DJC13_HUMAN
Evidence for PS localization
Functions
Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed, PubMed). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DJC13_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 44.8980 | 4 | no |
| GO:0017076 | purine nucleotide binding | 44.8980 | 5 | no |
| GO:0043168 | anion binding | 44.8980 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 42.8571 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.8163 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 38.7755 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 36.7347 | 5 | no |
| GO:0005524 | ATP binding | 34.6939 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 28.5714 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.5714 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.5714 | 6 | no |
| GO:0003723 | RNA binding | 24.4898 | 4 | no |
| GO:0019900 | kinase binding | 22.4490 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 22.4490 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 22.4490 | 4 | no |
| GO:0016887 | ATP hydrolysis activity | 22.4490 | 7 | no |
| GO:0019901 | protein kinase binding | 20.4082 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DJC13_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.2653 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 61.2245 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 59.1837 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 57.1429 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.0204 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.0204 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.9796 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.8980 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.8163 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.8163 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.8163 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.8163 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.8163 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.7755 | 5 | no |
| GO:0006996 | organelle organization | 36.7347 | 4 | yes |
| GO:0051049 | regulation of transport | 36.7347 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 36.7347 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.7347 | 5 | no |
| GO:0031399 | regulation of protein modification process | 36.7347 | 6 | no |
| GO:0008104 | protein localization | 34.6939 | 4 | yes |
| GO:0010468 | regulation of gene expression | 34.6939 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.6939 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.6531 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.6531 | 6 | no |
| GO:0033043 | regulation of organelle organization | 30.6122 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.6122 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.5714 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0009894 | regulation of catabolic process | 28.5714 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0071702 | organic substance transport | 26.5306 | 4 | yes |
| GO:0032880 | regulation of protein localization | 26.5306 | 5 | no |
| GO:0051726 | regulation of cell cycle | 26.5306 | 4 | no |
| GO:0015031 | protein transport | 24.4898 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 24.4898 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 24.4898 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.4898 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.4898 | 6 | no |
| GO:0036211 | protein modification process | 24.4898 | 4 | no |
| GO:0043412 | macromolecule modification | 24.4898 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.4898 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 24.4898 | 5 | no |
| GO:0022607 | cellular component assembly | 22.4490 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.4490 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 22.4490 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.4490 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.4490 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.4490 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 22.4490 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4490 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.4490 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 22.4490 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 22.4490 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.4490 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.4490 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4490 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.4490 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.4490 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.4490 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 22.4490 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.4082 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.4082 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.4082 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.4082 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.4082 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.4082 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.4082 | 4 | no |
| GO:0080134 | regulation of response to stress | 20.4082 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.4082 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.4082 | 7 | no |
| GO:0050821 | protein stabilization | 20.4082 | 4 | no |
| GO:0016050 | vesicle organization | 16.3265 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.3265 | 4 | yes |
| GO:0098657 | import into cell | 14.2857 | 4 | yes |
| GO:0032386 | regulation of intracellular transport | 10.2041 | 5 | yes |
| GO:0007032 | endosome organization | 6.1224 | 6 | yes |
| GO:0006898 | receptor-mediated endocytosis | 4.0816 | 4 | yes |
| GO:1902954 | regulation of early endosome to recycling endosome transport | 4.0816 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| RBNS5_HUMAN | [view interactions] | Low throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| GA45A_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A6_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| RFX5_HUMAN | [view interactions] | High throughput | no | yes |
| NOP9_HUMAN | [view interactions] | High throughput | no | no |
| SYCE2_HUMAN | [view interactions] | High throughput | no | no |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| FCN1_HUMAN | [view interactions] | High throughput | no | no |
| JPH4_HUMAN | [view interactions] | High throughput | no | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| LIPG_HUMAN | [view interactions] | High throughput | no | no |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCE_HUMAN | [view interactions] | High throughput | no | no |
| EDRF1_HUMAN | [view interactions] | High throughput | no | no |
| FYB2_HUMAN | [view interactions] | High throughput | no | no |
| I2BP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| MIME_HUMAN | [view interactions] | High throughput | no | no |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PPAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL2_HUMAN | [view interactions] | High throughput | no | no |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| RN128_HUMAN | [view interactions] | High throughput | no | yes |
| TM129_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHF1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHX40_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAP10_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIGH_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| TR19L_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K4_HUMAN | [view interactions] | High throughput | no | yes |
| WASC4_HUMAN | [view interactions] | High throughput | no | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| BIG1_HUMAN | [view interactions] | High throughput | no | yes |
| FKB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM7_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| AFTIN_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |