Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TAOK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating Thr-208 of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
17 Glu Gly Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) -
111 Ser Phe Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) -
150 Arg Ile Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) -
167 Leu Arg Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) -
298 Lys Glu Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) -
305 Asp Ala Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) -
548 Leu Pro Developmentaldelaywithorwithoutintellectualimpairmentorbehavioralabnormalities(DDIB) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TAOK1_HUMAN
GO:0000166 nucleotide binding 50.0000 4 yes
GO:0016301 kinase activity 50.0000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 50.0000 4 yes
GO:0017076 purine nucleotide binding 50.0000 5 yes
GO:0032555 purine ribonucleotide binding 50.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 yes
GO:0043168 anion binding 50.0000 4 yes
GO:0004674 protein serine/threonine kinase activity 44.4444 4 yes
GO:0005524 ATP binding 44.4444 5 yes
GO:0030554 adenyl nucleotide binding 44.4444 6 yes
GO:0032559 adenyl ribonucleotide binding 44.4444 5 yes
GO:0106310 protein serine kinase activity 44.4444 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0019887 protein kinase regulator activity 27.7778 4 yes
GO:0019901 protein kinase binding 27.7778 5 no
GO:0003723 RNA binding 22.2222 4 no
GO:0045296 cadherin binding 22.2222 4 no
GO:0015631 tubulin binding 16.6667 4 yes
GO:0019209 kinase activator activity 16.6667 4 yes
GO:0030295 protein kinase activator activity 16.6667 5 yes
GO:0048156 tau protein binding 16.6667 4 yes
GO:0050321 tau-protein kinase activity 16.6667 4 yes
GO:0043539 protein serine/threonine kinase activator activity 11.1111 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TAOK1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 83.3333 4 yes
GO:0080090 regulation of primary metabolic process 83.3333 4 yes
GO:0048523 negative regulation of cellular process 72.2222 4 yes
GO:0031323 regulation of cellular metabolic process 72.2222 4 no
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0051128 regulation of cellular component organization 61.1111 4 yes
GO:0009893 positive regulation of metabolic process 61.1111 4 yes
GO:0009966 regulation of signal transduction 61.1111 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 yes
GO:0031399 regulation of protein modification process 55.5556 6 yes
GO:0019220 regulation of phosphate metabolic process 55.5556 6 no
GO:0051174 regulation of phosphorus metabolic process 55.5556 5 no
GO:0008104 protein localization 55.5556 4 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0016310 phosphorylation 44.4444 5 yes
GO:0051247 positive regulation of protein metabolic process 44.4444 6 yes
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0031401 positive regulation of protein modification process 38.8889 7 yes
GO:0036211 protein modification process 38.8889 4 yes
GO:0043412 macromolecule modification 38.8889 4 yes
GO:0051726 regulation of cell cycle 38.8889 4 yes
GO:1902531 regulation of intracellular signal transduction 38.8889 5 yes
GO:0009892 negative regulation of metabolic process 38.8889 4 no
GO:0009968 negative regulation of signal transduction 38.8889 5 no
GO:0010648 negative regulation of cell communication 38.8889 5 no
GO:0023057 negative regulation of signaling 38.8889 4 no
GO:0048585 negative regulation of response to stimulus 38.8889 4 no
GO:0141124 intracellular signaling cassette 38.8889 4 no
GO:0006468 protein phosphorylation 38.8889 5 yes
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0023056 positive regulation of signaling 33.3333 4 yes
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0006996 organelle organization 33.3333 4 yes
GO:0033043 regulation of organelle organization 27.7778 5 yes
GO:0048584 positive regulation of response to stimulus 27.7778 4 yes
GO:0051129 negative regulation of cellular component organization 27.7778 5 yes
GO:0051493 regulation of cytoskeleton organization 27.7778 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 27.7778 6 no
GO:0030162 regulation of proteolysis 27.7778 6 no
GO:0043549 regulation of kinase activity 27.7778 5 no
GO:0045859 regulation of protein kinase activity 27.7778 6 no
GO:0045936 negative regulation of phosphate metabolic process 27.7778 7 no
GO:0051248 negative regulation of protein metabolic process 27.7778 6 no
GO:0051338 regulation of transferase activity 27.7778 4 no
GO:0030030 cell projection organization 27.7778 4 no
GO:0043085 positive regulation of catalytic activity 27.7778 4 no
GO:0071310 cellular response to organic substance 27.7778 4 no
GO:0007010 cytoskeleton organization 27.7778 5 yes
GO:0009967 positive regulation of signal transduction 27.7778 5 yes
GO:0010564 regulation of cell cycle process 22.2222 5 yes
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 yes
GO:0032970 regulation of actin filament-based process 22.2222 4 yes
GO:0043408 regulation of MAPK cascade 22.2222 6 yes
GO:0043410 positive regulation of MAPK cascade 22.2222 7 yes
GO:0090304 nucleic acid metabolic process 22.2222 4 yes
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 yes
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0006355 regulation of DNA-templated transcription 22.2222 7 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 22.2222 5 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0043269 regulation of monoatomic ion transport 22.2222 5 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0021762 substantia nigra development 22.2222 4 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0006605 protein targeting 22.2222 4 no
GO:0007346 regulation of mitotic cell cycle 22.2222 5 yes
GO:0045786 negative regulation of cell cycle 16.6667 5 yes
GO:0046328 regulation of JNK cascade 16.6667 7 yes
GO:0046330 positive regulation of JNK cascade 16.6667 8 yes
GO:0046777 protein autophosphorylation 16.6667 6 yes
GO:1901987 regulation of cell cycle phase transition 16.6667 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 16.6667 6 yes
GO:1902903 regulation of supramolecular fiber organization 16.6667 5 yes
GO:0006974 DNA damage response 16.6667 4 yes
GO:0010389 regulation of G2/M transition of mitotic cell cycle 11.1111 7 yes
GO:0010948 negative regulation of cell cycle process 11.1111 6 yes
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 11.1111 8 yes
GO:0031570 DNA integrity checkpoint signaling 11.1111 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 11.1111 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 11.1111 7 yes
GO:0032886 regulation of microtubule-based process 11.1111 4 yes
GO:0042770 signal transduction in response to DNA damage 11.1111 4 yes
GO:0044773 mitotic DNA damage checkpoint signaling 11.1111 6 yes
GO:0044774 mitotic DNA integrity checkpoint signaling 11.1111 5 yes
GO:0044818 mitotic G2/M transition checkpoint 11.1111 5 yes
GO:0045930 negative regulation of mitotic cell cycle 11.1111 6 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 11.1111 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 11.1111 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 11.1111 5 yes
GO:0080134 regulation of response to stress 11.1111 4 yes
GO:0080135 regulation of cellular response to stress 11.1111 4 yes
GO:1901988 negative regulation of cell cycle phase transition 11.1111 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 11.1111 7 yes
GO:1902749 regulation of cell cycle G2/M phase transition 11.1111 7 yes
GO:1902750 negative regulation of cell cycle G2/M phase transition 11.1111 8 yes
GO:0000075 cell cycle checkpoint signaling 11.1111 4 yes
GO:0000077 DNA damage checkpoint signaling 11.1111 5 yes
GO:0006259 DNA metabolic process 11.1111 5 yes
GO:0006281 DNA repair 11.1111 5 yes
GO:0007093 mitotic cell cycle checkpoint signaling 11.1111 4 yes
GO:0007095 mitotic G2 DNA damage checkpoint signaling 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MARK2_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K7_HUMAN [view interactions] Low throughput no yes
LRRK2_HUMAN [view interactions] Low throughput no yes
LATS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CH033_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
GEMI7_HUMAN [view interactions] High throughput no no
WT1_HUMAN [view interactions] High throughput no no
STK4_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
ABITM_HUMAN [view interactions] High throughput no yes
STK25_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD2_HUMAN [view interactions] High throughput no yes
HTRA4_HUMAN [view interactions] High throughput no no
MK15_HUMAN [view interactions] High throughput no no
TAOK3_HUMAN [view interactions] High throughput no yes
STK26_HUMAN [view interactions] High throughput no no
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
UBS3A_HUMAN [view interactions] High throughput no no
DYRK2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
P5F1B_HUMAN [view interactions] High throughput no no
PO5F1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
ANO7_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
BT3A1_HUMAN [view interactions] High throughput no yes
MAGA9_HUMAN [view interactions] High throughput no no
PKHN1_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
FABD_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
RASF2_HUMAN [view interactions] High throughput no yes
S10A7_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SPPL3_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
SRBD1_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes