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PAR2_HUMAN

Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at Ser-536; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PAR2_HUMAN
GO:0017076 purine nucleotide binding 37.8378 4 no
GO:0032555 purine ribonucleotide binding 37.8378 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.8378 4 no
GO:0005524 ATP binding 29.7297 5 no
GO:0030554 adenyl nucleotide binding 29.7297 5 no
GO:0032559 adenyl ribonucleotide binding 29.7297 5 no
GO:0046872 metal ion binding 29.7297 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PAR2_HUMAN
GO:0048523 negative regulation of cellular process 48.6486 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.6486 4 yes
GO:0010468 regulation of gene expression 43.2432 5 yes
GO:0010646 regulation of cell communication 43.2432 4 yes
GO:0031323 regulation of cellular metabolic process 43.2432 4 yes
GO:0048522 positive regulation of cellular process 43.2432 4 yes
GO:0051049 regulation of transport 43.2432 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 43.2432 4 yes
GO:0080090 regulation of primary metabolic process 43.2432 4 yes
GO:0051246 regulation of protein metabolic process 40.5405 5 no
GO:0009892 negative regulation of metabolic process 37.8378 4 yes
GO:0009893 positive regulation of metabolic process 37.8378 4 yes
GO:0009966 regulation of signal transduction 37.8378 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 37.8378 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 37.8378 5 yes
GO:0051128 regulation of cellular component organization 37.8378 4 yes
GO:0006996 organelle organization 35.1351 4 no
GO:0048585 negative regulation of response to stimulus 35.1351 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 32.4324 5 no
GO:0009968 negative regulation of signal transduction 32.4324 5 yes
GO:0010648 negative regulation of cell communication 32.4324 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.4324 5 yes
GO:0023057 negative regulation of signaling 32.4324 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 32.4324 5 yes
GO:2001141 regulation of RNA biosynthetic process 29.7297 6 yes
GO:0010941 regulation of cell death 29.7297 4 no
GO:0031399 regulation of protein modification process 29.7297 6 no
GO:0042981 regulation of apoptotic process 29.7297 6 no
GO:0043067 regulation of programmed cell death 29.7297 5 no
GO:0051247 positive regulation of protein metabolic process 29.7297 6 no
GO:0006355 regulation of DNA-templated transcription 29.7297 6 yes
GO:0022607 cellular component assembly 29.7297 4 no
GO:0009889 regulation of biosynthetic process 29.7297 4 yes
GO:0051248 negative regulation of protein metabolic process 29.7297 6 no
GO:0010556 regulation of macromolecule biosynthetic process 29.7297 5 yes
GO:0031325 positive regulation of cellular metabolic process 29.7297 5 yes
GO:0031326 regulation of cellular biosynthetic process 29.7297 5 yes
GO:0051252 regulation of RNA metabolic process 29.7297 5 yes
GO:1902531 regulation of intracellular signal transduction 29.7297 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 29.7297 7 yes
GO:0048878 chemical homeostasis 27.0270 4 no
GO:0042127 regulation of cell population proliferation 27.0270 4 no
GO:0071310 cellular response to organic substance 27.0270 4 no
GO:0048584 positive regulation of response to stimulus 27.0270 4 yes
GO:0051241 negative regulation of multicellular organismal process 27.0270 4 yes
GO:0001817 regulation of cytokine production 27.0270 4 yes
GO:0031324 negative regulation of cellular metabolic process 24.3243 5 no
GO:0043066 negative regulation of apoptotic process 24.3243 7 no
GO:0043069 negative regulation of programmed cell death 24.3243 6 no
GO:0060548 negative regulation of cell death 24.3243 5 no
GO:0014070 response to organic cyclic compound 24.3243 4 no
GO:0033993 response to lipid 24.3243 4 no
GO:0051129 negative regulation of cellular component organization 24.3243 5 no
GO:0009967 positive regulation of signal transduction 24.3243 5 yes
GO:0008104 protein localization 24.3243 4 no
GO:0008285 negative regulation of cell population proliferation 24.3243 5 no
GO:0010647 positive regulation of cell communication 24.3243 5 yes
GO:0023056 positive regulation of signaling 24.3243 4 yes
GO:0051050 positive regulation of transport 24.3243 4 yes
GO:0051240 positive regulation of multicellular organismal process 24.3243 4 yes
GO:0060341 regulation of cellular localization 24.3243 4 yes
GO:2000145 regulation of cell motility 24.3243 4 yes
GO:0010243 response to organonitrogen compound 21.6216 4 no
GO:0031401 positive regulation of protein modification process 21.6216 7 no
GO:0050801 ion homeostasis 21.6216 5 no
GO:0055065 metal ion homeostasis 21.6216 7 no
GO:0055080 cation homeostasis 21.6216 6 no
GO:0098771 inorganic ion homeostasis 21.6216 6 no
GO:2000026 regulation of multicellular organismal development 21.6216 4 no
GO:0030162 regulation of proteolysis 21.6216 6 no
GO:0043933 protein-containing complex organization 21.6216 4 no
GO:1901701 cellular response to oxygen-containing compound 21.6216 4 no
GO:0032880 regulation of protein localization 21.6216 5 yes
GO:0050776 regulation of immune response 21.6216 4 yes
GO:1902533 positive regulation of intracellular signal transduction 21.6216 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 18.9189 7 yes
GO:0010628 positive regulation of gene expression 18.9189 6 yes
GO:0010629 negative regulation of gene expression 18.9189 6 yes
GO:0030334 regulation of cell migration 18.9189 5 yes
GO:0033043 regulation of organelle organization 18.9189 5 yes
GO:0043085 positive regulation of catalytic activity 18.9189 4 yes
GO:0044087 regulation of cellular component biogenesis 18.9189 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 18.9189 6 yes
GO:0051130 positive regulation of cellular component organization 18.9189 5 yes
GO:0051254 positive regulation of RNA metabolic process 18.9189 6 yes
GO:0051336 regulation of hydrolase activity 18.9189 4 yes
GO:0060627 regulation of vesicle-mediated transport 18.9189 4 yes
GO:0080134 regulation of response to stress 18.9189 4 yes
GO:1902532 negative regulation of intracellular signal transduction 18.9189 6 yes
GO:0002694 regulation of leukocyte activation 16.2162 4 yes
GO:0009891 positive regulation of biosynthetic process 16.2162 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 16.2162 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 16.2162 6 yes
GO:0043408 regulation of MAPK cascade 16.2162 6 yes
GO:0045893 positive regulation of DNA-templated transcription 16.2162 7 yes
GO:0050865 regulation of cell activation 16.2162 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 16.2162 7 yes
GO:0001819 positive regulation of cytokine production 16.2162 5 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 16.2162 8 yes
GO:1903829 positive regulation of protein localization 16.2162 5 yes
GO:0010638 positive regulation of organelle organization 13.5135 6 yes
GO:0030335 positive regulation of cell migration 13.5135 6 yes
GO:0031344 regulation of cell projection organization 13.5135 5 yes
GO:0040017 positive regulation of locomotion 13.5135 4 yes
GO:0044057 regulation of system process 13.5135 4 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 13.5135 8 yes
GO:0051056 regulation of small GTPase mediated signal transduction 13.5135 6 yes
GO:0051222 positive regulation of protein transport 13.5135 5 yes
GO:0051223 regulation of protein transport 13.5135 5 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 13.5135 5 yes
GO:0070201 regulation of establishment of protein localization 13.5135 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 13.5135 7 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 13.5135 6 yes
GO:1904951 positive regulation of establishment of protein localization 13.5135 6 yes
GO:0002684 positive regulation of immune system process 13.5135 4 yes
GO:2000147 positive regulation of cell motility 13.5135 5 yes
GO:0002696 positive regulation of leukocyte activation 10.8108 5 yes
GO:0003018 vascular process in circulatory system 10.8108 4 yes
GO:0030100 regulation of endocytosis 10.8108 5 yes
GO:0031347 regulation of defense response 10.8108 5 yes
GO:0032101 regulation of response to external stimulus 10.8108 4 yes
GO:0032677 regulation of interleukin-8 production 10.8108 5 yes
GO:0034330 cell junction organization 10.8108 4 yes
GO:0043410 positive regulation of MAPK cascade 10.8108 7 yes
GO:0044089 positive regulation of cellular component biogenesis 10.8108 5 yes
GO:0045216 cell-cell junction organization 10.8108 5 yes
GO:0046578 regulation of Ras protein signal transduction 10.8108 7 yes
GO:0050778 positive regulation of immune response 10.8108 5 yes
GO:0050867 positive regulation of cell activation 10.8108 5 yes
GO:0051046 regulation of secretion 10.8108 5 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 10.8108 7 yes
GO:0051345 positive regulation of hydrolase activity 10.8108 5 yes
GO:0062208 positive regulation of pattern recognition receptor signaling pathway 10.8108 6 yes
GO:0080135 regulation of cellular response to stress 10.8108 4 yes
GO:0001818 negative regulation of cytokine production 10.8108 5 yes
GO:1902903 regulation of supramolecular fiber organization 10.8108 5 yes
GO:1903530 regulation of secretion by cell 10.8108 4 yes
GO:0002697 regulation of immune effector process 8.1081 4 yes
GO:0002699 positive regulation of immune effector process 8.1081 5 yes
GO:0002831 regulation of response to biotic stimulus 8.1081 4 yes
GO:0002833 positive regulation of response to biotic stimulus 8.1081 5 yes
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 8.1081 6 yes
GO:0017157 regulation of exocytosis 8.1081 5 yes
GO:0031346 positive regulation of cell projection organization 8.1081 6 yes
GO:0031349 positive regulation of defense response 8.1081 5 yes
GO:0032103 positive regulation of response to external stimulus 8.1081 5 yes
GO:0032675 regulation of interleukin-6 production 8.1081 5 yes
GO:0032757 positive regulation of interleukin-8 production 8.1081 6 yes
GO:0034121 regulation of toll-like receptor signaling pathway 8.1081 6 yes
GO:0035023 regulation of Rho protein signal transduction 8.1081 8 yes
GO:0043409 negative regulation of MAPK cascade 8.1081 7 yes
GO:0046579 positive regulation of Ras protein signal transduction 8.1081 8 yes
GO:0051493 regulation of cytoskeleton organization 8.1081 6 yes
GO:0051495 positive regulation of cytoskeleton organization 8.1081 7 yes
GO:0060759 regulation of response to cytokine stimulus 8.1081 4 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 8.1081 8 yes
GO:1902905 positive regulation of supramolecular fiber organization 8.1081 6 yes
GO:0001959 regulation of cytokine-mediated signaling pathway 8.1081 5 yes
GO:1903305 regulation of regulated secretory pathway 8.1081 6 yes
GO:0002685 regulation of leukocyte migration 8.1081 4 yes
GO:2000377 regulation of reactive oxygen species metabolic process 5.4054 5 yes
GO:0002700 regulation of production of molecular mediator of immune response 5.4054 5 yes
GO:0002702 positive regulation of production of molecular mediator of immune response 5.4054 6 yes
GO:0002703 regulation of leukocyte mediated immunity 5.4054 5 yes
GO:0002718 regulation of cytokine production involved in immune response 5.4054 5 yes
GO:0002720 positive regulation of cytokine production involved in immune response 5.4054 6 yes
GO:0002886 regulation of myeloid leukocyte mediated immunity 5.4054 6 yes
GO:0007599 hemostasis 5.4054 4 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 5.4054 6 yes
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 5.4054 7 yes
GO:0030099 myeloid cell differentiation 5.4054 4 yes
GO:0032535 regulation of cellular component size 5.4054 4 yes
GO:0032649 regulation of interferon-gamma production 5.4054 5 yes
GO:0032755 positive regulation of interleukin-6 production 5.4054 6 yes
GO:0034122 negative regulation of toll-like receptor signaling pathway 5.4054 6 yes
GO:0034123 positive regulation of toll-like receptor signaling pathway 5.4054 7 yes
GO:0034135 regulation of toll-like receptor 2 signaling pathway 5.4054 7 yes
GO:0034143 regulation of toll-like receptor 4 signaling pathway 5.4054 7 yes
GO:0035025 positive regulation of Rho protein signal transduction 5.4054 9 yes
GO:0035150 regulation of tube size 5.4054 4 yes
GO:0035296 regulation of tube diameter 5.4054 5 yes
GO:0043300 regulation of leukocyte degranulation 5.4054 5 yes
GO:0043954 cellular component maintenance 5.4054 4 yes
GO:0045807 positive regulation of endocytosis 5.4054 5 yes
GO:0050708 regulation of protein secretion 5.4054 5 yes
GO:0050714 positive regulation of protein secretion 5.4054 6 yes
GO:0050920 regulation of chemotaxis 5.4054 4 yes
GO:0051047 positive regulation of secretion 5.4054 5 yes
GO:0060491 regulation of cell projection assembly 5.4054 5 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 5.4054 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 5.4054 6 yes
GO:0097028 dendritic cell differentiation 5.4054 6 yes
GO:0097746 blood vessel diameter maintenance 5.4054 5 yes
GO:1903131 mononuclear cell differentiation 5.4054 5 yes
GO:0002064 epithelial cell development 5.4054 4 yes
GO:1903532 positive regulation of secretion by cell 5.4054 5 yes
GO:0002521 leukocyte differentiation 5.4054 4 yes
GO:0002687 positive regulation of leukocyte migration 5.4054 5 yes
GO:0002688 regulation of leukocyte chemotaxis 5.4054 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PAR2_HUMAN
DOID:0050700 cardiomyopathy 8.1081 4 no
DOID:0060036 intrinsic cardiomyopathy 8.1081 5 no
DOID:114 heart disease 8.1081 3 no
DOID:12930 dilated cardiomyopathy 8.1081 6 no
DOID:0050155 sensory system disease 5.4054 3 no
DOID:110 lens disease 5.4054 5 no
DOID:5614 eye disease 5.4054 4 no
DOID:83 cataract 5.4054 6 no
DOID:0080000 muscular disease 5.4054 3 no
DOID:423 myopathy 5.4054 5 no
DOID:66 muscle tissue disease 5.4054 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSN5_HUMAN [view interactions] Low throughput no yes
TMED2_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
TLR4_HUMAN [view interactions] Low throughput no yes
TMEDA_HUMAN [view interactions] Low throughput no yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TF_HUMAN [view interactions] Low throughput no no
HS71B_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
PRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
CRYAA_HUMAN [view interactions] Low throughput no no
CRYAB_HUMAN [view entry] [view interactions] Low throughput yes no
BIRC5_HUMAN [view interactions] Low throughput no no
CS025_HUMAN [view interactions] High throughput no no
INT12_HUMAN [view interactions] High throughput no yes
ABHEA_HUMAN [view interactions] High throughput no yes
ADCY2_HUMAN [view interactions] High throughput no yes
AR6P1_HUMAN [view interactions] High throughput no yes
ABCC8_HUMAN [view interactions] High throughput no yes
AT2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AT2C1_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
CNN3_HUMAN [view entry] [view interactions] High throughput yes yes
CRLS1_HUMAN [view interactions] High throughput no no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CD63_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
MORN4_HUMAN [view interactions] High throughput no yes
S18B1_HUMAN [view interactions] High throughput no yes
CPNS1_HUMAN [view interactions] High throughput no yes
NAT14_HUMAN [view interactions] High throughput no no
HLAE_HUMAN [view interactions] High throughput no no
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
ERD21_HUMAN [view interactions] High throughput no yes
ICAM2_HUMAN [view interactions] High throughput no no
P4HTM_HUMAN [view interactions] High throughput no yes
HERP1_HUMAN [view interactions] High throughput no yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
QSER1_HUMAN [view interactions] High throughput no yes
CXG2_HUMAN [view interactions] High throughput no no
CXB6_HUMAN [view entry] [view interactions] High throughput yes no
ERGI3_HUMAN [view interactions] High throughput no yes
OSTC_HUMAN [view interactions] High throughput no no
CLPT1_HUMAN [view entry] [view interactions] High throughput yes yes
VIAAT_HUMAN [view interactions] High throughput no yes
NBPFF_HUMAN [view interactions] High throughput no no
S12A5_HUMAN [view entry] [view interactions] High throughput yes yes
SATT_HUMAN [view interactions] High throughput no no
SCN1B_HUMAN [view interactions] High throughput no no
RGR_HUMAN [view interactions] High throughput no no
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
R3HD1_HUMAN [view interactions] High throughput no no
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
PHLA1_HUMAN [view interactions] High throughput no yes
PTSS2_HUMAN [view interactions] High throughput no yes
PIGU_HUMAN [view interactions] High throughput no no
COPT2_HUMAN [view interactions] High throughput no yes
S39AD_HUMAN [view interactions] High throughput no yes
LAT4_HUMAN [view interactions] High throughput no no
DHSD_HUMAN [view interactions] High throughput no yes
SNG2_HUMAN [view interactions] High throughput no no
MFS10_HUMAN [view interactions] High throughput no yes
S35A1_HUMAN [view interactions] High throughput no no
LFG3_HUMAN [view interactions] High throughput no yes
TMED1_HUMAN [view interactions] High throughput no yes
T161A_HUMAN [view interactions] High throughput no yes
TMM62_HUMAN [view interactions] High throughput no yes
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
TMX2_HUMAN [view interactions] High throughput no yes
PPM1J_HUMAN [view interactions] High throughput no yes
YIPF6_HUMAN [view interactions] High throughput no yes
YIPF1_HUMAN [view interactions] High throughput no no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
GEMI4_HUMAN [view interactions] High throughput no yes
ZW10_HUMAN [view interactions] High throughput no yes
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
RINT1_HUMAN [view interactions] High throughput no yes
GEMI6_HUMAN [view interactions] High throughput no yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
ATP8_HUMAN [view interactions] High throughput no no
B4GA1_HUMAN [view interactions] High throughput no yes
AQP3_HUMAN [view interactions] High throughput no no
SGCA_HUMAN [view interactions] High throughput no yes
GP182_HUMAN [view interactions] High throughput no no
ATP5J_HUMAN [view interactions] High throughput no yes
AR6P6_HUMAN [view interactions] High throughput no yes
TSN17_HUMAN [view interactions] High throughput no yes
GCN1_HUMAN [view interactions] High throughput no yes
AUP1_HUMAN [view interactions] High throughput no yes
UCK2_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
IPO8_HUMAN [view interactions] High throughput no no
ATLA2_HUMAN [view entry] [view interactions] High throughput yes yes
HEAT1_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
AT133_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
YIPF3_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
FAKD1_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
AT12A_HUMAN [view entry] [view interactions] High throughput yes no
GOGA5_HUMAN [view interactions] High throughput no yes
BTAF1_HUMAN [view interactions] High throughput no no
CP2S1_HUMAN [view interactions] High throughput no no
ZDH17_HUMAN [view interactions] High throughput no yes
S39A6_HUMAN [view interactions] High throughput no yes
BRAT1_HUMAN [view interactions] High throughput no yes
ECSIT_HUMAN [view interactions] High throughput no yes
MON2_HUMAN [view interactions] High throughput no no
TMCO1_HUMAN [view interactions] High throughput no yes
TMED4_HUMAN [view interactions] High throughput no yes
XPO5_HUMAN [view interactions] High throughput no yes
TAP1_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
CIP2A_HUMAN [view interactions] High throughput no yes
COG4_HUMAN [view interactions] High throughput no no
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
OXA1L_HUMAN [view interactions] High throughput no yes
ZNT9_HUMAN [view interactions] High throughput no yes
B3A2_HUMAN [view interactions] High throughput no yes
IPO13_HUMAN [view interactions] High throughput no yes
TTI1_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
OGFD3_HUMAN [view interactions] High throughput no no
F241B_HUMAN [view interactions] High throughput no yes
CA112_HUMAN [view interactions] High throughput no yes
NOMO1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC6_HUMAN [view interactions] High throughput no yes
AT2A3_HUMAN [view interactions] High throughput no yes
TELO2_HUMAN [view interactions] High throughput no yes
AT1B3_HUMAN [view interactions] High throughput no yes
FANCI_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
COQ8B_HUMAN [view interactions] High throughput no yes
RIF1_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
CSCL2_HUMAN [view interactions] High throughput no yes
TMM70_HUMAN [view interactions] High throughput no yes
THADA_HUMAN [view interactions] High throughput no yes
RAMP3_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
PDS5A_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TSN3_HUMAN [view interactions] High throughput no yes
INT1_HUMAN [view interactions] High throughput no yes
PEX19_HUMAN [view interactions] High throughput no yes
DYM_HUMAN [view interactions] High throughput no yes
TYW1_HUMAN [view interactions] High throughput no yes
ATP5L_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
XPO4_HUMAN [view interactions] High throughput no no
ATPB_HUMAN [view interactions] High throughput no yes
RUSF1_HUMAN [view interactions] High throughput no yes
TNPO3_HUMAN [view interactions] High throughput no yes
TNPO2_HUMAN [view interactions] High throughput no yes
CXCR4_HUMAN [view interactions] High throughput no no
IPO11_HUMAN [view interactions] High throughput no yes
TEX2_HUMAN [view interactions] High throughput no yes
B4GT3_HUMAN [view interactions] High throughput no yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
TBC9B_HUMAN [view interactions] High throughput no yes
NCLN_HUMAN [view interactions] High throughput no yes
TBC15_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
DNM3L_HUMAN [view interactions] High throughput no yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes