Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RPGF2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed, PubMed) or not (PubMed, PubMed, PubMed). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RPGF2_HUMAN
GO:0003723 RNA binding 24.5283 4 no
GO:0000166 nucleotide binding 22.6415 4 yes
GO:0017076 purine nucleotide binding 22.6415 5 yes
GO:0032555 purine ribonucleotide binding 22.6415 4 yes
GO:0043168 anion binding 22.6415 4 yes
GO:0045296 cadherin binding 22.6415 4 no
GO:0019900 kinase binding 22.6415 4 no
GO:0030554 adenyl nucleotide binding 18.8679 6 yes
GO:0032559 adenyl ribonucleotide binding 18.8679 5 yes
GO:0043169 cation binding 18.8679 4 yes
GO:0046872 metal ion binding 18.8679 5 yes
GO:0030695 GTPase regulator activity 16.9811 4 yes
GO:0005096 GTPase activator activity 13.2075 4 yes
GO:0001664 G protein-coupled receptor binding 11.3208 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 7.5472 5 yes
GO:0031690 adrenergic receptor binding 7.5472 5 yes
GO:0031697 beta-1 adrenergic receptor binding 5.6604 6 yes
GO:0030165 PDZ domain binding 3.7736 4 yes
GO:0030551 cyclic nucleotide binding 3.7736 5 yes
GO:0030552 cAMP binding 3.7736 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RPGF2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 66.0377 4 yes
GO:0080090 regulation of primary metabolic process 62.2642 4 yes
GO:0048522 positive regulation of cellular process 60.3774 4 yes
GO:0031323 regulation of cellular metabolic process 58.4906 4 yes
GO:0048523 negative regulation of cellular process 58.4906 4 yes
GO:0010646 regulation of cell communication 56.6038 4 yes
GO:0051128 regulation of cellular component organization 54.7170 4 yes
GO:0051049 regulation of transport 49.0566 4 no
GO:0051246 regulation of protein metabolic process 49.0566 5 yes
GO:0008104 protein localization 47.1698 4 yes
GO:0009966 regulation of signal transduction 47.1698 4 yes
GO:0009889 regulation of biosynthetic process 41.5094 4 yes
GO:0006996 organelle organization 39.6226 4 no
GO:0010556 regulation of macromolecule biosynthetic process 39.6226 5 no
GO:0031326 regulation of cellular biosynthetic process 39.6226 5 no
GO:0009893 positive regulation of metabolic process 39.6226 4 yes
GO:0010468 regulation of gene expression 37.7358 6 no
GO:0009892 negative regulation of metabolic process 37.7358 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 37.7358 5 yes
GO:0010647 positive regulation of cell communication 37.7358 5 yes
GO:0023056 positive regulation of signaling 37.7358 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 35.8491 5 no
GO:0031325 positive regulation of cellular metabolic process 35.8491 5 yes
GO:0031399 regulation of protein modification process 35.8491 6 yes
GO:0048584 positive regulation of response to stimulus 33.9623 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.0755 5 no
GO:0031324 negative regulation of cellular metabolic process 32.0755 5 no
GO:0031344 regulation of cell projection organization 32.0755 5 yes
GO:0051130 positive regulation of cellular component organization 32.0755 5 yes
GO:0051247 positive regulation of protein metabolic process 32.0755 6 yes
GO:1902531 regulation of intracellular signal transduction 32.0755 5 yes
GO:0060341 regulation of cellular localization 30.1887 4 no
GO:0009967 positive regulation of signal transduction 30.1887 5 yes
GO:0019220 regulation of phosphate metabolic process 30.1887 6 yes
GO:0042981 regulation of apoptotic process 30.1887 5 yes
GO:0043067 regulation of programmed cell death 30.1887 4 yes
GO:0045595 regulation of cell differentiation 30.1887 4 yes
GO:0051174 regulation of phosphorus metabolic process 30.1887 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.1887 6 yes
GO:0051252 regulation of RNA metabolic process 28.3019 5 no
GO:0022603 regulation of anatomical structure morphogenesis 28.3019 4 yes
GO:0042127 regulation of cell population proliferation 28.3019 4 yes
GO:0050804 modulation of chemical synaptic transmission 28.3019 5 yes
GO:0071310 cellular response to organic substance 28.3019 4 yes
GO:0099177 regulation of trans-synaptic signaling 28.3019 4 yes
GO:0032880 regulation of protein localization 26.4151 5 no
GO:0043269 regulation of monoatomic ion transport 26.4151 5 no
GO:0051050 positive regulation of transport 26.4151 4 no
GO:0006355 regulation of DNA-templated transcription 26.4151 7 no
GO:2001141 regulation of RNA biosynthetic process 26.4151 6 no
GO:0010648 negative regulation of cell communication 26.4151 5 no
GO:0023057 negative regulation of signaling 26.4151 4 no
GO:0071702 organic substance transport 26.4151 4 no
GO:0009890 negative regulation of biosynthetic process 26.4151 5 yes
GO:0044087 regulation of cellular component biogenesis 26.4151 4 yes
GO:0051094 positive regulation of developmental process 26.4151 4 yes
GO:2000026 regulation of multicellular organismal development 24.5283 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 24.5283 6 no
GO:0031327 negative regulation of cellular biosynthetic process 24.5283 6 no
GO:0009968 negative regulation of signal transduction 24.5283 5 no
GO:0043066 negative regulation of apoptotic process 24.5283 6 no
GO:0043069 negative regulation of programmed cell death 24.5283 5 no
GO:0048585 negative regulation of response to stimulus 24.5283 4 no
GO:0071705 nitrogen compound transport 24.5283 4 no
GO:0001932 regulation of protein phosphorylation 24.5283 7 yes
GO:0010975 regulation of neuron projection development 24.5283 7 yes
GO:0042325 regulation of phosphorylation 24.5283 7 yes
GO:0141124 intracellular signaling cassette 24.5283 4 yes
GO:0009894 regulation of catabolic process 22.6415 4 no
GO:0034762 regulation of transmembrane transport 22.6415 4 no
GO:0051248 negative regulation of protein metabolic process 22.6415 6 no
GO:0009891 positive regulation of biosynthetic process 22.6415 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.6415 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.6415 6 no
GO:0043085 positive regulation of catalytic activity 22.6415 4 yes
GO:0051338 regulation of transferase activity 22.6415 4 yes
GO:1901701 cellular response to oxygen-containing compound 22.6415 4 yes
GO:0042176 regulation of protein catabolic process 20.7547 5 no
GO:0007010 cytoskeleton organization 20.7547 5 no
GO:0033043 regulation of organelle organization 20.7547 5 no
GO:0015031 protein transport 20.7547 4 no
GO:0051726 regulation of cell cycle 20.7547 4 no
GO:0008285 negative regulation of cell population proliferation 20.7547 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 20.7547 6 yes
GO:0022607 cellular component assembly 20.7547 4 yes
GO:0030030 cell projection organization 20.7547 4 yes
GO:0031401 positive regulation of protein modification process 20.7547 7 yes
GO:0043549 regulation of kinase activity 20.7547 5 yes
GO:0045859 regulation of protein kinase activity 20.7547 6 yes
GO:0045937 positive regulation of phosphate metabolic process 20.7547 7 yes
GO:2000145 regulation of cell motility 18.8679 4 yes
GO:0001934 positive regulation of protein phosphorylation 18.8679 8 yes
GO:0030334 regulation of cell migration 18.8679 5 yes
GO:0031175 neuron projection development 18.8679 6 yes
GO:0031346 positive regulation of cell projection organization 18.8679 6 yes
GO:0042327 positive regulation of phosphorylation 18.8679 8 yes
GO:0051336 regulation of hydrolase activity 18.8679 4 yes
GO:0060284 regulation of cell development 18.8679 5 yes
GO:0120036 plasma membrane bounded cell projection organization 18.8679 5 yes
GO:0043408 regulation of MAPK cascade 16.9811 6 yes
GO:0045597 positive regulation of cell differentiation 16.9811 5 yes
GO:0051129 negative regulation of cellular component organization 16.9811 5 yes
GO:0051347 positive regulation of transferase activity 16.9811 5 yes
GO:1902533 positive regulation of intracellular signal transduction 15.0943 6 yes
