Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ALS2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ALS2_HUMAN
GO:0019887 protein kinase regulator activity 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0045309 protein phosphorylated amino acid binding 25.0000 4 no
GO:0050815 phosphoserine residue binding 25.0000 5 no
GO:0003723 RNA binding 25.0000 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 18.7500 5 yes
GO:0030695 GTPase regulator activity 18.7500 4 yes
GO:0042803 protein homodimerization activity 18.7500 4 yes
GO:0005096 GTPase activator activity 12.5000 4 yes
GO:0019209 kinase activator activity 12.5000 4 yes
GO:0030295 protein kinase activator activity 12.5000 5 yes
GO:0031267 small GTPase binding 12.5000 5 yes
GO:0043539 protein serine/threonine kinase activator activity 12.5000 6 yes
GO:0051020 GTPase binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ALS2_HUMAN
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0008104 protein localization 68.7500 4 yes
GO:0031323 regulation of cellular metabolic process 68.7500 4 yes
GO:0060255 regulation of macromolecule metabolic process 68.7500 4 yes
GO:0080090 regulation of primary metabolic process 68.7500 4 yes
GO:0048522 positive regulation of cellular process 62.5000 4 yes
GO:0009966 regulation of signal transduction 56.2500 4 yes
GO:0048523 negative regulation of cellular process 56.2500 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0019220 regulation of phosphate metabolic process 50.0000 6 yes
GO:0031399 regulation of protein modification process 50.0000 6 yes
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0009893 positive regulation of metabolic process 37.5000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 yes
GO:0022607 cellular component assembly 37.5000 4 yes
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 yes
GO:0048584 positive regulation of response to stimulus 37.5000 4 yes
GO:1902531 regulation of intracellular signal transduction 37.5000 5 yes
GO:0051049 regulation of transport 37.5000 4 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0001932 regulation of protein phosphorylation 31.2500 7 yes
GO:0009967 positive regulation of signal transduction 31.2500 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 31.2500 6 yes
GO:0010647 positive regulation of cell communication 31.2500 5 yes
GO:0023056 positive regulation of signaling 31.2500 4 yes
GO:0031401 positive regulation of protein modification process 31.2500 7 yes
GO:0042325 regulation of phosphorylation 31.2500 7 yes
GO:0043085 positive regulation of catalytic activity 31.2500 4 yes
GO:0043933 protein-containing complex organization 31.2500 4 yes
GO:0045937 positive regulation of phosphate metabolic process 31.2500 7 yes
GO:0051247 positive regulation of protein metabolic process 31.2500 6 yes
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0031344 regulation of cell projection organization 31.2500 5 no
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 yes
GO:0007268 chemical synaptic transmission 25.0000 7 yes
GO:0016050 vesicle organization 25.0000 5 yes
GO:0030030 cell projection organization 25.0000 4 yes
GO:0032535 regulation of cellular component size 25.0000 4 yes
GO:0042327 positive regulation of phosphorylation 25.0000 8 yes
GO:0043549 regulation of kinase activity 25.0000 5 yes
GO:0045859 regulation of protein kinase activity 25.0000 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 25.0000 6 yes
GO:0051338 regulation of transferase activity 25.0000 4 yes
GO:0065003 protein-containing complex assembly 25.0000 5 yes
GO:0098916 anterograde trans-synaptic signaling 25.0000 6 yes
GO:0099536 synaptic signaling 25.0000 4 yes
GO:0099537 trans-synaptic signaling 25.0000 5 yes
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0015031 protein transport 25.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0006605 protein targeting 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0007032 endosome organization 18.7500 6 yes
GO:0007034 vacuolar transport 18.7500 4 yes
GO:0007041 lysosomal transport 18.7500 5 yes
GO:0033674 positive regulation of kinase activity 18.7500 6 yes
GO:0035249 synaptic transmission, glutamatergic 18.7500 8 yes
GO:0045860 positive regulation of protein kinase activity 18.7500 7 yes
GO:0048812 neuron projection morphogenesis 18.7500 5 yes
GO:0051036 regulation of endosome size 18.7500 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 18.7500 7 yes
GO:0051336 regulation of hydrolase activity 18.7500 4 yes
GO:0051345 positive regulation of hydrolase activity 18.7500 5 yes
GO:0051347 positive regulation of transferase activity 18.7500 5 yes
GO:0097494 regulation of vesicle size 18.7500 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 18.7500 4 yes
GO:1902533 positive regulation of intracellular signal transduction 18.7500 6 yes
GO:0001662 behavioral fear response 12.5000 4 yes
GO:0001881 receptor recycling 12.5000 5 yes
GO:0007528 neuromuscular junction development 12.5000 6 yes
GO:0034330 cell junction organization 12.5000 4 yes
GO:0035020 regulation of Rac protein signal transduction 12.5000 7 yes
GO:0035022 positive regulation of Rac protein signal transduction 12.5000 8 yes
GO:0043087 regulation of GTPase activity 12.5000 5 yes
GO:0043112 receptor metabolic process 12.5000 4 yes
GO:0043547 positive regulation of GTPase activity 12.5000 6 yes
GO:0050808 synapse organization 12.5000 5 yes
GO:0051259 protein complex oligomerization 12.5000 6 yes
GO:0051260 protein homooligomerization 12.5000 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ALS2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
EEA1_HUMAN [view entry] [view interactions] Low throughput yes yes
IQEC1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
SODC_HUMAN [view interactions] Low throughput no yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
RBM6_HUMAN [view interactions] High throughput no yes
SDF2_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
PDC10_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
MD13L_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
KTU_HUMAN [view interactions] High throughput no yes
STXB6_HUMAN [view interactions] High throughput no yes
NEK1_HUMAN [view interactions] High throughput no yes
CF410_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
CHIN_HUMAN [view interactions] High throughput no no
ZYX_HUMAN [view interactions] High throughput no no
ATG4C_HUMAN [view interactions] High throughput no yes
AL2CL_HUMAN [view interactions] High throughput no yes
WDR20_HUMAN [view interactions] High throughput no no
DJB11_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ATG7_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes