Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S12A5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition . Involved in the regulation of dendritic spine formation and maturation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in S12A5_HUMAN
GO:0005216 ion channel activity 33.3333 4 yes
GO:0015267 channel activity 33.3333 4 yes
GO:0019900 kinase binding 33.3333 4 yes
GO:0005261 cation channel activity 27.7778 5 yes
GO:0008324 cation transmembrane transporter activity 27.7778 4 yes
GO:0019901 protein kinase binding 27.7778 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 27.7778 4 yes
GO:0046873 metal ion transmembrane transporter activity 22.2222 5 yes
GO:0003779 actin binding 22.2222 4 no
GO:0008509 anion transmembrane transporter activity 16.6667 4 yes
GO:0015079 potassium ion transmembrane transporter activity 16.6667 6 yes
GO:0015103 inorganic anion transmembrane transporter activity 16.6667 4 yes
GO:0015108 chloride transmembrane transporter activity 16.6667 5 yes
GO:0008519 ammonium transmembrane transporter activity 11.1111 6 yes
GO:0015291 secondary active transmembrane transporter activity 11.1111 4 yes
GO:0015293 symporter activity 11.1111 5 yes
GO:0015294 solute:cation symporter activity 11.1111 5 yes
GO:0015296 anion:cation symporter activity 11.1111 5 yes
GO:0015377 cation:chloride symporter activity 11.1111 6 yes
GO:0015379 potassium:chloride symporter activity 11.1111 7 yes
GO:0022853 active ion transmembrane transporter activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S12A5_HUMAN
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0022607 cellular component assembly 44.4444 4 no
GO:0030030 cell projection organization 38.8889 4 no
GO:0031344 regulation of cell projection organization 38.8889 5 no
GO:0120036 plasma membrane bounded cell projection organization 38.8889 5 no
GO:0048523 negative regulation of cellular process 38.8889 4 no
GO:0050890 cognition 33.3333 4 yes
GO:0031175 neuron projection development 33.3333 6 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0006996 organelle organization 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0007268 chemical synaptic transmission 27.7778 6 yes
GO:0007612 learning 27.7778 4 yes
GO:0098916 anterograde trans-synaptic signaling 27.7778 5 yes
GO:0099537 trans-synaptic signaling 27.7778 4 yes
GO:0009893 positive regulation of metabolic process 27.7778 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.7778 5 no
GO:0032880 regulation of protein localization 27.7778 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.7778 5 no
GO:0051246 regulation of protein metabolic process 27.7778 5 no
GO:0051493 regulation of cytoskeleton organization 27.7778 6 no
GO:0060341 regulation of cellular localization 27.7778 4 no
GO:0031323 regulation of cellular metabolic process 27.7778 4 no
GO:0031346 positive regulation of cell projection organization 27.7778 6 no
GO:0050804 modulation of chemical synaptic transmission 27.7778 5 no
GO:0099177 regulation of trans-synaptic signaling 27.7778 4 no
GO:0034329 cell junction assembly 27.7778 5 no
GO:0032535 regulation of cellular component size 22.2222 4 yes
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0032990 cell part morphogenesis 22.2222 4 no
GO:0048812 neuron projection morphogenesis 22.2222 7 no
GO:0048858 cell projection morphogenesis 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 6 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0007416 synapse assembly 22.2222 6 no
GO:0050808 synapse organization 22.2222 5 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:0006811 ion transport 16.6667 4 yes
GO:0006820 anion transport 16.6667 5 yes
GO:0006821 chloride transport 16.6667 7 yes
GO:0006873 cellular ion homeostasis 16.6667 4 yes
GO:0008361 regulation of cell size 16.6667 5 yes
GO:0015698 inorganic anion transport 16.6667 6 yes
GO:0030003 cellular cation homeostasis 16.6667 5 yes
GO:0048878 chemical homeostasis 16.6667 4 yes
GO:0050801 ion homeostasis 16.6667 5 yes
GO:0055065 metal ion homeostasis 16.6667 7 yes
GO:0055080 cation homeostasis 16.6667 6 yes
GO:0098656 anion transmembrane transport 16.6667 4 yes
GO:0098660 inorganic ion transmembrane transport 16.6667 4 yes
GO:0098661 inorganic anion transmembrane transport 16.6667 5 yes
GO:0098771 inorganic ion homeostasis 16.6667 6 yes
GO:1902476 chloride transmembrane transport 16.6667 6 yes
GO:0006812 cation transport 11.1111 5 yes
GO:0006813 potassium ion transport 11.1111 7 yes
GO:0006885 regulation of pH 11.1111 8 yes
GO:0006971 hypotonic response 11.1111 4 yes
GO:0030001 metal ion transport 11.1111 6 yes
GO:0030002 cellular anion homeostasis 11.1111 5 yes
GO:0030004 cellular monovalent inorganic cation homeostasis 11.1111 6 yes
GO:0030320 cellular monovalent inorganic anion homeostasis 11.1111 6 yes
GO:0030641 regulation of cellular pH 11.1111 7 yes
GO:0030644 cellular chloride ion homeostasis 11.1111 7 yes
GO:0051452 intracellular pH reduction 11.1111 9 yes
GO:0051453 regulation of intracellular pH 11.1111 8 yes
GO:0055064 chloride ion homeostasis 11.1111 8 yes
GO:0055067 monovalent inorganic cation homeostasis 11.1111 7 yes
GO:0055075 potassium ion homeostasis 11.1111 8 yes
GO:0055081 anion homeostasis 11.1111 6 yes
GO:0055083 monovalent inorganic anion homeostasis 11.1111 7 yes
GO:0071805 potassium ion transmembrane transport 11.1111 6 yes
GO:0098655 cation transmembrane transport 11.1111 4 yes
GO:0098657 import into cell 11.1111 4 yes
GO:0098659 inorganic cation import across plasma membrane 11.1111 5 yes
GO:0098662 inorganic cation transmembrane transport 11.1111 5 yes
GO:0099587 inorganic ion import across plasma membrane 11.1111 4 yes
GO:1990573 potassium ion import across plasma membrane 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MYCB2_HUMAN [view entry] [view interactions] Low throughput yes no
CBLB_HUMAN [view interactions] Low throughput no yes
S12A9_HUMAN [view interactions] Low throughput no yes
S12A5_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
YTDC1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CCR4_HUMAN [view interactions] High throughput no yes
PAR2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
MICU3_HUMAN [view interactions] High throughput no yes
S12A4_HUMAN [view interactions] High throughput no yes
S12A7_HUMAN [view interactions] High throughput no yes
TTC9B_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] Computational yes yes
GBRG2_HUMAN [view entry] [view interactions] Computational yes no
CKAP4_HUMAN [view entry] [view interactions] Computational yes yes
WNK3_HUMAN [view interactions] Computational no no
NETO2_HUMAN [view entry] [view interactions] Computational yes yes
ARHG7_HUMAN [view entry] [view interactions] Computational yes yes
GRIK2_HUMAN [view entry] [view interactions] Computational yes yes