CBLB_HUMAN
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003309 | DOC_MAPK_DCC_7 | DOC | 491 | 499 | - |
| ELMI003726 | LIG_SH2_CRK | LIG | 665 | 669 | - |
| ELMI003727 | LIG_SH2_CRK | LIG | 709 | 713 | - |
| ELMI003707 | LIG_SH2_STAP1 | LIG | 802 | 806 | - |
| ELMI004428 | LIG_SH3_CIN85_PxpxPR_1 | LIG | 906 | 911 | - |
| ELMI003309 | DOC_MAPK_DCC_7 | DOC | 491 | 499 | - |
| ELMI003726 | LIG_SH2_CRK | LIG | 665 | 669 | - |
| ELMI003727 | LIG_SH2_CRK | LIG | 709 | 713 | - |
| ELMI003707 | LIG_SH2_STAP1 | LIG | 802 | 806 | - |
| ELMI004428 | LIG_SH3_CIN85_PxpxPR_1 | LIG | 906 | 911 | - |
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CBLB_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 32.8767 | 4 | no |
| GO:0019900 | kinase binding | 31.5068 | 4 | yes |
| GO:0019901 | protein kinase binding | 30.1370 | 5 | yes |
| GO:0043169 | cation binding | 27.3973 | 4 | yes |
| GO:0046872 | metal ion binding | 27.3973 | 5 | yes |
| GO:0043168 | anion binding | 26.0274 | 4 | no |
| GO:0000166 | nucleotide binding | 23.2877 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.2877 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.2877 | 6 | no |
| GO:0045309 | protein phosphorylated amino acid binding | 21.9178 | 4 | yes |
| GO:0005524 | ATP binding | 21.9178 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.9178 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.9178 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.9178 | 4 | no |
| GO:0001784 | phosphotyrosine residue binding | 20.5479 | 5 | yes |
| GO:0046914 | transition metal ion binding | 13.6986 | 6 | yes |
| GO:0017124 | SH3 domain binding | 12.3288 | 4 | yes |
| GO:0030971 | receptor tyrosine kinase binding | 12.3288 | 4 | yes |
| GO:1990782 | protein tyrosine kinase binding | 12.3288 | 6 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 10.9589 | 4 | yes |
| GO:0008270 | zinc ion binding | 10.9589 | 7 | yes |
| GO:0016755 | aminoacyltransferase activity | 10.9589 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 9.5890 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 9.5890 | 4 | yes |
| GO:0005509 | calcium ion binding | 6.8493 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CBLB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.0137 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 60.2740 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 58.9041 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 56.1644 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.0548 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.6849 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 49.3151 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 49.3151 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 47.9452 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 47.9452 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 47.9452 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 47.9452 | 5 | no |
| GO:0010468 | regulation of gene expression | 45.2055 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.8356 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.4658 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 39.7260 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 39.7260 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 38.3562 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 38.3562 | 5 | no |
| GO:0023056 | positive regulation of signaling | 38.3562 | 4 | no |
| GO:0036211 | protein modification process | 36.9863 | 4 | yes |
| GO:0043412 | macromolecule modification | 36.9863 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 36.9863 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.6164 | 5 | no |
| GO:0002684 | positive regulation of immune system process | 32.8767 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.8767 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.8767 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 32.8767 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 32.8767 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.5068 | 5 | no |
| GO:0080134 | regulation of response to stress | 31.5068 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 31.5068 | 7 | no |
| GO:0022607 | cellular component assembly | 31.5068 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 31.5068 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.1370 | 6 | yes |
| GO:0050776 | regulation of immune response | 30.1370 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 30.1370 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 30.1370 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 30.1370 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.1370 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.1370 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.1370 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 27.3973 | 4 | yes |
| GO:0006996 | organelle organization | 27.3973 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 26.0274 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 26.0274 | 7 | yes |
| GO:0051049 | regulation of transport | 26.0274 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.0274 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.0274 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.0274 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.6575 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 24.6575 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 24.6575 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.6575 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.6575 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.6575 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.2877 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.2877 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.2877 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.2877 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.2877 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.2877 | 4 | no |
| GO:0008104 | protein localization | 21.9178 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 21.9178 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 21.9178 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 21.9178 | 4 | yes |
| GO:0030030 | cell projection organization | 21.9178 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 21.9178 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 21.9178 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.9178 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.9178 | 4 | no |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 20.5479 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 20.5479 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 20.5479 | 5 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 20.5479 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.5479 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.5479 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.5479 | 8 | no |
| GO:0043933 | protein-containing complex organization | 20.5479 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 20.5479 | 4 | no |
| GO:0002694 | regulation of leukocyte activation | 19.1781 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 19.1781 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 19.1781 | 5 | yes |
| GO:0043687 | post-translational protein modification | 19.1781 | 5 | yes |
| GO:0050865 | regulation of cell activation | 19.1781 | 4 | yes |
| GO:0051249 | regulation of lymphocyte activation | 19.1781 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 19.1781 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 17.8082 | 7 | yes |
| GO:0050863 | regulation of T cell activation | 17.8082 | 6 | yes |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 17.8082 | 6 | yes |
| GO:0002683 | negative regulation of immune system process | 16.4384 | 4 | yes |
| GO:0016567 | protein ubiquitination | 16.4384 | 8 | yes |
| GO:0033365 | protein localization to organelle | 15.0685 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 15.0685 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 13.6986 | 5 | yes |
| GO:0030163 | protein catabolic process | 13.6986 | 4 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 13.6986 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 13.6986 | 4 | yes |
| GO:0071702 | organic substance transport | 13.6986 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 13.6986 | 4 | yes |
| GO:0031396 | regulation of protein ubiquitination | 12.3288 | 9 | yes |
| GO:1901873 | regulation of post-translational protein modification | 12.3288 | 7 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 12.3288 | 8 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 10.9589 | 5 | yes |
| GO:0015031 | protein transport | 10.9589 | 4 | yes |
| GO:0042176 | regulation of protein catabolic process | 10.9589 | 5 | yes |
| GO:0050852 | T cell receptor signaling pathway | 10.9589 | 6 | yes |
| GO:0006886 | intracellular protein transport | 9.5890 | 4 | yes |
| GO:0042110 | T cell activation | 9.5890 | 4 | yes |
| GO:0007162 | negative regulation of cell adhesion | 8.2192 | 5 | yes |
| GO:0031398 | positive regulation of protein ubiquitination | 8.2192 | 10 | yes |
| GO:0070663 | regulation of leukocyte proliferation | 8.2192 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 8.2192 | 4 | yes |
| GO:1901875 | positive regulation of post-translational protein modification | 8.2192 | 8 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 8.2192 | 9 | yes |
| GO:0006913 | nucleocytoplasmic transport | 6.8493 | 5 | yes |
| GO:0032944 | regulation of mononuclear cell proliferation | 6.8493 | 6 | yes |
| GO:0034504 | protein localization to nucleus | 6.8493 | 6 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 6.8493 | 6 | yes |
| GO:0050670 | regulation of lymphocyte proliferation | 6.8493 | 6 | yes |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 6.8493 | 5 | yes |
| GO:0051169 | nuclear transport | 6.8493 | 4 | yes |
| GO:0006606 | protein import into nucleus | 5.4795 | 5 | yes |
| GO:0022408 | negative regulation of cell-cell adhesion | 5.4795 | 6 | yes |
| GO:0032943 | mononuclear cell proliferation | 5.4795 | 4 | yes |
| GO:0042098 | T cell proliferation | 5.4795 | 5 | yes |
| GO:0042129 | regulation of T cell proliferation | 5.4795 | 7 | yes |
| GO:0046631 | alpha-beta T cell activation | 5.4795 | 5 | yes |
| GO:0046651 | lymphocyte proliferation | 5.4795 | 4 | yes |
| GO:0050856 | regulation of T cell receptor signaling pathway | 5.4795 | 6 | yes |
| GO:0051170 | import into nucleus | 5.4795 | 6 | yes |
| GO:0002695 | negative regulation of leukocyte activation | 4.1096 | 5 | yes |
| GO:0010640 | regulation of platelet-derived growth factor receptor signaling pathway | 4.1096 | 5 | yes |
| GO:0032945 | negative regulation of mononuclear cell proliferation | 4.1096 | 7 | yes |
| GO:0050672 | negative regulation of lymphocyte proliferation | 4.1096 | 7 | yes |
| GO:0050866 | negative regulation of cell activation | 4.1096 | 5 | yes |
| GO:0051250 | negative regulation of lymphocyte activation | 4.1096 | 6 | yes |
| GO:0070664 | negative regulation of leukocyte proliferation | 4.1096 | 6 | yes |
| GO:0002643 | regulation of tolerance induction | 2.7397 | 4 | yes |
| GO:0002645 | positive regulation of tolerance induction | 2.7397 | 5 | yes |
| GO:0002664 | regulation of T cell tolerance induction | 2.7397 | 5 | yes |
| GO:0002666 | positive regulation of T cell tolerance induction | 2.7397 | 6 | yes |
| GO:0002667 | regulation of T cell anergy | 2.7397 | 6 | yes |
| GO:0002669 | positive regulation of T cell anergy | 2.7397 | 7 | yes |
| GO:0002870 | T cell anergy | 2.7397 | 4 | yes |
