Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EFR3A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed, PubMed, PubMed). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EFR3A_HUMAN
GO:0017076 purine nucleotide binding 51.3514 4 no
GO:0032555 purine ribonucleotide binding 48.6486 4 no
GO:0035639 purine ribonucleoside triphosphate binding 48.6486 4 no
GO:0003924 GTPase activity 37.8378 7 no
GO:0005525 GTP binding 37.8378 5 no
GO:0016462 pyrophosphatase activity 37.8378 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.8378 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.8378 6 no
GO:0019001 guanyl nucleotide binding 37.8378 5 no
GO:0032561 guanyl ribonucleotide binding 37.8378 5 no
GO:0019900 kinase binding 29.7297 4 no
GO:0019901 protein kinase binding 29.7297 5 no
GO:0019003 GDP binding 21.6216 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in EFR3A_HUMAN
GO:0048522 positive regulation of cellular process 75.6757 4 no
GO:0051128 regulation of cellular component organization 48.6486 4 no
GO:0022607 cellular component assembly 48.6486 4 no
GO:0060255 regulation of macromolecule metabolic process 45.9459 4 no
GO:0006996 organelle organization 45.9459 4 no
GO:0048523 negative regulation of cellular process 43.2432 4 no
GO:0009893 positive regulation of metabolic process 43.2432 4 no
GO:0031323 regulation of cellular metabolic process 43.2432 4 no
GO:0080090 regulation of primary metabolic process 43.2432 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.5405 5 no
GO:0010646 regulation of cell communication 40.5405 4 no
GO:0048584 positive regulation of response to stimulus 40.5405 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.5405 4 no
GO:0008104 protein localization 40.5405 4 yes
GO:0009966 regulation of signal transduction 37.8378 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.8378 5 no
GO:0009967 positive regulation of signal transduction 35.1351 5 no
GO:0010468 regulation of gene expression 35.1351 5 no
GO:0010647 positive regulation of cell communication 35.1351 5 no
GO:0023056 positive regulation of signaling 35.1351 4 no
GO:0030334 regulation of cell migration 35.1351 5 no
GO:0031325 positive regulation of cellular metabolic process 35.1351 5 no
GO:0051049 regulation of transport 35.1351 4 no
GO:0051246 regulation of protein metabolic process 35.1351 5 no
GO:1902531 regulation of intracellular signal transduction 35.1351 5 no
GO:2000145 regulation of cell motility 35.1351 4 no
GO:0030030 cell projection organization 35.1351 4 no
GO:0032970 regulation of actin filament-based process 32.4324 4 no
GO:0051130 positive regulation of cellular component organization 32.4324 5 no
GO:0120036 plasma membrane bounded cell projection organization 29.7297 5 no
GO:0007010 cytoskeleton organization 29.7297 5 no
GO:0007264 small GTPase mediated signal transduction 29.7297 4 no
GO:0031344 regulation of cell projection organization 29.7297 5 no
GO:0032956 regulation of actin cytoskeleton organization 29.7297 5 no
GO:0033043 regulation of organelle organization 29.7297 5 no
GO:0045595 regulation of cell differentiation 29.7297 4 no
GO:0051247 positive regulation of protein metabolic process 29.7297 6 no
GO:0051493 regulation of cytoskeleton organization 29.7297 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.7297 6 no
GO:0030155 regulation of cell adhesion 29.7297 4 no
GO:0042127 regulation of cell population proliferation 29.7297 4 no
GO:0007265 Ras protein signal transduction 27.0270 5 no
GO:0022603 regulation of anatomical structure morphogenesis 27.0270 4 no
GO:0030335 positive regulation of cell migration 27.0270 6 no
GO:0031399 regulation of protein modification process 27.0270 6 no
GO:0040017 positive regulation of locomotion 27.0270 4 no
GO:0044087 regulation of cellular component biogenesis 27.0270 4 no
GO:0051094 positive regulation of developmental process 27.0270 4 no
GO:0071310 cellular response to organic substance 27.0270 4 no
GO:1902533 positive regulation of intracellular signal transduction 27.0270 6 no
GO:2000147 positive regulation of cell motility 27.0270 5 no
GO:0071702 organic substance transport 27.0270 4 no
GO:0071705 nitrogen compound transport 27.0270 4 no
GO:0010941 regulation of cell death 27.0270 4 no
GO:0042981 regulation of apoptotic process 24.3243 6 no
GO:0043067 regulation of programmed cell death 24.3243 5 no
GO:0009892 negative regulation of metabolic process 24.3243 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.3243 5 no
GO:0019220 regulation of phosphate metabolic process 24.3243 6 no
GO:0042325 regulation of phosphorylation 24.3243 7 no
GO:0051174 regulation of phosphorus metabolic process 24.3243 5 no
GO:0016192 vesicle-mediated transport 24.3243 4 no
GO:0031175 neuron projection development 24.3243 6 no
GO:0008284 positive regulation of cell population proliferation 24.3243 5 no
GO:0006796 phosphate-containing compound metabolic process 24.3243 4 yes
GO:0097435 supramolecular fiber organization 24.3243 4 no
GO:0045785 positive regulation of cell adhesion 21.6216 5 no
GO:0001932 regulation of protein phosphorylation 21.6216 7 no
GO:0009889 regulation of biosynthetic process 21.6216 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.6216 6 no
GO:0010628 positive regulation of gene expression 21.6216 6 no
GO:0022604 regulation of cell morphogenesis 21.6216 5 no
GO:0031326 regulation of cellular biosynthetic process 21.6216 5 no
GO:0031401 positive regulation of protein modification process 21.6216 7 no
GO:0042327 positive regulation of phosphorylation 21.6216 8 no
GO:0044089 positive regulation of cellular component biogenesis 21.6216 5 no
GO:0045597 positive regulation of cell differentiation 21.6216 5 no
GO:0045937 positive regulation of phosphate metabolic process 21.6216 7 no
GO:0051240 positive regulation of multicellular organismal process 21.6216 4 no
GO:0031346 positive regulation of cell projection organization 21.6216 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.6216 5 no
GO:0036211 protein modification process 21.6216 4 no
GO:0043412 macromolecule modification 21.6216 4 no
GO:0007015 actin filament organization 21.6216 5 no
GO:0072657 protein localization to membrane 13.5135 4 yes
GO:0072659 protein localization to plasma membrane 13.5135 5 yes
GO:1990778 protein localization to cell periphery 13.5135 5 yes
GO:0006644 phospholipid metabolic process 10.8108 4 yes
GO:0006650 glycerophospholipid metabolic process 10.8108 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 10.8108 6 yes
GO:0008610 lipid biosynthetic process 10.8108 4 yes
GO:0008654 phospholipid biosynthetic process 10.8108 4 yes
GO:0045017 glycerolipid biosynthetic process 10.8108 4 yes
GO:0046474 glycerophospholipid biosynthetic process 10.8108 5 yes
GO:0046486 glycerolipid metabolic process 10.8108 4 yes
GO:0046488 phosphatidylinositol metabolic process 10.8108 6 yes
GO:0090407 organophosphate biosynthetic process 10.8108 4 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 8.1081 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in EFR3A_HUMAN
DOID:0111962 combined immunodeficiency 5.4054 4 no
DOID:612 primary immunodeficiency disease 5.4054 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NAA11_HUMAN [view interactions] High throughput no no
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
ELL2_HUMAN [view interactions] High throughput no no
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
TF2B_HUMAN [view interactions] High throughput no yes
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
K1107_HUMAN [view interactions] High throughput no yes
FBX31_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
T22D1_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRE_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
RING2_HUMAN [view interactions] High throughput no yes
HXB5_HUMAN [view interactions] High throughput no no
T185A_HUMAN [view interactions] High throughput no no
RGS20_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
TIGD5_HUMAN [view interactions] High throughput no no
SDC1_HUMAN [view interactions] High throughput no no
LPAR4_HUMAN [view interactions] High throughput no no
VPS4B_HUMAN [view interactions] High throughput no yes
MMP26_HUMAN [view interactions] High throughput no no
5HT2C_HUMAN [view interactions] High throughput no no
ZN517_HUMAN [view interactions] High throughput no no
ACM4_HUMAN [view entry] [view interactions] High throughput yes yes
ISG20_HUMAN [view interactions] High throughput no no
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
GTR12_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
MALL_HUMAN [view interactions] High throughput no no
PTH2R_HUMAN [view interactions] High throughput no no
S10A2_HUMAN [view interactions] High throughput no no
PEAR1_HUMAN [view interactions] High throughput no yes
GAGE5_HUMAN [view interactions] High throughput no no
AQP3_HUMAN [view interactions] High throughput no no
PO3F1_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
CX001_HUMAN [view interactions] High throughput no no
MAGA3_HUMAN [view interactions] High throughput no no
ARMS2_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
FPR1_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
EFR3A_HUMAN [view entry] [view interactions] High throughput yes yes
LEO1_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
SAE2_HUMAN [view interactions] High throughput no yes
VPS72_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
KS6A2_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PANX1_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
PI4KA_HUMAN [view entry] [view interactions] Computational yes yes