Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

R7BP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in R7BP_HUMAN
GO:0003924 GTPase activity 66.6667 7 no
GO:0005096 GTPase activator activity 66.6667 4 no
GO:0016462 pyrophosphatase activity 66.6667 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 66.6667 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 66.6667 6 no
GO:0030695 GTPase regulator activity 66.6667 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in R7BP_HUMAN
GO:0009966 regulation of signal transduction 83.3333 4 yes
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0048523 negative regulation of cellular process 83.3333 4 yes
GO:0009968 negative regulation of signal transduction 66.6667 5 yes
GO:0010648 negative regulation of cell communication 66.6667 5 yes
GO:0023057 negative regulation of signaling 66.6667 4 yes
GO:0048585 negative regulation of response to stimulus 66.6667 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 50.0000 5 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0043087 regulation of GTPase activity 50.0000 5 no
GO:0043547 positive regulation of GTPase activity 50.0000 6 no
GO:0051336 regulation of hydrolase activity 50.0000 4 no
GO:0051345 positive regulation of hydrolase activity 50.0000 5 no
GO:0010959 regulation of metal ion transport 50.0000 6 no
GO:0034762 regulation of transmembrane transport 50.0000 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 50.0000 5 no
GO:0043269 regulation of monoatomic ion transport 50.0000 5 no
GO:0051049 regulation of transport 50.0000 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 50.0000 6 no
GO:0009416 response to light stimulus 33.3333 4 no
GO:0009642 response to light intensity 33.3333 5 no
GO:0009646 response to absence of light 33.3333 6 no
GO:0036367 light adaption 33.3333 6 no
GO:0051924 regulation of calcium ion transport 33.3333 7 no
GO:0071478 cellular response to radiation 33.3333 4 no
GO:0071482 cellular response to light stimulus 33.3333 5 no
GO:0071484 cellular response to light intensity 33.3333 6 no
GO:0071485 cellular response to absence of light 33.3333 7 no
GO:1903169 regulation of calcium ion transmembrane transport 33.3333 7 no
GO:1990603 dark adaptation 33.3333 8 no
GO:0001975 response to amphetamine 33.3333 6 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0014075 response to amine 33.3333 5 no
GO:0048522 positive regulation of cellular process 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RGS9_HUMAN [view entry] [view interactions] Low throughput yes no
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS6_HUMAN [view entry] [view interactions] Low throughput yes no
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
MCM2_HUMAN [view interactions] High throughput no no
SDHF3_HUMAN [view interactions] High throughput no yes