Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KLH17_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KLH17_HUMAN
GO:0000166 nucleotide binding 35.7143 4 no
GO:0017076 purine nucleotide binding 35.7143 5 no
GO:0032555 purine ribonucleotide binding 35.7143 4 no
GO:0043168 anion binding 35.7143 4 no
GO:0031625 ubiquitin protein ligase binding 28.5714 5 no
GO:0044389 ubiquitin-like protein ligase binding 28.5714 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0031208 POZ domain binding 21.4286 4 yes
GO:0005524 ATP binding 21.4286 5 no
GO:0019901 protein kinase binding 21.4286 5 no
GO:0030695 GTPase regulator activity 21.4286 4 no
GO:0003779 actin binding 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KLH17_HUMAN
GO:0006996 organelle organization 57.1429 4 yes
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0007010 cytoskeleton organization 42.8571 5 yes
GO:0008104 protein localization 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0006915 apoptotic process 35.7143 4 no
GO:0009966 regulation of signal transduction 35.7143 4 no
GO:0010647 positive regulation of cell communication 35.7143 5 no
GO:0023056 positive regulation of signaling 35.7143 4 no
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0022607 cellular component assembly 35.7143 4 no
GO:0030030 cell projection organization 35.7143 4 no
GO:0031323 regulation of cellular metabolic process 35.7143 4 no
GO:0048584 positive regulation of response to stimulus 35.7143 4 no
GO:0060255 regulation of macromolecule metabolic process 35.7143 4 no
GO:0016567 protein ubiquitination 28.5714 8 yes
GO:0032446 protein modification by small protein conjugation 28.5714 7 yes
GO:0036211 protein modification process 28.5714 4 yes
GO:0043412 macromolecule modification 28.5714 4 yes
GO:0043687 post-translational protein modification 28.5714 5 yes
GO:0070647 protein modification by small protein conjugation or removal 28.5714 6 yes
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0048812 neuron projection morphogenesis 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0034330 cell junction organization 28.5714 4 no
GO:0007264 small GTPase-mediated signal transduction 28.5714 5 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:0009894 regulation of catabolic process 21.4286 4 yes
GO:0140250 regulation protein catabolic process at synapse 21.4286 5 yes
GO:0140252 regulation protein catabolic process at postsynapse 21.4286 6 yes
GO:0007268 chemical synaptic transmission 21.4286 7 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0043113 receptor clustering 21.4286 5 no
GO:0043523 regulation of neuron apoptotic process 21.4286 6 no
GO:0043524 negative regulation of neuron apoptotic process 21.4286 7 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0048168 regulation of neuronal synaptic plasticity 21.4286 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 21.4286 5 no
GO:0051402 neuron apoptotic process 21.4286 5 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0098916 anterograde trans-synaptic signaling 21.4286 6 no
GO:0099536 synaptic signaling 21.4286 4 no
GO:0099537 trans-synaptic signaling 21.4286 5 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0030100 regulation of endocytosis 21.4286 5 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:1902414 protein localization to cell junction 21.4286 5 no
GO:0006355 regulation of DNA-templated transcription 21.4286 7 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010564 regulation of cell cycle process 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0031032 actomyosin structure organization 21.4286 4 no
GO:0042127 regulation of cell population proliferation 21.4286 4 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0002009 morphogenesis of an epithelium 21.4286 4 no
GO:0007043 cell-cell junction assembly 21.4286 6 no
GO:0007409 axonogenesis 21.4286 6 no
GO:0010810 regulation of cell-substrate adhesion 21.4286 5 no
GO:0030334 regulation of cell migration 21.4286 5 no
GO:0030335 positive regulation of cell migration 21.4286 6 no
GO:0034329 cell junction assembly 21.4286 5 no
GO:0040017 positive regulation of locomotion 21.4286 4 no
GO:0045216 cell-cell junction organization 21.4286 5 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:2000147 positive regulation of cell motility 21.4286 5 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0045785 positive regulation of cell adhesion 21.4286 5 no
GO:0060284 regulation of cell development 21.4286 5 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NHRF3_HUMAN [view interactions] Low throughput no no
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
KLH17_HUMAN [view entry] [view interactions] Low throughput yes no
ACTG_HUMAN [view entry] [view interactions] Low throughput yes yes
PDZ1P_HUMAN [view interactions] High throughput no no
PGS2_HUMAN [view interactions] High throughput no no
KLH12_HUMAN [view interactions] High throughput no no
FXL17_HUMAN [view interactions] High throughput no yes
KLHL2_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
KLHL3_HUMAN [view interactions] High throughput no no
PGTA_HUMAN [view interactions] High throughput no yes
TKFC_HUMAN [view interactions] High throughput no no
TSN5_HUMAN [view interactions] High throughput no no
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
KLH18_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
KLHL8_HUMAN [view interactions] High throughput no no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
NS1BP_HUMAN [view interactions] High throughput no yes
KLH11_HUMAN [view interactions] High throughput no yes
KBTB8_HUMAN [view interactions] High throughput no no
KLH23_HUMAN [view interactions] High throughput no no
CTR2_HUMAN [view interactions] High throughput no no
SPOPL_HUMAN [view interactions] High throughput no yes
TIM44_HUMAN [view interactions] High throughput no yes
KLH29_HUMAN [view interactions] High throughput no yes
KLH38_HUMAN [view interactions] High throughput no no
KLHL7_HUMAN [view interactions] High throughput no yes
KLHL9_HUMAN [view interactions] High throughput no no
ANPRB_HUMAN [view interactions] High throughput no no
RPGF4_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no