| GO:0002911 | regulation of lymphocyte anergy | 2.7397 | 5 | yes |
| GO:0002913 | positive regulation of lymphocyte anergy | 2.7397 | 6 | yes |
| GO:0006607 | NLS-bearing protein import into nucleus | 2.7397 | 6 | yes |
| GO:0035710 | CD4-positive, alpha-beta T cell activation | 2.7397 | 6 | yes |
| GO:0035739 | CD4-positive, alpha-beta T cell proliferation | 2.7397 | 7 | yes |
| GO:0042130 | negative regulation of T cell proliferation | 2.7397 | 8 | yes |
| GO:0046633 | alpha-beta T cell proliferation | 2.7397 | 6 | yes |
| GO:0046634 | regulation of alpha-beta T cell activation | 2.7397 | 7 | yes |
| GO:0046636 | negative regulation of alpha-beta T cell activation | 2.7397 | 8 | yes |
| GO:0046640 | regulation of alpha-beta T cell proliferation | 2.7397 | 8 | yes |
| GO:0046642 | negative regulation of alpha-beta T cell proliferation | 2.7397 | 9 | yes |
| GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway | 2.7397 | 5 | yes |
| GO:0050860 | negative regulation of T cell receptor signaling pathway | 2.7397 | 6 | yes |
| GO:0050868 | negative regulation of T cell activation | 2.7397 | 7 | yes |
| GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 2.7397 | 7 | yes |
| GO:2000514 | regulation of CD4-positive, alpha-beta T cell activation | 2.7397 | 8 | yes |
| GO:2000515 | negative regulation of CD4-positive, alpha-beta T cell activation | 2.7397 | 9 | yes |
| GO:2000561 | regulation of CD4-positive, alpha-beta T cell proliferation | 2.7397 | 9 | yes |
| GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation | 2.7397 | 10 | yes |
| GO:2000583 | regulation of platelet-derived growth factor receptor-alpha signaling pathway | 2.7397 | 6 | yes |
Disease
No data found.
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD2AP_HUMAN | [view interactions] | Low throughput | no | no |
| MYD88_HUMAN | [view interactions] | Low throughput | no | yes |
| TCAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| DDR2_HUMAN | [view interactions] | Low throughput | no | no |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | Low throughput | no | yes |
| CAR11_HUMAN | [view interactions] | Low throughput | no | no |
| CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | Low throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASAP2_HUMAN | [view interactions] | Low throughput | no | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| VAV2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ZAP70_HUMAN | [view interactions] | Low throughput | no | no |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| UBS3A_HUMAN | [view interactions] | Low throughput | no | no |
| CD5_HUMAN | [view interactions] | Low throughput | no | no |
| CSK_HUMAN | [view interactions] | Low throughput | no | yes |
| CFLAR_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| VAV_HUMAN | [view interactions] | Low throughput | no | no |
| TGFI1_HUMAN | [view interactions] | Low throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| BTK_HUMAN | [view interactions] | Low throughput | no | no |
| PLCG2_HUMAN | [view interactions] | Low throughput | no | yes |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| KSYK_HUMAN | [view interactions] | Low throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TLR4_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANK_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P85B_HUMAN | [view interactions] | Low throughput | no | yes |
| CBLB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBLC_HUMAN | [view interactions] | Low throughput | no | yes |
| SPY1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD7_HUMAN | [view interactions] | Low throughput | no | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DTX1_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCT_HUMAN | [view interactions] | Low throughput | no | no |
| SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SP7_HUMAN | [view interactions] | Low throughput | no | no |
| PTN6_HUMAN | [view interactions] | Low throughput | no | no |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| TR10B_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| STA5A_HUMAN | [view interactions] | Low throughput | no | no |
| NLRP3_HUMAN | [view interactions] | Low throughput | no | no |
| S12A5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITK_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE2C_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FCERB_HUMAN | [view interactions] | Low throughput | no | no |
| UBP12_HUMAN | [view interactions] | Low throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| IPO8_HUMAN | [view interactions] | High throughput | no | no |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| APT_HUMAN | [view interactions] | High throughput | no | yes |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| DR4L2_HUMAN | [view interactions] | High throughput | no | no |
| DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAT_HUMAN | [view interactions] | High throughput | no | no |
| LCP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRAP2_HUMAN | [view interactions] | High throughput | no | no |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAX1_HUMAN | [view interactions] | High throughput | no | no |
| RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL37A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| ANM2_HUMAN | [view interactions] | High throughput | no | yes |
| VP26C_HUMAN | [view interactions] | High throughput | no | yes |
| VAV3_HUMAN | [view interactions] | High throughput | no | yes |
| PTK6_HUMAN | [view interactions] | High throughput | no | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NC2B_HUMAN | [view interactions] | High throughput | no | yes |
| TF2B_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| OSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |