RAP2C_HUMAN
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RAP2C_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 67.7419 | 4 | yes |
GO:0017076 | purine nucleotide binding | 67.7419 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 67.7419 | 4 | yes |
GO:0043168 | anion binding | 67.7419 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 64.5161 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 64.5161 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 64.5161 | 6 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 64.5161 | 4 | yes |
GO:0003924 | GTPase activity | 38.7097 | 7 | yes |
GO:0005525 | GTP binding | 38.7097 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 38.7097 | 6 | yes |
GO:0032561 | guanyl ribonucleotide binding | 38.7097 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 29.0323 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 29.0323 | 5 | no |
GO:0005524 | ATP binding | 25.8065 | 5 | no |
GO:0016887 | ATP hydrolysis activity | 25.8065 | 7 | no |
GO:0003723 | RNA binding | 22.5806 | 4 | no |
GO:0019003 | GDP binding | 19.3548 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RAP2C_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.9677 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 61.2903 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 58.0645 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 58.0645 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 58.0645 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 58.0645 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 58.0645 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 54.8387 | 5 | yes |
GO:0033043 | regulation of organelle organization | 51.6129 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 48.3871 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 48.3871 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 48.3871 | 5 | no |
GO:0022607 | cellular component assembly | 48.3871 | 4 | no |
GO:0048523 | negative regulation of cellular process | 41.9355 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 41.9355 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 41.9355 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 41.9355 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 41.9355 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.7097 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 35.4839 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 35.4839 | 6 | yes |
GO:0141124 | intracellular signaling cassette | 35.4839 | 4 | yes |
GO:0010638 | positive regulation of organelle organization | 35.4839 | 6 | no |
GO:0032880 | regulation of protein localization | 35.4839 | 5 | no |
GO:0060341 | regulation of cellular localization | 35.4839 | 4 | no |
GO:0070201 | regulation of establishment of protein localization | 35.4839 | 6 | no |
GO:0007264 | small GTPase-mediated signal transduction | 32.2581 | 5 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 32.2581 | 5 | no |
GO:1903829 | positive regulation of protein localization | 32.2581 | 5 | no |
GO:1904951 | positive regulation of establishment of protein localization | 29.0323 | 6 | no |
GO:0006996 | organelle organization | 29.0323 | 4 | no |
GO:0009966 | regulation of signal transduction | 29.0323 | 4 | no |
GO:0010646 | regulation of cell communication | 29.0323 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 29.0323 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 25.8065 | 7 | yes |
GO:0019220 | regulation of phosphate metabolic process | 25.8065 | 6 | yes |
GO:0030334 | regulation of cell migration | 25.8065 | 5 | yes |
GO:0031399 | regulation of protein modification process | 25.8065 | 6 | yes |
GO:0031401 | positive regulation of protein modification process | 25.8065 | 7 | yes |
GO:0042325 | regulation of phosphorylation | 25.8065 | 7 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 25.8065 | 5 | yes |
GO:0051338 | regulation of transferase activity | 25.8065 | 4 | yes |
GO:2000145 | regulation of cell motility | 25.8065 | 4 | yes |
GO:0050821 | protein stabilization | 25.8065 | 4 | no |
GO:0010468 | regulation of gene expression | 25.8065 | 6 | no |
GO:0043933 | protein-containing complex organization | 25.8065 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 25.8065 | 4 | no |
GO:0065003 | protein-containing complex assembly | 25.8065 | 5 | no |
GO:0097435 | supramolecular fiber organization | 25.8065 | 4 | no |
GO:0008104 | protein localization | 25.8065 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 22.5806 | 8 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 22.5806 | 6 | yes |
GO:0042327 | positive regulation of phosphorylation | 22.5806 | 8 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 22.5806 | 7 | yes |
GO:0032204 | regulation of telomere maintenance | 22.5806 | 6 | no |
GO:0032206 | positive regulation of telomere maintenance | 22.5806 | 7 | no |
GO:0032210 | regulation of telomere maintenance via telomerase | 22.5806 | 7 | no |
GO:0032212 | positive regulation of telomere maintenance via telomerase | 22.5806 | 8 | no |
GO:0033044 | regulation of chromosome organization | 22.5806 | 6 | no |
GO:0051052 | regulation of DNA metabolic process | 22.5806 | 5 | no |
GO:0051054 | positive regulation of DNA metabolic process | 22.5806 | 6 | no |
GO:0070202 | regulation of establishment of protein localization to chromosome | 22.5806 | 7 | no |
GO:0070203 | regulation of establishment of protein localization to telomere | 22.5806 | 7 | no |
GO:1900180 | regulation of protein localization to nucleus | 22.5806 | 6 | no |
GO:1900182 | positive regulation of protein localization to nucleus | 22.5806 | 6 | no |
GO:1904356 | regulation of telomere maintenance via telomere lengthening | 22.5806 | 7 | no |
GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 22.5806 | 8 | no |
GO:1904814 | regulation of protein localization to chromosome, telomeric region | 22.5806 | 6 | no |
GO:1904816 | positive regulation of protein localization to chromosome, telomeric region | 22.5806 | 6 | no |
GO:1904851 | positive regulation of establishment of protein localization to telomere | 22.5806 | 7 | no |
GO:1904869 | regulation of protein localization to Cajal body | 22.5806 | 7 | no |
GO:1904871 | positive regulation of protein localization to Cajal body | 22.5806 | 7 | no |
GO:1904872 | regulation of telomerase RNA localization to Cajal body | 22.5806 | 4 | no |
GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | 22.5806 | 4 | no |
GO:2000278 | regulation of DNA biosynthetic process | 22.5806 | 6 | no |
GO:2000573 | positive regulation of DNA biosynthetic process | 22.5806 | 7 | no |
GO:2001252 | positive regulation of chromosome organization | 22.5806 | 7 | no |
GO:0009967 | positive regulation of signal transduction | 22.5806 | 5 | no |
GO:0010647 | positive regulation of cell communication | 22.5806 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.5806 | 4 | no |
GO:0032970 | regulation of actin filament-based process | 22.5806 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 22.5806 | 4 | no |
GO:0051049 | regulation of transport | 22.5806 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 22.5806 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 22.5806 | 4 | no |
GO:0030336 | negative regulation of cell migration | 16.1290 | 6 | yes |
GO:0040013 | negative regulation of locomotion | 16.1290 | 4 | yes |
GO:0043549 | regulation of kinase activity | 16.1290 | 5 | yes |
GO:2000146 | negative regulation of cell motility | 16.1290 | 5 | yes |
GO:0045859 | regulation of protein kinase activity | 12.9032 | 6 | yes |
GO:0031952 | regulation of protein autophosphorylation | 6.4516 | 8 | yes |
GO:0031954 | positive regulation of protein autophosphorylation | 6.4516 | 9 | yes |
GO:0032486 | Rap protein signal transduction | 6.4516 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RB40B_HUMAN | [view interactions] | Low throughput | no | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHLP_HUMAN | [view interactions] | High throughput | no | yes |
TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
M4K4_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
R144A_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
APR_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPCS3_HUMAN | [view interactions] | High throughput | no | yes |
FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CL16A_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
RN149_HUMAN | [view interactions] | High throughput | no | no |
GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |