Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOCK9_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOCK9_HUMAN
GO:0000166 nucleotide binding 41.6667 4 no
GO:0016462 pyrophosphatase activity 41.6667 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 41.6667 4 no
GO:0017076 purine nucleotide binding 41.6667 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 41.6667 6 no
GO:0032555 purine ribonucleotide binding 41.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 41.6667 4 no
GO:0043168 anion binding 41.6667 4 no
GO:0003924 GTPase activity 37.5000 7 no
GO:0005525 GTP binding 37.5000 5 no
GO:0019001 guanyl nucleotide binding 37.5000 6 no
GO:0032561 guanyl ribonucleotide binding 37.5000 5 no
GO:0019900 kinase binding 33.3333 4 no
GO:0045296 cadherin binding 29.1667 4 yes
GO:0019901 protein kinase binding 29.1667 5 no
GO:0043169 cation binding 20.8333 4 no
GO:0046872 metal ion binding 20.8333 5 no
GO:0005085 guanyl-nucleotide exchange factor activity 12.5000 5 yes
GO:0030695 GTPase regulator activity 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOCK9_HUMAN
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:0048523 negative regulation of cellular process 58.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 no
GO:0141124 intracellular signaling cassette 54.1667 4 yes
GO:0007264 small GTPase-mediated signal transduction 50.0000 5 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:2000145 regulation of cell motility 41.6667 4 no
GO:0008104 protein localization 41.6667 4 no
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0030334 regulation of cell migration 41.6667 5 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:2000147 positive regulation of cell motility 29.1667 5 no
GO:0032880 regulation of protein localization 29.1667 5 no
GO:0060341 regulation of cellular localization 29.1667 4 no
GO:0006996 organelle organization 29.1667 4 no
GO:0009892 negative regulation of metabolic process 29.1667 4 no
GO:0010468 regulation of gene expression 29.1667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 29.1667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 29.1667 5 no
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0030030 cell projection organization 29.1667 4 no
GO:0030335 positive regulation of cell migration 29.1667 6 no
GO:0031325 positive regulation of cellular metabolic process 29.1667 5 no
GO:0031326 regulation of cellular biosynthetic process 29.1667 5 no
GO:0040017 positive regulation of locomotion 29.1667 4 no
GO:0044087 regulation of cellular component biogenesis 29.1667 4 no
GO:0051049 regulation of transport 29.1667 4 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0060491 regulation of cell projection assembly 25.0000 5 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 20.8333 6 no
GO:0008284 positive regulation of cell population proliferation 20.8333 5 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0070201 regulation of establishment of protein localization 20.8333 6 no
GO:1904951 positive regulation of establishment of protein localization 20.8333 6 no
GO:0006355 regulation of DNA-templated transcription 20.8333 7 no
GO:0006915 apoptotic process 20.8333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0031328 positive regulation of cellular biosynthetic process 20.8333 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.8333 5 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:2001141 regulation of RNA biosynthetic process 20.8333 6 no
GO:0009968 negative regulation of signal transduction 20.8333 5 no
GO:0010648 negative regulation of cell communication 20.8333 5 no
GO:0023057 negative regulation of signaling 20.8333 4 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:0048585 negative regulation of response to stimulus 20.8333 4 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:0071702 organic substance transport 20.8333 4 no
GO:0071705 nitrogen compound transport 20.8333 4 no
GO:0043085 positive regulation of catalytic activity 20.8333 4 yes
GO:0051336 regulation of hydrolase activity 20.8333 4 yes
GO:0001932 regulation of protein phosphorylation 20.8333 7 no
GO:0010810 regulation of cell-substrate adhesion 20.8333 5 no
GO:0031346 positive regulation of cell projection organization 20.8333 6 no
GO:0032956 regulation of actin cytoskeleton organization 20.8333 5 no
GO:0032970 regulation of actin filament-based process 20.8333 4 no
GO:0042325 regulation of phosphorylation 20.8333 7 no
GO:0044089 positive regulation of cellular component biogenesis 20.8333 5 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0051130 positive regulation of cellular component organization 20.8333 5 no
GO:0051493 regulation of cytoskeleton organization 20.8333 6 no
GO:0043087 regulation of GTPase activity 16.6667 5 yes
GO:0043547 positive regulation of GTPase activity 16.6667 6 yes
GO:0051345 positive regulation of hydrolase activity 16.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD2_HUMAN [view interactions] Low throughput no yes
SMAD3_HUMAN [view interactions] Low throughput no yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
DOC10_HUMAN [view entry] [view interactions] High throughput yes yes
PAAT_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
CAMP3_HUMAN [view interactions] High throughput no no
CCNT1_HUMAN [view interactions] High throughput no yes
CIRBP_HUMAN [view interactions] High throughput no no
LBR_HUMAN [view interactions] High throughput no yes
NSRP1_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
MOB3B_HUMAN [view interactions] High throughput no no
MUC18_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CHD1_HUMAN [view interactions] High throughput no yes
CNBP_HUMAN [view interactions] High throughput no no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
DOC11_HUMAN [view interactions] High throughput no yes
CUL4B_HUMAN [view interactions] High throughput no yes
ATG12_HUMAN [view interactions] High throughput no yes
CLK1_HUMAN [view interactions] High throughput no yes
FHL1_HUMAN [view interactions] High throughput no no
MYOTI_HUMAN [view interactions] High throughput no no
NEBU_HUMAN [view interactions] High throughput no no
CASL_HUMAN [view interactions] High throughput no yes
NUCKS_HUMAN [view interactions] High throughput no yes
2A5E_HUMAN [view interactions] High throughput no yes
SNAPN_HUMAN [view interactions] High throughput no yes
TAF1_HUMAN [view interactions] High throughput no yes