FN3K_HUMAN
Evidence for PS localization
Functions
Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed, PubMed, PubMed). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed, PubMed). Involved in intracellular deglycation in erythrocytes (PubMed). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function . Also able to phosphorylate psicosamines and ribulosamines (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FN3K_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 60.0000 | 4 | no |
| GO:0005524 | ATP binding | 40.0000 | 5 | yes |
| GO:0016301 | kinase activity | 40.0000 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 40.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 40.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 40.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 40.0000 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | yes |
| GO:0008270 | zinc ion binding | 40.0000 | 6 | no |
| GO:0046914 | transition metal ion binding | 40.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FN3K_HUMAN |
|---|---|---|---|---|
| GO:0036211 | protein modification process | 40.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | yes |
| GO:0061024 | membrane organization | 40.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 40.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 40.0000 | 4 | no |
| GO:0045787 | positive regulation of cell cycle | 40.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| GMFG_HUMAN | [view interactions] | High throughput | no | yes |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| BIRC5_HUMAN | [view interactions] | High throughput | no | no |
| ANPRA_HUMAN | [view interactions] | High throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |