Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FBX31_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FBX31_HUMAN
GO:0005524 ATP binding 27.2727 5 no
GO:0017076 purine nucleotide binding 27.2727 4 no
GO:0019900 kinase binding 27.2727 4 no
GO:0019901 protein kinase binding 27.2727 5 no
GO:0030554 adenyl nucleotide binding 27.2727 5 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0032559 adenyl ribonucleotide binding 27.2727 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.2727 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FBX31_HUMAN
GO:0009057 macromolecule catabolic process 45.4545 4 yes
GO:0016567 protein ubiquitination 45.4545 7 yes
GO:0032446 protein modification by small protein conjugation 45.4545 6 yes
GO:0036211 protein modification process 45.4545 4 yes
GO:0043412 macromolecule modification 45.4545 4 yes
GO:0048522 positive regulation of cellular process 45.4545 4 yes
GO:0070647 protein modification by small protein conjugation or removal 45.4545 5 yes
GO:0008104 protein localization 45.4545 4 no
GO:0019941 modification-dependent protein catabolic process 36.3636 6 yes
GO:0030163 protein catabolic process 36.3636 4 yes
GO:0043632 modification-dependent macromolecule catabolic process 36.3636 5 yes
GO:0044265 cellular macromolecule catabolic process 36.3636 4 yes
GO:0048523 negative regulation of cellular process 36.3636 4 yes
GO:0051603 proteolysis involved in protein catabolic process 36.3636 5 yes
GO:1901565 organonitrogen compound catabolic process 36.3636 4 yes
GO:2000026 regulation of multicellular organismal development 36.3636 4 yes
GO:0006796 phosphate-containing compound metabolic process 36.3636 4 no
GO:0010646 regulation of cell communication 36.3636 4 no
GO:0031323 regulation of cellular metabolic process 36.3636 4 no
GO:0080090 regulation of primary metabolic process 36.3636 4 no
GO:0006508 proteolysis 36.3636 4 yes
GO:0007346 regulation of mitotic cell cycle 27.2727 5 yes
GO:0010498 proteasomal protein catabolic process 27.2727 5 yes
GO:0010564 regulation of cell cycle process 27.2727 5 yes
GO:0040017 positive regulation of locomotion 27.2727 4 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 27.2727 6 yes
GO:0045595 regulation of cell differentiation 27.2727 4 yes
GO:0045597 positive regulation of cell differentiation 27.2727 5 yes
GO:0051094 positive regulation of developmental process 27.2727 4 yes
GO:0051128 regulation of cellular component organization 27.2727 4 yes
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 yes
GO:0051726 regulation of cell cycle 27.2727 4 yes
GO:0051960 regulation of nervous system development 27.2727 5 yes
GO:0060284 regulation of cell development 27.2727 5 yes
GO:0006996 organelle organization 27.2727 4 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0009966 regulation of signal transduction 27.2727 4 no
GO:0009968 negative regulation of signal transduction 27.2727 5 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0010648 negative regulation of cell communication 27.2727 5 no
GO:0023057 negative regulation of signaling 27.2727 4 no
GO:0031325 positive regulation of cellular metabolic process 27.2727 5 no
GO:0031399 regulation of protein modification process 27.2727 6 no
GO:0031401 positive regulation of protein modification process 27.2727 7 no
GO:0048585 negative regulation of response to stimulus 27.2727 4 no
GO:0051171 regulation of nitrogen compound metabolic process 27.2727 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.2727 5 no
GO:0051246 regulation of protein metabolic process 27.2727 5 no
GO:0051247 positive regulation of protein metabolic process 27.2727 6 no
GO:0060255 regulation of macromolecule metabolic process 27.2727 4 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 27.2727 7 no
GO:0006886 intracellular protein transport 27.2727 4 no
GO:0015031 protein transport 27.2727 4 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0071705 nitrogen compound transport 27.2727 4 no
GO:0008284 positive regulation of cell population proliferation 27.2727 5 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0042127 regulation of cell population proliferation 27.2727 4 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:2000008 regulation of protein localization to cell surface 27.2727 6 no
GO:0006511 ubiquitin-dependent protein catabolic process 27.2727 7 yes
GO:0010720 positive regulation of cell development 18.1818 6 yes
GO:0010975 regulation of neuron projection development 18.1818 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 18.1818 4 yes
GO:0030334 regulation of cell migration 18.1818 5 yes
GO:0030335 positive regulation of cell migration 18.1818 6 yes
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 18.1818 7 yes
GO:0031344 regulation of cell projection organization 18.1818 5 yes
GO:0045786 negative regulation of cell cycle 18.1818 5 yes
GO:0045930 negative regulation of mitotic cell cycle 18.1818 6 yes
GO:0050767 regulation of neurogenesis 18.1818 6 yes
GO:0050769 positive regulation of neurogenesis 18.1818 6 yes
GO:0051130 positive regulation of cellular component organization 18.1818 5 yes
GO:0051962 positive regulation of nervous system development 18.1818 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 18.1818 6 yes
GO:1901987 regulation of cell cycle phase transition 18.1818 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 18.1818 6 yes
GO:1902806 regulation of cell cycle G1/S phase transition 18.1818 7 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 18.1818 7 yes
GO:2000145 regulation of cell motility 18.1818 4 yes
GO:2000147 positive regulation of cell motility 18.1818 5 yes
GO:0006974 cellular response to DNA damage stimulus 18.1818 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SKP1_HUMAN [view interactions] Low throughput no yes
CUL1_HUMAN [view interactions] Low throughput no yes
CCND1_HUMAN [view interactions] Low throughput no yes
ATM_HUMAN [view interactions] Low throughput no yes
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
PAR6A_HUMAN [view interactions] Low throughput no yes
MP2K6_HUMAN [view interactions] Low throughput no yes
CDT1_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
FOXM1_HUMAN [view interactions] Low throughput no yes
SNAI2_HUMAN [view interactions] Low throughput no yes
SNAI1_HUMAN [view interactions] Low throughput no yes
FZR1_HUMAN [view interactions] Low throughput no no
CDC20_HUMAN [view interactions] Low throughput no no
UBP53_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
KCTD5_HUMAN [view interactions] High throughput no no
C170L_HUMAN [view entry] [view interactions] High throughput yes no
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
RT27_HUMAN [view interactions] High throughput no yes
EFR3A_HUMAN [view entry] [view interactions] High throughput yes yes
EDRF1_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
ZCHC9_HUMAN [view interactions] High throughput no yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI1_HUMAN [view interactions] High throughput no yes
FA98A_HUMAN [view interactions] High throughput no no
STYX_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
STX3_HUMAN [view entry] [view interactions] High throughput yes no
QSER1_HUMAN [view interactions] High throughput no yes
CCNQ_HUMAN [view interactions] High throughput no yes
ZN131_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
GHR_HUMAN [view interactions] High throughput no yes