Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GHC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GHC2_HUMAN
GO:0017076 purine nucleotide binding 35.2941 4 no
GO:0032555 purine ribonucleotide binding 35.2941 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.2941 4 no
GO:0046872 metal ion binding 35.2941 4 no
GO:0005524 ATP binding 29.4118 5 no
GO:0030554 adenyl nucleotide binding 29.4118 5 no
GO:0032559 adenyl ribonucleotide binding 29.4118 5 no
GO:0003723 RNA binding 23.5294 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0019901 protein kinase binding 23.5294 5 no
GO:0005280 amino acid:proton symporter activity 11.7647 7 yes
GO:0005310 dicarboxylic acid transmembrane transporter activity 11.7647 5 yes
GO:0005313 L-glutamate transmembrane transporter activity 11.7647 6 yes
GO:0005416 amino acid:cation symporter activity 11.7647 6 yes
GO:0008324 cation transmembrane transporter activity 11.7647 4 yes
GO:0008509 anion transmembrane transporter activity 11.7647 4 yes
GO:0008514 organic anion transmembrane transporter activity 11.7647 5 yes
GO:0015078 proton transmembrane transporter activity 11.7647 5 yes
GO:0015171 amino acid transmembrane transporter activity 11.7647 5 yes
GO:0015172 acidic amino acid transmembrane transporter activity 11.7647 6 yes
GO:0015179 L-amino acid transmembrane transporter activity 11.7647 6 yes
GO:0015183 L-aspartate transmembrane transporter activity 11.7647 6 yes
GO:0015291 secondary active transmembrane transporter activity 11.7647 4 yes
GO:0015293 symporter activity 11.7647 5 yes
GO:0015294 solute:cation symporter activity 11.7647 5 yes
GO:0015295 solute:proton symporter activity 11.7647 6 yes
GO:0015556 C4-dicarboxylate transmembrane transporter activity 11.7647 6 yes
GO:0022853 active ion transmembrane transporter activity 11.7647 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 11.7647 4 yes
GO:0046943 carboxylic acid transmembrane transporter activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GHC2_HUMAN
GO:0048522 positive regulation of cellular process 70.5882 4 no
GO:0048523 negative regulation of cellular process 70.5882 4 no
GO:0010646 regulation of cell communication 58.8235 4 no
GO:0051171 regulation of nitrogen compound metabolic process 52.9412 4 no
GO:0060255 regulation of macromolecule metabolic process 52.9412 4 no
GO:0080090 regulation of primary metabolic process 52.9412 4 no
GO:0009966 regulation of signal transduction 52.9412 4 no
GO:0010468 regulation of gene expression 47.0588 5 no
GO:0006996 organelle organization 47.0588 4 no
GO:0051128 regulation of cellular component organization 47.0588 4 no
GO:0009889 regulation of biosynthetic process 41.1765 4 no
GO:0031323 regulation of cellular metabolic process 41.1765 4 no
GO:0031326 regulation of cellular biosynthetic process 41.1765 5 no
GO:0051240 positive regulation of multicellular organismal process 41.1765 4 no
GO:0008104 protein localization 41.1765 4 no
GO:0036211 protein modification process 41.1765 4 no
GO:0043412 macromolecule modification 41.1765 4 no
GO:0048585 negative regulation of response to stimulus 41.1765 4 no
GO:0009893 positive regulation of metabolic process 41.1765 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.1765 5 no
GO:0010941 regulation of cell death 41.1765 4 no
GO:0042981 regulation of apoptotic process 41.1765 6 no
GO:0043067 regulation of programmed cell death 41.1765 5 no
GO:0048584 positive regulation of response to stimulus 41.1765 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.1765 5 no
GO:0071702 organic substance transport 35.2941 4 yes
GO:0071705 nitrogen compound transport 35.2941 4 yes
GO:0001817 regulation of cytokine production 35.2941 4 no
GO:0006355 regulation of DNA-templated transcription 35.2941 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.2941 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.2941 5 no
GO:0051252 regulation of RNA metabolic process 35.2941 5 no
GO:1903506 regulation of nucleic acid-templated transcription 35.2941 7 no
GO:2001141 regulation of RNA biosynthetic process 35.2941 6 no
GO:0009968 negative regulation of signal transduction 35.2941 5 no
GO:0010648 negative regulation of cell communication 35.2941 5 no
GO:0023057 negative regulation of signaling 35.2941 4 no
GO:0009967 positive regulation of signal transduction 35.2941 5 no
GO:0010628 positive regulation of gene expression 35.2941 6 no
GO:0010647 positive regulation of cell communication 35.2941 5 no
GO:0023056 positive regulation of signaling 35.2941 4 no
GO:0051246 regulation of protein metabolic process 35.2941 5 no
GO:0051247 positive regulation of protein metabolic process 35.2941 6 no
GO:0009892 negative regulation of metabolic process 29.4118 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0022607 cellular component assembly 29.4118 4 no
GO:0051094 positive regulation of developmental process 29.4118 4 no
GO:2000026 regulation of multicellular organismal development 29.4118 4 no
GO:0051049 regulation of transport 29.4118 4 no
GO:0051726 regulation of cell cycle 29.4118 4 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0050776 regulation of immune response 29.4118 4 no
GO:0009057 macromolecule catabolic process 23.5294 4 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0042127 regulation of cell population proliferation 23.5294 4 no
GO:0043933 protein-containing complex organization 23.5294 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.5294 5 no
GO:0051960 regulation of nervous system development 23.5294 5 no
GO:0051962 positive regulation of nervous system development 23.5294 5 no
GO:0090304 nucleic acid metabolic process 23.5294 4 no
GO:0015031 protein transport 23.5294 4 no
GO:0070647 protein modification by small protein conjugation or removal 23.5294 5 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:1902532 negative regulation of intracellular signal transduction 23.5294 6 no
GO:0001819 positive regulation of cytokine production 23.5294 5 no
GO:0002684 positive regulation of immune system process 23.5294 4 no
GO:0010942 positive regulation of cell death 23.5294 5 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0050778 positive regulation of immune response 23.5294 5 no
GO:0051336 regulation of hydrolase activity 23.5294 4 no
GO:0051345 positive regulation of hydrolase activity 23.5294 5 no
GO:0044087 regulation of cellular component biogenesis 23.5294 4 no
GO:0030162 regulation of proteolysis 23.5294 6 no
GO:0045862 positive regulation of proteolysis 23.5294 7 no
GO:0080134 regulation of response to stress 23.5294 4 no
GO:0006811 ion transport 17.6471 4 yes
GO:0003333 amino acid transmembrane transport 11.7647 5 yes
GO:0006820 anion transport 11.7647 5 yes
GO:0006835 dicarboxylic acid transport 11.7647 7 yes
GO:0006865 amino acid transport 11.7647 5 yes
GO:0015711 organic anion transport 11.7647 5 yes
GO:0015740 C4-dicarboxylate transport 11.7647 8 yes
GO:0015800 acidic amino acid transport 11.7647 6 yes
GO:0015807 L-amino acid transport 11.7647 5 yes
GO:0015810 aspartate transmembrane transport 11.7647 5 yes
GO:0015813 L-glutamate transmembrane transport 11.7647 5 yes
GO:0015849 organic acid transport 11.7647 5 yes
GO:0043490 malate-aspartate shuttle 11.7647 4 yes
GO:0046942 carboxylic acid transport 11.7647 6 yes
GO:0051938 L-glutamate import 11.7647 6 yes
GO:0098656 anion transmembrane transport 11.7647 4 yes
GO:1902475 L-alpha-amino acid transmembrane transport 11.7647 6 yes
GO:1905039 carboxylic acid transmembrane transport 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ICT1_HUMAN [view interactions] High throughput no yes
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
FGR_HUMAN [view interactions] High throughput no no
MP2K5_HUMAN [view interactions] High throughput no yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MOT11_HUMAN [view interactions] High throughput no no
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
VGFR3_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
KRA93_HUMAN [view interactions] High throughput no no
CRTP1_HUMAN [view interactions] High throughput no yes
KR132_HUMAN [view interactions] High throughput no no
KR196_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
PJA1_HUMAN [view interactions] High throughput no yes
DMXL1_HUMAN [view interactions] High throughput no yes
ZNHI2_HUMAN [view interactions] High throughput no no
ANR40_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
TRI32_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CE164_HUMAN [view interactions] High throughput no yes
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
RBM14_HUMAN [view interactions] High throughput no yes
ANGE1_HUMAN [view interactions] High throughput no yes
TMX3_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
G3PT_HUMAN [view interactions] High throughput no no
VTDB_HUMAN [view interactions] Computational no yes
CO3_HUMAN [view entry] [view interactions] Computational yes no
GUCNB_HUMAN [view interactions] Computational no no