GHC1_HUMAN
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GHC1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 33.3333 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
GO:0046872 | metal ion binding | 29.6296 | 4 | no |
GO:0019900 | kinase binding | 29.6296 | 4 | no |
GO:0019901 | protein kinase binding | 25.9259 | 5 | no |
GO:0005524 | ATP binding | 25.9259 | 5 | no |
GO:0016301 | kinase activity | 25.9259 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 25.9259 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 25.9259 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 25.9259 | 5 | no |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 22.2222 | 4 | no |
GO:0008324 | cation transmembrane transporter activity | 18.5185 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 18.5185 | 4 | yes |
GO:0015291 | secondary active transmembrane transporter activity | 14.8148 | 4 | yes |
GO:0022853 | active ion transmembrane transporter activity | 14.8148 | 4 | yes |
GO:0005310 | dicarboxylic acid transmembrane transporter activity | 11.1111 | 5 | yes |
GO:0005313 | L-glutamate transmembrane transporter activity | 11.1111 | 6 | yes |
GO:0005416 | amino acid:cation symporter activity | 11.1111 | 6 | yes |
GO:0008509 | anion transmembrane transporter activity | 11.1111 | 4 | yes |
GO:0008514 | organic anion transmembrane transporter activity | 11.1111 | 5 | yes |
GO:0015171 | amino acid transmembrane transporter activity | 11.1111 | 5 | yes |
GO:0015172 | acidic amino acid transmembrane transporter activity | 11.1111 | 6 | yes |
GO:0015179 | L-amino acid transmembrane transporter activity | 11.1111 | 6 | yes |
GO:0015183 | L-aspartate transmembrane transporter activity | 11.1111 | 6 | yes |
GO:0015293 | symporter activity | 11.1111 | 5 | yes |
GO:0015294 | solute:cation symporter activity | 11.1111 | 5 | yes |
GO:0015556 | C4-dicarboxylate transmembrane transporter activity | 11.1111 | 6 | yes |
GO:0046943 | carboxylic acid transmembrane transporter activity | 11.1111 | 4 | yes |
GO:0005280 | amino acid:proton symporter activity | 7.4074 | 7 | yes |
GO:0015078 | proton transmembrane transporter activity | 7.4074 | 5 | yes |
GO:0015295 | solute:proton symporter activity | 7.4074 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GHC1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.3704 | 4 | no |
GO:0010646 | regulation of cell communication | 62.9630 | 4 | no |
GO:0048523 | negative regulation of cellular process | 59.2593 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 59.2593 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 55.5556 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 55.5556 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 55.5556 | 4 | no |
GO:0009966 | regulation of signal transduction | 55.5556 | 4 | no |
GO:0051128 | regulation of cellular component organization | 55.5556 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 51.8519 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 48.1481 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 48.1481 | 5 | no |
GO:0010647 | positive regulation of cell communication | 48.1481 | 5 | no |
GO:0023056 | positive regulation of signaling | 48.1481 | 4 | no |
GO:0031399 | regulation of protein modification process | 48.1481 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 44.4444 | 6 | no |
GO:0042325 | regulation of phosphorylation | 44.4444 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 44.4444 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.4444 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 44.4444 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 44.4444 | 6 | no |
GO:0006996 | organelle organization | 44.4444 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 40.7407 | 7 | no |
GO:0036211 | protein modification process | 40.7407 | 4 | no |
GO:0043412 | macromolecule modification | 40.7407 | 4 | no |
GO:0010468 | regulation of gene expression | 40.7407 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 40.7407 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 40.7407 | 4 | no |
GO:0008104 | protein localization | 37.0370 | 4 | no |
GO:0010941 | regulation of cell death | 37.0370 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 37.0370 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 37.0370 | 7 | no |
GO:0043549 | regulation of kinase activity | 37.0370 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 37.0370 | 5 | no |
GO:0051338 | regulation of transferase activity | 37.0370 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 37.0370 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 37.0370 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 37.0370 | 5 | no |
GO:0022607 | cellular component assembly | 37.0370 | 4 | no |
GO:0030030 | cell projection organization | 37.0370 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 37.0370 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 37.0370 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 33.3333 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 33.3333 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 33.3333 | 7 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 33.3333 | 4 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:0033043 | regulation of organelle organization | 33.3333 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0006811 | ion transport | 29.6296 | 4 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 29.6296 | 8 | no |
GO:0032880 | regulation of protein localization | 29.6296 | 5 | no |
GO:0033674 | positive regulation of kinase activity | 29.6296 | 6 | no |
GO:0042981 | regulation of apoptotic process | 29.6296 | 6 | no |
GO:0043067 | regulation of programmed cell death | 29.6296 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 29.6296 | 6 | no |
GO:0050890 | cognition | 29.6296 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 29.6296 | 5 | no |
GO:0060341 | regulation of cellular localization | 29.6296 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 29.6296 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 29.6296 | 5 | no |
GO:0031344 | regulation of cell projection organization | 29.6296 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 29.6296 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 29.6296 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 29.6296 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 29.6296 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 29.6296 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 29.6296 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.6296 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 29.6296 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 29.6296 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 29.6296 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 29.6296 | 6 | no |
GO:0071702 | organic substance transport | 25.9259 | 4 | yes |
GO:0071705 | nitrogen compound transport | 25.9259 | 4 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 25.9259 | 4 | no |
GO:0010243 | response to organonitrogen compound | 25.9259 | 4 | no |
GO:0014070 | response to organic cyclic compound | 25.9259 | 4 | no |
GO:0030162 | regulation of proteolysis | 25.9259 | 6 | no |
GO:0034330 | cell junction organization | 25.9259 | 4 | no |
GO:0045860 | positive regulation of protein kinase activity | 25.9259 | 7 | no |
GO:0050808 | synapse organization | 25.9259 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.9259 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 25.9259 | 5 | no |
GO:0007010 | cytoskeleton organization | 25.9259 | 5 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 25.9259 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 25.9259 | 4 | no |
GO:0031400 | negative regulation of protein modification process | 25.9259 | 7 | no |
GO:0043086 | negative regulation of catalytic activity | 25.9259 | 4 | no |
GO:0043933 | protein-containing complex organization | 25.9259 | 4 | no |
GO:0045595 | regulation of cell differentiation | 25.9259 | 4 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 25.9259 | 7 | no |
GO:0051094 | positive regulation of developmental process | 25.9259 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 25.9259 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 25.9259 | 6 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.9259 | 6 | no |
GO:1903829 | positive regulation of protein localization | 25.9259 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 25.9259 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.9259 | 6 | no |
GO:0009968 | negative regulation of signal transduction | 25.9259 | 5 | no |
GO:0010648 | negative regulation of cell communication | 25.9259 | 5 | no |
GO:0023057 | negative regulation of signaling | 25.9259 | 4 | no |
GO:0051050 | positive regulation of transport | 25.9259 | 4 | no |
GO:0006468 | protein phosphorylation | 22.2222 | 5 | no |
GO:0006812 | cation transport | 22.2222 | 5 | no |
GO:0007612 | learning | 22.2222 | 4 | no |
GO:0010038 | response to metal ion | 22.2222 | 4 | no |
GO:0016310 | phosphorylation | 22.2222 | 5 | no |
GO:0045862 | positive regulation of proteolysis | 22.2222 | 7 | no |
GO:0060548 | negative regulation of cell death | 22.2222 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 22.2222 | 6 | no |
GO:0071417 | cellular response to organonitrogen compound | 22.2222 | 4 | no |
GO:1901214 | regulation of neuron death | 22.2222 | 5 | no |
GO:1901699 | cellular response to nitrogen compound | 22.2222 | 4 | no |
GO:0010638 | positive regulation of organelle organization | 22.2222 | 6 | no |
GO:0010975 | regulation of neuron projection development | 22.2222 | 7 | no |
GO:0031175 | neuron projection development | 22.2222 | 6 | no |
GO:0042326 | negative regulation of phosphorylation | 22.2222 | 8 | no |
GO:0051960 | regulation of nervous system development | 22.2222 | 5 | no |
GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | no |
GO:0097435 | supramolecular fiber organization | 22.2222 | 4 | no |
GO:1902903 | regulation of supramolecular fiber organization | 22.2222 | 5 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 22.2222 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 22.2222 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
GO:0071900 | regulation of protein serine/threonine kinase activity | 22.2222 | 7 | no |
GO:0043269 | regulation of ion transport | 22.2222 | 5 | no |
GO:0003333 | amino acid transmembrane transport | 14.8148 | 5 | yes |
GO:0006820 | anion transport | 14.8148 | 5 | yes |
GO:0006835 | dicarboxylic acid transport | 14.8148 | 7 | yes |
GO:0006865 | amino acid transport | 14.8148 | 5 | yes |
GO:0015711 | organic anion transport | 14.8148 | 5 | yes |
GO:0015800 | acidic amino acid transport | 14.8148 | 6 | yes |
GO:0015807 | L-amino acid transport | 14.8148 | 5 | yes |
GO:0015813 | L-glutamate transmembrane transport | 14.8148 | 5 | yes |
GO:0015849 | organic acid transport | 14.8148 | 5 | yes |
GO:0046942 | carboxylic acid transport | 14.8148 | 6 | yes |
GO:0051938 | L-glutamate import | 14.8148 | 6 | yes |
GO:0098656 | anion transmembrane transport | 14.8148 | 4 | yes |
GO:1902475 | L-alpha-amino acid transmembrane transport | 14.8148 | 6 | yes |
GO:1905039 | carboxylic acid transmembrane transport | 14.8148 | 4 | yes |
GO:0015740 | C4-dicarboxylate transport | 11.1111 | 8 | yes |
GO:0015810 | aspartate transmembrane transport | 7.4074 | 5 | yes |
GO:0043490 | malate-aspartate shuttle | 7.4074 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in GHC1_HUMAN |
---|---|---|---|---|
DOID:1289 | neurodegenerative disease | 7.4074 | 4 | no |
DOID:331 | central nervous system disease | 7.4074 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
MDC1_HUMAN | [view interactions] | High throughput | no | yes |
CLN5_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
MERL_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
HIF1A_HUMAN | [view interactions] | High throughput | no | no |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
SENP2_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
GRWD1_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRP6_HUMAN | [view interactions] | High throughput | no | no |
CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHG4_HUMAN | [view interactions] | High throughput | no | no |
DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
BRD1_HUMAN | [view interactions] | High throughput | no | yes |
INS_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7L_HUMAN | [view interactions] | High throughput | no | yes |
MICB_HUMAN | [view interactions] | High throughput | no | no |
NFXL1_HUMAN | [view interactions] | High throughput | no | yes |
IPO13_HUMAN | [view interactions] | High throughput | no | yes |
TM263_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB38_HUMAN | [view interactions] | High throughput | no | no |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
SDHB_HUMAN | [view interactions] | High throughput | no | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGO4_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLN3_HUMAN | [view interactions] | High throughput | no | no |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
S38A1_HUMAN | [view interactions] | High throughput | no | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
ARAF_HUMAN | [view interactions] | High throughput | no | yes |
IKKB_HUMAN | [view interactions] | High throughput | no | yes |
ILK_HUMAN | [view interactions] | High throughput | no | no |
LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
CDC16_HUMAN | [view interactions] | High throughput | no | yes |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
KRBX4_HUMAN | [view interactions] | High throughput | no | no |
KDM5C_HUMAN | [view interactions] | High throughput | no | no |
TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEST_HUMAN | [view interactions] | High throughput | no | no |
CBX7_HUMAN | [view interactions] | High throughput | no | yes |
GHC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DNLZ_HUMAN | [view interactions] | High throughput | no | no |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
FGR_HUMAN | [view interactions] | High throughput | no | no |
MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
ELK1_HUMAN | [view interactions] | High throughput | no | yes |
PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BRAF_HUMAN | [view interactions] | High throughput | no | yes |
VAV_HUMAN | [view interactions] | High throughput | no | no |
RHG31_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLT3_HUMAN | [view interactions] | High throughput | no | no |
LIMK1_HUMAN | [view interactions] | High throughput | no | yes |
ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSD13_HUMAN | [view interactions] | High throughput | no | yes |
CASP4_HUMAN | [view interactions] | High throughput | no | yes |
WRP73_HUMAN | [view interactions] | High throughput | no | no |
TNR14_HUMAN | [view interactions] | High throughput | no | no |
T22D1_HUMAN | [view interactions] | High throughput | no | no |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
RAB30_HUMAN | [view interactions] | High throughput | no | yes |
KATIP_HUMAN | [view interactions] | High throughput | no | yes |
S15A4_HUMAN | [view interactions] | High throughput | no | yes |
GUCNB_HUMAN | [view interactions] | Computational | no | no |