Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FN3K_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed, PubMed, PubMed). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed, PubMed). Involved in intracellular deglycation in erythrocytes (PubMed). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function . Also able to phosphorylate psicosamines and ribulosamines (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FN3K_HUMAN
GO:0043169 cation binding 66.6667 4 no
GO:0046872 metal ion binding 66.6667 5 no
GO:0008270 zinc ion binding 50.0000 7 no
GO:0046914 transition metal ion binding 50.0000 6 no
GO:0000166 nucleotide binding 33.3333 4 yes
GO:0005524 ATP binding 33.3333 5 yes
GO:0016301 kinase activity 33.3333 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 yes
GO:0017076 purine nucleotide binding 33.3333 5 yes
GO:0030554 adenyl nucleotide binding 33.3333 6 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0032559 adenyl ribonucleotide binding 33.3333 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0043168 anion binding 33.3333 4 yes
GO:0003779 actin binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FN3K_HUMAN
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0036211 protein modification process 50.0000 4 yes
GO:0043412 macromolecule modification 50.0000 4 yes
GO:0043687 post-translational protein modification 50.0000 5 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0098657 import into cell 50.0000 4 no
GO:0045787 positive regulation of cell cycle 33.3333 5 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0061024 membrane organization 33.3333 4 no
GO:0016310 phosphorylation 33.3333 5 yes
GO:0001504 neurotransmitter uptake 33.3333 5 no
GO:0006836 neurotransmitter transport 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0014070 response to organic cyclic compound 33.3333 4 no
GO:0015844 monoamine transport 33.3333 5 no
GO:0015850 organic hydroxy compound transport 33.3333 5 no
GO:0016236 macroautophagy 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0022411 cellular component disassembly 33.3333 4 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0044788 modulation by host of viral process 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0048638 regulation of developmental growth 33.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0050890 cognition 33.3333 4 no
GO:0051046 regulation of secretion 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051093 negative regulation of developmental process 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0051851 modulation by host of symbiont process 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0071407 cellular response to organic cyclic compound 33.3333 5 no
GO:0071417 cellular response to organonitrogen compound 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0098810 neurotransmitter reuptake 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:1903530 regulation of secretion by cell 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
WRP73_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
RBM11_HUMAN [view interactions] High throughput no no
DSCR9_HUMAN [view interactions] High throughput no no
EYA4_HUMAN [view interactions] High throughput no yes
MTMRE_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
GMFG_HUMAN [view interactions] High throughput no yes
DOK2_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
BIRC5_HUMAN [view interactions] High throughput no no
ANPRA_HUMAN [view interactions] High throughput no no
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K5_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes