RPGF2_HUMAN
Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed, PubMed) or not (PubMed, PubMed, PubMed). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RPGF2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 30.3571 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 30.3571 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.7857 | 4 | no |
GO:0045296 | cadherin binding | 23.2143 | 4 | no |
GO:0003723 | RNA binding | 23.2143 | 4 | no |
GO:0016462 | pyrophosphatase activity | 21.4286 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.4286 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.4286 | 6 | no |
GO:0019900 | kinase binding | 21.4286 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 17.8571 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 17.8571 | 5 | yes |
GO:0030695 | GTPase regulator activity | 16.0714 | 4 | yes |
GO:0046872 | metal ion binding | 16.0714 | 4 | yes |
GO:0005096 | GTPase activator activity | 12.5000 | 4 | yes |
GO:0001664 | G protein-coupled receptor binding | 10.7143 | 4 | yes |
GO:0005085 | guanyl-nucleotide exchange factor activity | 7.1429 | 5 | yes |
GO:0031690 | adrenergic receptor binding | 7.1429 | 5 | yes |
GO:0031697 | beta-1 adrenergic receptor binding | 5.3571 | 6 | yes |
GO:0030165 | PDZ domain binding | 3.5714 | 4 | yes |
GO:0030551 | cyclic nucleotide binding | 3.5714 | 4 | yes |
GO:0030552 | cAMP binding | 3.5714 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RPGF2_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 64.2857 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 60.7143 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 60.7143 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 60.7143 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | yes |
GO:0010646 | regulation of cell communication | 55.3571 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 53.5714 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 51.7857 | 4 | yes |
GO:0009966 | regulation of signal transduction | 48.2143 | 4 | yes |
GO:0051049 | regulation of transport | 48.2143 | 4 | no |
GO:0008104 | protein localization | 46.4286 | 4 | yes |
GO:0031399 | regulation of protein modification process | 42.8571 | 6 | yes |
GO:0009893 | positive regulation of metabolic process | 39.2857 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 37.5000 | 6 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 37.5000 | 5 | yes |
GO:0006996 | organelle organization | 37.5000 | 4 | no |
GO:0010647 | positive regulation of cell communication | 35.7143 | 5 | yes |
GO:0023056 | positive regulation of signaling | 35.7143 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.7143 | 5 | yes |
GO:0010468 | regulation of gene expression | 35.7143 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 33.9286 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 33.9286 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 33.9286 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 33.9286 | 6 | yes |
GO:1902531 | regulation of intracellular signal transduction | 33.9286 | 5 | yes |
GO:0042325 | regulation of phosphorylation | 32.1429 | 7 | yes |
GO:0071702 | organic substance transport | 32.1429 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 32.1429 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 30.3571 | 7 | yes |
GO:0009967 | positive regulation of signal transduction | 30.3571 | 5 | yes |
GO:0010941 | regulation of cell death | 30.3571 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 30.3571 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 30.3571 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 30.3571 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 30.3571 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 30.3571 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 30.3571 | 5 | yes |
GO:0051338 | regulation of transferase activity | 30.3571 | 4 | yes |
GO:0071310 | cellular response to organic substance | 30.3571 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 30.3571 | 4 | yes |
GO:0071705 | nitrogen compound transport | 30.3571 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | yes |
GO:0031344 | regulation of cell projection organization | 28.5714 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 26.7857 | 4 | yes |
GO:0031401 | positive regulation of protein modification process | 26.7857 | 7 | yes |
GO:0043549 | regulation of kinase activity | 26.7857 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.7857 | 6 | yes |
GO:0015031 | protein transport | 26.7857 | 4 | no |
GO:0060341 | regulation of cellular localization | 26.7857 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 26.7857 | 5 | no |
GO:0010648 | negative regulation of cell communication | 26.7857 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.7857 | 5 | no |
GO:0023057 | negative regulation of signaling | 26.7857 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | yes |
GO:0045859 | regulation of protein kinase activity | 25.0000 | 6 | yes |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0043066 | negative regulation of apoptotic process | 25.0000 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 25.0000 | 6 | no |
GO:0060548 | negative regulation of cell death | 25.0000 | 5 | no |
GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 23.2143 | 6 | yes |
GO:0043085 | positive regulation of catalytic activity | 23.2143 | 4 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 23.2143 | 7 | yes |
GO:0051094 | positive regulation of developmental process | 23.2143 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 23.2143 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 23.2143 | 4 | yes |
GO:0006886 | intracellular protein transport | 23.2143 | 4 | no |
GO:0032880 | regulation of protein localization | 23.2143 | 5 | no |
GO:0043269 | regulation of ion transport | 23.2143 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 23.2143 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 23.2143 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 21.4286 | 8 | yes |
GO:0007264 | small GTPase mediated signal transduction | 21.4286 | 4 | yes |
GO:0010975 | regulation of neuron projection development | 21.4286 | 7 | yes |
GO:0042327 | positive regulation of phosphorylation | 21.4286 | 8 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 21.4286 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 21.4286 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
GO:0007010 | cytoskeleton organization | 21.4286 | 5 | no |
GO:0007265 | Ras protein signal transduction | 19.6429 | 5 | yes |
GO:0008285 | negative regulation of cell population proliferation | 19.6429 | 5 | yes |
GO:0030030 | cell projection organization | 19.6429 | 4 | yes |
GO:0030334 | regulation of cell migration | 19.6429 | 5 | yes |
GO:0051336 | regulation of hydrolase activity | 19.6429 | 4 | yes |
GO:2000145 | regulation of cell motility | 19.6429 | 4 | yes |
GO:0002064 | epithelial cell development | 17.8571 | 4 | yes |
GO:0022607 | cellular component assembly | 17.8571 | 4 | yes |
GO:0031175 | neuron projection development | 17.8571 | 6 | yes |
GO:0031346 | positive regulation of cell projection organization | 17.8571 | 6 | yes |
GO:0043408 | regulation of MAPK cascade | 17.8571 | 6 | yes |
GO:0051347 | positive regulation of transferase activity | 17.8571 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 17.8571 | 5 | yes |
GO:1901699 | cellular response to nitrogen compound | 17.8571 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 16.0714 | 4 | yes |
GO:0014070 | response to organic cyclic compound | 16.0714 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 16.0714 | 5 | yes |
GO:0051129 | negative regulation of cellular component organization | 16.0714 | 5 | yes |
GO:0071407 | cellular response to organic cyclic compound | 16.0714 | 5 | yes |
GO:0071417 | cellular response to organonitrogen compound | 16.0714 | 4 | yes |
GO:0000165 | MAPK cascade | 14.2857 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 14.2857 | 5 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 14.2857 | 6 | yes |
GO:0033674 | positive regulation of kinase activity | 14.2857 | 6 | yes |
GO:0045596 | negative regulation of cell differentiation | 14.2857 | 5 | yes |
GO:0045860 | positive regulation of protein kinase activity | 14.2857 | 7 | yes |
GO:0051093 | negative regulation of developmental process | 14.2857 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 14.2857 | 4 | yes |
GO:0001885 | endothelial cell development | 12.5000 | 5 | yes |
GO:0043410 | positive regulation of MAPK cascade | 12.5000 | 7 | yes |
GO:0050767 | regulation of neurogenesis | 12.5000 | 6 | yes |
GO:0051960 | regulation of nervous system development | 12.5000 | 5 | yes |
GO:0060284 | regulation of cell development | 12.5000 | 5 | yes |
GO:0061028 | establishment of endothelial barrier | 12.5000 | 6 | yes |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 12.5000 | 7 | yes |
GO:0072657 | protein localization to membrane | 12.5000 | 4 | yes |
GO:0010942 | positive regulation of cell death | 10.7143 | 5 | yes |
GO:0010976 | positive regulation of neuron projection development | 10.7143 | 7 | yes |
GO:0043065 | positive regulation of apoptotic process | 10.7143 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 10.7143 | 6 | yes |
GO:0051345 | positive regulation of hydrolase activity | 10.7143 | 5 | yes |
GO:0070848 | response to growth factor | 10.7143 | 4 | yes |
GO:0071900 | regulation of protein serine/threonine kinase activity | 10.7143 | 7 | yes |
GO:0030335 | positive regulation of cell migration | 8.9286 | 6 | yes |
GO:0040017 | positive regulation of locomotion | 8.9286 | 4 | yes |
GO:0043087 | regulation of GTPase activity | 8.9286 | 5 | yes |
GO:0050773 | regulation of dendrite development | 8.9286 | 4 | yes |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 8.9286 | 8 | yes |
GO:0071363 | cellular response to growth factor stimulus | 8.9286 | 5 | yes |
GO:1901888 | regulation of cell junction assembly | 8.9286 | 5 | yes |
GO:2000147 | positive regulation of cell motility | 8.9286 | 5 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 7.1429 | 4 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 7.1429 | 5 | yes |
GO:0010721 | negative regulation of cell development | 7.1429 | 6 | yes |
GO:0014074 | response to purine-containing compound | 7.1429 | 5 | yes |
GO:0032486 | Rap protein signal transduction | 7.1429 | 6 | yes |
GO:0038179 | neurotrophin signaling pathway | 7.1429 | 4 | yes |
GO:0046683 | response to organophosphorus | 7.1429 | 4 | yes |
GO:0050768 | negative regulation of neurogenesis | 7.1429 | 6 | yes |
GO:0051961 | negative regulation of nervous system development | 7.1429 | 5 | yes |
GO:0090557 | establishment of endothelial intestinal barrier | 7.1429 | 7 | yes |
GO:0001764 | neuron migration | 5.3571 | 4 | yes |
GO:0030031 | cell projection assembly | 5.3571 | 5 | yes |
GO:0031345 | negative regulation of cell projection organization | 5.3571 | 6 | yes |
GO:0038180 | nerve growth factor signaling pathway | 5.3571 | 5 | yes |
GO:0043547 | positive regulation of GTPase activity | 5.3571 | 6 | yes |
GO:0048814 | regulation of dendrite morphogenesis | 5.3571 | 5 | yes |
GO:0051099 | positive regulation of binding | 5.3571 | 4 | yes |
GO:0051591 | response to cAMP | 5.3571 | 4 | yes |
GO:0071320 | cellular response to cAMP | 5.3571 | 5 | yes |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | 5.3571 | 8 | yes |
GO:0120031 | plasma membrane bounded cell projection assembly | 5.3571 | 6 | yes |
GO:1990090 | cellular response to nerve growth factor stimulus | 5.3571 | 4 | yes |
GO:1990778 | protein localization to cell periphery | 5.3571 | 5 | yes |
GO:2001222 | regulation of neuron migration | 5.3571 | 6 | yes |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 3.5714 | 4 | yes |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 3.5714 | 5 | yes |
GO:0048666 | neuron development | 3.5714 | 4 | yes |
GO:0050774 | negative regulation of dendrite morphogenesis | 3.5714 | 6 | yes |
GO:0070305 | response to cGMP | 3.5714 | 4 | yes |
GO:0071321 | cellular response to cGMP | 3.5714 | 5 | yes |
GO:0072659 | protein localization to plasma membrane | 3.5714 | 5 | yes |
GO:2000479 | regulation of cAMP-dependent protein kinase activity | 3.5714 | 8 | yes |
GO:2001212 | regulation of vasculogenesis | 3.5714 | 5 | yes |
GO:2001214 | positive regulation of vasculogenesis | 3.5714 | 6 | yes |
GO:2001224 | positive regulation of neuron migration | 3.5714 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in RPGF2_HUMAN |
---|---|---|---|---|
DOID:423 | myopathy | 5.3571 | 5 | no |
DOID:66 | muscle tissue disease | 5.3571 | 4 | no |
DOID:9884 | muscular dystrophy | 5.3571 | 6 | no |
DOID:0080000 | muscular disease | 5.3571 | 3 | no |
DOID:0050700 | cardiomyopathy | 3.5714 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 3.5714 | 5 | no |
DOID:114 | heart disease | 3.5714 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MAGI1_HUMAN | [view interactions] | Low throughput | no | no |
RAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCN7A_HUMAN | [view interactions] | Low throughput | no | no |
GNDS_HUMAN | [view interactions] | Low throughput | no | yes |
FBW1B_HUMAN | [view interactions] | Low throughput | no | yes |
FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
RAP2B_HUMAN | [view interactions] | Low throughput | no | no |
1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
RGAP1_HUMAN | [view interactions] | High throughput | no | no |
MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRM6_HUMAN | [view interactions] | High throughput | no | yes |
MESD_HUMAN | [view interactions] | High throughput | no | yes |
URFB1_HUMAN | [view interactions] | High throughput | no | no |
LLR1_HUMAN | [view interactions] | High throughput | no | yes |
Z512B_HUMAN | [view interactions] | High throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SR1IP_HUMAN | [view interactions] | High throughput | no | no |
ANO3_HUMAN | [view interactions] | High throughput | no | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
ATPMK_HUMAN | [view interactions] | High throughput | no | no |
ERI3_HUMAN | [view interactions] | High throughput | no | yes |
COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XIAP_HUMAN | [view interactions] | High throughput | no | yes |
VPS50_HUMAN | [view interactions] | High throughput | no | yes |
H31T_HUMAN | [view interactions] | High throughput | no | yes |
H15_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NED4L_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
ATP8_HUMAN | [view interactions] | High throughput | no | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PHOCN_HUMAN | [view interactions] | High throughput | no | yes |
OSTP_HUMAN | [view interactions] | High throughput | no | yes |
IL16_HUMAN | [view interactions] | High throughput | no | no |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E41L5_HUMAN | [view interactions] | High throughput | no | no |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
PTN13_HUMAN | [view interactions] | High throughput | no | yes |
FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCD17_HUMAN | [view interactions] | High throughput | no | yes |
MAGI3_HUMAN | [view interactions] | High throughput | no | no |
ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
HMCN1_HUMAN | [view interactions] | High throughput | no | no |
PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TITIN_HUMAN | [view interactions] | High throughput | no | no |
AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
VSIG8_HUMAN | [view interactions] | High throughput | no | no |
SNH28_HUMAN | [view interactions] | High throughput | no | no |
KPRA_HUMAN | [view interactions] | High throughput | no | no |
UBP11_HUMAN | [view interactions] | High throughput | no | yes |
WDR91_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BDP1_HUMAN | [view interactions] | High throughput | no | no |
SP14L_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
BRD8_HUMAN | [view interactions] | High throughput | no | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RPGF6_HUMAN | [view interactions] | High throughput | no | yes |
MAGA9_HUMAN | [view interactions] | High throughput | no | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
LPXN_HUMAN | [view interactions] | High throughput | no | yes |
OPHN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHG15_HUMAN | [view interactions] | High throughput | no | no |
RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG42_HUMAN | [view interactions] | High throughput | no | yes |
CHIO_HUMAN | [view interactions] | High throughput | no | yes |
DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RGF1B_HUMAN | [view interactions] | High throughput | no | no |
SRGP1_HUMAN | [view interactions] | High throughput | no | no |
RRAS2_HUMAN | [view interactions] | Computational | no | yes |
ZO2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RASM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RRAS_HUMAN | [view interactions] | Computational | no | yes |
RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RAP2C_HUMAN | [view entry] [view interactions] | Computational | yes | no |