Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS6_HUMAN
GO:0016462 pyrophosphatase activity 66.6667 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 66.6667 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 66.6667 6 yes
GO:0003924 GTPase activity 44.4444 7 yes
GO:0030159 signaling receptor complex adaptor activity 44.4444 4 no
GO:0051020 GTPase binding 33.3333 4 no
GO:0005096 GTPase activator activity 22.2222 4 yes
GO:0030695 GTPase regulator activity 22.2222 4 yes
GO:0000166 nucleotide binding 22.2222 4 no
GO:0003723 RNA binding 22.2222 4 no
GO:0005524 ATP binding 22.2222 5 no
GO:0016887 ATP hydrolysis activity 22.2222 7 no
GO:0017076 purine nucleotide binding 22.2222 5 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0023026 MHC class II protein complex binding 22.2222 4 no
GO:0030554 adenyl nucleotide binding 22.2222 6 no
GO:0030911 TPR domain binding 22.2222 4 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0042803 protein homodimerization activity 22.2222 4 no
GO:0042826 histone deacetylase binding 22.2222 4 no
GO:0043168 anion binding 22.2222 4 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0048156 tau protein binding 22.2222 4 no
GO:0070182 DNA polymerase binding 22.2222 4 no
GO:0097718 disordered domain specific binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RGS6_HUMAN
GO:0043085 positive regulation of catalytic activity 44.4444 4 yes
GO:0048523 negative regulation of cellular process 44.4444 4 yes
GO:0009966 regulation of signal transduction 33.3333 4 yes
GO:0010646 regulation of cell communication 33.3333 4 yes
GO:0051336 regulation of hydrolase activity 33.3333 4 yes
GO:0051345 positive regulation of hydrolase activity 33.3333 5 yes
GO:0051049 regulation of transport 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0042176 regulation of protein catabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0006986 response to unfolded protein 22.2222 4 no
GO:0006996 organelle organization 22.2222 4 no
GO:0007004 telomere maintenance via telomerase 22.2222 7 no
GO:0009059 macromolecule biosynthetic process 22.2222 4 no
GO:0009889 regulation of biosynthetic process 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0010833 telomere maintenance via telomere lengthening 22.2222 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0022618 protein-RNA complex assembly 22.2222 6 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0031326 regulation of cellular biosynthetic process 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0031396 regulation of protein ubiquitination 22.2222 9 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0032200 telomere organization 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0034605 cellular response to heat 22.2222 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0045428 regulation of nitric oxide biosynthetic process 22.2222 5 no
GO:0045429 positive regulation of nitric oxide biosynthetic process 22.2222 6 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0048522 positive regulation of cellular process 22.2222 4 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0050821 protein stabilization 22.2222 4 no
GO:0051052 regulation of DNA metabolic process 22.2222 5 no
GO:0051054 positive regulation of DNA metabolic process 22.2222 6 no
GO:0051131 chaperone-mediated protein complex assembly 22.2222 6 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051276 chromosome organization 22.2222 5 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0051972 regulation of telomerase activity 22.2222 5 no
GO:0051973 positive regulation of telomerase activity 22.2222 6 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0071826 protein-RNA complex organization 22.2222 5 no
GO:0071897 DNA biosynthetic process 22.2222 5 no
GO:0080164 regulation of nitric oxide metabolic process 22.2222 4 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:0141187 nucleic acid biosynthetic process 22.2222 5 no
GO:1901362 organic cyclic compound biosynthetic process 22.2222 4 no
GO:1901873 regulation of post-translational protein modification 22.2222 7 no
GO:1902947 regulation of tau-protein kinase activity 22.2222 7 no
GO:1902949 positive regulation of tau-protein kinase activity 22.2222 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 22.2222 8 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1904407 positive regulation of nitric oxide metabolic process 22.2222 5 no
GO:1905323 telomerase holoenzyme complex assembly 22.2222 7 no
GO:2000278 regulation of DNA biosynthetic process 22.2222 6 no
GO:2000573 positive regulation of DNA biosynthetic process 22.2222 7 no
GO:0009968 negative regulation of signal transduction 22.2222 5 yes
GO:0010648 negative regulation of cell communication 22.2222 5 yes
GO:0023057 negative regulation of signaling 22.2222 4 yes
GO:0043087 regulation of GTPase activity 22.2222 5 yes
GO:0043547 positive regulation of GTPase activity 22.2222 6 yes
GO:0048585 negative regulation of response to stimulus 22.2222 4 yes
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 22.2222 5 no
GO:0043269 regulation of monoatomic ion transport 22.2222 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 22.2222 6 no
GO:0009057 macromolecule catabolic process 22.2222 4 no
GO:0030163 protein catabolic process 22.2222 4 no
GO:1901565 organonitrogen compound catabolic process 22.2222 4 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0000723 telomere maintenance 22.2222 6 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0006259 DNA metabolic process 22.2222 5 no
GO:0006278 RNA-templated DNA biosynthetic process 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DMAP1_HUMAN [view interactions] Low throughput no yes
STMN2_HUMAN [view interactions] Low throughput no no
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
R7BP_HUMAN [view entry] [view interactions] Low throughput yes yes
DNMT1_HUMAN [view interactions] Low throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
H2BFS_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB3_HUMAN [view interactions] High throughput no yes
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CC85B_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
HMGA1_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes