PYC_HUMAN
Evidence for PS localization
Functions
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PYC_HUMAN |
|---|---|---|---|---|
| GO:0032555 | purine ribonucleotide binding | 37.0968 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.0968 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 37.0968 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.6452 | 5 | yes |
| GO:0005524 | ATP binding | 30.6452 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 30.6452 | 5 | yes |
| GO:0003723 | RNA binding | 27.4194 | 4 | no |
| GO:0046872 | metal ion binding | 24.1935 | 4 | yes |
| GO:0031406 | carboxylic acid binding | 9.6774 | 4 | yes |
| GO:0033293 | monocarboxylic acid binding | 6.4516 | 5 | yes |
| GO:0004736 | pyruvate carboxylase activity | 3.2258 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PYC_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 38.7097 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.0968 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 35.4839 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 35.4839 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 33.8710 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.8710 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.2581 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.2581 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.2581 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.6452 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.6452 | 5 | no |
| GO:0010646 | regulation of cell communication | 30.6452 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.0323 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.4194 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.8065 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 25.8065 | 5 | no |
| GO:0022607 | cellular component assembly | 24.1935 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.1935 | 4 | no |
| GO:0036211 | protein modification process | 22.5806 | 4 | no |
| GO:0043412 | macromolecule modification | 22.5806 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.5806 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.5806 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 22.5806 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.5806 | 5 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 20.9677 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 20.9677 | 6 | no |
| GO:0033043 | regulation of organelle organization | 20.9677 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.9677 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.9677 | 5 | no |
| GO:0051049 | regulation of transport | 20.9677 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 19.3548 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 16.1290 | 5 | yes |
| GO:0006090 | pyruvate metabolic process | 11.2903 | 7 | yes |
| GO:0010629 | negative regulation of gene expression | 8.0645 | 6 | yes |
| GO:0006006 | glucose metabolic process | 6.4516 | 5 | yes |
| GO:0019318 | hexose metabolic process | 6.4516 | 4 | yes |
| GO:0016051 | carbohydrate biosynthetic process | 4.8387 | 4 | yes |
| GO:0035891 | exit from host cell | 4.8387 | 5 | yes |
| GO:0044000 | movement in host | 4.8387 | 4 | yes |
| GO:0006094 | gluconeogenesis | 3.2258 | 6 | yes |
| GO:0019319 | hexose biosynthetic process | 3.2258 | 5 | yes |
| GO:0044788 | modulation by host of viral process | 3.2258 | 5 | yes |
| GO:0044794 | positive regulation by host of viral process | 3.2258 | 6 | yes |
| GO:0046364 | monosaccharide biosynthetic process | 3.2258 | 4 | yes |
| GO:0051851 | modulation by host of symbiont process | 3.2258 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PYC_HUMAN |
|---|---|---|---|---|
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 3.2258 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.2258 | 6 | no |
| DOID:440 | neuromuscular disease | 3.2258 | 5 | no |
| DOID:574 | peripheral nervous system disease | 3.2258 | 3 | no |
| DOID:870 | neuropathy | 3.2258 | 4 | no |
| DOID:0050686 | organ system cancer | 3.2258 | 3 | no |
| DOID:120 | female reproductive organ cancer | 3.2258 | 5 | no |
| DOID:193 | reproductive organ cancer | 3.2258 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAOX_HUMAN | [view interactions] | Low throughput | no | yes |
| MDHC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PYC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AATC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT1_HUMAN | [view interactions] | High throughput | no | no |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBE_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFT88_HUMAN | [view interactions] | High throughput | no | no |
| BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| DEF5_HUMAN | [view interactions] | High throughput | no | no |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRYB2_HUMAN | [view interactions] | High throughput | no | no |
| 3BHS2_HUMAN | [view interactions] | High throughput | no | no |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN9_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| TSHR_HUMAN | [view interactions] | High throughput | no | no |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| DTWD2_HUMAN | [view interactions] | High throughput | no | no |
| DNS2B_HUMAN | [view interactions] | High throughput | no | no |
| CBWD1_HUMAN | [view interactions] | High throughput | no | yes |
| PSG1_HUMAN | [view interactions] | High throughput | no | no |
| TSP3_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS3_HUMAN | [view interactions] | High throughput | no | yes |
| IGFN1_HUMAN | [view interactions] | High throughput | no | no |
| FCN3_HUMAN | [view interactions] | High throughput | no | no |
| LYRM7_HUMAN | [view interactions] | High throughput | no | yes |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| C1T9B_HUMAN | [view interactions] | High throughput | no | no |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| AMACR_HUMAN | [view interactions] | High throughput | no | yes |
| SHC2_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| ADAM7_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NACAM_HUMAN | [view interactions] | High throughput | no | no |
| PPT2_HUMAN | [view interactions] | High throughput | no | no |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| CP27A_HUMAN | [view interactions] | High throughput | no | yes |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHE4_HUMAN | [view interactions] | Computational | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MUTA_HUMAN | [view interactions] | Computational | no | yes |
| ARLY_HUMAN | [view interactions] | Computational | no | no |
| NIT2_HUMAN | [view interactions] | Computational | no | yes |
| ACS2L_HUMAN | [view interactions] | Computational | no | yes |
| KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PCKGM_HUMAN | [view interactions] | Computational | no | no |
| PUR8_HUMAN | [view interactions] | Computational | no | yes |
| ACSA_HUMAN | [view interactions] | Computational | no | no |
| ODPAT_HUMAN | [view interactions] | Computational | no | no |
| CISY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LDH6A_HUMAN | [view interactions] | Computational | no | no |
| LDHD_HUMAN | [view interactions] | Computational | no | yes |
| MAOM_HUMAN | [view interactions] | Computational | no | yes |
| PCKGC_HUMAN | [view interactions] | Computational | no | no |
| AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LDH6B_HUMAN | [view interactions] | Computational | no | no |
| ODP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MAON_HUMAN | [view interactions] | Computational | no | yes |
| LDHC_HUMAN | [view interactions] | Computational | no | no |
| BPL1_HUMAN | [view interactions] | Computational | no | yes |
| KFA_HUMAN | [view interactions] | Computational | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SSDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIMKB_HUMAN | [view interactions] | Computational | no | no |
| ODPB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AATC2_HUMAN | [view interactions] | Computational | no | no |
| KPYM_HUMAN | [view interactions] | Computational | no | yes |