Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GHC1_HUMAN

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GHC1_HUMAN
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0046872 metal ion binding 29.6296 4 no
GO:0019900 kinase binding 29.6296 4 no
GO:0019901 protein kinase binding 25.9259 5 no
GO:0005524 ATP binding 25.9259 5 no
GO:0016301 kinase activity 25.9259 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.9259 4 no
GO:0030554 adenyl nucleotide binding 25.9259 5 no
GO:0032559 adenyl ribonucleotide binding 25.9259 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 22.2222 4 no
GO:0008324 cation transmembrane transporter activity 18.5185 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 18.5185 4 yes
GO:0015291 secondary active transmembrane transporter activity 14.8148 4 yes
GO:0022853 active ion transmembrane transporter activity 14.8148 4 yes
GO:0005310 dicarboxylic acid transmembrane transporter activity 11.1111 5 yes
GO:0005313 L-glutamate transmembrane transporter activity 11.1111 6 yes
GO:0005416 amino acid:cation symporter activity 11.1111 6 yes
GO:0008509 anion transmembrane transporter activity 11.1111 4 yes
GO:0008514 organic anion transmembrane transporter activity 11.1111 5 yes
GO:0015171 amino acid transmembrane transporter activity 11.1111 5 yes
GO:0015172 acidic amino acid transmembrane transporter activity 11.1111 6 yes
GO:0015179 L-amino acid transmembrane transporter activity 11.1111 6 yes
GO:0015183 L-aspartate transmembrane transporter activity 11.1111 6 yes
GO:0015293 symporter activity 11.1111 5 yes
GO:0015294 solute:cation symporter activity 11.1111 5 yes
GO:0015556 C4-dicarboxylate transmembrane transporter activity 11.1111 6 yes
GO:0046943 carboxylic acid transmembrane transporter activity 11.1111 4 yes
GO:0005280 amino acid:proton symporter activity 7.4074 7 yes
GO:0015078 proton transmembrane transporter activity 7.4074 5 yes
GO:0015295 solute:proton symporter activity 7.4074 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GHC1_HUMAN
GO:0048522 positive regulation of cellular process 70.3704 4 no
GO:0010646 regulation of cell communication 62.9630 4 no
GO:0048523 negative regulation of cellular process 59.2593 4 no
GO:0060255 regulation of macromolecule metabolic process 59.2593 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0051246 regulation of protein metabolic process 51.8519 5 no
GO:0009893 positive regulation of metabolic process 48.1481 4 no
GO:0010604 positive regulation of macromolecule metabolic process 48.1481 5 no
GO:0010647 positive regulation of cell communication 48.1481 5 no
GO:0023056 positive regulation of signaling 48.1481 4 no
GO:0031399 regulation of protein modification process 48.1481 6 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0043085 positive regulation of catalytic activity 44.4444 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0051247 positive regulation of protein metabolic process 44.4444 6 no
GO:0006996 organelle organization 44.4444 4 no
GO:0001932 regulation of protein phosphorylation 40.7407 7 no
GO:0036211 protein modification process 40.7407 4 no
GO:0043412 macromolecule modification 40.7407 4 no
GO:0010468 regulation of gene expression 40.7407 5 no
GO:1902531 regulation of intracellular signal transduction 40.7407 5 no
GO:0048584 positive regulation of response to stimulus 40.7407 4 no
GO:0008104 protein localization 37.0370 4 no
GO:0010941 regulation of cell death 37.0370 4 no
GO:0031325 positive regulation of cellular metabolic process 37.0370 5 no
GO:0031401 positive regulation of protein modification process 37.0370 7 no
GO:0043549 regulation of kinase activity 37.0370 5 no
GO:0050804 modulation of chemical synaptic transmission 37.0370 5 no
GO:0051338 regulation of transferase activity 37.0370 4 no
GO:0099177 regulation of trans-synaptic signaling 37.0370 4 no
GO:0009892 negative regulation of metabolic process 37.0370 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.0370 5 no
GO:0022607 cellular component assembly 37.0370 4 no
GO:0030030 cell projection organization 37.0370 4 no
GO:0051130 positive regulation of cellular component organization 37.0370 5 no
GO:0009967 positive regulation of signal transduction 37.0370 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0006811 ion transport 29.6296 4 yes
GO:0001934 positive regulation of protein phosphorylation 29.6296 8 no
GO:0032880 regulation of protein localization 29.6296 5 no
GO:0033674 positive regulation of kinase activity 29.6296 6 no
GO:0042981 regulation of apoptotic process 29.6296 6 no
GO:0043067 regulation of programmed cell death 29.6296 5 no
GO:0045859 regulation of protein kinase activity 29.6296 6 no
GO:0050890 cognition 29.6296 4 no
GO:0051347 positive regulation of transferase activity 29.6296 5 no
GO:0060341 regulation of cellular localization 29.6296 4 no
GO:1901701 cellular response to oxygen-containing compound 29.6296 4 no
GO:0031324 negative regulation of cellular metabolic process 29.6296 5 no
GO:0031344 regulation of cell projection organization 29.6296 5 no
GO:0051248 negative regulation of protein metabolic process 29.6296 6 no
GO:0120036 plasma membrane bounded cell projection organization 29.6296 5 no
GO:0043408 regulation of MAPK cascade 29.6296 6 no
GO:0006355 regulation of DNA-templated transcription 29.6296 6 no
GO:0009889 regulation of biosynthetic process 29.6296 4 no
GO:0010556 regulation of macromolecule biosynthetic process 29.6296 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.6296 5 no
GO:0031326 regulation of cellular biosynthetic process 29.6296 5 no
GO:0048585 negative regulation of response to stimulus 29.6296 4 no
GO:0051252 regulation of RNA metabolic process 29.6296 5 no
GO:1903506 regulation of nucleic acid-templated transcription 29.6296 7 no
GO:2001141 regulation of RNA biosynthetic process 29.6296 6 no
GO:0071702 organic substance transport 25.9259 4 yes
GO:0071705 nitrogen compound transport 25.9259 4 yes
GO:0006796 phosphate-containing compound metabolic process 25.9259 4 no
GO:0010243 response to organonitrogen compound 25.9259 4 no
GO:0014070 response to organic cyclic compound 25.9259 4 no
GO:0030162 regulation of proteolysis 25.9259 6 no
GO:0034330 cell junction organization 25.9259 4 no
GO:0045860 positive regulation of protein kinase activity 25.9259 7 no
GO:0050808 synapse organization 25.9259 5 no
GO:0051240 positive regulation of multicellular organismal process 25.9259 4 no
GO:0051345 positive regulation of hydrolase activity 25.9259 5 no
GO:0007010 cytoskeleton organization 25.9259 5 no
GO:0010563 negative regulation of phosphorus metabolic process 25.9259 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.9259 4 no
GO:0031400 negative regulation of protein modification process 25.9259 7 no
GO:0043086 negative regulation of catalytic activity 25.9259 4 no
GO:0043933 protein-containing complex organization 25.9259 4 no
GO:0045595 regulation of cell differentiation 25.9259 4 no
GO:0045936 negative regulation of phosphate metabolic process 25.9259 7 no
GO:0051094 positive regulation of developmental process 25.9259 4 no
GO:0051129 negative regulation of cellular component organization 25.9259 5 no
GO:0051493 regulation of cytoskeleton organization 25.9259 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.9259 6 no
GO:1903829 positive regulation of protein localization 25.9259 5 no
GO:2000026 regulation of multicellular organismal development 25.9259 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.9259 6 no
GO:0009968 negative regulation of signal transduction 25.9259 5 no
GO:0010648 negative regulation of cell communication 25.9259 5 no
GO:0023057 negative regulation of signaling 25.9259 4 no
GO:0051050 positive regulation of transport 25.9259 4 no
GO:0006468 protein phosphorylation 22.2222 5 no
GO:0006812 cation transport 22.2222 5 no
GO:0007612 learning 22.2222 4 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0016310 phosphorylation 22.2222 5 no
GO:0045862 positive regulation of proteolysis 22.2222 7 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:1901214 regulation of neuron death 22.2222 5 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0051960 regulation of nervous system development 22.2222 5 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.2222 7 no
GO:0043269 regulation of ion transport 22.2222 5 no
GO:0003333 amino acid transmembrane transport 14.8148 5 yes
GO:0006820 anion transport 14.8148 5 yes
GO:0006835 dicarboxylic acid transport 14.8148 7 yes
GO:0006865 amino acid transport 14.8148 5 yes
GO:0015711 organic anion transport 14.8148 5 yes
GO:0015800 acidic amino acid transport 14.8148 6 yes
GO:0015807 L-amino acid transport 14.8148 5 yes
GO:0015813 L-glutamate transmembrane transport 14.8148 5 yes
GO:0015849 organic acid transport 14.8148 5 yes
GO:0046942 carboxylic acid transport 14.8148 6 yes
GO:0051938 L-glutamate import 14.8148 6 yes
GO:0098656 anion transmembrane transport 14.8148 4 yes
GO:1902475 L-alpha-amino acid transmembrane transport 14.8148 6 yes
GO:1905039 carboxylic acid transmembrane transport 14.8148 4 yes
GO:0015740 C4-dicarboxylate transport 11.1111 8 yes
GO:0015810 aspartate transmembrane transport 7.4074 5 yes
GO:0043490 malate-aspartate shuttle 7.4074 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in GHC1_HUMAN
DOID:1289 neurodegenerative disease 7.4074 4 no
DOID:331 central nervous system disease 7.4074 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FHI1B_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
MDC1_HUMAN [view interactions] High throughput no yes
CLN5_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
WDTC1_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
ABCG1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
HIF1N_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
HIF1A_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
SENP2_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
CTDP1_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
MRP6_HUMAN [view interactions] High throughput no no
CLUA1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHG4_HUMAN [view interactions] High throughput no no
DEP1B_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
BRD1_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ICAM1_HUMAN [view interactions] High throughput no no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7L_HUMAN [view interactions] High throughput no yes
MICB_HUMAN [view interactions] High throughput no no
NFXL1_HUMAN [view interactions] High throughput no yes
IPO13_HUMAN [view interactions] High throughput no yes
TM263_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
RAB38_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
SDHB_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
AGO4_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CLN3_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
S38A1_HUMAN [view interactions] High throughput no yes
LMTK1_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
IKKB_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
LIMK2_HUMAN [view interactions] High throughput no yes
CDC16_HUMAN [view interactions] High throughput no yes
KCTD5_HUMAN [view interactions] High throughput no no
KRBX4_HUMAN [view interactions] High throughput no no
KDM5C_HUMAN [view interactions] High throughput no no
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
NEST_HUMAN [view interactions] High throughput no no
CBX7_HUMAN [view interactions] High throughput no yes
GHC2_HUMAN [view entry] [view interactions] High throughput yes no
DNLZ_HUMAN [view interactions] High throughput no no
MD2L2_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
COQ9_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
FGR_HUMAN [view interactions] High throughput no no
MP2K5_HUMAN [view interactions] High throughput no yes
ELK1_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
BRAF_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
RHG31_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MOT11_HUMAN [view interactions] High throughput no no
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
FLT3_HUMAN [view interactions] High throughput no no
LIMK1_HUMAN [view interactions] High throughput no yes
ST32C_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
INSR_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PSD13_HUMAN [view interactions] High throughput no yes
CASP4_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
TNR14_HUMAN [view interactions] High throughput no no
T22D1_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
RAB30_HUMAN [view interactions] High throughput no yes
KATIP_HUMAN [view interactions] High throughput no yes
S15A4_HUMAN [view interactions] High throughput no yes
GUCNB_HUMAN [view interactions] Computational no no