EFR3A_HUMAN
Evidence for PS localization
Functions
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed, PubMed, PubMed). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EFR3A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 48.7179 | 4 | no |
| GO:0000166 | nucleotide binding | 46.1538 | 4 | no |
| GO:0017076 | purine nucleotide binding | 46.1538 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 46.1538 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 46.1538 | 4 | no |
| GO:0003924 | GTPase activity | 35.8974 | 7 | no |
| GO:0005525 | GTP binding | 35.8974 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 35.8974 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.8974 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.8974 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 35.8974 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 35.8974 | 5 | no |
| GO:0019900 | kinase binding | 25.6410 | 4 | no |
| GO:0019901 | protein kinase binding | 25.6410 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EFR3A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 79.4872 | 4 | no |
| GO:0022607 | cellular component assembly | 48.7179 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.7179 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7179 | 4 | no |
| GO:0008104 | protein localization | 46.1538 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 46.1538 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.5897 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.5897 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 43.5897 | 4 | no |
| GO:0006996 | organelle organization | 41.0256 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.0256 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.0256 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.4615 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.4615 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.4615 | 5 | no |
| GO:0030334 | regulation of cell migration | 38.4615 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.4615 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.4615 | 5 | no |
| GO:2000145 | regulation of cell motility | 38.4615 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 35.8974 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 35.8974 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.8974 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.8974 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.8974 | 5 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 30.7692 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.7692 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 30.7692 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.7692 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 30.7692 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 30.7692 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 28.2051 | 6 | no |
| GO:0031399 | regulation of protein modification process | 28.2051 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 28.2051 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.2051 | 5 | no |
| GO:0071702 | organic substance transport | 28.2051 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 28.2051 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 28.2051 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.2051 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 25.6410 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.6410 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.6410 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.6410 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.6410 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.6410 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.6410 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.6410 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.6410 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.6410 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.6410 | 6 | no |
| GO:0072657 | protein localization to membrane | 23.0769 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 23.0769 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
| GO:0002684 | positive regulation of immune system process | 23.0769 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 23.0769 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.0769 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 23.0769 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.5128 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 20.5128 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 20.5128 | 5 | yes |
| GO:0006915 | apoptotic process | 20.5128 | 4 | no |
| GO:0007015 | actin filament organization | 20.5128 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.5128 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5128 | 6 | no |
| GO:0031175 | neuron projection development | 20.5128 | 6 | no |
| GO:0031346 | positive regulation of cell projection organization | 20.5128 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 20.5128 | 4 | no |
| GO:0032103 | positive regulation of response to external stimulus | 20.5128 | 5 | no |
| GO:0036211 | protein modification process | 20.5128 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.5128 | 8 | no |
| GO:0043412 | macromolecule modification | 20.5128 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5128 | 7 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.5128 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.5128 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.5128 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.5128 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5128 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 20.5128 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.5128 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.5128 | 7 | no |
| GO:0006644 | phospholipid metabolic process | 7.6923 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 7.6923 | 5 | yes |
| GO:0006661 | phosphatidylinositol biosynthetic process | 7.6923 | 6 | yes |
| GO:0008610 | lipid biosynthetic process | 7.6923 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 7.6923 | 5 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 7.6923 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 7.6923 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 7.6923 | 4 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 7.6923 | 6 | yes |
| GO:0090407 | organophosphate biosynthetic process | 7.6923 | 4 | yes |
| GO:0046854 | phosphatidylinositol phosphate biosynthetic process | 5.1282 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NAA11_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELL2_HUMAN | [view interactions] | High throughput | no | no |
| SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF2B_HUMAN | [view interactions] | High throughput | no | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTBD8_HUMAN | [view interactions] | High throughput | no | yes |
| FBX31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| RGS20_HUMAN | [view interactions] | High throughput | no | no |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| TIGD5_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| LPAR4_HUMAN | [view interactions] | High throughput | no | no |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| MMP26_HUMAN | [view interactions] | High throughput | no | no |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| ZN517_HUMAN | [view interactions] | High throughput | no | no |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG20_HUMAN | [view interactions] | High throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTR12_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| PTH2R_HUMAN | [view interactions] | High throughput | no | no |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| PEAR1_HUMAN | [view interactions] | High throughput | no | yes |
| GAGE5_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| PO3F1_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| ARMS2_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS72_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |