Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOC10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOC10_HUMAN
GO:0017076 purine nucleotide binding 36.3636 4 no
GO:0019900 kinase binding 36.3636 4 no
GO:0019901 protein kinase binding 36.3636 5 no
GO:0032555 purine ribonucleotide binding 36.3636 4 no
GO:0035639 purine ribonucleoside triphosphate binding 36.3636 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 27.2727 5 yes
GO:0030695 GTPase regulator activity 27.2727 4 yes
GO:0003924 GTPase activity 27.2727 7 no
GO:0005525 GTP binding 27.2727 5 no
GO:0016462 pyrophosphatase activity 27.2727 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 27.2727 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 27.2727 6 no
GO:0019001 guanyl nucleotide binding 27.2727 5 no
GO:0032561 guanyl ribonucleotide binding 27.2727 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in DOC10_HUMAN
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0120036 plasma membrane bounded cell projection organization 45.4545 5 yes
GO:0051128 regulation of cellular component organization 45.4545 4 no
GO:0007264 small GTPase mediated signal transduction 45.4545 4 yes
GO:0030030 cell projection organization 45.4545 4 yes
GO:0031175 neuron projection development 45.4545 6 yes
GO:0022607 cellular component assembly 36.3636 4 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0006996 organelle organization 36.3636 4 no
GO:0007010 cytoskeleton organization 36.3636 5 no
GO:0031323 regulation of cellular metabolic process 36.3636 4 no
GO:0031344 regulation of cell projection organization 36.3636 5 no
GO:0051171 regulation of nitrogen compound metabolic process 36.3636 4 no
GO:0060255 regulation of macromolecule metabolic process 36.3636 4 no
GO:0080090 regulation of primary metabolic process 36.3636 4 no
GO:0097435 supramolecular fiber organization 36.3636 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.3636 6 no
GO:0009966 regulation of signal transduction 36.3636 4 no
GO:0010646 regulation of cell communication 36.3636 4 no
GO:0016055 Wnt signaling pathway 36.3636 5 no
GO:0033043 regulation of organelle organization 36.3636 5 no
GO:0045595 regulation of cell differentiation 36.3636 4 no
GO:0051493 regulation of cytoskeleton organization 36.3636 6 no
GO:1902531 regulation of intracellular signal transduction 36.3636 5 no
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 36.3636 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 27.2727 6 yes
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0010468 regulation of gene expression 27.2727 5 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0031325 positive regulation of cellular metabolic process 27.2727 5 no
GO:0031326 regulation of cellular biosynthetic process 27.2727 5 no
GO:0051129 negative regulation of cellular component organization 27.2727 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.2727 5 no
GO:0007015 actin filament organization 27.2727 5 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0010720 positive regulation of cell development 27.2727 6 no
GO:0010769 regulation of cell morphogenesis involved in differentiation 27.2727 6 no
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 27.2727 7 no
GO:0010810 regulation of cell-substrate adhesion 27.2727 5 no
GO:0010811 positive regulation of cell-substrate adhesion 27.2727 6 no
GO:0022603 regulation of anatomical structure morphogenesis 27.2727 4 no
GO:0022604 regulation of cell morphogenesis 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0030031 cell projection assembly 27.2727 5 no
GO:0030155 regulation of cell adhesion 27.2727 4 no
GO:0032956 regulation of actin cytoskeleton organization 27.2727 5 no
GO:0032970 regulation of actin filament-based process 27.2727 4 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0045597 positive regulation of cell differentiation 27.2727 5 no
GO:0045785 positive regulation of cell adhesion 27.2727 5 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0051094 positive regulation of developmental process 27.2727 4 no
GO:0060284 regulation of cell development 27.2727 5 no
GO:0060491 regulation of cell projection assembly 27.2727 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 27.2727 6 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 27.2727 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 27.2727 7 no
GO:0032990 cell part morphogenesis 27.2727 4 yes
GO:0043085 positive regulation of catalytic activity 27.2727 4 yes
GO:0048812 neuron projection morphogenesis 27.2727 7 yes
GO:0048858 cell projection morphogenesis 27.2727 5 yes
GO:2000145 regulation of cell motility 18.1818 4 yes
GO:0002521 leukocyte differentiation 18.1818 4 yes
GO:0030334 regulation of cell migration 18.1818 5 yes
GO:0043087 regulation of GTPase activity 18.1818 5 yes
GO:0043547 positive regulation of GTPase activity 18.1818 6 yes
GO:0048872 homeostasis of number of cells 18.1818 4 yes
GO:0051336 regulation of hydrolase activity 18.1818 4 yes
GO:0051345 positive regulation of hydrolase activity 18.1818 5 yes
GO:0060997 dendritic spine morphogenesis 18.1818 6 yes
GO:0097061 dendritic spine organization 18.1818 5 yes
GO:0099173 postsynapse organization 18.1818 4 yes
GO:0106027 neuron projection organization 18.1818 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in DOC10_HUMAN
DOID:0060038 specific developmental disorder 18.1818 3 no
DOID:0060307 autosomal dominant intellectual developmental disorder 18.1818 5 no
DOID:1059 intellectual disability 18.1818 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC3_HUMAN [view entry] [view interactions] Low throughput yes no
HUTH_HUMAN [view interactions] High throughput no yes
KI67_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
CSTF1_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
LAT_HUMAN [view interactions] High throughput no no
MAGAB_HUMAN [view interactions] High throughput no no
C102B_HUMAN [view interactions] High throughput no yes
SHLB1_HUMAN [view interactions] High throughput no yes
LURA1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
DOCK9_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ACSF2_HUMAN [view interactions] High throughput no no
SUCB2_HUMAN [view interactions] High throughput no no
GSTO1_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes
DHX37_HUMAN [view interactions] Computational no yes