RFIP2_HUMAN
Evidence for PS localization
Functions
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RFIP2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.8837 | 4 | no |
| GO:0000166 | nucleotide binding | 27.9070 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.9070 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.9070 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.5814 | 4 | no |
| GO:0045296 | cadherin binding | 25.5814 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.9302 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.9302 | 5 | no |
| GO:0019900 | kinase binding | 18.6047 | 4 | yes |
| GO:0019901 | protein kinase binding | 18.6047 | 5 | yes |
| GO:0051020 | GTPase binding | 16.2791 | 4 | yes |
| GO:0031267 | small GTPase binding | 13.9535 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 6.9767 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RFIP2_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 58.1395 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.8372 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.8605 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.5349 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.5349 | 4 | no |
| GO:0071702 | organic substance transport | 39.5349 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 39.5349 | 4 | yes |
| GO:0010646 | regulation of cell communication | 37.2093 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 37.2093 | 4 | no |
| GO:0015031 | protein transport | 37.2093 | 4 | yes |
| GO:0006996 | organelle organization | 37.2093 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.5581 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.2326 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.9070 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.9070 | 5 | no |
| GO:0022607 | cellular component assembly | 27.9070 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.9070 | 4 | yes |
| GO:0051049 | regulation of transport | 27.9070 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.9070 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.5814 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.5814 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.5814 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.5814 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.2558 | 5 | no |
| GO:0010468 | regulation of gene expression | 23.2558 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 20.9302 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.9302 | 4 | no |
| GO:0030030 | cell projection organization | 20.9302 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.9302 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.9302 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.9302 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.9302 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.9302 | 4 | yes |
| GO:0098657 | import into cell | 18.6047 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 13.9535 | 4 | yes |
| GO:0046903 | secretion | 13.9535 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 11.6279 | 4 | yes |
| GO:0050776 | regulation of immune response | 11.6279 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 11.6279 | 4 | yes |
| GO:0080134 | regulation of response to stress | 11.6279 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 11.6279 | 5 | yes |
| GO:0002790 | peptide secretion | 9.3023 | 5 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 9.3023 | 4 | yes |
| GO:0009306 | protein secretion | 9.3023 | 4 | yes |
| GO:0009914 | hormone transport | 9.3023 | 4 | yes |
| GO:0015833 | peptide transport | 9.3023 | 5 | yes |
| GO:0023061 | signal release | 9.3023 | 4 | yes |
| GO:0030072 | peptide hormone secretion | 9.3023 | 6 | yes |
| GO:0030073 | insulin secretion | 9.3023 | 5 | yes |
| GO:0031347 | regulation of defense response | 9.3023 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 9.3023 | 4 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 9.3023 | 4 | yes |
| GO:0035773 | insulin secretion involved in cellular response to glucose stimulus | 9.3023 | 4 | yes |
| GO:0042886 | amide transport | 9.3023 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 9.3023 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 9.3023 | 6 | yes |
| GO:0045055 | regulated exocytosis | 9.3023 | 4 | yes |
| GO:0045088 | regulation of innate immune response | 9.3023 | 5 | yes |
| GO:0046879 | hormone secretion | 9.3023 | 5 | yes |
| GO:0050778 | positive regulation of immune response | 9.3023 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 9.3023 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 9.3023 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 9.3023 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 9.3023 | 6 | yes |
| GO:0002221 | pattern recognition receptor signaling pathway | 6.9767 | 5 | yes |
| GO:0002758 | innate immune response-activating signaling pathway | 6.9767 | 4 | yes |
| GO:0002833 | positive regulation of response to biotic stimulus | 6.9767 | 5 | yes |
| GO:0031349 | positive regulation of defense response | 6.9767 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 6.9767 | 5 | yes |
| GO:0045089 | positive regulation of innate immune response | 6.9767 | 6 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 6.9767 | 7 | yes |
| GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 4.6512 | 5 | yes |
| GO:0002224 | toll-like receptor signaling pathway | 4.6512 | 6 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 4.6512 | 4 | yes |
| GO:0002752 | cell surface pattern recognition receptor signaling pathway | 4.6512 | 6 | yes |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 4.6512 | 7 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 4.6512 | 4 | yes |
| GO:0006909 | phagocytosis | 4.6512 | 4 | yes |
| GO:0034142 | toll-like receptor 4 signaling pathway | 4.6512 | 8 | yes |
| GO:0035668 | TRAM-dependent toll-like receptor signaling pathway | 4.6512 | 8 | yes |
| GO:0035669 | TRAM-dependent toll-like receptor 4 signaling pathway | 4.6512 | 9 | yes |
| GO:0140895 | cell surface toll-like receptor signaling pathway | 4.6512 | 7 | yes |
| GO:1903078 | positive regulation of protein localization to plasma membrane | 4.6512 | 7 | yes |
| GO:1904377 | positive regulation of protein localization to cell periphery | 4.6512 | 6 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 4.6512 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CXCR2_HUMAN | [view interactions] | Low throughput | no | no |
| REPS1_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WDR26_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM3_HUMAN | [view interactions] | Low throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | Low throughput | no | no |
| RFIP4_HUMAN | [view interactions] | Low throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| CC85A_HUMAN | [view interactions] | High throughput | no | yes |
| F174C_HUMAN | [view interactions] | High throughput | no | yes |
| GPAT3_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP1_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| CXB2_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| CLCN2_HUMAN | [view interactions] | High throughput | no | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKNK2_HUMAN | [view interactions] | High throughput | no | yes |
| KI21A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| FBX17_HUMAN | [view interactions] | High throughput | no | no |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |