Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOC10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOC10_HUMAN
GO:0000166 nucleotide binding 41.6667 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 33.3333 5 yes
GO:0030695 GTPase regulator activity 33.3333 4 yes
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0019001 guanyl nucleotide binding 25.0000 6 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0031267 small GTPase binding 16.6667 5 yes
GO:0051020 GTPase binding 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOC10_HUMAN
GO:0141124 intracellular signaling cassette 66.6667 4 yes
GO:0030030 cell projection organization 58.3333 4 yes
GO:0031175 neuron projection development 58.3333 6 yes
GO:0120036 plasma membrane bounded cell projection organization 58.3333 5 yes
GO:0007264 small GTPase-mediated signal transduction 50.0000 5 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0030334 regulation of cell migration 41.6667 5 yes
GO:2000145 regulation of cell motility 41.6667 4 yes
GO:0022607 cellular component assembly 41.6667 4 no
GO:0051128 regulation of cellular component organization 41.6667 4 no
GO:0048812 neuron projection morphogenesis 33.3333 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 4 yes
GO:0006996 organelle organization 33.3333 4 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0016055 Wnt signaling pathway 33.3333 4 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0045785 positive regulation of cell adhesion 33.3333 5 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0002521 leukocyte differentiation 25.0000 4 yes
GO:0043085 positive regulation of catalytic activity 25.0000 4 yes
GO:0043087 regulation of GTPase activity 25.0000 5 yes
GO:0043547 positive regulation of GTPase activity 25.0000 6 yes
GO:0051336 regulation of hydrolase activity 25.0000 4 yes
GO:0051345 positive regulation of hydrolase activity 25.0000 5 yes
GO:0060997 dendritic spine morphogenesis 25.0000 6 yes
GO:0097061 dendritic spine organization 25.0000 5 yes
GO:0099173 postsynapse organization 25.0000 4 yes
GO:0106027 neuron projection organization 25.0000 6 yes
GO:1903131 mononuclear cell differentiation 25.0000 5 yes
GO:0006911 phagocytosis, engulfment 25.0000 7 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0007411 axon guidance 25.0000 8 no
GO:0010324 membrane invagination 25.0000 5 no
GO:0010810 regulation of cell-substrate adhesion 25.0000 5 no
GO:0010811 positive regulation of cell-substrate adhesion 25.0000 6 no
GO:0030031 cell projection assembly 25.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0097485 neuron projection guidance 25.0000 7 no
GO:0099024 plasma membrane invagination 25.0000 6 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 25.0000 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 25.0000 7 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0060491 regulation of cell projection assembly 25.0000 5 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 25.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0001782 B cell homeostasis 16.6667 4 yes
GO:0002285 lymphocyte activation involved in immune response 16.6667 4 yes
GO:0002312 B cell activation involved in immune response 16.6667 5 yes
GO:0002313 mature B cell differentiation involved in immune response 16.6667 6 yes
GO:0002315 marginal zone B cell differentiation 16.6667 7 yes
GO:0002335 mature B cell differentiation 16.6667 6 yes
GO:0030098 lymphocyte differentiation 16.6667 4 yes
GO:0030183 B cell differentiation 16.6667 5 yes
GO:0042113 B cell activation 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
RAC3_HUMAN [view entry] [view interactions] Low throughput yes no
HERC2_HUMAN [view interactions] Low throughput no yes
DOC10_HUMAN [view entry] [view interactions] Low throughput yes yes
HUTH_HUMAN [view interactions] High throughput no yes
KI67_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
CSTF1_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
LAT_HUMAN [view interactions] High throughput no no
TLK2_HUMAN [view interactions] High throughput no no
MAGAB_HUMAN [view interactions] High throughput no no
C102B_HUMAN [view interactions] High throughput no yes
SHLB1_HUMAN [view interactions] High throughput no yes
LURA1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
DOCK9_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RHG24_HUMAN [view interactions] High throughput no yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ACSF2_HUMAN [view interactions] High throughput no no
SUCB2_HUMAN [view interactions] High throughput no no
GSTO1_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes