TAOK1_HUMAN
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating Thr-208 of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. [View more on UniProt]
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Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
17 | Glu | Gly | Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) | - |
111 | Ser | Phe | Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) | - |
150 | Arg | Ile | Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) | - |
167 | Leu | Arg | Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) | - |
298 | Lys | Glu | Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) | - |
305 | Asp | Ala | Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) | - |
548 | Leu | Pro | Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TAOK1_HUMAN |
---|---|---|---|---|
GO:0016301 | kinase activity | 50.0000 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 50.0000 | 4 | yes |
GO:0017076 | purine nucleotide binding | 50.0000 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 42.8571 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 42.8571 | 4 | yes |
GO:0005524 | ATP binding | 42.8571 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 42.8571 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 42.8571 | 5 | yes |
GO:0106310 | protein serine kinase activity | 42.8571 | 4 | yes |
GO:0019900 | kinase binding | 42.8571 | 4 | no |
GO:0019887 | protein kinase regulator activity | 35.7143 | 4 | yes |
GO:0019901 | protein kinase binding | 35.7143 | 5 | no |
GO:0019209 | kinase activator activity | 21.4286 | 4 | yes |
GO:0030295 | protein kinase activator activity | 21.4286 | 5 | yes |
GO:0048156 | tau protein binding | 21.4286 | 4 | yes |
GO:0050321 | tau-protein kinase activity | 21.4286 | 4 | yes |
GO:0045296 | cadherin binding | 21.4286 | 4 | no |
GO:0003723 | RNA binding | 21.4286 | 4 | no |
GO:0015631 | tubulin binding | 14.2857 | 4 | yes |
GO:0043539 | protein serine/threonine kinase activator activity | 14.2857 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TAOK1_HUMAN |
---|---|---|---|---|
GO:0051171 | regulation of nitrogen compound metabolic process | 85.7143 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 85.7143 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 85.7143 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 78.5714 | 4 | no |
GO:0010646 | regulation of cell communication | 71.4286 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 71.4286 | 4 | yes |
GO:0009966 | regulation of signal transduction | 64.2857 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 64.2857 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 64.2857 | 5 | yes |
GO:0008104 | protein localization | 57.1429 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 50.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
GO:0016310 | phosphorylation | 50.0000 | 5 | yes |
GO:0031399 | regulation of protein modification process | 50.0000 | 6 | yes |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 50.0000 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 50.0000 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 50.0000 | 5 | no |
GO:0006468 | protein phosphorylation | 42.8571 | 5 | yes |
GO:0036211 | protein modification process | 42.8571 | 4 | yes |
GO:0043412 | macromolecule modification | 42.8571 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 42.8571 | 5 | no |
GO:0042325 | regulation of phosphorylation | 42.8571 | 7 | no |
GO:0071310 | cellular response to organic substance | 35.7143 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 35.7143 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 35.7143 | 5 | yes |
GO:0023056 | positive regulation of signaling | 35.7143 | 4 | yes |
GO:0030030 | cell projection organization | 35.7143 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 35.7143 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 35.7143 | 6 | yes |
GO:0051726 | regulation of cell cycle | 35.7143 | 4 | yes |
GO:0006886 | intracellular protein transport | 35.7143 | 4 | no |
GO:0010468 | regulation of gene expression | 35.7143 | 5 | no |
GO:0015031 | protein transport | 35.7143 | 4 | no |
GO:0045595 | regulation of cell differentiation | 35.7143 | 4 | no |
GO:0071702 | organic substance transport | 35.7143 | 4 | no |
GO:0071705 | nitrogen compound transport | 35.7143 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 35.7143 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 35.7143 | 4 | no |
GO:0043549 | regulation of kinase activity | 35.7143 | 5 | no |
GO:0051338 | regulation of transferase activity | 35.7143 | 4 | no |
GO:0043393 | regulation of protein binding | 28.5714 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 28.5714 | 4 | no |
GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
GO:0006996 | organelle organization | 28.5714 | 4 | yes |
GO:0007010 | cytoskeleton organization | 28.5714 | 5 | yes |
GO:0007346 | regulation of mitotic cell cycle | 28.5714 | 5 | yes |
GO:0010564 | regulation of cell cycle process | 28.5714 | 5 | yes |
GO:0031401 | positive regulation of protein modification process | 28.5714 | 7 | yes |
GO:0033043 | regulation of organelle organization | 28.5714 | 5 | yes |
GO:0043408 | regulation of MAPK cascade | 28.5714 | 6 | yes |
GO:0043410 | positive regulation of MAPK cascade | 28.5714 | 7 | yes |
GO:0046777 | protein autophosphorylation | 28.5714 | 6 | yes |
GO:0051493 | regulation of cytoskeleton organization | 28.5714 | 6 | yes |
GO:0090304 | nucleic acid metabolic process | 28.5714 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 28.5714 | 6 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
GO:0021762 | substantia nigra development | 28.5714 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 28.5714 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 28.5714 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 28.5714 | 4 | no |
GO:0006605 | protein targeting | 28.5714 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 28.5714 | 6 | no |
GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
GO:0033674 | positive regulation of kinase activity | 28.5714 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 28.5714 | 8 | no |
GO:0045859 | regulation of protein kinase activity | 28.5714 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 28.5714 | 7 | no |
GO:0051347 | positive regulation of transferase activity | 28.5714 | 5 | no |
GO:0018209 | peptidyl-serine modification | 21.4286 | 6 | no |
GO:0031175 | neuron projection development | 21.4286 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 21.4286 | 5 | no |
GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 21.4286 | 4 | no |
GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 21.4286 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 21.4286 | 7 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 21.4286 | 7 | no |
GO:0051248 | negative regulation of protein metabolic process | 21.4286 | 6 | no |
GO:0071417 | cellular response to organonitrogen compound | 21.4286 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 21.4286 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 21.4286 | 5 | no |
GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 21.4286 | 4 | no |
GO:1903829 | positive regulation of protein localization | 21.4286 | 5 | no |
GO:0000165 | MAPK cascade | 21.4286 | 4 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 21.4286 | 4 | yes |
GO:0032872 | regulation of stress-activated MAPK cascade | 21.4286 | 6 | yes |
GO:0032874 | positive regulation of stress-activated MAPK cascade | 21.4286 | 7 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 21.4286 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 21.4286 | 4 | yes |
GO:0032990 | cell part morphogenesis | 21.4286 | 4 | yes |
GO:0046328 | regulation of JNK cascade | 21.4286 | 7 | yes |
GO:0046330 | positive regulation of JNK cascade | 21.4286 | 8 | yes |
GO:0048812 | neuron projection morphogenesis | 21.4286 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 21.4286 | 5 | yes |
GO:0051129 | negative regulation of cellular component organization | 21.4286 | 5 | yes |
GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 21.4286 | 5 | yes |
GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 21.4286 | 6 | yes |
GO:0080134 | regulation of response to stress | 21.4286 | 4 | yes |
GO:0080135 | regulation of cellular response to stress | 21.4286 | 4 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 21.4286 | 6 | yes |
GO:1901987 | regulation of cell cycle phase transition | 21.4286 | 6 | yes |
GO:1901990 | regulation of mitotic cell cycle phase transition | 21.4286 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
GO:0031344 | regulation of cell projection organization | 21.4286 | 5 | no |
GO:0045664 | regulation of neuron differentiation | 21.4286 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.4286 | 6 | no |
GO:0051049 | regulation of transport | 21.4286 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.4286 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 21.4286 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
GO:0001558 | regulation of cell growth | 21.4286 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 21.4286 | 8 | no |
GO:0022604 | regulation of cell morphogenesis | 21.4286 | 5 | no |
GO:0045860 | positive regulation of protein kinase activity | 21.4286 | 7 | no |
GO:0016055 | Wnt signaling pathway | 21.4286 | 5 | no |
GO:0018105 | peptidyl-serine phosphorylation | 21.4286 | 6 | no |
GO:0018193 | peptidyl-amino acid modification | 21.4286 | 5 | no |
GO:0000075 | cell cycle checkpoint signaling | 14.2857 | 4 | yes |
GO:0000077 | DNA damage checkpoint signaling | 14.2857 | 5 | yes |
GO:0006259 | DNA metabolic process | 14.2857 | 4 | yes |
GO:0006281 | DNA repair | 14.2857 | 5 | yes |
GO:0007093 | mitotic cell cycle checkpoint signaling | 14.2857 | 4 | yes |
GO:0007095 | mitotic G2 DNA damage checkpoint signaling | 14.2857 | 6 | yes |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 14.2857 | 7 | yes |
GO:0010948 | negative regulation of cell cycle process | 14.2857 | 6 | yes |
GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 14.2857 | 8 | yes |
GO:0031570 | DNA integrity checkpoint signaling | 14.2857 | 5 | yes |
GO:0032886 | regulation of microtubule-based process | 14.2857 | 4 | yes |
GO:0042770 | signal transduction in response to DNA damage | 14.2857 | 4 | yes |
GO:0044773 | mitotic DNA damage checkpoint signaling | 14.2857 | 6 | yes |
GO:0044774 | mitotic DNA integrity checkpoint signaling | 14.2857 | 5 | yes |
GO:0044818 | mitotic G2/M transition checkpoint | 14.2857 | 5 | yes |
GO:0045786 | negative regulation of cell cycle | 14.2857 | 5 | yes |
GO:0045930 | negative regulation of mitotic cell cycle | 14.2857 | 6 | yes |
GO:0070507 | regulation of microtubule cytoskeleton organization | 14.2857 | 5 | yes |
GO:1901988 | negative regulation of cell cycle phase transition | 14.2857 | 7 | yes |
GO:1901991 | negative regulation of mitotic cell cycle phase transition | 14.2857 | 7 | yes |
GO:1902749 | regulation of cell cycle G2/M phase transition | 14.2857 | 7 | yes |
GO:1902750 | negative regulation of cell cycle G2/M phase transition | 14.2857 | 8 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 14.2857 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
CH033_HUMAN | [view interactions] | High throughput | no | yes |
KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GEMI7_HUMAN | [view interactions] | High throughput | no | no |
WT1_HUMAN | [view interactions] | High throughput | no | no |
STK4_HUMAN | [view interactions] | High throughput | no | yes |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
ABITM_HUMAN | [view interactions] | High throughput | no | yes |
STK25_HUMAN | [view interactions] | High throughput | no | no |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
HTRA4_HUMAN | [view interactions] | High throughput | no | no |
MK15_HUMAN | [view interactions] | High throughput | no | no |
TAOK3_HUMAN | [view interactions] | High throughput | no | yes |
STK26_HUMAN | [view interactions] | High throughput | no | no |
TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
P5F1B_HUMAN | [view interactions] | High throughput | no | no |
PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
ANO7_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
ACK1_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
BT3A1_HUMAN | [view interactions] | High throughput | no | yes |
MAGA9_HUMAN | [view interactions] | High throughput | no | no |
PKHN1_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FABD_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASF2_HUMAN | [view interactions] | High throughput | no | yes |
S10A7_HUMAN | [view interactions] | High throughput | no | no |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
SRBD1_HUMAN | [view interactions] | High throughput | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MP2K3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
YAP1_HUMAN | [view interactions] | Computational | no | yes |
MP2K6_HUMAN | [view interactions] | Computational | no | yes |
SCHI1_HUMAN | [view interactions] | Computational | no | yes |
IQIP1_HUMAN | [view interactions] | Computational | no | yes |
ATM_HUMAN | [view interactions] | Computational | no | yes |