Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABHEB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABHEB_HUMAN
GO:0043168 anion binding 62.5000 4 no
GO:0000166 nucleotide binding 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043169 cation binding 37.5000 4 no
GO:0046872 metal ion binding 37.5000 5 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0004674 protein serine/threonine kinase activity 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0106310 protein serine kinase activity 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ABHEB_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 62.5000 4 yes
GO:0009889 regulation of biosynthetic process 62.5000 4 yes
GO:0009893 positive regulation of metabolic process 62.5000 4 yes
GO:0010468 regulation of gene expression 62.5000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 62.5000 5 yes
GO:0031323 regulation of cellular metabolic process 62.5000 4 yes
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 yes
GO:0031326 regulation of cellular biosynthetic process 62.5000 5 yes
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 yes
GO:0080090 regulation of primary metabolic process 62.5000 4 yes
GO:0009966 regulation of signal transduction 62.5000 4 no
GO:0009968 negative regulation of signal transduction 62.5000 5 no
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0010648 negative regulation of cell communication 62.5000 5 no
GO:0023057 negative regulation of signaling 62.5000 4 no
GO:0043408 regulation of MAPK cascade 62.5000 6 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0048585 negative regulation of response to stimulus 62.5000 4 no
GO:1902531 regulation of intracellular signal transduction 62.5000 5 no
GO:0006355 regulation of DNA-templated transcription 50.0000 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 50.0000 8 yes
GO:0009891 positive regulation of biosynthetic process 50.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 yes
GO:0045893 positive regulation of DNA-templated transcription 50.0000 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 50.0000 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 50.0000 9 yes
GO:0051252 regulation of RNA metabolic process 50.0000 5 yes
GO:0051254 positive regulation of RNA metabolic process 50.0000 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 50.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:1902532 negative regulation of intracellular signal transduction 50.0000 6 no
GO:0008104 protein localization 37.5000 4 no
GO:0032386 regulation of intracellular transport 37.5000 5 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 no
GO:0071702 organic substance transport 37.5000 4 no
GO:0071705 nitrogen compound transport 37.5000 4 no
GO:0141124 intracellular signaling cassette 37.5000 4 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0036211 protein modification process 37.5000 4 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0042981 regulation of apoptotic process 37.5000 5 no
GO:0043066 negative regulation of apoptotic process 37.5000 6 no
GO:0043067 regulation of programmed cell death 37.5000 4 no
GO:0043069 negative regulation of programmed cell death 37.5000 5 no
GO:0043086 negative regulation of catalytic activity 37.5000 4 no
GO:0043409 negative regulation of MAPK cascade 37.5000 7 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0051338 regulation of transferase activity 37.5000 4 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0080134 regulation of response to stress 37.5000 4 no
GO:0080135 regulation of cellular response to stress 37.5000 4 no
GO:1901701 cellular response to oxygen-containing compound 37.5000 4 no
GO:1902533 positive regulation of intracellular signal transduction 37.5000 6 no
GO:2001233 regulation of apoptotic signaling pathway 37.5000 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 37.5000 6 no
GO:0042127 regulation of cell population proliferation 37.5000 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 37.5000 7 no
GO:0006163 purine nucleotide metabolic process 25.0000 5 yes
GO:0006753 nucleoside phosphate metabolic process 25.0000 4 yes
GO:0009117 nucleotide metabolic process 25.0000 5 yes
GO:0019693 ribose phosphate metabolic process 25.0000 4 yes
GO:0043436 oxoacid metabolic process 25.0000 4 yes
GO:0072521 purine-containing compound metabolic process 25.0000 4 yes
GO:0001558 regulation of cell growth 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0017157 regulation of exocytosis 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0032388 positive regulation of intracellular transport 25.0000 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0048638 regulation of developmental growth 25.0000 4 no
GO:0050821 protein stabilization 25.0000 4 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:2000641 regulation of early endosome to late endosome transport 25.0000 5 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0001959 regulation of cytokine-mediated signaling pathway 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007417 central nervous system development 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010506 regulation of autophagy 25.0000 6 no
GO:0010508 positive regulation of autophagy 25.0000 7 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 25.0000 6 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0016236 macroautophagy 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0031331 positive regulation of cellular catabolic process 25.0000 6 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0033673 negative regulation of kinase activity 25.0000 6 no
GO:0034599 cellular response to oxidative stress 25.0000 4 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0043122 regulation of canonical NF-kappaB signal transduction 25.0000 6 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0046328 regulation of JNK cascade 25.0000 7 no
GO:0046329 negative regulation of JNK cascade 25.0000 8 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051348 negative regulation of transferase activity 25.0000 5 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0060759 regulation of response to cytokine stimulus 25.0000 4 no
GO:0062197 cellular response to chemical stress 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0071241 cellular response to inorganic substance 25.0000 4 no
GO:0071248 cellular response to metal ion 25.0000 5 no
GO:0098657 import into cell 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:2000377 regulation of reactive oxygen species metabolic process 25.0000 5 no
GO:0000165 MAPK cascade 25.0000 5 no
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0008286 insulin receptor signaling pathway 25.0000 6 no
GO:0014044 Schwann cell development 25.0000 5 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0019221 cytokine-mediated signaling pathway 25.0000 4 no
GO:0021782 glial cell development 25.0000 4 no
GO:0030878 thyroid gland development 25.0000 5 no
GO:0031279 regulation of cyclase activity 25.0000 4 no
GO:0031281 positive regulation of cyclase activity 25.0000 5 no
GO:0038127 ERBB signaling pathway 25.0000 6 no
GO:0038128 ERBB2 signaling pathway 25.0000 7 no
GO:0038129 ERBB3 signaling pathway 25.0000 7 no
GO:0038133 ERBB2-ERBB3 signaling pathway 25.0000 8 no
GO:0042552 myelination 25.0000 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043410 positive regulation of MAPK cascade 25.0000 7 no
GO:0048009 insulin-like growth factor receptor signaling pathway 25.0000 6 no
GO:0048534 hematopoietic or lymphoid organ development 25.0000 4 no
GO:0048538 thymus development 25.0000 5 no
GO:0048732 gland development 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:2001236 regulation of extrinsic apoptotic signaling pathway 25.0000 6 no
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 25.0000 7 no
GO:0000302 response to reactive oxygen species 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032872 regulation of stress-activated MAPK cascade 25.0000 6 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 25.0000 5 no
GO:0070373 negative regulation of ERK1 and ERK2 cascade 25.0000 8 no
GO:0070663 regulation of leukocyte proliferation 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MTR1A_HUMAN [view interactions] High throughput no no
SH2D3_HUMAN [view interactions] High throughput no no
STAP2_HUMAN [view interactions] High throughput no yes
TENS3_HUMAN [view interactions] High throughput no no
TXK_HUMAN [view interactions] High throughput no no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
TLK2_HUMAN [view interactions] High throughput no no
TLK1_HUMAN [view interactions] High throughput no yes
EGLN_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
DUS1_HUMAN [view interactions] High throughput no no
DUS2_HUMAN [view interactions] High throughput no no
DUS4_HUMAN [view entry] [view interactions] High throughput yes no
AAR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
S22A4_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
SIAS_HUMAN [view interactions] High throughput no yes
CHRD1_HUMAN [view interactions] High throughput no yes
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes