MP2K3_HUMAN
Evidence for PS localization
Functions
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MP2K3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 47.3684 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 47.3684 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 47.3684 | 4 | yes |
| GO:0003723 | RNA binding | 40.0000 | 4 | no |
| GO:0005524 | ATP binding | 36.8421 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.8421 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 36.8421 | 5 | yes |
| GO:0019900 | kinase binding | 30.5263 | 4 | yes |
| GO:0019901 | protein kinase binding | 30.5263 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 24.2105 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.2105 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.2105 | 6 | no |
| GO:0016301 | kinase activity | 18.9474 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.9474 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 17.8947 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 15.7895 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 14.7368 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 6.3158 | 4 | yes |
| GO:0004708 | MAP kinase kinase activity | 5.2632 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.1053 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.7368 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.6842 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.6316 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.5789 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 51.5789 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.5789 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 47.3684 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.2632 | 5 | yes |
| GO:0010468 | regulation of gene expression | 44.2105 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 44.2105 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.1053 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 41.0526 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 41.0526 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.0526 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.9474 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.9474 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 38.9474 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 36.8421 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 36.8421 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 35.7895 | 5 | yes |
| GO:0006996 | organelle organization | 35.7895 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 34.7368 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 34.7368 | 5 | yes |
| GO:0010941 | regulation of cell death | 34.7368 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 34.7368 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 34.7368 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.6316 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 32.6316 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 32.6316 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 32.6316 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 32.6316 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 32.6316 | 6 | yes |
| GO:0022607 | cellular component assembly | 32.6316 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 30.5263 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 30.5263 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.5263 | 4 | no |
| GO:0036211 | protein modification process | 30.5263 | 4 | no |
| GO:0043412 | macromolecule modification | 30.5263 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.4737 | 7 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 29.4737 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 29.4737 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 29.4737 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4737 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 28.4211 | 7 | yes |
| GO:0051338 | regulation of transferase activity | 28.4211 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 28.4211 | 5 | no |
| GO:0080134 | regulation of response to stress | 28.4211 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 27.3684 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 27.3684 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.3684 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 27.3684 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 27.3684 | 6 | no |
| GO:0008104 | protein localization | 27.3684 | 4 | no |
| GO:0051049 | regulation of transport | 27.3684 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 27.3684 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.3158 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.3158 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 26.3158 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 26.3158 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.2632 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 25.2632 | 5 | no |
| GO:0080135 | regulation of cellular response to stress | 25.2632 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 24.2105 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.2105 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 24.2105 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 24.2105 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 23.1579 | 6 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 23.1579 | 6 | yes |
| GO:2000145 | regulation of cell motility | 23.1579 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 23.1579 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.1579 | 5 | no |
| GO:0016310 | phosphorylation | 23.1579 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.1053 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 22.1053 | 8 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 22.1053 | 7 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.1053 | 7 | yes |
| GO:0090304 | nucleic acid metabolic process | 22.1053 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 22.1053 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 22.1053 | 6 | no |
| GO:0007010 | cytoskeleton organization | 22.1053 | 5 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:0006468 | protein phosphorylation | 21.0526 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.0000 | 8 | yes |
| GO:0030334 | regulation of cell migration | 20.0000 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.0000 | 7 | yes |
| GO:0051347 | positive regulation of transferase activity | 20.0000 | 5 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.0000 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 20.0000 | 8 | yes |
| GO:0030335 | positive regulation of cell migration | 15.7895 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 15.7895 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 15.7895 | 5 | yes |
| GO:0001817 | regulation of cytokine production | 14.7368 | 4 | yes |
| GO:0033674 | positive regulation of kinase activity | 14.7368 | 6 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 14.7368 | 4 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 14.7368 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 13.6842 | 7 | yes |
| GO:0000165 | MAPK cascade | 12.6316 | 4 | yes |
| GO:0033993 | response to lipid | 12.6316 | 4 | yes |
| GO:0070848 | response to growth factor | 12.6316 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 10.5263 | 5 | yes |
| GO:0010632 | regulation of epithelial cell migration | 9.4737 | 4 | yes |
| GO:0071396 | cellular response to lipid | 9.4737 | 5 | yes |
| GO:0010594 | regulation of endothelial cell migration | 7.3684 | 5 | yes |
| GO:0010634 | positive regulation of epithelial cell migration | 7.3684 | 5 | yes |
| GO:0007507 | heart development | 6.3158 | 4 | yes |
| GO:0010595 | positive regulation of endothelial cell migration | 6.3158 | 6 | yes |
| GO:0031098 | stress-activated protein kinase signaling cascade | 6.3158 | 4 | yes |
| GO:0051403 | stress-activated MAPK cascade | 6.3158 | 5 | yes |
| GO:0006954 | inflammatory response | 5.2632 | 4 | yes |
| GO:0043535 | regulation of blood vessel endothelial cell migration | 5.2632 | 6 | yes |
| GO:0002237 | response to molecule of bacterial origin | 4.2105 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 4.2105 | 4 | yes |
| GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 4.2105 | 6 | yes |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | 4.2105 | 7 | yes |
| GO:0006936 | muscle contraction | 3.1579 | 4 | yes |
| GO:0006941 | striated muscle contraction | 3.1579 | 5 | yes |
| GO:0009743 | response to carbohydrate | 3.1579 | 4 | yes |
| GO:0051769 | regulation of nitric-oxide synthase biosynthetic process | 3.1579 | 6 | yes |
| GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process | 3.1579 | 7 | yes |
| GO:0060048 | cardiac muscle contraction | 3.1579 | 6 | yes |
| GO:0071219 | cellular response to molecule of bacterial origin | 3.1579 | 4 | yes |
| GO:0071222 | cellular response to lipopolysaccharide | 3.1579 | 5 | yes |
| GO:0035330 | regulation of hippo signaling | 2.1053 | 6 | yes |
| GO:0035331 | negative regulation of hippo signaling | 2.1053 | 7 | yes |
| GO:0038066 | p38MAPK cascade | 2.1053 | 6 | yes |
| GO:0071322 | cellular response to carbohydrate stimulus | 2.1053 | 5 | yes |
| GO:0072708 | response to sorbitol | 2.1053 | 5 | yes |
| GO:0072709 | cellular response to sorbitol | 2.1053 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K3_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.1579 | 3 | no |
| DOID:0060038 | specific developmental disorder | 2.1053 | 3 | no |
| DOID:1059 | intellectual disability | 2.1053 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.1053 | 3 | no |
| DOID:120 | female reproductive organ cancer | 2.1053 | 5 | no |
| DOID:193 | reproductive organ cancer | 2.1053 | 4 | no |
| DOID:6457 | Cowden syndrome | 2.1053 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.1053 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.1053 | 5 | no |
| DOID:114 | heart disease | 2.1053 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 2.1053 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PKN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K6_HUMAN | [view interactions] | Low throughput | no | yes |
| DYR1B_HUMAN | [view interactions] | Low throughput | no | no |
| TAOK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K4_HUMAN | [view interactions] | Low throughput | no | yes |
| PLCB2_HUMAN | [view interactions] | Low throughput | no | no |
| SMAD7_HUMAN | [view interactions] | Low throughput | no | yes |
| JIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPA_HUMAN | [view interactions] | Low throughput | no | yes |
| JIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JIP4_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | Low throughput | no | no |
| FGFR4_HUMAN | [view interactions] | Low throughput | no | no |
| PGFRA_HUMAN | [view interactions] | Low throughput | no | no |
| RASF1_HUMAN | [view interactions] | Low throughput | no | yes |
| STK11_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPHN_HUMAN | [view interactions] | Low throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| HAT1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM3_HUMAN | [view interactions] | High throughput | no | yes |
| M3K6_HUMAN | [view interactions] | High throughput | no | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9Y_HUMAN | [view interactions] | High throughput | no | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF1AX_HUMAN | [view interactions] | High throughput | no | yes |
| IF1AY_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| HAP28_HUMAN | [view interactions] | High throughput | no | yes |
| FAT1_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| ROBO1_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCL_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA3_HUMAN | [view interactions] | High throughput | no | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| FOXS1_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| BMR1B_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| HXB9_HUMAN | [view interactions] | High throughput | no | no |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA2_HUMAN | [view interactions] | High throughput | no | yes |
| RS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIM1_HUMAN | [view interactions] | High throughput | no | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| BUD13_HUMAN | [view interactions] | High throughput | no | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| RL29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATN2_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSG11_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| CDK20_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| DNAI2_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K2_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| CDK6_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| GLIS2_HUMAN | [view interactions] | High throughput | no | no |
| ERD22_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| CD44_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| CDN2C_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| KAT2A_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFIC_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD1_HUMAN | [view interactions] | High throughput | no | yes |
| TEAD2_HUMAN | [view interactions] | High throughput | no | no |
| TERT_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK12_HUMAN | [view interactions] | Computational | no | no |
| RIPK2_HUMAN | [view interactions] | Computational | no | yes |
| TAB3_HUMAN | [view interactions] | Computational | no | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TRAF5_HUMAN | [view interactions] | Computational | no | yes |
| MAPK5_HUMAN | [view interactions] | Computational | no | yes |
| MK13_HUMAN | [view interactions] | Computational | no | yes |
| CCM2_HUMAN | [view interactions] | Computational | no | yes |
| TAOK3_HUMAN | [view interactions] | Computational | no | yes |
| TNR1A_HUMAN | [view interactions] | Computational | no | yes |
| IRAK1_HUMAN | [view interactions] | Computational | no | yes |
| M3K7_HUMAN | [view interactions] | Computational | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG1_HUMAN | [view interactions] | Computational | no | no |
| MKKS_HUMAN | [view interactions] | Computational | no | yes |
| TAB2_HUMAN | [view interactions] | Computational | no | yes |
| TAB1_HUMAN | [view interactions] | Computational | no | yes |
| TRAF2_HUMAN | [view interactions] | Computational | no | yes |
| NEMO_HUMAN | [view interactions] | Computational | no | yes |
| MAPK3_HUMAN | [view interactions] | Computational | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CXCR3_HUMAN | [view interactions] | Computational | no | no |
| FPR1_HUMAN | [view interactions] | Computational | no | no |
| NOD2_HUMAN | [view interactions] | Computational | no | yes |
| RIPK1_HUMAN | [view interactions] | Computational | no | yes |
| M3K10_HUMAN | [view interactions] | Computational | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNA15_HUMAN | [view interactions] | Computational | no | yes |
| DAXX_HUMAN | [view interactions] | Computational | no | yes |
| NOD1_HUMAN | [view interactions] | Computational | no | no |
| KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK11_HUMAN | [view interactions] | Computational | no | yes |
| TAOK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PPM1A_HUMAN | [view interactions] | Computational | no | yes |
| TNFL6_HUMAN | [view interactions] | Computational | no | yes |
| CXL10_HUMAN | [view interactions] | Computational | no | no |
| M3K1_HUMAN | [view interactions] | Computational | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GA45G_HUMAN | [view interactions] | Computational | no | yes |
| PLF4_HUMAN | [view interactions] | Computational | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| IRAK2_HUMAN | [view interactions] | Computational | no | yes |
| FAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TNFA_HUMAN | [view interactions] | Computational | no | no |
| PEBP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK08_HUMAN | [view interactions] | Computational | no | yes |
| MP2K4_HUMAN | [view interactions] | Computational | no | yes |
| TRAF6_HUMAN | [view interactions] | Computational | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CXL11_HUMAN | [view interactions] | Computational | no | no |
| MK09_HUMAN | [view interactions] | Computational | no | yes |
| GA45B_HUMAN | [view interactions] | Computational | no | yes |
| CXCL9_HUMAN | [view interactions] | Computational | no | no |
| RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MAPK2_HUMAN | [view interactions] | Computational | no | yes |
| M3K11_HUMAN | [view interactions] | Computational | no | yes |
| TRADD_HUMAN | [view interactions] | Computational | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |