ACO13_HUMAN
Evidence for PS localization
Functions
Catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed, PubMed). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (PubMed, PubMed). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (PubMed, PubMed). May play a role in controlling adaptive thermogenesis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACO13_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.2500 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 31.2500 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 31.2500 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 31.2500 | 5 | no |
| GO:0046872 | metal ion binding | 25.0000 | 4 | yes |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0016289 | CoA hydrolase activity | 18.7500 | 5 | yes |
| GO:0016290 | palmitoyl-CoA hydrolase activity | 18.7500 | 7 | yes |
| GO:0016790 | thiolester hydrolase activity | 18.7500 | 4 | yes |
| GO:0047617 | acyl-CoA hydrolase activity | 18.7500 | 6 | yes |
| GO:0102991 | myristoyl-CoA hydrolase activity | 18.7500 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACO13_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 31.2500 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 25.0000 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0051259 | protein complex oligomerization | 18.7500 | 6 | yes |
| GO:0051260 | protein homooligomerization | 18.7500 | 7 | yes |
| GO:0051262 | protein tetramerization | 18.7500 | 7 | yes |
| GO:0051289 | protein homotetramerization | 18.7500 | 8 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 12.5000 | 4 | yes |
| GO:0120163 | negative regulation of cold-induced thermogenesis | 12.5000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PPCT_HUMAN | [view interactions] | Low throughput | no | yes |
| ACO13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBBP6_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| MYDGF_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF2_HUMAN | [view interactions] | High throughput | no | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB31_HUMAN | [view interactions] | High throughput | no | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
| NH2L1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPA_HUMAN | [view interactions] | High throughput | no | yes |
| TENN_HUMAN | [view interactions] | High throughput | no | no |
| TRNT1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| BACH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| K0319_HUMAN | [view interactions] | Computational | no | yes |
| ACO11_HUMAN | [view interactions] | Computational | no | yes |
| TYDP2_HUMAN | [view interactions] | Computational | no | no |