RGS6_HUMAN
Evidence for PS localization
Functions
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RGS6_HUMAN |
|---|---|---|---|---|
| GO:0016462 | pyrophosphatase activity | 80.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 80.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 80.0000 | 6 | yes |
| GO:0003924 | GTPase activity | 66.6667 | 7 | yes |
| GO:0005096 | GTPase activator activity | 46.6667 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 46.6667 | 4 | yes |
| GO:0030159 | signaling receptor complex adaptor activity | 33.3333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RGS6_HUMAN |
|---|---|---|---|---|
| GO:0009966 | regulation of signal transduction | 60.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 53.3333 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 53.3333 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 46.6667 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 46.6667 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 46.6667 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 40.0000 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 40.0000 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 33.3333 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 33.3333 | 6 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 26.6667 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 26.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 26.6667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.6667 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DMAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| STMN2_HUMAN | [view interactions] | Low throughput | no | no |
| GNB5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| R7BP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNMT1_HUMAN | [view interactions] | Low throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2BFS_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB3_HUMAN | [view interactions] | High throughput | no | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| RGS8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGS4_HUMAN | [view interactions] | Computational | no | no |
| RGS21_HUMAN | [view interactions] | Computational | no | no |
| RGS5_HUMAN | [view interactions] | Computational | no | no |
| RGS11_HUMAN | [view interactions] | Computational | no | yes |
| RGS13_HUMAN | [view interactions] | Computational | no | no |
| RGS16_HUMAN | [view interactions] | Computational | no | no |
| RGS3_HUMAN | [view interactions] | Computational | no | no |
| RGS9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RGS20_HUMAN | [view interactions] | Computational | no | no |
| RGS10_HUMAN | [view interactions] | Computational | no | yes |
| GGT5_HUMAN | [view interactions] | Computational | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGS12_HUMAN | [view interactions] | Computational | no | no |
| RGS7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGS17_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGS19_HUMAN | [view interactions] | Computational | no | yes |
| RGS18_HUMAN | [view interactions] | Computational | no | yes |
| RGS1_HUMAN | [view interactions] | Computational | no | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SUCB2_HUMAN | [view interactions] | Computational | no | no |