MYH11_HUMAN
Muscle contraction. [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
1758 | Arg | Gln | Aorticaneurysm,familialthoracic4(AAT4) | - |
677 | Arg | His | Megacystis-microcolon-intestinalhypoperistalsissyndrome2(MMIHS2) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MYH11_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 35.7143 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 35.7143 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 35.7143 | 4 | yes |
GO:0019900 | kinase binding | 32.1429 | 4 | no |
GO:0003779 | actin binding | 30.3571 | 4 | yes |
GO:0019901 | protein kinase binding | 30.3571 | 5 | no |
GO:0005524 | ATP binding | 28.5714 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 28.5714 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 28.5714 | 5 | yes |
GO:0045296 | cadherin binding | 23.2143 | 4 | no |
GO:0003723 | RNA binding | 21.4286 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MYH11_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 58.9286 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 55.3571 | 4 | no |
GO:0051128 | regulation of cellular component organization | 55.3571 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 53.5714 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.7857 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0006996 | organelle organization | 48.2143 | 4 | yes |
GO:0033043 | regulation of organelle organization | 41.0714 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 41.0714 | 4 | no |
GO:0010646 | regulation of cell communication | 41.0714 | 4 | no |
GO:0009966 | regulation of signal transduction | 39.2857 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
GO:0010468 | regulation of gene expression | 37.5000 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.7143 | 5 | no |
GO:0008104 | protein localization | 35.7143 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 35.7143 | 5 | no |
GO:0007010 | cytoskeleton organization | 33.9286 | 5 | yes |
GO:0022607 | cellular component assembly | 33.9286 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.9286 | 5 | no |
GO:0031399 | regulation of protein modification process | 33.9286 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 33.9286 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 32.1429 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 32.1429 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 32.1429 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 32.1429 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 32.1429 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 32.1429 | 6 | no |
GO:1902903 | regulation of supramolecular fiber organization | 30.3571 | 5 | no |
GO:0036211 | protein modification process | 30.3571 | 4 | no |
GO:0043412 | macromolecule modification | 30.3571 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 30.3571 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 30.3571 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 30.3571 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 30.3571 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 28.5714 | 5 | no |
GO:0110053 | regulation of actin filament organization | 26.7857 | 6 | no |
GO:2000145 | regulation of cell motility | 26.7857 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 26.7857 | 5 | no |
GO:0030334 | regulation of cell migration | 26.7857 | 5 | no |
GO:0042325 | regulation of phosphorylation | 26.7857 | 7 | no |
GO:0048584 | positive regulation of response to stimulus | 26.7857 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0097435 | supramolecular fiber organization | 25.0000 | 4 | yes |
GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
GO:0051049 | regulation of transport | 25.0000 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 23.2143 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 23.2143 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 23.2143 | 6 | no |
GO:0007015 | actin filament organization | 23.2143 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 23.2143 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 23.2143 | 5 | no |
GO:0010647 | positive regulation of cell communication | 23.2143 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.2143 | 4 | no |
GO:0042981 | regulation of apoptotic process | 23.2143 | 6 | no |
GO:0043067 | regulation of programmed cell death | 23.2143 | 5 | no |
GO:0010638 | positive regulation of organelle organization | 21.4286 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 21.4286 | 7 | no |
GO:0016192 | vesicle-mediated transport | 21.4286 | 4 | no |
GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
GO:0009894 | regulation of catabolic process | 21.4286 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 21.4286 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.4286 | 6 | no |
GO:0006936 | muscle contraction | 14.2857 | 4 | yes |
GO:0043933 | protein-containing complex organization | 12.5000 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 10.7143 | 5 | yes |
GO:0006939 | smooth muscle contraction | 5.3571 | 5 | yes |
GO:0030198 | extracellular matrix organization | 3.5714 | 5 | yes |
GO:0043062 | extracellular structure organization | 3.5714 | 4 | yes |
GO:0045229 | external encapsulating structure organization | 3.5714 | 4 | yes |
GO:0055001 | muscle cell development | 3.5714 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in MYH11_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 5.3571 | 3 | no |
DOID:0050851 | glomerulosclerosis | 3.5714 | 6 | no |
DOID:10952 | nephritis | 3.5714 | 4 | no |
DOID:1312 | focal segmental glomerulosclerosis | 3.5714 | 7 | no |
DOID:2921 | glomerulonephritis | 3.5714 | 5 | no |
DOID:557 | kidney disease | 3.5714 | 3 | no |
DOID:574 | peripheral nervous system disease | 3.5714 | 3 | no |
DOID:870 | neuropathy | 3.5714 | 4 | no |
DOID:331 | central nervous system disease | 3.5714 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ML12B_HUMAN | [view interactions] | Low throughput | no | no |
TF2B_HUMAN | [view interactions] | Low throughput | no | yes |
MYOC_HUMAN | [view interactions] | Low throughput | no | no |
SLX4_HUMAN | [view interactions] | High throughput | no | yes |
SLX1_HUMAN | [view interactions] | High throughput | no | yes |
RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARPC5_HUMAN | [view interactions] | High throughput | no | yes |
CING_HUMAN | [view interactions] | High throughput | no | no |
SVIL_HUMAN | [view interactions] | High throughput | no | yes |
UBX2A_HUMAN | [view interactions] | High throughput | no | no |
RAD51_HUMAN | [view interactions] | High throughput | no | yes |
LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MED4_HUMAN | [view interactions] | High throughput | no | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
C4BPA_HUMAN | [view interactions] | High throughput | no | no |
UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ASTE1_HUMAN | [view interactions] | High throughput | no | no |
ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLBL2_HUMAN | [view interactions] | High throughput | no | yes |
RWD2B_HUMAN | [view interactions] | High throughput | no | no |
EM55_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GDF9_HUMAN | [view interactions] | High throughput | no | no |
OVCA2_HUMAN | [view interactions] | High throughput | no | no |
COQ2_HUMAN | [view interactions] | High throughput | no | yes |
COX15_HUMAN | [view interactions] | High throughput | no | yes |
ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOAT1_HUMAN | [view interactions] | High throughput | no | no |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
IKKA_HUMAN | [view interactions] | High throughput | no | yes |
AURKC_HUMAN | [view interactions] | High throughput | no | no |
WRP73_HUMAN | [view interactions] | High throughput | no | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DAXX_HUMAN | [view interactions] | High throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
TNAP3_HUMAN | [view interactions] | High throughput | no | yes |
TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SP1_HUMAN | [view interactions] | High throughput | no | yes |
FBX25_HUMAN | [view interactions] | High throughput | no | no |
SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
LGR4_HUMAN | [view interactions] | High throughput | no | yes |
CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
POC1A_HUMAN | [view interactions] | High throughput | no | yes |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBC31_HUMAN | [view interactions] | High throughput | no | yes |
PDES1_HUMAN | [view interactions] | High throughput | no | no |
ZN746_HUMAN | [view interactions] | High throughput | no | no |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
LARP7_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
LRC31_HUMAN | [view interactions] | High throughput | no | no |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SL9A8_HUMAN | [view interactions] | High throughput | no | yes |
BMPR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNPI2_HUMAN | [view interactions] | High throughput | no | yes |
ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
FGD5_HUMAN | [view interactions] | High throughput | no | yes |
SIK2_HUMAN | [view interactions] | High throughput | no | yes |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTA_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SLN11_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | Computational | no | no |
MYCD_HUMAN | [view interactions] | Computational | no | yes |
PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MYH10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TAGL_HUMAN | [view interactions] | Computational | no | no |
LMOD1_HUMAN | [view interactions] | Computational | no | no |
CALD1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MYPT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MYL5_HUMAN | [view interactions] | Computational | no | no |
TPM1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MLRA_HUMAN | [view interactions] | Computational | no | no |
PAK2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ML12A_HUMAN | [view interactions] | Computational | no | no |
MYLK_HUMAN | [view interactions] | Computational | no | no |
RHOB_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MLRV_HUMAN | [view interactions] | Computational | no | no |
VINC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CNN1_HUMAN | [view interactions] | Computational | no | no |
ACTH_HUMAN | [view interactions] | Computational | no | no |
MYH8_HUMAN | [view interactions] | Computational | no | no |
RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MYL3_HUMAN | [view interactions] | Computational | no | no |
ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MYL10_HUMAN | [view interactions] | Computational | no | no |
MYL9_HUMAN | [view interactions] | Computational | no | no |
MYPT2_HUMAN | [view interactions] | Computational | no | no |
MYL6B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MYL1_HUMAN | [view interactions] | Computational | no | no |
MLRS_HUMAN | [view interactions] | Computational | no | no |
TPM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ROCK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ROCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |