Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FBX31_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FBX31_HUMAN
GO:0031625 ubiquitin protein ligase binding 30.7692 5 no
GO:0044389 ubiquitin-like protein ligase binding 30.7692 4 no
GO:0043168 anion binding 30.7692 4 no
GO:0043169 cation binding 23.0769 4 no
GO:0046872 metal ion binding 23.0769 5 no
GO:0019900 kinase binding 23.0769 4 no
GO:0019901 protein kinase binding 23.0769 5 no
GO:0000166 nucleotide binding 23.0769 4 no
GO:0005524 ATP binding 23.0769 5 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0030554 adenyl nucleotide binding 23.0769 6 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0032559 adenyl ribonucleotide binding 23.0769 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FBX31_HUMAN
GO:0006508 proteolysis 46.1538 4 yes
GO:0009057 macromolecule catabolic process 46.1538 4 yes
GO:0016567 protein ubiquitination 46.1538 8 yes
GO:0019941 modification-dependent protein catabolic process 46.1538 6 yes
GO:0032446 protein modification by small protein conjugation 46.1538 7 yes
GO:0036211 protein modification process 46.1538 4 yes
GO:0043412 macromolecule modification 46.1538 4 yes
GO:0043632 modification-dependent macromolecule catabolic process 46.1538 5 yes
GO:0043687 post-translational protein modification 46.1538 5 yes
GO:0048523 negative regulation of cellular process 46.1538 4 yes
GO:0051603 proteolysis involved in protein catabolic process 46.1538 5 yes
GO:0070647 protein modification by small protein conjugation or removal 46.1538 6 yes
GO:0031323 regulation of cellular metabolic process 46.1538 4 no
GO:0008104 protein localization 46.1538 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 38.4615 7 yes
GO:0010498 proteasomal protein catabolic process 38.4615 5 yes
GO:0030163 protein catabolic process 38.4615 4 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 38.4615 6 yes
GO:1901565 organonitrogen compound catabolic process 38.4615 4 yes
GO:0009889 regulation of biosynthetic process 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.4615 5 no
GO:0010646 regulation of cell communication 38.4615 4 no
GO:0031326 regulation of cellular biosynthetic process 38.4615 5 no
GO:0048522 positive regulation of cellular process 38.4615 4 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0007346 regulation of mitotic cell cycle 30.7692 5 yes
GO:0010564 regulation of cell cycle process 30.7692 5 yes
GO:0051726 regulation of cell cycle 30.7692 4 yes
GO:0009890 negative regulation of biosynthetic process 30.7692 5 no
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0009966 regulation of signal transduction 30.7692 4 no
GO:0009968 negative regulation of signal transduction 30.7692 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 30.7692 6 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0010605 negative regulation of macromolecule metabolic process 30.7692 5 no
GO:0010629 negative regulation of gene expression 30.7692 7 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0010648 negative regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0023057 negative regulation of signaling 30.7692 4 no
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 no
GO:0031327 negative regulation of cellular biosynthetic process 30.7692 6 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0048585 negative regulation of response to stimulus 30.7692 4 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0141124 intracellular signaling cassette 30.7692 4 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:0008284 positive regulation of cell population proliferation 30.7692 5 no
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0042981 regulation of apoptotic process 30.7692 5 no
GO:0043066 negative regulation of apoptotic process 30.7692 6 no
GO:0043067 regulation of programmed cell death 30.7692 4 no
GO:0043069 negative regulation of programmed cell death 30.7692 5 no
GO:0051094 positive regulation of developmental process 30.7692 4 no
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0060341 regulation of cellular localization 30.7692 4 no
GO:2000026 regulation of multicellular organismal development 30.7692 4 no
GO:0006996 organelle organization 30.7692 4 no
GO:0006796 phosphate-containing compound metabolic process 30.7692 4 no
GO:0006974 DNA damage response 23.0769 4 yes
GO:0045786 negative regulation of cell cycle 23.0769 5 yes
GO:0045930 negative regulation of mitotic cell cycle 23.0769 6 yes
GO:1901987 regulation of cell cycle phase transition 23.0769 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 23.0769 6 yes
GO:1902806 regulation of cell cycle G1/S phase transition 23.0769 7 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 23.0769 7 yes
GO:0000209 protein polyubiquitination 23.0769 9 no
GO:0009411 response to UV 23.0769 5 no
GO:0009416 response to light stimulus 23.0769 4 no
GO:0009894 regulation of catabolic process 23.0769 4 no
GO:0009896 positive regulation of catabolic process 23.0769 5 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0030162 regulation of proteolysis 23.0769 6 no
GO:0031396 regulation of protein ubiquitination 23.0769 9 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 23.0769 6 no
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 23.0769 7 no
GO:0042176 regulation of protein catabolic process 23.0769 5 no
GO:0045732 positive regulation of protein catabolic process 23.0769 6 no
GO:0045862 positive regulation of proteolysis 23.0769 7 no
GO:0061136 regulation of proteasomal protein catabolic process 23.0769 6 no
GO:0062197 cellular response to chemical stress 23.0769 4 no
GO:1901800 positive regulation of proteasomal protein catabolic process 23.0769 7 no
GO:1901873 regulation of post-translational protein modification 23.0769 7 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 23.0769 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 23.0769 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 23.0769 8 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 23.0769 5 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 23.0769 6 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0006357 regulation of transcription by RNA polymerase II 23.0769 8 no
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010628 positive regulation of gene expression 23.0769 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0022607 cellular component assembly 23.0769 4 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0769 6 no
GO:0033993 response to lipid 23.0769 4 no
GO:0045595 regulation of cell differentiation 23.0769 4 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 no
GO:0048660 regulation of smooth muscle cell proliferation 23.0769 5 no
GO:0050807 regulation of synapse organization 23.0769 5 no
GO:0051049 regulation of transport 23.0769 4 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0051248 negative regulation of protein metabolic process 23.0769 6 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0071363 cellular response to growth factor stimulus 23.0769 4 no
GO:0071417 cellular response to organonitrogen compound 23.0769 4 no
GO:0097305 response to alcohol 23.0769 4 no
GO:0097306 cellular response to alcohol 23.0769 5 no
GO:1901699 cellular response to nitrogen compound 23.0769 4 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:1902532 negative regulation of intracellular signal transduction 23.0769 6 no
GO:2000008 regulation of protein localization to cell surface 23.0769 6 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:2001233 regulation of apoptotic signaling pathway 23.0769 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 23.0769 6 no
GO:2001242 regulation of intrinsic apoptotic signaling pathway 23.0769 6 no
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 23.0769 7 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0097435 supramolecular fiber organization 23.0769 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:0033365 protein localization to organelle 23.0769 5 no
GO:0040017 positive regulation of locomotion 23.0769 4 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:0006886 intracellular protein transport 23.0769 4 no
GO:0015031 protein transport 23.0769 4 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0000075 cell cycle checkpoint signaling 15.3846 4 yes
GO:0000077 DNA damage checkpoint signaling 15.3846 5 yes
GO:0007093 mitotic cell cycle checkpoint signaling 15.3846 4 yes
GO:0010948 negative regulation of cell cycle process 15.3846 6 yes
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 15.3846 7 yes
GO:0031570 DNA integrity checkpoint signaling 15.3846 5 yes
GO:0031571 mitotic G1 DNA damage checkpoint signaling 15.3846 6 yes
GO:0042770 signal transduction in response to DNA damage 15.3846 4 yes
GO:0044773 mitotic DNA damage checkpoint signaling 15.3846 6 yes
GO:0044774 mitotic DNA integrity checkpoint signaling 15.3846 5 yes
GO:0044819 mitotic G1/S transition checkpoint signaling 15.3846 5 yes
GO:1901988 negative regulation of cell cycle phase transition 15.3846 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 15.3846 7 yes
GO:1902807 negative regulation of cell cycle G1/S phase transition 15.3846 8 yes
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 15.3846 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SKP1_HUMAN [view interactions] Low throughput no yes
CUL1_HUMAN [view interactions] Low throughput no yes
CCND1_HUMAN [view interactions] Low throughput no yes
ATM_HUMAN [view interactions] Low throughput no yes
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
PAR6A_HUMAN [view interactions] Low throughput no yes
MP2K6_HUMAN [view interactions] Low throughput no yes
CDT1_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
FOXM1_HUMAN [view interactions] Low throughput no yes
SNAI2_HUMAN [view interactions] Low throughput no yes
SNAI1_HUMAN [view interactions] Low throughput no yes
FZR1_HUMAN [view interactions] Low throughput no no
CDC20_HUMAN [view interactions] Low throughput no no
UBP53_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
FXL20_HUMAN [view interactions] Low throughput no no
MYC_HUMAN [view interactions] Low throughput no yes
COF1_HUMAN [view entry] [view interactions] Low throughput yes no
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
KCTD5_HUMAN [view interactions] High throughput no no
C170L_HUMAN [view entry] [view interactions] High throughput yes no
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
PDLI1_HUMAN [view interactions] High throughput no yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
ZCHC9_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
EDRF1_HUMAN [view interactions] High throughput no no
EFR3A_HUMAN [view entry] [view interactions] High throughput yes yes
RT27_HUMAN [view interactions] High throughput no yes
FA98A_HUMAN [view interactions] High throughput no no
STYX_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
STX3_HUMAN [view entry] [view interactions] High throughput yes no
QSER1_HUMAN [view interactions] High throughput no no
CCNQ_HUMAN [view interactions] High throughput no yes
ZN131_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
HERC5_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
GHR_HUMAN [view interactions] High throughput no yes
R113A_HUMAN [view interactions] High throughput no yes