GO:0007264 small GTPase-mediated signal transduction 15.0943 5 yes
GO:0014070 response to organic cyclic compound 15.0943 4 yes
GO:0033674 positive regulation of kinase activity 15.0943 6 yes
GO:0045860 positive regulation of protein kinase activity 15.0943 7 yes
GO:0051241 negative regulation of multicellular organismal process 15.0943 4 yes
GO:0002064 epithelial cell development 13.2075 4 yes
GO:0010243 response to organonitrogen compound 13.2075 4 yes
GO:0045596 negative regulation of cell differentiation 13.2075 5 yes
GO:0050767 regulation of neurogenesis 13.2075 6 yes
GO:0051093 negative regulation of developmental process 13.2075 4 yes
GO:0051960 regulation of nervous system development 13.2075 5 yes
GO:0071407 cellular response to organic cyclic compound 13.2075 5 yes
GO:0071417 cellular response to organonitrogen compound 13.2075 4 yes
GO:0072657 protein localization to membrane 13.2075 4 yes
GO:1901699 cellular response to nitrogen compound 13.2075 4 yes
GO:0000165 MAPK cascade 11.3208 5 yes
GO:0006508 proteolysis 11.3208 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 11.3208 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 11.3208 5 yes
GO:0010976 positive regulation of neuron projection development 11.3208 7 yes
GO:0043065 positive regulation of apoptotic process 11.3208 6 yes
GO:0043068 positive regulation of programmed cell death 11.3208 5 yes
GO:0043410 positive regulation of MAPK cascade 11.3208 7 yes
GO:0050773 regulation of dendrite development 11.3208 4 yes
GO:0051345 positive regulation of hydrolase activity 11.3208 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 11.3208 7 yes
GO:2000147 positive regulation of cell motility 9.4340 5 yes
GO:0007265 Ras protein signal transduction 9.4340 6 yes
GO:0030335 positive regulation of cell migration 9.4340 6 yes
GO:0040017 positive regulation of locomotion 9.4340 4 yes
GO:0071363 cellular response to growth factor stimulus 9.4340 4 yes
GO:1901888 regulation of cell junction assembly 9.4340 5 yes
GO:0001885 endothelial cell development 7.5472 5 yes
GO:0010721 negative regulation of cell development 7.5472 6 yes
GO:0038179 neurotrophin signaling pathway 7.5472 4 yes
GO:0043087 regulation of GTPase activity 7.5472 5 yes
GO:0048814 regulation of dendrite morphogenesis 7.5472 5 yes
GO:0050768 negative regulation of neurogenesis 7.5472 6 yes
GO:0051961 negative regulation of nervous system development 7.5472 5 yes
GO:0061028 establishment of endothelial barrier 7.5472 6 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 7.5472 8 yes
GO:0071900 regulation of protein serine/threonine kinase activity 7.5472 7 yes
GO:1990089 response to nerve growth factor 5.6604 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 5.6604 5 yes
GO:1990778 protein localization to cell periphery 5.6604 5 yes
GO:2001222 regulation of neuron migration 5.6604 6 yes
GO:0001764 neuron migration 5.6604 4 yes
GO:0014074 response to purine-containing compound 5.6604 5 yes
GO:0030031 cell projection assembly 5.6604 5 yes
GO:0031345 negative regulation of cell projection organization 5.6604 6 yes
GO:0038180 nerve growth factor signaling pathway 5.6604 5 yes
GO:0043547 positive regulation of GTPase activity 5.6604 6 yes
GO:0046683 response to organophosphorus 5.6604 4 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 5.6604 8 yes
GO:0120031 plasma membrane bounded cell projection assembly 5.6604 6 yes
GO:2000479 regulation of cAMP-dependent protein kinase activity 3.7736 8 yes
GO:2001212 regulation of vasculogenesis 3.7736 5 yes
GO:2001214 positive regulation of vasculogenesis 3.7736 6 yes
GO:2001224 positive regulation of neuron migration 3.7736 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 3.7736 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 3.7736 5 yes
GO:0032486 Rap protein signal transduction 3.7736 6 yes
GO:0048666 neuron development 3.7736 4 yes
GO:0050774 negative regulation of dendrite morphogenesis 3.7736 6 yes
GO:0051591 response to cAMP 3.7736 4 yes
GO:0070305 response to cGMP 3.7736 4 yes
GO:0071320 cellular response to cAMP 3.7736 5 yes
GO:0071321 cellular response to cGMP 3.7736 5 yes
GO:0072659 protein localization to plasma membrane 3.7736 5 yes
GO:0090557 establishment of endothelial intestinal barrier 3.7736 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI1_HUMAN [view interactions] Low throughput no no
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN7A_HUMAN [view interactions] Low throughput no no
GNDS_HUMAN [view interactions] Low throughput no yes
FBW1B_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
RAP2B_HUMAN [view interactions] Low throughput no no
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
RGAP1_HUMAN [view interactions] High throughput no no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
XIAP_HUMAN [view interactions] High throughput no yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
ERI3_HUMAN [view interactions] High throughput no yes
ATPMK_HUMAN [view interactions] High throughput no no
SEC62_HUMAN [view interactions] High throughput no yes
ANO3_HUMAN [view interactions] High throughput no yes
MESD_HUMAN [view interactions] High throughput no yes
SR1IP_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
Z512B_HUMAN [view interactions] High throughput no yes
LLR1_HUMAN [view interactions] High throughput no yes
BLT3A_HUMAN [view interactions] High throughput no no
TRM6_HUMAN [view interactions] High throughput no yes
VPS50_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
H31T_HUMAN [view interactions] High throughput no yes
H15_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
ATP8_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
OSTP_HUMAN [view interactions] High throughput no yes
IL16_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
E41L5_HUMAN [view interactions] High throughput no no
KIF11_HUMAN [view interactions] High throughput no yes
PTN13_HUMAN [view interactions] High throughput no yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
SCYL2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
KCD17_HUMAN [view interactions] High throughput no yes
MAGI3_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
CTTB2_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD5_HUMAN [view interactions] High throughput no no
HMCN1_HUMAN [view interactions] High throughput no no
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
TITIN_HUMAN [view interactions] High throughput no no
AMPL_HUMAN [view entry] [view interactions] High throughput yes no
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
TNKS1_HUMAN [view interactions] High throughput no yes
VSIG8_HUMAN [view interactions] High throughput no no
SNH28_HUMAN [view interactions] High throughput no no
KPRA_HUMAN [view interactions] High throughput no no
UBP11_HUMAN [view interactions] High throughput no yes
WDR91_HUMAN [view entry] [view interactions] High throughput yes no
BDP1_HUMAN [view interactions] High throughput no no
SP14L_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
BRD8_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RPGF6_HUMAN [view interactions] High throughput no yes
MAGA9_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
LPXN_HUMAN [view interactions] High throughput no yes
OPHN1_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
RHG15_HUMAN [view interactions] High throughput no no
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG42_HUMAN [view interactions] High throughput no yes
CHIO_HUMAN [view interactions] High throughput no yes
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF4_HUMAN [view entry] [view interactions] High throughput yes yes
RGF1B_HUMAN [view interactions] High throughput no no
SRGP1_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
ARL16_HUMAN [view interactions] High throughput no no
NUP43_HUMAN [view interactions] High throughput no yes