Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAP2C_HUMAN

GO
G2C
SynGO

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RAP2C_HUMAN
GO:0000166 nucleotide binding 67.7419 4 yes
GO:0017076 purine nucleotide binding 67.7419 5 yes
GO:0032555 purine ribonucleotide binding 67.7419 4 yes
GO:0043168 anion binding 67.7419 4 yes
GO:0016462 pyrophosphatase activity 64.5161 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 64.5161 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 64.5161 6 yes
GO:0035639 purine ribonucleoside triphosphate binding 64.5161 4 yes
GO:0003924 GTPase activity 38.7097 7 yes
GO:0005525 GTP binding 38.7097 5 yes
GO:0019001 guanyl nucleotide binding 38.7097 6 yes
GO:0032561 guanyl ribonucleotide binding 38.7097 5 yes
GO:0030554 adenyl nucleotide binding 29.0323 6 no
GO:0032559 adenyl ribonucleotide binding 29.0323 5 no
GO:0005524 ATP binding 25.8065 5 no
GO:0016887 ATP hydrolysis activity 25.8065 7 no
GO:0003723 RNA binding 22.5806 4 no
GO:0019003 GDP binding 19.3548 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAP2C_HUMAN
GO:0048522 positive regulation of cellular process 70.9677 4 yes
GO:0051128 regulation of cellular component organization 61.2903 4 no
GO:0009893 positive regulation of metabolic process 58.0645 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 58.0645 5 yes
GO:0031323 regulation of cellular metabolic process 58.0645 4 yes
GO:0060255 regulation of macromolecule metabolic process 58.0645 4 yes
GO:0080090 regulation of primary metabolic process 58.0645 4 yes
GO:0031325 positive regulation of cellular metabolic process 54.8387 5 yes
GO:0033043 regulation of organelle organization 51.6129 5 no
GO:0009889 regulation of biosynthetic process 48.3871 4 no
GO:0010556 regulation of macromolecule biosynthetic process 48.3871 5 no
GO:0031326 regulation of cellular biosynthetic process 48.3871 5 no
GO:0022607 cellular component assembly 48.3871 4 no
GO:0048523 negative regulation of cellular process 41.9355 4 yes
GO:0009891 positive regulation of biosynthetic process 41.9355 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 41.9355 6 no
GO:0031328 positive regulation of cellular biosynthetic process 41.9355 6 no
GO:0051130 positive regulation of cellular component organization 41.9355 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.7097 5 no
GO:0051246 regulation of protein metabolic process 35.4839 5 yes
GO:0051247 positive regulation of protein metabolic process 35.4839 6 yes
GO:0141124 intracellular signaling cassette 35.4839 4 yes
GO:0010638 positive regulation of organelle organization 35.4839 6 no
GO:0032880 regulation of protein localization 35.4839 5 no
GO:0060341 regulation of cellular localization 35.4839 4 no
GO:0070201 regulation of establishment of protein localization 35.4839 6 no
GO:0007264 small GTPase-mediated signal transduction 32.2581 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 32.2581 5 no
GO:1903829 positive regulation of protein localization 32.2581 5 no
GO:1904951 positive regulation of establishment of protein localization 29.0323 6 no
GO:0006996 organelle organization 29.0323 4 no
GO:0009966 regulation of signal transduction 29.0323 4 no
GO:0010646 regulation of cell communication 29.0323 4 no
GO:1902531 regulation of intracellular signal transduction 29.0323 5 no
GO:0001932 regulation of protein phosphorylation 25.8065 7 yes
GO:0019220 regulation of phosphate metabolic process 25.8065 6 yes
GO:0030334 regulation of cell migration 25.8065 5 yes
GO:0031399 regulation of protein modification process 25.8065 6 yes
GO:0031401 positive regulation of protein modification process 25.8065 7 yes
GO:0042325 regulation of phosphorylation 25.8065 7 yes
GO:0051174 regulation of phosphorus metabolic process 25.8065 5 yes
GO:0051338 regulation of transferase activity 25.8065 4 yes
GO:2000145 regulation of cell motility 25.8065 4 yes
GO:0050821 protein stabilization 25.8065 4 no
GO:0010468 regulation of gene expression 25.8065 6 no
GO:0043933 protein-containing complex organization 25.8065 4 no
GO:0048584 positive regulation of response to stimulus 25.8065 4 no
GO:0065003 protein-containing complex assembly 25.8065 5 no
GO:0097435 supramolecular fiber organization 25.8065 4 no
GO:0008104 protein localization 25.8065 4 no
GO:0001934 positive regulation of protein phosphorylation 22.5806 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 22.5806 6 yes
GO:0042327 positive regulation of phosphorylation 22.5806 8 yes
GO:0045937 positive regulation of phosphate metabolic process 22.5806 7 yes
GO:0032204 regulation of telomere maintenance 22.5806 6 no
GO:0032206 positive regulation of telomere maintenance 22.5806 7 no
GO:0032210 regulation of telomere maintenance via telomerase 22.5806 7 no
GO:0032212 positive regulation of telomere maintenance via telomerase 22.5806 8 no
GO:0033044 regulation of chromosome organization 22.5806 6 no
GO:0051052 regulation of DNA metabolic process 22.5806 5 no
GO:0051054 positive regulation of DNA metabolic process 22.5806 6 no
GO:0070202 regulation of establishment of protein localization to chromosome 22.5806 7 no
GO:0070203 regulation of establishment of protein localization to telomere 22.5806 7 no
GO:1900180 regulation of protein localization to nucleus 22.5806 6 no
GO:1900182 positive regulation of protein localization to nucleus 22.5806 6 no
GO:1904356 regulation of telomere maintenance via telomere lengthening 22.5806 7 no
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 22.5806 8 no
GO:1904814 regulation of protein localization to chromosome, telomeric region 22.5806 6 no
GO:1904816 positive regulation of protein localization to chromosome, telomeric region 22.5806 6 no
GO:1904851 positive regulation of establishment of protein localization to telomere 22.5806 7 no
GO:1904869 regulation of protein localization to Cajal body 22.5806 7 no
GO:1904871 positive regulation of protein localization to Cajal body 22.5806 7 no
GO:1904872 regulation of telomerase RNA localization to Cajal body 22.5806 4 no
GO:1904874 positive regulation of telomerase RNA localization to Cajal body 22.5806 4 no
GO:2000278 regulation of DNA biosynthetic process 22.5806 6 no
GO:2000573 positive regulation of DNA biosynthetic process 22.5806 7 no
GO:2001252 positive regulation of chromosome organization 22.5806 7 no
GO:0009967 positive regulation of signal transduction 22.5806 5 no
GO:0010647 positive regulation of cell communication 22.5806 5 no
GO:0023056 positive regulation of signaling 22.5806 4 no
GO:0032970 regulation of actin filament-based process 22.5806 4 no
GO:0044087 regulation of cellular component biogenesis 22.5806 4 no
GO:0051049 regulation of transport 22.5806 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.5806 6 no
GO:0043085 positive regulation of catalytic activity 22.5806 4 no
GO:0030336 negative regulation of cell migration 16.1290 6 yes
GO:0040013 negative regulation of locomotion 16.1290 4 yes
GO:0043549 regulation of kinase activity 16.1290 5 yes
GO:2000146 negative regulation of cell motility 16.1290 5 yes
GO:0045859 regulation of protein kinase activity 12.9032 6 yes
GO:0031952 regulation of protein autophosphorylation 6.4516 8 yes
GO:0031954 positive regulation of protein autophosphorylation 6.4516 9 yes
GO:0032486 Rap protein signal transduction 6.4516 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RB40B_HUMAN [view interactions] Low throughput no no
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
PGTB2_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP_HUMAN [view interactions] High throughput no yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
WDTC1_HUMAN [view interactions] High throughput no yes
M4K4_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
R144A_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
RAP2A_HUMAN [view entry] [view interactions] High throughput yes yes
SPCS3_HUMAN [view interactions] High throughput no yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
SPRTN_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CL16A_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
GRM2_HUMAN [view entry] [view interactions] High throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes