RFIP2_HUMAN
Evidence for PS localization
Functions
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RFIP2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.5000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.5000 | 4 | no |
| GO:0045296 | cadherin binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 20.0000 | 4 | yes |
| GO:0019901 | protein kinase binding | 20.0000 | 5 | yes |
| GO:0031267 | small GTPase binding | 17.5000 | 5 | yes |
| GO:0051020 | GTPase binding | 17.5000 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RFIP2_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 55.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0015031 | protein transport | 47.5000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 32.5000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.5000 | 4 | no |
| GO:0006996 | organelle organization | 32.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.5000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.5000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.5000 | 5 | no |
| GO:0006886 | intracellular protein transport | 27.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.5000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.5000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.5000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.5000 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.0000 | 4 | yes |
| GO:0006887 | exocytosis | 15.0000 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 15.0000 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 15.0000 | 6 | yes |
| GO:0046903 | secretion | 15.0000 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 15.0000 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 15.0000 | 5 | yes |
| GO:0002790 | peptide secretion | 10.0000 | 5 | yes |
| GO:0009306 | protein secretion | 10.0000 | 4 | yes |
| GO:0009914 | hormone transport | 10.0000 | 4 | yes |
| GO:0015833 | peptide transport | 10.0000 | 5 | yes |
| GO:0023061 | signal release | 10.0000 | 4 | yes |
| GO:0030072 | peptide hormone secretion | 10.0000 | 6 | yes |
| GO:0030073 | insulin secretion | 10.0000 | 5 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 10.0000 | 4 | yes |
| GO:0035773 | insulin secretion involved in cellular response to glucose stimulus | 10.0000 | 4 | yes |
| GO:0042886 | amide transport | 10.0000 | 5 | yes |
| GO:0045055 | regulated exocytosis | 10.0000 | 5 | yes |
| GO:0046879 | hormone secretion | 10.0000 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 10.0000 | 5 | yes |
| GO:0050776 | regulation of immune response | 7.5000 | 4 | yes |
| GO:0002221 | pattern recognition receptor signaling pathway | 5.0000 | 4 | yes |
| GO:0002224 | toll-like receptor signaling pathway | 5.0000 | 5 | yes |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 5.0000 | 6 | yes |
| GO:0006909 | phagocytosis | 5.0000 | 5 | yes |
| GO:0034142 | toll-like receptor 4 signaling pathway | 5.0000 | 6 | yes |
| GO:0035668 | TRAM-dependent toll-like receptor signaling pathway | 5.0000 | 7 | yes |
| GO:0035669 | TRAM-dependent toll-like receptor 4 signaling pathway | 5.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB25_HUMAN | [view interactions] | Low throughput | no | no |
| RFIP4_HUMAN | [view interactions] | Low throughput | no | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CXCR2_HUMAN | [view interactions] | Low throughput | no | no |
| REPS1_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WDR26_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM3_HUMAN | [view interactions] | Low throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKNK2_HUMAN | [view interactions] | High throughput | no | yes |
| KI21A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| FBX17_HUMAN | [view interactions] | High throughput | no | no |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| CC85A_HUMAN | [view interactions] | High throughput | no | yes |
| F174C_HUMAN | [view interactions] | High throughput | no | yes |
| GPAT3_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP1_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| CXB2_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| CLCN2_HUMAN | [view interactions] | High throughput | no | yes |
| AQP2_HUMAN | [view interactions] | Computational | no | no |
| RFIP3_HUMAN | [view entry] [view interactions] | Computational | yes | no |