DEST_HUMAN
Evidence for PS localization
Functions
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DEST_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 33.3333 | 4 | yes |
| GO:0019900 | kinase binding | 24.5614 | 4 | no |
| GO:0005524 | ATP binding | 22.8070 | 5 | no |
| GO:0017076 | purine nucleotide binding | 22.8070 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.8070 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.8070 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.8070 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.8070 | 4 | no |
| GO:0046872 | metal ion binding | 22.8070 | 4 | no |
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DEST_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.1579 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.6316 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.8772 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.1228 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.3684 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.3684 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.8596 | 4 | no |
| GO:0006996 | organelle organization | 42.1053 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.8421 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.8421 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.0877 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.0877 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.0877 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.0877 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 31.5789 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5789 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 31.5789 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 31.5789 | 5 | no |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:0033043 | regulation of organelle organization | 28.0702 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 28.0702 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.0702 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.0702 | 5 | no |
| GO:0051049 | regulation of transport | 28.0702 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.3158 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 26.3158 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.3158 | 4 | no |
| GO:0007010 | cytoskeleton organization | 26.3158 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 26.3158 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 26.3158 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.3158 | 6 | no |
| GO:0060548 | negative regulation of cell death | 26.3158 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.5614 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 24.5614 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 24.5614 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.5614 | 4 | no |
| GO:0036211 | protein modification process | 24.5614 | 4 | no |
| GO:0043412 | macromolecule modification | 24.5614 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.5614 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.8070 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 22.8070 | 7 | no |
| GO:0032880 | regulation of protein localization | 22.8070 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.8070 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.8070 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.8070 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.8070 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.8070 | 4 | no |
| GO:0080134 | regulation of response to stress | 22.8070 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.8070 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.8070 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.8070 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.0526 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.0526 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 21.0526 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.0526 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.0526 | 5 | no |
| GO:0030030 | cell projection organization | 21.0526 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.0526 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.0526 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.0526 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.0526 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.0526 | 6 | no |
| GO:0007015 | actin filament organization | 19.2982 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 17.5439 | 6 | yes |
| GO:0032970 | regulation of actin filament-based process | 17.5439 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 17.5439 | 5 | yes |
| GO:0022411 | cellular component disassembly | 15.7895 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 15.7895 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 14.0351 | 6 | yes |
| GO:0032984 | protein-containing complex disassembly | 12.2807 | 5 | yes |
| GO:0008154 | actin polymerization or depolymerization | 10.5263 | 6 | yes |
| GO:0030042 | actin filament depolymerization | 10.5263 | 7 | yes |
| GO:0032535 | regulation of cellular component size | 10.5263 | 4 | yes |
| GO:0051261 | protein depolymerization | 10.5263 | 6 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 10.5263 | 7 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 10.5263 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 8.7719 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 8.7719 | 5 | yes |
| GO:0030043 | actin filament fragmentation | 7.0175 | 8 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 7.0175 | 7 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 7.0175 | 5 | yes |
| GO:1901879 | regulation of protein depolymerization | 7.0175 | 6 | yes |
| GO:0030836 | positive regulation of actin filament depolymerization | 5.2632 | 7 | yes |
| GO:0043243 | positive regulation of protein-containing complex disassembly | 5.2632 | 6 | yes |
| GO:1901881 | positive regulation of protein depolymerization | 5.2632 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DEST_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 5.2632 | 4 | no |
| DOID:331 | central nervous system disease | 5.2632 | 3 | no |
| DOID:0050890 | synucleinopathy | 3.5088 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 3.5088 | 7 | no |
| DOID:14330 | Parkinsons disease | 3.5088 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| SSH1_HUMAN | [view interactions] | Low throughput | no | yes |
| TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA3_HUMAN | [view interactions] | High throughput | no | yes |
| DJB12_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| KYNU_HUMAN | [view interactions] | High throughput | no | no |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FABPH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COA6_HUMAN | [view interactions] | High throughput | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPHK1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINX1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SAMH1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DTX4_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| PIEZ1_HUMAN | [view interactions] | High throughput | no | no |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| URM1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| DPP3_HUMAN | [view interactions] | High throughput | no | no |
| IBP7_HUMAN | [view interactions] | High throughput | no | no |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| OCTC_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP4R2_HUMAN | [view interactions] | High throughput | no | yes |
| DNPH1_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FCL_HUMAN | [view interactions] | High throughput | no | yes |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN2_HUMAN | [view interactions] | High throughput | no | no |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| NMI_HUMAN | [view interactions] | High throughput | no | yes |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| LIMK1_HUMAN | [view interactions] | Computational | no | yes |
| TWF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RS6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |