Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SARM1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed, PubMed, PubMed). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed, PubMed, PubMed, PubMed). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed). Can activate neuronal cell death in response to stress (PubMed). Regulates dendritic arborization through the MAPK4-JNK pathway . Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SARM1_HUMAN
GO:0043169 cation binding 43.7500 4 no
GO:0046872 metal ion binding 43.7500 5 no
GO:0003953 NAD+ nucleosidase activity 12.5000 5 yes
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 12.5000 4 yes
GO:0050135 NADP+ nucleosidase activity 12.5000 5 yes
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating 12.5000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SARM1_HUMAN
GO:0009966 regulation of signal transduction 56.2500 4 yes
GO:0010646 regulation of cell communication 56.2500 4 yes
GO:0051128 regulation of cellular component organization 56.2500 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0008104 protein localization 43.7500 4 yes
GO:0010975 regulation of neuron projection development 43.7500 7 yes
GO:0031344 regulation of cell projection organization 43.7500 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 43.7500 6 yes
GO:0045595 regulation of cell differentiation 43.7500 4 no
GO:0051094 positive regulation of developmental process 43.7500 4 no
GO:0006996 organelle organization 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0045597 positive regulation of cell differentiation 37.5000 5 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 no
GO:0060284 regulation of cell development 37.5000 5 no
GO:2000026 regulation of multicellular organismal development 37.5000 4 no
GO:0032101 regulation of response to external stimulus 31.2500 4 yes
GO:0033365 protein localization to organelle 31.2500 5 yes
GO:0042981 regulation of apoptotic process 31.2500 5 yes
GO:0043067 regulation of programmed cell death 31.2500 4 yes
GO:0080134 regulation of response to stress 31.2500 4 yes
GO:0030030 cell projection organization 31.2500 4 no
GO:0120036 plasma membrane bounded cell projection organization 31.2500 5 no
GO:0010720 positive regulation of cell development 31.2500 6 no
GO:0050767 regulation of neurogenesis 31.2500 6 no
GO:0051960 regulation of nervous system development 31.2500 5 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0031323 regulation of cellular metabolic process 31.2500 4 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0060255 regulation of macromolecule metabolic process 31.2500 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0070585 protein localization to mitochondrion 25.0000 6 yes
GO:0140546 defense response to symbiont 25.0000 4 yes
GO:0031175 neuron projection development 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0050769 positive regulation of neurogenesis 25.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051962 positive regulation of nervous system development 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0001558 regulation of cell growth 25.0000 4 no
GO:0048638 regulation of developmental growth 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0007005 mitochondrion organization 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0002831 regulation of response to biotic stimulus 18.7500 4 yes
GO:0006796 phosphate-containing compound metabolic process 18.7500 4 yes
GO:0009968 negative regulation of signal transduction 18.7500 5 yes
GO:0010648 negative regulation of cell communication 18.7500 5 yes
GO:0023057 negative regulation of signaling 18.7500 4 yes
GO:0031347 regulation of defense response 18.7500 5 yes
GO:0043523 regulation of neuron apoptotic process 18.7500 6 yes
GO:0045088 regulation of innate immune response 18.7500 5 yes
GO:0050776 regulation of immune response 18.7500 4 yes
GO:0002683 negative regulation of immune system process 12.5000 4 yes
GO:0006163 purine nucleotide metabolic process 12.5000 5 yes
GO:0006195 purine nucleotide catabolic process 12.5000 6 yes
GO:0006753 nucleoside phosphate metabolic process 12.5000 4 yes
GO:0007399 nervous system development 12.5000 4 yes
GO:0009117 nucleotide metabolic process 12.5000 5 yes
GO:0009166 nucleotide catabolic process 12.5000 6 yes
GO:0009743 response to carbohydrate 12.5000 4 yes
GO:0009746 response to hexose 12.5000 6 yes
GO:0009749 response to glucose 12.5000 7 yes
GO:0019362 pyridine nucleotide metabolic process 12.5000 5 yes
GO:0019364 pyridine nucleotide catabolic process 12.5000 6 yes
GO:0019674 NAD metabolic process 12.5000 6 yes
GO:0019677 NAD catabolic process 12.5000 7 yes
GO:0034121 regulation of toll-like receptor signaling pathway 12.5000 6 yes
GO:0034122 negative regulation of toll-like receptor signaling pathway 12.5000 5 yes
GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway 12.5000 7 yes
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway 12.5000 6 yes
GO:0034284 response to monosaccharide 12.5000 5 yes
GO:0034655 nucleobase-containing compound catabolic process 12.5000 4 yes
GO:0046434 organophosphate catabolic process 12.5000 4 yes
GO:0046496 nicotinamide nucleotide metabolic process 12.5000 6 yes
GO:0048678 response to axon injury 12.5000 4 yes
GO:0048814 regulation of dendrite morphogenesis 12.5000 5 yes
GO:0050773 regulation of dendrite development 12.5000 4 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 12.5000 5 yes
GO:0072521 purine-containing compound metabolic process 12.5000 4 yes
GO:0072523 purine-containing compound catabolic process 12.5000 5 yes
GO:0072524 pyridine-containing compound metabolic process 12.5000 4 yes
GO:0072526 pyridine-containing compound catabolic process 12.5000 5 yes
GO:1901292 nucleoside phosphate catabolic process 12.5000 5 yes
GO:1901361 organic cyclic compound catabolic process 12.5000 4 yes
GO:1901565 organonitrogen compound catabolic process 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MYD88_HUMAN [view interactions] Low throughput no yes
TCAM1_HUMAN [view interactions] Low throughput no yes
TIRAP_HUMAN [view interactions] Low throughput no no
TCAM2_HUMAN [view interactions] Low throughput no no
AT1A3_HUMAN [view entry] [view interactions] Low throughput yes no
SARM1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK08_HUMAN [view interactions] Low throughput no yes
BCAP_HUMAN [view interactions] Low throughput no no
CCD47_HUMAN [view interactions] High throughput no yes
CDIPT_HUMAN [view entry] [view interactions] High throughput yes yes
CLGN_HUMAN [view interactions] High throughput no no
NFXL1_HUMAN [view interactions] High throughput no yes
IRAK1_HUMAN [view interactions] High throughput no yes
NLRX1_HUMAN [view interactions] High throughput no yes
IRAK2_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
STT3A_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
POC1B_HUMAN [view interactions] High throughput no no
ACM4_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
CARME_HUMAN [view interactions] High throughput no yes
PAUF_HUMAN [view interactions] High throughput no no
XLRS1_HUMAN [view interactions] High throughput no no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DYR1A_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
RING2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
CA087_HUMAN [view interactions] High throughput no no
TTC23_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
TACD2_HUMAN [view interactions] High throughput no no
SHSA3_HUMAN [view interactions] High throughput no no
KDSR_HUMAN [view interactions] High throughput no yes
CEL2A_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
HCST_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes