Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

XRCC1_HUMAN

Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
431 Lys Asn Spinocerebellarataxia,autosomalrecessive,26(SCAR26) -
ELM instance Name Type Start End Partner
ELMI000986 LIG_FHA_2 LIG 521 527 -
ELMI002139 MOD_CK2_1 MOD 515 521 -
ELMI002166 MOD_CK2_1 MOD 520 526 -
ELMI000959 MOD_PIKK_1 MOD 368 374 -
ELMI000986 LIG_FHA_2 LIG 521 527 -
ELMI002139 MOD_CK2_1 MOD 515 521 -
ELMI002166 MOD_CK2_1 MOD 520 526 -
ELMI000959 MOD_PIKK_1 MOD 368 374 -

Molecular function

Term Name % Distance from the top of the tree Annotated in XRCC1_HUMAN
GO:0000166 nucleotide binding 44.8276 4 no
GO:0017076 purine nucleotide binding 41.3793 5 no
GO:0043168 anion binding 41.3793 4 no
GO:0032555 purine ribonucleotide binding 37.9310 4 no
GO:0003723 RNA binding 37.9310 4 no
GO:0035639 purine ribonucleoside triphosphate binding 34.4828 4 no
GO:0030554 adenyl nucleotide binding 31.0345 6 no
GO:0032559 adenyl ribonucleotide binding 27.5862 5 no
GO:0003677 DNA binding 24.1379 4 yes
GO:0005524 ATP binding 24.1379 5 no
GO:0043169 cation binding 24.1379 4 no
GO:0046872 metal ion binding 24.1379 5 no
GO:0016301 kinase activity 20.6897 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.6897 4 no
GO:0003684 damaged DNA binding 13.7931 5 yes
GO:0000014 single-stranded DNA endodeoxyribonuclease activity 6.8966 6 yes
GO:0004518 nuclease activity 6.8966 4 yes
GO:0004519 endonuclease activity 6.8966 5 yes
GO:0004520 DNA endonuclease activity 6.8966 5 yes
GO:0004536 DNA nuclease activity 6.8966 4 yes
GO:0032356 oxidized DNA binding 6.8966 6 yes
GO:0160002 ADP-D-ribose modification-dependent protein binding 6.8966 4 yes
GO:1990599 3 overhang single-stranded DNA endodeoxyribonuclease activity 6.8966 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in XRCC1_HUMAN
GO:0048522 positive regulation of cellular process 72.4138 4 yes
GO:0048523 negative regulation of cellular process 65.5172 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.5172 4 yes
GO:0080090 regulation of primary metabolic process 65.5172 4 yes
GO:0051128 regulation of cellular component organization 58.6207 4 yes
GO:0009893 positive regulation of metabolic process 51.7241 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 51.7241 5 yes
GO:0031323 regulation of cellular metabolic process 48.2759 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 48.2759 5 yes
GO:0009889 regulation of biosynthetic process 44.8276 4 no
GO:0010468 regulation of gene expression 44.8276 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.8276 5 no
GO:0031326 regulation of cellular biosynthetic process 44.8276 5 no
GO:0006996 organelle organization 44.8276 4 yes
GO:0009892 negative regulation of metabolic process 44.8276 4 yes
GO:0090304 nucleic acid metabolic process 44.8276 4 yes
GO:0009966 regulation of signal transduction 44.8276 4 no
GO:0010646 regulation of cell communication 44.8276 4 no
GO:0042981 regulation of apoptotic process 41.3793 5 no
GO:0043067 regulation of programmed cell death 41.3793 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.3793 5 yes
GO:0048584 positive regulation of response to stimulus 41.3793 4 yes
GO:0048585 negative regulation of response to stimulus 41.3793 4 yes
GO:0051246 regulation of protein metabolic process 37.9310 5 no
GO:0022607 cellular component assembly 37.9310 4 no
GO:0008104 protein localization 37.9310 4 no
GO:0031324 negative regulation of cellular metabolic process 34.4828 5 no
GO:0031325 positive regulation of cellular metabolic process 34.4828 5 no
GO:0043933 protein-containing complex organization 34.4828 4 no
GO:0032880 regulation of protein localization 34.4828 5 no
GO:0060341 regulation of cellular localization 34.4828 4 no
GO:0051129 negative regulation of cellular component organization 34.4828 5 yes
GO:0080134 regulation of response to stress 34.4828 4 yes
GO:1901701 cellular response to oxygen-containing compound 31.0345 4 no
GO:1902531 regulation of intracellular signal transduction 31.0345 5 no
GO:0009968 negative regulation of signal transduction 31.0345 5 no
GO:0010648 negative regulation of cell communication 31.0345 5 no
GO:0023057 negative regulation of signaling 31.0345 4 no
GO:0036211 protein modification process 31.0345 4 no
GO:0043412 macromolecule modification 31.0345 4 no
GO:0051247 positive regulation of protein metabolic process 31.0345 6 no
GO:0065003 protein-containing complex assembly 31.0345 5 no
GO:0006259 DNA metabolic process 31.0345 5 yes
GO:0051052 regulation of DNA metabolic process 31.0345 5 yes
GO:0010243 response to organonitrogen compound 31.0345 4 no
GO:0071310 cellular response to organic substance 31.0345 4 no
GO:1901699 cellular response to nitrogen compound 27.5862 4 no
GO:0006796 phosphate-containing compound metabolic process 27.5862 4 no
GO:0009890 negative regulation of biosynthetic process 27.5862 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 27.5862 6 no
GO:0031327 negative regulation of cellular biosynthetic process 27.5862 6 no
GO:0006355 regulation of DNA-templated transcription 27.5862 7 no
GO:0051252 regulation of RNA metabolic process 27.5862 5 no
GO:2001141 regulation of RNA biosynthetic process 27.5862 6 no
GO:0051240 positive regulation of multicellular organismal process 27.5862 4 no
GO:0043085 positive regulation of catalytic activity 27.5862 4 yes
GO:0006915 apoptotic process 24.1379 4 no
GO:0009894 regulation of catabolic process 24.1379 4 no
GO:0042127 regulation of cell population proliferation 24.1379 4 no
GO:0043066 negative regulation of apoptotic process 24.1379 6 no
GO:0043069 negative regulation of programmed cell death 24.1379 5 no
GO:0009891 positive regulation of biosynthetic process 24.1379 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.1379 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.1379 6 no
GO:0015031 protein transport 24.1379 4 no
GO:0033365 protein localization to organelle 24.1379 5 no
GO:0071702 organic substance transport 24.1379 4 no
GO:0071705 nitrogen compound transport 24.1379 4 no
GO:0050776 regulation of immune response 24.1379 4 no
GO:1903829 positive regulation of protein localization 24.1379 5 no
GO:0043068 positive regulation of programmed cell death 24.1379 5 no
GO:0006974 DNA damage response 24.1379 4 yes
GO:0010639 negative regulation of organelle organization 24.1379 6 yes
GO:0033043 regulation of organelle organization 24.1379 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 24.1379 5 yes
GO:0051276 chromosome organization 24.1379 5 yes
GO:0009967 positive regulation of signal transduction 24.1379 5 no
GO:0010647 positive regulation of cell communication 24.1379 5 no
GO:0023056 positive regulation of signaling 24.1379 4 no
GO:0051049 regulation of transport 24.1379 4 no
GO:0071417 cellular response to organonitrogen compound 24.1379 4 no
GO:0010629 negative regulation of gene expression 20.6897 7 no
GO:0016310 phosphorylation 20.6897 5 no
GO:0018193 peptidyl-amino acid modification 20.6897 5 no
GO:0030162 regulation of proteolysis 20.6897 6 no
GO:0051726 regulation of cell cycle 20.6897 4 no
GO:0006357 regulation of transcription by RNA polymerase II 20.6897 8 no
GO:0031344 regulation of cell projection organization 20.6897 5 no
GO:0051241 negative regulation of multicellular organismal process 20.6897 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:0070201 regulation of establishment of protein localization 20.6897 6 no
GO:0019220 regulation of phosphate metabolic process 20.6897 6 no
GO:0031399 regulation of protein modification process 20.6897 6 no
GO:0051174 regulation of phosphorus metabolic process 20.6897 5 no
GO:0016070 RNA metabolic process 20.6897 5 no
GO:0043065 positive regulation of apoptotic process 20.6897 6 no
GO:0051094 positive regulation of developmental process 20.6897 4 no
GO:0006281 DNA repair 20.6897 5 yes
GO:0006302 double-strand break repair 20.6897 6 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 20.6897 5 yes
GO:0051054 positive regulation of DNA metabolic process 20.6897 6 yes
GO:0051338 regulation of transferase activity 20.6897 4 yes
GO:0080135 regulation of cellular response to stress 20.6897 4 yes
GO:0014070 response to organic cyclic compound 20.6897 4 no
GO:0044087 regulation of cellular component biogenesis 20.6897 4 no
GO:0051130 positive regulation of cellular component organization 20.6897 5 no
GO:0000723 telomere maintenance 17.2414 6 yes
GO:0006282 regulation of DNA repair 17.2414 5 yes
GO:0032200 telomere organization 17.2414 6 yes
GO:0033044 regulation of chromosome organization 17.2414 6 yes
GO:0043086 negative regulation of catalytic activity 17.2414 4 yes
GO:0006303 double-strand break repair via nonhomologous end joining 13.7931 7 yes
GO:0032204 regulation of telomere maintenance 13.7931 6 yes
GO:0036293 response to decreased oxygen levels 13.7931 4 yes
GO:0045739 positive regulation of DNA repair 13.7931 5 yes
GO:0051053 negative regulation of DNA metabolic process 13.7931 6 yes
GO:0006310 DNA recombination 10.3448 6 yes
GO:0032205 negative regulation of telomere maintenance 10.3448 7 yes
GO:0051348 negative regulation of transferase activity 10.3448 5 yes
GO:1903516 regulation of single strand break repair 10.3448 6 yes
GO:1903518 positive regulation of single strand break repair 10.3448 6 yes
GO:2001251 negative regulation of chromosome organization 10.3448 7 yes
GO:0000012 single strand break repair 6.8966 6 yes
GO:0000722 telomere maintenance via recombination 6.8966 7 yes
GO:0000724 double-strand break repair via homologous recombination 6.8966 7 yes
GO:0000725 recombinational repair 6.8966 6 yes
GO:0006284 base-excision repair 6.8966 6 yes
GO:0006312 mitotic recombination 6.8966 7 yes
GO:0010835 regulation of protein ADP-ribosylation 6.8966 5 yes
GO:0010836 negative regulation of protein ADP-ribosylation 6.8966 6 yes
GO:0033194 response to hydroperoxide 6.8966 4 yes
GO:0050882 voluntary musculoskeletal movement 6.8966 4 yes
GO:0050905 neuromuscular process 6.8966 4 yes
GO:0051105 regulation of DNA ligation 6.8966 6 yes
GO:0051106 positive regulation of DNA ligation 6.8966 7 yes
GO:0051340 regulation of ligase activity 6.8966 4 yes
GO:0051351 positive regulation of ligase activity 6.8966 5 yes
GO:0061819 telomeric DNA-containing double minutes formation 6.8966 8 yes
GO:1904353 regulation of telomere capping 6.8966 7 yes
GO:1904354 negative regulation of telomere capping 6.8966 8 yes
GO:1904505 regulation of telomere maintenance in response to DNA damage 6.8966 5 yes
GO:1904506 negative regulation of telomere maintenance in response to DNA damage 6.8966 5 yes
GO:1904875 regulation of DNA ligase activity 6.8966 5 yes
GO:1904877 positive regulation of DNA ligase activity 6.8966 6 yes
GO:1905764 regulation of protection from non-homologous end joining at telomere 6.8966 6 yes
GO:1905765 negative regulation of protection from non-homologous end joining at telomere 6.8966 6 yes
GO:1990414 replication-born double-strand break repair via sister chromatid exchange 6.8966 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NEIL1_HUMAN [view interactions] Low throughput no yes
UHRF2_HUMAN [view interactions] Low throughput no no
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
REV1_HUMAN [view interactions] Low throughput no yes
XRCC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SP100_HUMAN [view interactions] Low throughput no no
PML_HUMAN [view interactions] Low throughput no yes
ORC5_HUMAN [view interactions] Low throughput no yes
IMA1_HUMAN [view entry] [view interactions] Low throughput yes yes
APTX_HUMAN [view interactions] Low throughput no yes
APLF_HUMAN [view interactions] Low throughput no no
DPOLB_HUMAN [view interactions] Low throughput no yes
CHK2_HUMAN [view interactions] Low throughput no yes
3MG_HUMAN [view interactions] Low throughput no yes
CCNO_HUMAN [view interactions] Low throughput no no
DPOLL_HUMAN [view interactions] Low throughput no no
PARP1_HUMAN [view entry] [view interactions] Low throughput yes yes
POLI_HUMAN [view interactions] Low throughput no yes
PNKP_HUMAN [view interactions] Low throughput no yes
DNLI3_HUMAN [view interactions] Low throughput no yes
RN146_HUMAN [view interactions] Low throughput no yes
TYDP1_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
APEX1_HUMAN [view interactions] Low throughput no yes
H2AX_HUMAN [view interactions] Low throughput no yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
OGG1_HUMAN [view interactions] Low throughput no yes
PCNA_HUMAN [view interactions] Low throughput no no
PARP2_HUMAN [view interactions] Low throughput no yes
CHD1L_HUMAN [view interactions] Low throughput no yes
CND3_HUMAN [view interactions] Low throughput no yes
RAN_HUMAN [view entry] [view interactions] Low throughput yes no
PRAF3_HUMAN [view interactions] Low throughput no yes
XPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
TOPRS_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
SIR1_HUMAN [view interactions] Low throughput no yes
PELI1_HUMAN [view interactions] Low throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
CCL3_HUMAN [view interactions] High throughput no no
H2A1_HUMAN [view interactions] High throughput no yes
VNN1_HUMAN [view interactions] High throughput no no
EMX2_HUMAN [view interactions] High throughput no yes
DLX6_HUMAN [view interactions] High throughput no no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
CF062_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
EFNA2_HUMAN [view interactions] High throughput no no
ST7_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
RD23B_HUMAN [view interactions] High throughput no yes
TDG_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
SKP2_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
MRE11_HUMAN [view interactions] High throughput no yes
DPOLQ_HUMAN [view interactions] High throughput no no
H2B2E_HUMAN [view interactions] High throughput no yes
HMGN5_HUMAN [view interactions] High throughput no no
NUMA1_HUMAN [view interactions] High throughput no yes
TOPK_HUMAN [view interactions] High throughput no no
SSRP1_HUMAN [view interactions] High throughput no yes
TOP1_HUMAN [view interactions] High throughput no yes
FOXA1_HUMAN [view interactions] High throughput no no
E2F4_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
SUH_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SMC5_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
PARG_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
SEP11_HUMAN [view entry] [view interactions] High throughput yes yes
RBM4_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
S10AG_HUMAN [view interactions] High throughput no no
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
RM12_HUMAN [view interactions] High throughput no yes
TIM_HUMAN [view interactions] High throughput no yes
RECQ1_HUMAN [view interactions] High throughput no yes
SMC2_HUMAN [view interactions] High throughput no yes
CND2_HUMAN [view interactions] High throughput no no
CND1_HUMAN [view interactions] High throughput no yes
SMC4_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
RPA34_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
TE2IP_HUMAN [view interactions] High throughput no yes
ZN330_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SNR40_HUMAN [view interactions] High throughput no yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
TF2L1_HUMAN [view interactions] High throughput no yes
AIM2_HUMAN [view interactions] High throughput no no
TPX2_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
CDKA1_HUMAN [view interactions] High throughput no yes
JUNB_HUMAN [view interactions] High throughput no yes
S39AA_HUMAN [view interactions] High throughput no no
SF3B6_HUMAN [view interactions] High throughput no yes
PPIH_HUMAN [view interactions] High throughput no yes
GCC1_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
DPH7_HUMAN [view interactions] High throughput no no
M3K20_HUMAN [view interactions] High throughput no yes
RUSD4_HUMAN [view interactions] High throughput no yes
XPOT_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
KSR2_HUMAN [view interactions] High throughput no yes
H2B1A_HUMAN [view interactions] High throughput no no
RN166_HUMAN [view interactions] High throughput no no
PCDBB_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
SRF_HUMAN [view interactions] High throughput no yes
GRHL1_HUMAN [view interactions] High throughput no yes
ARGL1_HUMAN [view interactions] High throughput no yes
MAX_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
IRF2_HUMAN [view interactions] High throughput no yes
MB212_HUMAN [view interactions] High throughput no no
SSBP3_HUMAN [view interactions] High throughput no no
TBCK_HUMAN [view interactions] High throughput no yes
KLF10_HUMAN [view interactions] High throughput no no
KLF6_HUMAN [view interactions] High throughput no yes
GATA4_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
LITD1_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
P5F1B_HUMAN [view interactions] High throughput no no
PO5F1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CREB1_HUMAN [view interactions] High throughput no yes
FOXB1_HUMAN [view interactions] High throughput no no
FOXD3_HUMAN [view interactions] High throughput no no
FOXP1_HUMAN [view interactions] High throughput no yes
H2AZ_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
H31_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1C_HUMAN [view interactions] High throughput no yes
CC14B_HUMAN [view interactions] High throughput no no
POLK_HUMAN [view interactions] High throughput no no
DPOD1_HUMAN [view interactions] High throughput no yes
CEBPB_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BRPF1_HUMAN [view interactions] High throughput no yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
GT2D1_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
NFAC2_HUMAN [view interactions] High throughput no yes
CTIP_HUMAN [view interactions] High throughput no no
NKX21_HUMAN [view interactions] High throughput no no
CRBN_HUMAN [view interactions] High throughput no yes
CDX2_HUMAN [view interactions] High throughput no no
ERR2_HUMAN [view interactions] High throughput no no
H2A1B_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes