Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S12A5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition . Involved in the regulation of dendritic spine formation and maturation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in S12A5_HUMAN
GO:0019900 kinase binding 42.8571 4 yes
GO:0043169 cation binding 35.7143 4 yes
GO:0046872 metal ion binding 35.7143 5 yes
GO:0019901 protein kinase binding 28.5714 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 21.4286 4 yes
GO:0015267 channel activity 21.4286 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 21.4286 4 yes
GO:0046873 metal ion transmembrane transporter activity 21.4286 5 yes
GO:0008270 zinc ion binding 21.4286 7 no
GO:0046914 transition metal ion binding 21.4286 6 no
GO:0003779 actin binding 21.4286 4 no
GO:0017124 SH3 domain binding 21.4286 4 no
GO:0019902 phosphatase binding 21.4286 4 no
GO:0019903 protein phosphatase binding 21.4286 5 no
GO:0008509 monoatomic anion transmembrane transporter activity 14.2857 4 yes
GO:0008519 ammonium transmembrane transporter activity 14.2857 5 yes
GO:0015079 potassium ion transmembrane transporter activity 14.2857 6 yes
GO:0015103 inorganic anion transmembrane transporter activity 14.2857 4 yes
GO:0015108 chloride transmembrane transporter activity 14.2857 5 yes
GO:0015291 secondary active transmembrane transporter activity 14.2857 4 yes
GO:0015293 symporter activity 14.2857 5 yes
GO:0015294 solute:monoatomic cation symporter activity 14.2857 5 yes
GO:0015296 monoatomic anion:monoatomic cation symporter activity 14.2857 5 yes
GO:0015377 chloride:monoatomic cation symporter activity 14.2857 6 yes
GO:0015379 potassium:chloride symporter activity 14.2857 7 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S12A5_HUMAN
GO:0051128 regulation of cellular component organization 64.2857 4 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0050890 cognition 42.8571 4 yes
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0030030 cell projection organization 42.8571 4 no
GO:0031175 neuron projection development 42.8571 6 no
GO:0031344 regulation of cell projection organization 42.8571 5 no
GO:0033043 regulation of organelle organization 42.8571 5 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0120036 plasma membrane bounded cell projection organization 42.8571 5 no
GO:0008104 protein localization 42.8571 4 no
GO:0022607 cellular component assembly 42.8571 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0007612 learning 35.7143 4 yes
GO:0031323 regulation of cellular metabolic process 35.7143 4 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.7143 6 no
GO:0006996 organelle organization 35.7143 4 no
GO:0051130 positive regulation of cellular component organization 35.7143 5 no
GO:0032535 regulation of cellular component size 28.5714 4 yes
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0048812 neuron projection morphogenesis 28.5714 5 no
GO:0051493 regulation of cytoskeleton organization 28.5714 6 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 no
GO:0034330 cell junction organization 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0007268 chemical synaptic transmission 21.4286 7 yes
GO:0008361 regulation of cell size 21.4286 5 yes
GO:0098916 anterograde trans-synaptic signaling 21.4286 6 yes
GO:0099536 synaptic signaling 21.4286 4 yes
GO:0099537 trans-synaptic signaling 21.4286 5 yes
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0016567 protein ubiquitination 21.4286 8 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0032446 protein modification by small protein conjugation 21.4286 7 no
GO:0043687 post-translational protein modification 21.4286 5 no
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:0050905 neuromuscular process 21.4286 4 no
GO:0070647 protein modification by small protein conjugation or removal 21.4286 6 no
GO:0007416 synapse assembly 21.4286 6 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0010639 negative regulation of organelle organization 21.4286 6 no
GO:0010647 positive regulation of cell communication 21.4286 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0034329 cell junction assembly 21.4286 5 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0050808 synapse organization 21.4286 5 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0070925 organelle assembly 21.4286 5 no
GO:1902903 regulation of supramolecular fiber organization 21.4286 5 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0051051 negative regulation of transport 21.4286 4 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 no
GO:1903829 positive regulation of protein localization 21.4286 5 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 no
GO:1902531 regulation of intracellular signal transduction 21.4286 5 no
GO:0006811 monoatomic ion transport 14.2857 4 yes
GO:0006812 monoatomic cation transport 14.2857 5 yes
GO:0006813 potassium ion transport 14.2857 7 yes
GO:0006820 monoatomic anion transport 14.2857 5 yes
GO:0006821 chloride transport 14.2857 5 yes
GO:0006873 intracellular monoatomic ion homeostasis 14.2857 4 yes
GO:0006971 hypotonic response 14.2857 4 yes
GO:0015698 inorganic anion transport 14.2857 4 yes
GO:0030001 metal ion transport 14.2857 6 yes
GO:0030002 intracellular monoatomic anion homeostasis 14.2857 5 yes
GO:0030003 intracellular monoatomic cation homeostasis 14.2857 5 yes
GO:0030644 intracellular chloride ion homeostasis 14.2857 5 yes
GO:0051452 intracellular pH reduction 14.2857 4 yes
GO:0055064 chloride ion homeostasis 14.2857 4 yes
GO:0055075 potassium ion homeostasis 14.2857 4 yes
GO:0055080 monoatomic cation homeostasis 14.2857 4 yes
GO:0055081 monoatomic anion homeostasis 14.2857 4 yes
GO:0071805 potassium ion transmembrane transport 14.2857 5 yes
GO:0098655 monoatomic cation transmembrane transport 14.2857 4 yes
GO:0098656 monoatomic anion transmembrane transport 14.2857 4 yes
GO:0098657 import into cell 14.2857 4 yes
GO:0098659 inorganic cation import across plasma membrane 14.2857 5 yes
GO:0098661 inorganic anion transmembrane transport 14.2857 4 yes
GO:0098662 inorganic cation transmembrane transport 14.2857 4 yes
GO:0099587 inorganic ion import across plasma membrane 14.2857 4 yes
GO:1902476 chloride transmembrane transport 14.2857 5 yes
GO:1990573 potassium ion import across plasma membrane 14.2857 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MYCB2_HUMAN [view entry] [view interactions] Low throughput yes no
CBLB_HUMAN [view entry] [view interactions] Low throughput yes yes
S12A9_HUMAN [view interactions] Low throughput no yes
S12A5_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
YTDC1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CCR4_HUMAN [view interactions] High throughput no yes
PAR2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
MICU3_HUMAN [view interactions] High throughput no yes
S12A4_HUMAN [view interactions] High throughput no yes
S12A7_HUMAN [view interactions] High throughput no yes
TTC9B_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes