Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ROCK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability . Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed). Required for centrosome positioning and centrosome-dependent exit from mitosis . Plays a role in terminal erythroid differentiation (PubMed). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 . Promotes keratinocyte terminal differentiation (PubMed). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization . May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001925 CLV_C14_Caspase3-7 CLV 1110 1114 -
ELMI001627 DOC_AGCK_PIF_1 DOC 394 399 -
ELMI001925 CLV_C14_Caspase3-7 CLV 1110 1114 -
ELMI001627 DOC_AGCK_PIF_1 DOC 394 399 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ROCK1_HUMAN
GO:0000166 nucleotide binding 53.8462 4 yes
GO:0017076 purine nucleotide binding 53.8462 5 yes
GO:0043168 anion binding 53.8462 4 yes
GO:0032555 purine ribonucleotide binding 52.3077 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 49.2308 4 yes
GO:0016462 pyrophosphatase activity 35.3846 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 35.3846 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 35.3846 6 no
GO:0030554 adenyl nucleotide binding 30.7692 6 yes
GO:0032559 adenyl ribonucleotide binding 29.2308 5 yes
GO:0005524 ATP binding 26.1538 5 yes
GO:0003924 GTPase activity 24.6154 7 no
GO:0019001 guanyl nucleotide binding 24.6154 6 no
GO:0032561 guanyl ribonucleotide binding 24.6154 5 no
GO:0005525 GTP binding 23.0769 5 no
GO:0003723 RNA binding 23.0769 4 no
GO:0043169 cation binding 21.5385 4 yes
GO:0046872 metal ion binding 21.5385 5 yes
GO:0016301 kinase activity 12.3077 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 12.3077 4 yes
GO:0051020 GTPase binding 10.7692 4 yes
GO:0031267 small GTPase binding 9.2308 5 yes
GO:0004674 protein serine/threonine kinase activity 7.6923 4 yes
GO:0106310 protein serine kinase activity 7.6923 4 yes
GO:0048156 tau protein binding 6.1538 4 yes
GO:0004866 endopeptidase inhibitor activity 4.6154 5 yes
GO:0019828 aspartic-type endopeptidase inhibitor activity 4.6154 6 yes
GO:0030414 peptidase inhibitor activity 4.6154 4 yes
GO:0050321 tau-protein kinase activity 4.6154 4 yes
GO:0061135 endopeptidase regulator activity 4.6154 4 yes
GO:0072518 Rho-dependent protein serine/threonine kinase activity 4.6154 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ROCK1_HUMAN
GO:0048522 positive regulation of cellular process 80.0000 4 yes
GO:0051128 regulation of cellular component organization 69.2308 4 yes
GO:0048523 negative regulation of cellular process 66.1538 4 yes
GO:0060255 regulation of macromolecule metabolic process 63.0769 4 yes
GO:0031323 regulation of cellular metabolic process 61.5385 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:0010646 regulation of cell communication 55.3846 4 yes
GO:0006996 organelle organization 53.8462 4 yes
GO:0009889 regulation of biosynthetic process 53.8462 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 53.8462 5 yes
GO:0031326 regulation of cellular biosynthetic process 53.8462 5 yes
GO:0010468 regulation of gene expression 52.3077 6 yes
GO:0009893 positive regulation of metabolic process 50.7692 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.7692 5 yes
GO:0009966 regulation of signal transduction 49.2308 4 yes
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 yes
GO:0009892 negative regulation of metabolic process 44.6154 4 yes
GO:0022607 cellular component assembly 44.6154 4 yes
GO:0051049 regulation of transport 44.6154 4 yes
GO:0051246 regulation of protein metabolic process 44.6154 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 43.0769 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.5385 5 yes
GO:0031324 negative regulation of cellular metabolic process 41.5385 5 yes
GO:0033043 regulation of organelle organization 41.5385 5 yes
GO:0048584 positive regulation of response to stimulus 40.0000 4 yes
GO:0008104 protein localization 38.4615 4 yes
GO:0031399 regulation of protein modification process 38.4615 6 yes
GO:0044087 regulation of cellular component biogenesis 38.4615 4 yes
GO:0051130 positive regulation of cellular component organization 38.4615 5 yes
GO:1902531 regulation of intracellular signal transduction 36.9231 5 yes
GO:0009891 positive regulation of biosynthetic process 36.9231 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 36.9231 6 yes
GO:0010647 positive regulation of cell communication 36.9231 5 yes
GO:0023056 positive regulation of signaling 36.9231 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 36.9231 6 yes
GO:0051252 regulation of RNA metabolic process 36.9231 5 yes
GO:0042127 regulation of cell population proliferation 33.8462 4 no
GO:0009890 negative regulation of biosynthetic process 33.8462 5 no
GO:0007010 cytoskeleton organization 33.8462 5 yes
GO:0009967 positive regulation of signal transduction 33.8462 5 yes
GO:0019220 regulation of phosphate metabolic process 33.8462 6 yes
GO:0042981 regulation of apoptotic process 33.8462 5 yes
GO:0043067 regulation of programmed cell death 33.8462 4 yes
GO:0051174 regulation of phosphorus metabolic process 33.8462 5 yes
GO:2000145 regulation of cell motility 32.3077 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 32.3077 6 no
GO:0031327 negative regulation of cellular biosynthetic process 32.3077 6 no
GO:0060341 regulation of cellular localization 32.3077 4 no
GO:0030334 regulation of cell migration 32.3077 5 yes
GO:0051241 negative regulation of multicellular organismal process 32.3077 4 yes
GO:0030155 regulation of cell adhesion 30.7692 4 yes
GO:0042325 regulation of phosphorylation 30.7692 7 yes
GO:0060627 regulation of vesicle-mediated transport 30.7692 4 yes
GO:0141124 intracellular signaling cassette 30.7692 4 yes
GO:2000026 regulation of multicellular organismal development 29.2308 4 yes
GO:0071310 cellular response to organic substance 29.2308 4 no
GO:0032880 regulation of protein localization 29.2308 5 no
GO:0006355 regulation of DNA-templated transcription 29.2308 7 no
GO:2001141 regulation of RNA biosynthetic process 29.2308 6 no
GO:0030030 cell projection organization 29.2308 4 yes
GO:0051129 negative regulation of cellular component organization 29.2308 5 yes
GO:0051240 positive regulation of multicellular organismal process 29.2308 4 yes
GO:1902533 positive regulation of intracellular signal transduction 27.6923 6 yes
GO:0001932 regulation of protein phosphorylation 27.6923 7 no
GO:0051247 positive regulation of protein metabolic process 27.6923 6 no
GO:0071702 organic substance transport 27.6923 4 no
GO:0071705 nitrogen compound transport 27.6923 4 no
GO:0045595 regulation of cell differentiation 27.6923 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.6923 5 yes
GO:0051493 regulation of cytoskeleton organization 27.6923 6 yes
GO:0009968 negative regulation of signal transduction 26.1538 5 no
GO:0010648 negative regulation of cell communication 26.1538 5 no
GO:0023057 negative regulation of signaling 26.1538 4 no
GO:0048585 negative regulation of response to stimulus 26.1538 4 no
GO:0051094 positive regulation of developmental process 26.1538 4 no
GO:0010629 negative regulation of gene expression 26.1538 7 no
GO:0043933 protein-containing complex organization 26.1538 4 no
GO:0051726 regulation of cell cycle 26.1538 4 no
GO:0007264 small GTPase-mediated signal transduction 26.1538 5 yes
GO:0044089 positive regulation of cellular component biogenesis 26.1538 5 yes
GO:0031344 regulation of cell projection organization 24.6154 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.6154 6 no
GO:1903829 positive regulation of protein localization 24.6154 5 no
GO:0010628 positive regulation of gene expression 24.6154 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 24.6154 4 yes
GO:0120036 plasma membrane bounded cell projection organization 24.6154 5 yes
GO:0032101 regulation of response to external stimulus 23.0769 4 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:0097435 supramolecular fiber organization 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051248 negative regulation of protein metabolic process 23.0769 6 yes
GO:0060284 regulation of cell development 23.0769 5 yes
GO:0001817 regulation of cytokine production 21.5385 4 no
GO:0002684 positive regulation of immune system process 21.5385 4 no
GO:0030335 positive regulation of cell migration 21.5385 6 no
GO:0040017 positive regulation of locomotion 21.5385 4 no
GO:2000147 positive regulation of cell motility 21.5385 5 no
GO:0015031 protein transport 21.5385 4 no
GO:0006796 phosphate-containing compound metabolic process 21.5385 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 21.5385 6 yes
GO:0031400 negative regulation of protein modification process 21.5385 7 yes
GO:0032970 regulation of actin filament-based process 21.5385 4 yes
GO:0036211 protein modification process 21.5385 4 yes
GO:0043066 negative regulation of apoptotic process 21.5385 6 yes
GO:0043069 negative regulation of programmed cell death 21.5385 5 yes
GO:0043412 macromolecule modification 21.5385 4 yes
GO:0045937 positive regulation of phosphate metabolic process 21.5385 7 yes
GO:0051254 positive regulation of RNA metabolic process 21.5385 6 yes
GO:1902903 regulation of supramolecular fiber organization 20.0000 5 yes
GO:0009894 regulation of catabolic process 20.0000 4 yes
GO:0010243 response to organonitrogen compound 20.0000 4 yes
GO:0031175 neuron projection development 20.0000 6 yes
GO:0032956 regulation of actin cytoskeleton organization 20.0000 5 yes
GO:0043408 regulation of MAPK cascade 20.0000 6 yes
GO:0006915 apoptotic process 18.4615 4 yes
GO:0043085 positive regulation of catalytic activity 18.4615 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 16.9231 6 yes
GO:0010810 regulation of cell-substrate adhesion 16.9231 5 yes
GO:0030100 regulation of endocytosis 16.9231 5 yes
GO:0044057 regulation of system process 16.9231 4 yes
GO:0045785 positive regulation of cell adhesion 16.9231 5 yes
GO:0045936 negative regulation of phosphate metabolic process 16.9231 7 yes
GO:0051093 negative regulation of developmental process 16.9231 4 yes
GO:0032886 regulation of microtubule-based process 15.3846 4 yes
GO:0043410 positive regulation of MAPK cascade 15.3846 7 yes
GO:0043523 regulation of neuron apoptotic process 15.3846 6 yes
GO:0051336 regulation of hydrolase activity 15.3846 4 yes
GO:0051345 positive regulation of hydrolase activity 15.3846 5 yes
GO:0110053 regulation of actin filament organization 15.3846 6 yes
GO:0030031 cell projection assembly 13.8462 5 yes
GO:0030162 regulation of proteolysis 13.8462 6 yes
GO:0043086 negative regulation of catalytic activity 13.8462 4 yes
GO:0050807 regulation of synapse organization 13.8462 5 yes
GO:0072657 protein localization to membrane 13.8462 4 yes
GO:1901888 regulation of cell junction assembly 13.8462 5 yes
GO:0006468 protein phosphorylation 12.3077 5 yes
GO:0007266 Rho protein signal transduction 12.3077 6 yes
GO:0016310 phosphorylation 12.3077 5 yes
GO:0018193 peptidyl-amino acid modification 12.3077 5 yes
GO:0030865 cortical cytoskeleton organization 12.3077 6 yes
GO:0031032 actomyosin structure organization 12.3077 4 yes
GO:0042326 negative regulation of phosphorylation 12.3077 8 yes
GO:0043434 response to peptide hormone 12.3077 4 yes
GO:0070507 regulation of microtubule cytoskeleton organization 12.3077 5 yes
GO:0090257 regulation of muscle system process 12.3077 5 yes
GO:1990778 protein localization to cell periphery 10.7692 5 yes
GO:0009896 positive regulation of catabolic process 10.7692 5 yes
GO:0032231 regulation of actin filament bundle assembly 10.7692 5 yes
GO:0042176 regulation of protein catabolic process 10.7692 5 yes
GO:0051492 regulation of stress fiber assembly 10.7692 6 yes
GO:0072659 protein localization to plasma membrane 10.7692 5 yes
GO:0110020 regulation of actomyosin structure organization 10.7692 6 yes
GO:0150116 regulation of cell-substrate junction organization 10.7692 5 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 9.2308 6 yes
GO:1903311 regulation of mRNA metabolic process 9.2308 6 yes
GO:0000281 mitotic cytokinesis 9.2308 4 yes
GO:0001837 epithelial to mesenchymal transition 9.2308 5 yes
GO:0001952 regulation of cell-matrix adhesion 9.2308 6 yes
GO:0010611 regulation of cardiac muscle hypertrophy 9.2308 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 9.2308 6 yes
GO:0014743 regulation of muscle hypertrophy 9.2308 6 yes
GO:0030856 regulation of epithelial cell differentiation 9.2308 5 yes
GO:0043502 regulation of muscle adaptation 9.2308 4 yes
GO:0045664 regulation of neuron differentiation 9.2308 5 yes
GO:0048762 mesenchymal cell differentiation 9.2308 4 yes
GO:0051402 neuron apoptotic process 9.2308 5 yes
GO:0051893 regulation of focal adhesion assembly 9.2308 7 yes
GO:0061640 cytoskeleton-dependent cytokinesis 9.2308 4 yes
GO:0090109 regulation of cell-substrate junction assembly 9.2308 6 yes
GO:0120031 plasma membrane bounded cell projection assembly 9.2308 6 yes
GO:1901890 positive regulation of cell junction assembly 7.6923 6 yes
GO:1902003 regulation of amyloid-beta formation 7.6923 5 yes
GO:0001667 ameboidal-type cell migration 7.6923 4 yes
GO:0003018 vascular process in circulatory system 7.6923 4 yes
GO:0010506 regulation of autophagy 7.6923 6 yes
GO:0010608 post-transcriptional regulation of gene expression 7.6923 7 yes
GO:0030866 cortical actin cytoskeleton organization 7.6923 4 yes
GO:0031329 regulation of cellular catabolic process 7.6923 5 yes
GO:0034248 regulation of amide metabolic process 7.6923 4 yes
GO:0035150 regulation of tube size 7.6923 4 yes
GO:0035296 regulation of tube diameter 7.6923 5 yes
GO:0035303 regulation of dephosphorylation 7.6923 7 yes
GO:0035304 regulation of protein dephosphorylation 7.6923 7 yes
GO:0043393 regulation of protein binding 7.6923 4 yes
GO:0043524 negative regulation of neuron apoptotic process 7.6923 7 yes
GO:0045601 regulation of endothelial cell differentiation 7.6923 6 yes
GO:0045765 regulation of angiogenesis 7.6923 5 yes
GO:0048812 neuron projection morphogenesis 7.6923 5 yes
GO:0097746 blood vessel diameter maintenance 7.6923 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 7.6923 4 yes
GO:1901342 regulation of vasculature development 7.6923 5 yes
GO:1903140 regulation of establishment of endothelial barrier 6.1538 7 yes
GO:1903313 positive regulation of mRNA metabolic process 6.1538 7 yes
GO:2000181 negative regulation of blood vessel morphogenesis 6.1538 5 yes
GO:0003180 aortic valve morphogenesis 6.1538 4 yes
GO:0007159 leukocyte cell-cell adhesion 6.1538 4 yes
GO:0010613 positive regulation of cardiac muscle hypertrophy 6.1538 6 yes
GO:0010631 epithelial cell migration 6.1538 5 yes
GO:0010921 regulation of phosphatase activity 6.1538 5 yes
GO:0014742 positive regulation of muscle hypertrophy 6.1538 5 yes
GO:0016525 negative regulation of angiogenesis 6.1538 6 yes
GO:0018105 peptidyl-serine phosphorylation 6.1538 6 yes
GO:0018209 peptidyl-serine modification 6.1538 6 yes
GO:0035305 negative regulation of dephosphorylation 6.1538 8 yes
GO:0035308 negative regulation of protein dephosphorylation 6.1538 8 yes
GO:0043488 regulation of mRNA stability 6.1538 4 yes
GO:0043666 regulation of phosphoprotein phosphatase activity 6.1538 6 yes
GO:0045604 regulation of epidermal cell differentiation 6.1538 5 yes
GO:0045616 regulation of keratinocyte differentiation 6.1538 6 yes
GO:0045682 regulation of epidermis development 6.1538 4 yes
GO:0045861 negative regulation of proteolysis 6.1538 7 yes
GO:0050779 RNA destabilization 6.1538 4 yes
GO:0051346 negative regulation of hydrolase activity 6.1538 5 yes
GO:0061013 regulation of mRNA catabolic process 6.1538 5 yes
GO:0061014 positive regulation of mRNA catabolic process 6.1538 6 yes
GO:0061157 mRNA destabilization 6.1538 5 yes
GO:0070167 regulation of biomineral tissue development 6.1538 5 yes
GO:0070168 negative regulation of biomineral tissue development 6.1538 5 yes
GO:0150117 positive regulation of cell-substrate junction organization 6.1538 6 yes
GO:1901343 negative regulation of vasculature development 6.1538 5 yes
GO:1901550 regulation of endothelial cell development 6.1538 6 yes
GO:1901889 negative regulation of cell junction assembly 4.6154 6 yes
GO:1902430 negative regulation of amyloid-beta formation 4.6154 6 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 4.6154 7 yes
GO:1903347 negative regulation of bicellular tight junction assembly 4.6154 7 yes
GO:1905203 regulation of connective tissue replacement 4.6154 5 yes
GO:1905205 positive regulation of connective tissue replacement 4.6154 6 yes
GO:1990776 response to angiotensin 4.6154 5 yes
GO:2000114 regulation of establishment of cell polarity 4.6154 5 yes
GO:2000671 regulation of motor neuron apoptotic process 4.6154 7 yes
GO:2000672 negative regulation of motor neuron apoptotic process 4.6154 8 yes
GO:2000810 regulation of bicellular tight junction assembly 4.6154 6 yes
GO:0001954 positive regulation of cell-matrix adhesion 4.6154 7 yes
GO:0006936 muscle contraction 4.6154 4 yes
GO:0006939 smooth muscle contraction 4.6154 5 yes
GO:0007249 canonical NF-kappaB signal transduction 4.6154 5 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 4.6154 5 yes
GO:0009895 negative regulation of catabolic process 4.6154 5 yes
GO:0010508 positive regulation of autophagy 4.6154 7 yes
GO:0010922 positive regulation of phosphatase activity 4.6154 6 yes
GO:0010923 negative regulation of phosphatase activity 4.6154 6 yes
GO:0031331 positive regulation of cellular catabolic process 4.6154 6 yes
GO:0032515 negative regulation of phosphoprotein phosphatase activity 4.6154 7 yes
GO:0032878 regulation of establishment or maintenance of cell polarity 4.6154 4 yes
GO:0034103 regulation of tissue remodeling 4.6154 4 yes
GO:0034105 positive regulation of tissue remodeling 4.6154 5 yes
GO:0034249 negative regulation of amide metabolic process 4.6154 5 yes
GO:0035306 positive regulation of dephosphorylation 4.6154 8 yes
GO:0035507 regulation of myosin-light-chain-phosphatase activity 4.6154 7 yes
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity 4.6154 8 yes
GO:0042177 negative regulation of protein catabolic process 4.6154 6 yes
GO:0050901 leukocyte tethering or rolling 4.6154 6 yes
GO:0051894 positive regulation of focal adhesion assembly 4.6154 7 yes
GO:0061756 leukocyte adhesion to vascular endothelial cell 4.6154 5 yes
GO:0071559 response to transforming growth factor beta 4.6154 4 yes
GO:0097049 motor neuron apoptotic process 4.6154 6 yes
GO:0110061 regulation of angiotensin-activated signaling pathway 4.6154 6 yes
GO:1903421 regulation of synaptic vesicle recycling 3.0769 5 yes
GO:0003383 apical constriction 3.0769 5 yes
GO:0014812 muscle cell migration 3.0769 4 yes
GO:0031330 negative regulation of cellular catabolic process 3.0769 6 yes
GO:0032060 bleb assembly 3.0769 7 yes
GO:0032091 negative regulation of protein binding 3.0769 5 yes
GO:0051043 regulation of membrane protein ectodomain proteolysis 3.0769 6 yes
GO:0051045 negative regulation of membrane protein ectodomain proteolysis 3.0769 7 yes
GO:0051100 negative regulation of binding 3.0769 4 yes
GO:0051451 myoblast migration 3.0769 5 yes
GO:0070252 actin-mediated cell contraction 3.0769 4 yes
GO:0090128 regulation of synapse maturation 3.0769 4 yes
GO:0090521 podocyte cell migration 3.0769 6 yes
GO:0140058 neuron projection arborization 3.0769 6 yes
GO:1900221 regulation of amyloid-beta clearance 3.0769 4 yes
GO:1900223 positive regulation of amyloid-beta clearance 3.0769 5 yes
GO:1900242 regulation of synaptic vesicle endocytosis 3.0769 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHRM3_HUMAN [view interactions] Low throughput no yes
MPIP1_HUMAN [view interactions] Low throughput no no
IKKB_HUMAN [view interactions] Low throughput no yes
MLC1_HUMAN [view interactions] Low throughput no no
TPPP_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD5_HUMAN [view interactions] Low throughput no no
GAB1_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
SHRM2_HUMAN [view interactions] Low throughput no yes
TS101_HUMAN [view entry] [view interactions] Low throughput yes yes
FRMD5_HUMAN [view interactions] Low throughput no no
MYH9_HUMAN [view entry] [view interactions] Low throughput yes no
RND3_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS71B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS71A_HUMAN [view entry] [view interactions] Low throughput yes yes
NEBU_HUMAN [view interactions] Low throughput no no
NUCL_HUMAN [view interactions] Low throughput no yes
MYBPH_HUMAN [view interactions] Low throughput no no
ROCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG24_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
PROF2_HUMAN [view entry] [view interactions] Low throughput yes yes
COF1_HUMAN [view entry] [view interactions] Low throughput yes no
SL9A1_HUMAN [view interactions] Low throughput no no
CDKN3_HUMAN [view interactions] Low throughput no no
LIMK2_HUMAN [view interactions] Low throughput no yes
RHBT1_HUMAN [view interactions] Low throughput no yes
MED17_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
BBS1_HUMAN [view interactions] High throughput no no
KPB2_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
RHOC_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
HDAC2_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
NCAM1_HUMAN [view entry] [view interactions] High throughput yes no
CASP3_HUMAN [view entry] [view interactions] High throughput yes yes
CASP7_HUMAN [view interactions] High throughput no no
UBE2T_HUMAN [view interactions] High throughput no no
TRI15_HUMAN [view interactions] High throughput no no
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
MON2_HUMAN [view interactions] High throughput no no
WAC2A_HUMAN [view interactions] High throughput no yes
WASC4_HUMAN [view interactions] High throughput no yes
ALKB3_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
NUD14_HUMAN [view interactions] High throughput no yes
CPZIP_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LGMN_HUMAN [view interactions] High throughput no yes
S10AB_HUMAN [view interactions] High throughput no no
SMC6_HUMAN [view interactions] High throughput no no
TAOK3_HUMAN [view interactions] High throughput no yes
TBCD5_HUMAN [view interactions] High throughput no yes
TFIP8_HUMAN [view interactions] High throughput no no
WAC2C_HUMAN [view interactions] High throughput no yes
DFFA_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
DIAP1_HUMAN [view interactions] High throughput no yes
BRE1B_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
ASML_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
HEXA_HUMAN [view interactions] High throughput no yes
NFIC_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
PLCB3_HUMAN [view entry] [view interactions] High throughput yes no
NSUN2_HUMAN [view interactions] High throughput no yes
DNJC3_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
IL18_HUMAN [view interactions] High throughput no yes
EFL1_HUMAN [view interactions] High throughput no yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
RUFY1_HUMAN [view interactions] High throughput no yes
NAA15_HUMAN [view interactions] High throughput no yes
NUF2_HUMAN [view interactions] High throughput no no
UN45A_HUMAN [view interactions] High throughput no yes
MO4L1_HUMAN [view interactions] High throughput no yes
NUDT5_HUMAN [view interactions] High throughput no no
TLN1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
AMPN_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
MUC18_HUMAN [view interactions] High throughput no yes
SMAD2_HUMAN [view interactions] High throughput no yes
HMGB2_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
FTM_HUMAN [view interactions] High throughput no yes
TRPM7_HUMAN [view interactions] High throughput no no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD3_HUMAN [view interactions] High throughput no yes
XRCC5_HUMAN [view interactions] High throughput no yes
SNP29_HUMAN [view interactions] High throughput no yes
DOCK5_HUMAN [view entry] [view interactions] High throughput yes no
RETR3_HUMAN [view interactions] High throughput no yes
CEPT1_HUMAN [view interactions] High throughput no no
GPAA1_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
HMGX4_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
GPTC4_HUMAN [view interactions] High throughput no no
RAD51_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
DOCK6_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
S39AA_HUMAN [view interactions] High throughput no no
VPP2_HUMAN [view interactions] High throughput no yes
ENY2_HUMAN [view interactions] High throughput no yes
FBH1_HUMAN [view interactions] High throughput no no
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
NEIL3_HUMAN [view interactions] High throughput no no
I20RA_HUMAN [view interactions] High throughput no no
MAGB4_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
ELK4_HUMAN [view interactions] High throughput no yes
TENS2_HUMAN [view interactions] High throughput no no
DCAF7_HUMAN [view interactions] High throughput no yes
MED23_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
F124A_HUMAN [view interactions] High throughput no no
CF206_HUMAN [view interactions] High throughput no yes
RPC3_HUMAN [view interactions] High throughput no yes
NOTC1_HUMAN [view entry] [view interactions] High throughput yes yes
KDM4D_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
CDK15_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
SSRG_HUMAN [view interactions] High throughput no yes
IFT88_HUMAN [view interactions] High throughput no no
SIR6_HUMAN [view interactions] High throughput no yes
STX18_HUMAN [view interactions] High throughput no yes
PSRC1_HUMAN [view interactions] High throughput no no
GA2L3_HUMAN [view interactions] High throughput no no
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
TAF4_HUMAN [view interactions] High throughput no yes
CHERP_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
EDEM1_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
HTRA3_HUMAN [view interactions] High throughput no no
SYCE1_HUMAN [view interactions] High throughput no no
AHR_HUMAN [view interactions] High throughput no yes
ANR49_HUMAN [view interactions] High throughput no yes
HEMH_HUMAN [view interactions] High throughput no yes
APC16_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes