CSTN1_HUMAN
Evidence for PS localization
Functions
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002926 | LIG_KLC1_WD_1 | LIG | 901 | 910 | - |
| ELMI002927 | LIG_KLC1_WD_1 | LIG | 972 | 979 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CSTN1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 26.9231 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 23.0769 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0005509 | calcium ion binding | 15.3846 | 5 | yes |
| GO:0019894 | kinesin binding | 15.3846 | 4 | yes |
| GO:0001540 | amyloid-beta binding | 11.5385 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CSTN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.5385 | 4 | yes |
| GO:0008104 | protein localization | 46.1538 | 4 | yes |
| GO:0071702 | organic substance transport | 46.1538 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 46.1538 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.3077 | 4 | yes |
| GO:0015031 | protein transport | 42.3077 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 38.4615 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 38.4615 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 38.4615 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 38.4615 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 38.4615 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 38.4615 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 34.6154 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 34.6154 | 4 | yes |
| GO:0006996 | organelle organization | 34.6154 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 30.7692 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.7692 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 30.7692 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 30.7692 | 4 | no |
| GO:0051049 | regulation of transport | 30.7692 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.7692 | 4 | no |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.9231 | 4 | yes |
| GO:0030030 | cell projection organization | 26.9231 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.9231 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 26.9231 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.9231 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 26.9231 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.9231 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 26.9231 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 26.9231 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.9231 | 4 | no |
| GO:0036211 | protein modification process | 26.9231 | 4 | no |
| GO:0043412 | macromolecule modification | 26.9231 | 4 | no |
| GO:0035418 | protein localization to synapse | 23.0769 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 23.0769 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 23.0769 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 23.0769 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 23.0769 | 5 | yes |
| GO:0006886 | intracellular protein transport | 23.0769 | 4 | no |
| GO:0043269 | regulation of ion transport | 23.0769 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.0769 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 23.0769 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 23.0769 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.0769 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.0769 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.0769 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.0769 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 23.0769 | 4 | no |
| GO:1901652 | response to peptide | 23.0769 | 4 | no |
| GO:1901653 | cellular response to peptide | 23.0769 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.0769 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.0769 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | no |
| GO:0051963 | regulation of synapse assembly | 19.2308 | 6 | yes |
| GO:0072657 | protein localization to membrane | 19.2308 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 19.2308 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 19.2308 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 19.2308 | 5 | yes |
| GO:0001558 | regulation of cell growth | 15.3846 | 4 | yes |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 15.3846 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 15.3846 | 5 | yes |
| GO:0051965 | positive regulation of synapse assembly | 15.3846 | 6 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 15.3846 | 4 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 15.3846 | 6 | yes |
| GO:0062237 | protein localization to postsynapse | 11.5385 | 7 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 11.5385 | 4 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 11.5385 | 4 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 11.5385 | 5 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 11.5385 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 11.5385 | 5 | yes |
| GO:0090128 | regulation of synapse maturation | 7.6923 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CSTN1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 11.5385 | 3 | no |
| DOID:2476 | hereditary spastic paraplegia | 7.6923 | 5 | no |
| DOID:607 | paraplegia | 7.6923 | 4 | no |
| DOID:936 | brain disease | 7.6923 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
| APBB1_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| L1CAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| GANP_HUMAN | [view interactions] | High throughput | no | yes |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAHC1_HUMAN | [view interactions] | High throughput | no | yes |
| TOPB1_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RNF10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| PAX8_HUMAN | [view interactions] | High throughput | no | yes |
| T2FB_HUMAN | [view interactions] | High throughput | no | yes |
| TM2D3_HUMAN | [view interactions] | High throughput | no | yes |
| PVRIG_HUMAN | [view interactions] | High throughput | no | yes |
| GINM1_HUMAN | [view interactions] | High throughput | no | yes |
| TACT_HUMAN | [view interactions] | High throughput | no | no |
| CHST8_HUMAN | [view interactions] | High throughput | no | no |
| DEF5_HUMAN | [view interactions] | High throughput | no | no |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| PCDA4_HUMAN | [view interactions] | High throughput | no | yes |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| CDCP1_HUMAN | [view interactions] | High throughput | no | yes |
| LYPD5_HUMAN | [view interactions] | High throughput | no | yes |
| GML_HUMAN | [view interactions] | High throughput | no | no |
| MGT4C_HUMAN | [view interactions] | High throughput | no | yes |
| ADA33_HUMAN | [view interactions] | High throughput | no | yes |
| LRRT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RX5_HUMAN | [view interactions] | High throughput | no | no |
| PCD20_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| KDIS_HUMAN | [view interactions] | High throughput | no | yes |
| NOP56_HUMAN | [view interactions] | High throughput | no | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMTC4_HUMAN | [view interactions] | High throughput | no | yes |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| OZF_HUMAN | [view interactions] | High throughput | no | yes |
| PLD1_HUMAN | [view interactions] | High throughput | no | no |
| POTEE_HUMAN | [view interactions] | High throughput | no | no |
| CSTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| MBRL_HUMAN | [view interactions] | High throughput | no | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| CN093_HUMAN | [view interactions] | High throughput | no | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN629_HUMAN | [view interactions] | High throughput | no | no |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| CDHR3_HUMAN | [view interactions] | High throughput | no | no |
| BACE2_HUMAN | [view interactions] | High throughput | no | yes |
| MBB1A_HUMAN | [view interactions] | High throughput | no | yes |
| EAA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| CEBPZ_HUMAN | [view interactions] | High throughput | no | no |
| EGFLA_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UTP20_HUMAN | [view interactions] | High throughput | no | no |
| COT2_HUMAN | [view interactions] | High throughput | no | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OIT3_HUMAN | [view interactions] | High throughput | no | no |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| CAH10_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| I12R1_HUMAN | [view interactions] | High throughput | no | no |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| P2RX2_HUMAN | [view interactions] | High throughput | no | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| CD48_HUMAN | [view interactions] | High throughput | no | no |
| C1QB_HUMAN | [view interactions] | High throughput | no | no |
| SIA8E_HUMAN | [view interactions] | High throughput | no | yes |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| GMFG_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| LIPE_HUMAN | [view interactions] | High throughput | no | no |
| CST8_HUMAN | [view interactions] | High throughput | no | no |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |