DEST_HUMAN
Evidence for PS localization
Functions
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DEST_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 28.5714 | 4 | yes |
| GO:0043168 | anion binding | 26.9841 | 4 | no |
| GO:0000166 | nucleotide binding | 25.3968 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.3968 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.3968 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 22.2222 | 5 | no |
| GO:0005524 | ATP binding | 20.6349 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.6349 | 4 | no |
| GO:0003723 | RNA binding | 20.6349 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DEST_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.9683 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.9683 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.9683 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.7937 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.2063 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 46.0317 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 46.0317 | 4 | no |
| GO:0006996 | organelle organization | 44.4444 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 44.4444 | 5 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.8571 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.6825 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.6825 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.0952 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | no |
| GO:0008104 | protein localization | 34.9206 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.9206 | 5 | no |
| GO:0022607 | cellular component assembly | 31.7460 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 31.7460 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.1587 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.1587 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.1587 | 5 | no |
| GO:0043933 | protein-containing complex organization | 28.5714 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.9841 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.9841 | 4 | no |
| GO:0007010 | cytoskeleton organization | 26.9841 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.9841 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.9841 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.9841 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.9841 | 6 | no |
| GO:0051049 | regulation of transport | 26.9841 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.9841 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.9841 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.3968 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 25.3968 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.3968 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.3968 | 6 | no |
| GO:0036211 | protein modification process | 25.3968 | 4 | no |
| GO:0043412 | macromolecule modification | 25.3968 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.3968 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.3968 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 23.8095 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.8095 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.8095 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.8095 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.8095 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.8095 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.8095 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.8095 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0030030 | cell projection organization | 22.2222 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 20.6349 | 7 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.6349 | 6 | no |
| GO:0071310 | cellular response to organic substance | 20.6349 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.6349 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.6349 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.6349 | 6 | no |
| GO:0071702 | organic substance transport | 20.6349 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.6349 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 19.0476 | 6 | yes |
| GO:0007015 | actin filament organization | 17.4603 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 15.8730 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 15.8730 | 5 | yes |
| GO:0022411 | cellular component disassembly | 14.2857 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 14.2857 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 12.6984 | 5 | yes |
| GO:0032984 | protein-containing complex disassembly | 11.1111 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 11.1111 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 9.5238 | 4 | yes |
| GO:0051261 | protein depolymerization | 9.5238 | 6 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 9.5238 | 7 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 9.5238 | 6 | yes |
| GO:0008154 | actin polymerization or depolymerization | 7.9365 | 6 | yes |
| GO:0030042 | actin filament depolymerization | 7.9365 | 7 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 6.3492 | 6 | yes |
| GO:0030043 | actin filament fragmentation | 6.3492 | 8 | yes |
| GO:0030832 | regulation of actin filament length | 6.3492 | 5 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 4.7619 | 7 | yes |
| GO:0030836 | positive regulation of actin filament depolymerization | 4.7619 | 7 | yes |
| GO:0043243 | positive regulation of protein-containing complex disassembly | 4.7619 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 4.7619 | 5 | yes |
| GO:1901879 | regulation of protein depolymerization | 4.7619 | 6 | yes |
| GO:1901881 | positive regulation of protein depolymerization | 4.7619 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| SSH1_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| KYNU_HUMAN | [view interactions] | High throughput | no | no |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FABPH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COA6_HUMAN | [view interactions] | High throughput | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLTP_HUMAN | [view interactions] | High throughput | no | no |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPHK1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINX1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SAMH1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DTX4_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| PIEZ1_HUMAN | [view interactions] | High throughput | no | no |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| URM1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| DPP3_HUMAN | [view interactions] | High throughput | no | no |
| IBP7_HUMAN | [view interactions] | High throughput | no | no |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| OCTC_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP4R2_HUMAN | [view interactions] | High throughput | no | yes |
| DNPH1_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FCL_HUMAN | [view interactions] | High throughput | no | yes |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN2_HUMAN | [view interactions] | High throughput | no | no |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| NMI_HUMAN | [view interactions] | High throughput | no | yes |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA3_HUMAN | [view interactions] | High throughput | no | yes |
| DJB12_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |