Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAP2C_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAP2C_HUMAN
GO:0017076 purine nucleotide binding 75.0000 4 yes
GO:0032555 purine ribonucleotide binding 75.0000 4 yes
GO:0016462 pyrophosphatase activity 71.4286 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 71.4286 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 71.4286 6 yes
GO:0035639 purine ribonucleoside triphosphate binding 71.4286 4 yes
GO:0003924 GTPase activity 42.8571 7 yes
GO:0005525 GTP binding 42.8571 5 yes
GO:0019001 guanyl nucleotide binding 42.8571 5 yes
GO:0032561 guanyl ribonucleotide binding 42.8571 5 yes
GO:0030554 adenyl nucleotide binding 32.1429 5 no
GO:0032559 adenyl ribonucleotide binding 32.1429 5 no
GO:0005524 ATP binding 28.5714 5 no
GO:0016887 ATP hydrolysis activity 28.5714 7 no
GO:0019003 GDP binding 25.0000 4 yes
GO:0003723 RNA binding 25.0000 4 no
GO:0019900 kinase binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in RAP2C_HUMAN
GO:0048522 positive regulation of cellular process 78.5714 4 yes
GO:0031323 regulation of cellular metabolic process 67.8571 4 yes
GO:0009893 positive regulation of metabolic process 64.2857 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 64.2857 5 yes
GO:0031325 positive regulation of cellular metabolic process 64.2857 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 64.2857 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 64.2857 5 yes
GO:0060255 regulation of macromolecule metabolic process 64.2857 4 yes
GO:0080090 regulation of primary metabolic process 64.2857 4 yes
GO:0051128 regulation of cellular component organization 64.2857 4 no
GO:0022607 cellular component assembly 57.1429 4 no
GO:0033043 regulation of organelle organization 57.1429 5 no
GO:0009889 regulation of biosynthetic process 46.4286 4 no
GO:0031326 regulation of cellular biosynthetic process 46.4286 5 no
GO:0051130 positive regulation of cellular component organization 46.4286 5 no
GO:0048523 negative regulation of cellular process 42.8571 4 yes
GO:0007264 small GTPase mediated signal transduction 39.2857 4 yes
GO:0051246 regulation of protein metabolic process 39.2857 5 yes
GO:0051247 positive regulation of protein metabolic process 39.2857 6 yes
GO:0009891 positive regulation of biosynthetic process 39.2857 5 no
GO:0010556 regulation of macromolecule biosynthetic process 39.2857 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 39.2857 6 no
GO:0010638 positive regulation of organelle organization 39.2857 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 39.2857 5 no
GO:0031328 positive regulation of cellular biosynthetic process 39.2857 6 no
GO:0007265 Ras protein signal transduction 35.7143 5 yes
GO:0006996 organelle organization 35.7143 4 no
GO:0032880 regulation of protein localization 32.1429 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 32.1429 6 no
GO:0060341 regulation of cellular localization 32.1429 4 no
GO:0070201 regulation of establishment of protein localization 32.1429 6 no
GO:1903829 positive regulation of protein localization 32.1429 5 no
GO:1904951 positive regulation of establishment of protein localization 32.1429 6 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 yes
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 yes
GO:0019220 regulation of phosphate metabolic process 28.5714 6 yes
GO:0030334 regulation of cell migration 28.5714 5 yes
GO:0031399 regulation of protein modification process 28.5714 6 yes
GO:0031401 positive regulation of protein modification process 28.5714 7 yes
GO:0042325 regulation of phosphorylation 28.5714 7 yes
GO:0042327 positive regulation of phosphorylation 28.5714 8 yes
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 yes
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 yes
GO:0051338 regulation of transferase activity 28.5714 4 yes
GO:2000145 regulation of cell motility 28.5714 4 yes
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0032204 regulation of telomere maintenance 25.0000 6 no
GO:0032206 positive regulation of telomere maintenance 25.0000 7 no
GO:0032210 regulation of telomere maintenance via telomerase 25.0000 7 no
GO:0032212 positive regulation of telomere maintenance via telomerase 25.0000 8 no
GO:0033044 regulation of chromosome organization 25.0000 6 no
GO:0050821 protein stabilization 25.0000 4 no
GO:0051052 regulation of DNA metabolic process 25.0000 5 no
GO:0051054 positive regulation of DNA metabolic process 25.0000 6 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0070202 regulation of establishment of protein localization to chromosome 25.0000 7 no
GO:0070203 regulation of establishment of protein localization to telomere 25.0000 7 no
GO:1900180 regulation of protein localization to nucleus 25.0000 6 no
GO:1900182 positive regulation of protein localization to nucleus 25.0000 6 no
GO:1901998 toxin transport 25.0000 4 no
GO:1904356 regulation of telomere maintenance via telomere lengthening 25.0000 7 no
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 25.0000 8 no
GO:1904814 regulation of protein localization to chromosome, telomeric region 25.0000 6 no
GO:1904816 positive regulation of protein localization to chromosome, telomeric region 25.0000 6 no
GO:1904851 positive regulation of establishment of protein localization to telomere 25.0000 7 no
GO:1904869 regulation of protein localization to Cajal body 25.0000 7 no
GO:1904871 positive regulation of protein localization to Cajal body 25.0000 7 no
GO:1904872 regulation of telomerase RNA localization to Cajal body 25.0000 4 no
GO:1904874 positive regulation of telomerase RNA localization to Cajal body 25.0000 4 no
GO:2000278 regulation of DNA biosynthetic process 25.0000 6 no
GO:2000573 positive regulation of DNA biosynthetic process 25.0000 7 no
GO:2001252 positive regulation of chromosome organization 25.0000 7 no
GO:0008104 protein localization 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0010646 regulation of cell communication 25.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0010941 regulation of cell death 21.4286 4 no
GO:0042981 regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 5 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0010647 positive regulation of cell communication 21.4286 5 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0030335 positive regulation of cell migration 21.4286 6 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0040017 positive regulation of locomotion 21.4286 4 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 no
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:2000147 positive regulation of cell motility 21.4286 5 no
GO:0007015 actin filament organization 21.4286 5 no
GO:0030336 negative regulation of cell migration 17.8571 6 yes
GO:0040013 negative regulation of locomotion 17.8571 4 yes
GO:0043549 regulation of kinase activity 17.8571 5 yes
GO:0045859 regulation of protein kinase activity 17.8571 6 yes
GO:2000146 negative regulation of cell motility 17.8571 5 yes
GO:0032486 Rap protein signal transduction 10.7143 6 yes
GO:0001885 endothelial cell development 7.1429 5 yes
GO:0002064 epithelial cell development 7.1429 4 yes
GO:0031952 regulation of protein autophosphorylation 7.1429 8 yes
GO:0031954 positive regulation of protein autophosphorylation 7.1429 9 yes
GO:0061028 establishment of endothelial barrier 7.1429 6 yes
GO:0090557 establishment of endothelial intestinal barrier 7.1429 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
PGTB2_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
WDTC1_HUMAN [view interactions] High throughput no yes
M4K4_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
R144A_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
RAP2A_HUMAN [view entry] [view interactions] High throughput yes yes
SPCS3_HUMAN [view interactions] High throughput no yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
SPRTN_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
RAB28_HUMAN [view interactions] Computational no yes
RPGF2_HUMAN [view entry] [view interactions] Computational yes no