ALS2_HUMAN
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ALS2_HUMAN |
---|---|---|---|---|
GO:0030695 | GTPase regulator activity | 28.5714 | 4 | yes |
GO:0003723 | RNA binding | 23.8095 | 4 | no |
GO:0016462 | pyrophosphatase activity | 23.8095 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.8095 | 4 | no |
GO:0017076 | purine nucleotide binding | 23.8095 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.8095 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
GO:0031267 | small GTPase binding | 19.0476 | 5 | yes |
GO:0051020 | GTPase binding | 19.0476 | 4 | yes |
GO:0005085 | guanyl-nucleotide exchange factor activity | 19.0476 | 5 | yes |
GO:0005096 | GTPase activator activity | 19.0476 | 4 | yes |
GO:0019887 | protein kinase regulator activity | 19.0476 | 4 | yes |
GO:0042803 | protein homodimerization activity | 14.2857 | 4 | yes |
GO:0043539 | protein serine/threonine kinase activator activity | 9.5238 | 6 | yes |
GO:0019209 | kinase activator activity | 9.5238 | 4 | yes |
GO:0030295 | protein kinase activator activity | 9.5238 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ALS2_HUMAN |
---|---|---|---|---|
GO:0008104 | protein localization | 76.1905 | 4 | yes |
GO:0015031 | protein transport | 61.9048 | 4 | no |
GO:0071702 | organic substance transport | 61.9048 | 4 | no |
GO:0071705 | nitrogen compound transport | 61.9048 | 4 | no |
GO:0051128 | regulation of cellular component organization | 57.1429 | 4 | no |
GO:0010646 | regulation of cell communication | 52.3810 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 52.3810 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 52.3810 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 52.3810 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 52.3810 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 52.3810 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | yes |
GO:0006886 | intracellular protein transport | 52.3810 | 4 | no |
GO:0048523 | negative regulation of cellular process | 52.3810 | 4 | no |
GO:0006996 | organelle organization | 42.8571 | 4 | yes |
GO:0009966 | regulation of signal transduction | 42.8571 | 4 | yes |
GO:0051049 | regulation of transport | 42.8571 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 38.0952 | 6 | yes |
GO:0031399 | regulation of protein modification process | 38.0952 | 6 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 38.0952 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 38.0952 | 5 | yes |
GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | no |
GO:0007264 | small GTPase mediated signal transduction | 28.5714 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | yes |
GO:0022607 | cellular component assembly | 28.5714 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | yes |
GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 23.8095 | 7 | yes |
GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 23.8095 | 6 | yes |
GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | yes |
GO:0016050 | vesicle organization | 23.8095 | 5 | yes |
GO:0023056 | positive regulation of signaling | 23.8095 | 4 | yes |
GO:0030030 | cell projection organization | 23.8095 | 4 | yes |
GO:0031401 | positive regulation of protein modification process | 23.8095 | 7 | yes |
GO:0042325 | regulation of phosphorylation | 23.8095 | 7 | yes |
GO:0043933 | protein-containing complex organization | 23.8095 | 4 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 23.8095 | 7 | yes |
GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 23.8095 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 23.8095 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | yes |
GO:0006605 | protein targeting | 23.8095 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.8095 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 23.8095 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 23.8095 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | no |
GO:0030100 | regulation of endocytosis | 23.8095 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 23.8095 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 23.8095 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.8095 | 6 | no |
GO:0006897 | endocytosis | 23.8095 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 19.0476 | 8 | yes |
GO:0007032 | endosome organization | 19.0476 | 6 | yes |
GO:0007265 | Ras protein signal transduction | 19.0476 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 19.0476 | 6 | yes |
GO:0016197 | endosomal transport | 19.0476 | 4 | yes |
GO:0032535 | regulation of cellular component size | 19.0476 | 4 | yes |
GO:0042327 | positive regulation of phosphorylation | 19.0476 | 8 | yes |
GO:0043087 | regulation of GTPase activity | 19.0476 | 5 | yes |
GO:0043549 | regulation of kinase activity | 19.0476 | 5 | yes |
GO:0045859 | regulation of protein kinase activity | 19.0476 | 6 | yes |
GO:0046578 | regulation of Ras protein signal transduction | 19.0476 | 7 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 19.0476 | 6 | yes |
GO:0051338 | regulation of transferase activity | 19.0476 | 4 | yes |
GO:0051345 | positive regulation of hydrolase activity | 19.0476 | 5 | yes |
GO:0065003 | protein-containing complex assembly | 19.0476 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 19.0476 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 19.0476 | 4 | yes |
GO:0007034 | vacuolar transport | 14.2857 | 4 | yes |
GO:0007041 | lysosomal transport | 14.2857 | 5 | yes |
GO:0016601 | Rac protein signal transduction | 14.2857 | 6 | yes |
GO:0032990 | cell part morphogenesis | 14.2857 | 4 | yes |
GO:0033674 | positive regulation of kinase activity | 14.2857 | 6 | yes |
GO:0035249 | synaptic transmission, glutamatergic | 14.2857 | 7 | yes |
GO:0043547 | positive regulation of GTPase activity | 14.2857 | 6 | yes |
GO:0045860 | positive regulation of protein kinase activity | 14.2857 | 7 | yes |
GO:0046579 | positive regulation of Ras protein signal transduction | 14.2857 | 8 | yes |
GO:0048812 | neuron projection morphogenesis | 14.2857 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 14.2857 | 5 | yes |
GO:0051036 | regulation of endosome size | 14.2857 | 6 | yes |
GO:0051057 | positive regulation of small GTPase mediated signal transduction | 14.2857 | 7 | yes |
GO:0051347 | positive regulation of transferase activity | 14.2857 | 5 | yes |
GO:0097494 | regulation of vesicle size | 14.2857 | 5 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 14.2857 | 6 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 14.2857 | 6 | yes |
GO:0001662 | behavioral fear response | 9.5238 | 4 | yes |
GO:0001701 | in utero embryonic development | 9.5238 | 6 | yes |
GO:0001881 | receptor recycling | 9.5238 | 5 | yes |
GO:0007409 | axonogenesis | 9.5238 | 8 | yes |
GO:0007528 | neuromuscular junction development | 9.5238 | 6 | yes |
GO:0009792 | embryo development ending in birth or egg hatching | 9.5238 | 4 | yes |
GO:0034330 | cell junction organization | 9.5238 | 4 | yes |
GO:0035020 | regulation of Rac protein signal transduction | 9.5238 | 8 | yes |
GO:0035022 | positive regulation of Rac protein signal transduction | 9.5238 | 9 | yes |
GO:0043009 | chordate embryonic development | 9.5238 | 5 | yes |
GO:0043112 | receptor metabolic process | 9.5238 | 4 | yes |
GO:0050808 | synapse organization | 9.5238 | 5 | yes |
GO:0051259 | protein complex oligomerization | 9.5238 | 6 | yes |
GO:0051260 | protein homooligomerization | 9.5238 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ALS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IQEC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SODC_HUMAN | [view interactions] | Low throughput | no | yes |
GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
RBM6_HUMAN | [view interactions] | High throughput | no | yes |
SDF2_HUMAN | [view interactions] | High throughput | no | no |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDC10_HUMAN | [view interactions] | High throughput | no | yes |
CHIO_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
STXB6_HUMAN | [view interactions] | High throughput | no | yes |
NEK1_HUMAN | [view interactions] | High throughput | no | yes |
CF410_HUMAN | [view interactions] | High throughput | no | yes |
TFE3_HUMAN | [view interactions] | High throughput | no | yes |
CHIN_HUMAN | [view interactions] | High throughput | no | no |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
ATG4C_HUMAN | [view interactions] | High throughput | no | yes |
AL2CL_HUMAN | [view interactions] | High throughput | no | yes |
WDR20_HUMAN | [view interactions] | High throughput | no | no |
DJB11_HUMAN | [view interactions] | High throughput | no | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
ATG3_HUMAN | [view interactions] | High throughput | no | yes |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
RAE1_HUMAN | [view interactions] | Computational | no | yes |
RAB5B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SETX_HUMAN | [view interactions] | Computational | no | yes |
RAE2_HUMAN | [view interactions] | Computational | no | yes |
RAB5C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GAPD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |