397 | 7 | yes |
GO:0046636 | negative regulation of alpha-beta T cell activation | 2.7397 | 8 | yes |
GO:0046640 | regulation of alpha-beta T cell proliferation | 2.7397 | 8 | yes |
GO:0046642 | negative regulation of alpha-beta T cell proliferation | 2.7397 | 9 | yes |
GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway | 2.7397 | 5 | yes |
GO:0050860 | negative regulation of T cell receptor signaling pathway | 2.7397 | 6 | yes |
GO:0050868 | negative regulation of T cell activation | 2.7397 | 7 | yes |
GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 2.7397 | 7 | yes |
GO:2000514 | regulation of CD4-positive, alpha-beta T cell activation | 2.7397 | 8 | yes |
GO:2000515 | negative regulation of CD4-positive, alpha-beta T cell activation | 2.7397 | 9 | yes |
GO:2000561 | regulation of CD4-positive, alpha-beta T cell proliferation | 2.7397 | 9 | yes |
GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation | 2.7397 | 10 | yes |
GO:2000583 | regulation of platelet-derived growth factor receptor-alpha signaling pathway | 2.7397 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CD2AP_HUMAN | [view interactions] | Low throughput | no | no |
MYD88_HUMAN | [view interactions] | Low throughput | no | yes |
TCAM1_HUMAN | [view interactions] | Low throughput | no | yes |
DDR2_HUMAN | [view interactions] | Low throughput | no | no |
NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
NR2C2_HUMAN | [view interactions] | Low throughput | no | yes |
CAR11_HUMAN | [view interactions] | Low throughput | no | no |
CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ULK1_HUMAN | [view interactions] | Low throughput | no | no |
PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ASAP2_HUMAN | [view interactions] | Low throughput | no | yes |
SRBS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
VAV2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ZAP70_HUMAN | [view interactions] | Low throughput | no | no |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
UBS3A_HUMAN | [view interactions] | Low throughput | no | no |
CD5_HUMAN | [view interactions] | Low throughput | no | no |
CSK_HUMAN | [view interactions] | Low throughput | no | yes |
CFLAR_HUMAN | [view interactions] | Low throughput | no | yes |
CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
VAV_HUMAN | [view interactions] | Low throughput | no | no |
TGFI1_HUMAN | [view interactions] | Low throughput | no | no |
NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P85A_HUMAN | [view interactions] | Low throughput | no | yes |
BTK_HUMAN | [view interactions] | Low throughput | no | no |
PLCG2_HUMAN | [view interactions] | Low throughput | no | yes |
KIT_HUMAN | [view interactions] | Low throughput | no | no |
KSYK_HUMAN | [view interactions] | Low throughput | no | no |
IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TLR4_HUMAN | [view interactions] | Low throughput | no | yes |
PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TANK_HUMAN | [view interactions] | Low throughput | no | yes |
TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
P85B_HUMAN | [view interactions] | Low throughput | no | yes |
CBLB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CBLC_HUMAN | [view interactions] | Low throughput | no | yes |
SPY1_HUMAN | [view interactions] | Low throughput | no | yes |
SMAD7_HUMAN | [view interactions] | Low throughput | no | yes |
WASP_HUMAN | [view interactions] | Low throughput | no | yes |
FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DTX1_HUMAN | [view interactions] | Low throughput | no | yes |
KPCT_HUMAN | [view interactions] | Low throughput | no | no |
SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SP7_HUMAN | [view interactions] | Low throughput | no | no |
PTN6_HUMAN | [view interactions] | Low throughput | no | no |
PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
TR10B_HUMAN | [view interactions] | Low throughput | no | no |
TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
CYLD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P53_HUMAN | [view interactions] | Low throughput | no | no |
STA5A_HUMAN | [view interactions] | Low throughput | no | no |
NLRP3_HUMAN | [view interactions] | Low throughput | no | no |
S12A5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITK_HUMAN | [view interactions] | Low throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HNRPK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBE2C_HUMAN | [view interactions] | Low throughput | no | yes |
UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FCERB_HUMAN | [view interactions] | Low throughput | no | no |
UBP12_HUMAN | [view interactions] | Low throughput | no | yes |
ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CE152_HUMAN | [view interactions] | High throughput | no | yes |
IPO8_HUMAN | [view interactions] | High throughput | no | no |
NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
APT_HUMAN | [view interactions] | High throughput | no | yes |
GRB7_HUMAN | [view interactions] | High throughput | no | no |
RT31_HUMAN | [view interactions] | High throughput | no | yes |
DR4L2_HUMAN | [view interactions] | High throughput | no | no |
DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAT_HUMAN | [view interactions] | High throughput | no | no |
LCP2_HUMAN | [view interactions] | High throughput | no | yes |
UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
GRAP_HUMAN | [view interactions] | High throughput | no | no |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRAP2_HUMAN | [view interactions] | High throughput | no | no |
RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAX1_HUMAN | [view interactions] | High throughput | no | no |
RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMD3_HUMAN | [view interactions] | High throughput | no | yes |
PRS8_HUMAN | [view interactions] | High throughput | no | yes |
RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL37A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AN13A_HUMAN | [view interactions] | High throughput | no | yes |
H32_HUMAN | [view interactions] | High throughput | no | yes |
H31_HUMAN | [view interactions] | High throughput | no | yes |
RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSD13_HUMAN | [view interactions] | High throughput | no | yes |
RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
ATPD_HUMAN | [view interactions] | High throughput | no | yes |
RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
GORS2_HUMAN | [view interactions] | High throughput | no | yes |
ANM2_HUMAN | [view interactions] | High throughput | no | yes |
VP26C_HUMAN | [view interactions] | High throughput | no | yes |
VAV3_HUMAN | [view interactions] | High throughput | no | yes |
PTK6_HUMAN | [view interactions] | High throughput | no | yes |
YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NC2B_HUMAN | [view interactions] | High throughput | no | yes |
TF2B_HUMAN | [view interactions] | High throughput | no | yes |
TF3C3_HUMAN | [view interactions] | High throughput | no | no |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TADBP_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
CRY1_HUMAN | [view interactions] | High throughput | no | yes |
VINEX_HUMAN | [view interactions] | High throughput | no | no |
LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
OSTF1_HUMAN | [view interactions] | High throughput | no | yes |
SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
CD81_HUMAN | [view interactions] | High throughput | no | no |
OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEN1_HUMAN | [view interactions] | High throughput | no | yes |
HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNF11_HUMAN | [view interactions] | High throughput | no | yes |