MYH11_HUMAN
Evidence for PS localization
Functions
Muscle contraction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 1758 | Arg | Gln | Aorticaneurysm,familialthoracic4(AAT4) | - |
| 677 | Arg | His | Megacystis-microcolon-intestinalhypoperistalsissyndrome2(MMIHS2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYH11_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 30.2326 | 4 | yes |
| GO:0043168 | anion binding | 27.9070 | 4 | yes |
| GO:0019900 | kinase binding | 27.9070 | 4 | no |
| GO:0000166 | nucleotide binding | 25.5814 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.5814 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.5814 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.5814 | 4 | yes |
| GO:0019901 | protein kinase binding | 25.5814 | 5 | no |
| GO:0005524 | ATP binding | 23.2558 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.2558 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.2558 | 5 | yes |
| GO:0043169 | cation binding | 20.9302 | 4 | no |
| GO:0003723 | RNA binding | 20.9302 | 4 | no |
| GO:0045296 | cadherin binding | 20.9302 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYH11_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 58.1395 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.8140 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.4884 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.4884 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.4884 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.5116 | 4 | no |
| GO:0006996 | organelle organization | 44.1860 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 41.8605 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.8605 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.8605 | 5 | no |
| GO:0010646 | regulation of cell communication | 41.8605 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.8605 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.8605 | 5 | no |
| GO:0009966 | regulation of signal transduction | 39.5349 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.2093 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 37.2093 | 5 | no |
| GO:0033043 | regulation of organelle organization | 37.2093 | 5 | no |
| GO:0022607 | cellular component assembly | 34.8837 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 34.8837 | 7 | no |
| GO:0008104 | protein localization | 34.8837 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.8837 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 34.8837 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 32.5581 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.5581 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.5581 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.2326 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.2326 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.2326 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.2326 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.2326 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.2326 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.2326 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.2326 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.9070 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 25.5814 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 25.5814 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.5814 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.5814 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.5814 | 6 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 25.5814 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.5814 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.5814 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 25.5814 | 6 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 25.5814 | 7 | no |
| GO:0043933 | protein-containing complex organization | 23.2558 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.2558 | 8 | no |
| GO:0009968 | negative regulation of signal transduction | 23.2558 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.2558 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.2558 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.2558 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.2558 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.2558 | 4 | no |
| GO:0051049 | regulation of transport | 23.2558 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.2558 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.2558 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.2558 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 23.2558 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.2558 | 6 | no |
| GO:0007010 | cytoskeleton organization | 20.9302 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.9302 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 20.9302 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.9302 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.9302 | 4 | no |
| GO:0036211 | protein modification process | 20.9302 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 20.9302 | 7 | no |
| GO:0043412 | macromolecule modification | 20.9302 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.9302 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.9302 | 6 | no |
| GO:0080134 | regulation of response to stress | 20.9302 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.9302 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.9302 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.9302 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.9302 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 20.9302 | 6 | no |
| GO:0007015 | actin filament organization | 20.9302 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 18.6047 | 5 | yes |
| GO:0006936 | muscle contraction | 4.6512 | 4 | yes |
| GO:0030198 | extracellular matrix organization | 4.6512 | 5 | yes |
| GO:0043062 | extracellular structure organization | 4.6512 | 4 | yes |
| GO:0045229 | external encapsulating structure organization | 4.6512 | 4 | yes |
| GO:0055001 | muscle cell development | 4.6512 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ML12B_HUMAN | [view interactions] | Low throughput | no | no |
| TF2B_HUMAN | [view interactions] | Low throughput | no | yes |
| MYOC_HUMAN | [view interactions] | Low throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| AURKC_HUMAN | [view interactions] | High throughput | no | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| UD2B7_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TNAP3_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC31_HUMAN | [view interactions] | High throughput | no | yes |
| PDES1_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SL9A8_HUMAN | [view interactions] | High throughput | no | yes |
| BMPR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNPI2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| SLX1_HUMAN | [view interactions] | High throughput | no | yes |
| PLBL2_HUMAN | [view interactions] | High throughput | no | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASTE1_HUMAN | [view interactions] | High throughput | no | no |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C4BPA_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| UBX2A_HUMAN | [view interactions] | High throughput | no | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RWD2B_HUMAN | [view interactions] | High throughput | no | no |
| EM55_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDF9_HUMAN | [view interactions] | High throughput | no | no |
| OVCA2_HUMAN | [view interactions] | High throughput | no | no |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |