DOCK9_HUMAN
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DOCK9_HUMAN |
---|---|---|---|---|
GO:0016462 | pyrophosphatase activity | 43.4783 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 43.4783 | 4 | no |
GO:0017076 | purine nucleotide binding | 43.4783 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 43.4783 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 43.4783 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 43.4783 | 4 | no |
GO:0019900 | kinase binding | 39.1304 | 4 | no |
GO:0003924 | GTPase activity | 39.1304 | 7 | no |
GO:0005525 | GTP binding | 39.1304 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 39.1304 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 39.1304 | 5 | no |
GO:0019901 | protein kinase binding | 34.7826 | 5 | no |
GO:0045296 | cadherin binding | 30.4348 | 4 | yes |
GO:0005085 | guanyl-nucleotide exchange factor activity | 13.0435 | 5 | yes |
GO:0030695 | GTPase regulator activity | 13.0435 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DOCK9_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 65.2174 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 65.2174 | 4 | no |
GO:0048522 | positive regulation of cellular process | 65.2174 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 60.8696 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 60.8696 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 60.8696 | 4 | no |
GO:0007264 | small GTPase mediated signal transduction | 52.1739 | 4 | yes |
GO:0010646 | regulation of cell communication | 52.1739 | 4 | no |
GO:0008104 | protein localization | 47.8261 | 4 | no |
GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
GO:0009966 | regulation of signal transduction | 43.4783 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 43.4783 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 43.4783 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 43.4783 | 5 | no |
GO:0015031 | protein transport | 39.1304 | 4 | no |
GO:0071702 | organic substance transport | 39.1304 | 4 | no |
GO:0071705 | nitrogen compound transport | 39.1304 | 4 | no |
GO:0030334 | regulation of cell migration | 39.1304 | 5 | no |
GO:2000145 | regulation of cell motility | 39.1304 | 4 | no |
GO:0006996 | organelle organization | 39.1304 | 4 | no |
GO:0051049 | regulation of transport | 39.1304 | 4 | no |
GO:0010941 | regulation of cell death | 34.7826 | 4 | no |
GO:0042981 | regulation of apoptotic process | 34.7826 | 6 | no |
GO:0043067 | regulation of programmed cell death | 34.7826 | 5 | no |
GO:0006886 | intracellular protein transport | 34.7826 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 34.7826 | 6 | no |
GO:0031399 | regulation of protein modification process | 34.7826 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 34.7826 | 5 | no |
GO:0007265 | Ras protein signal transduction | 34.7826 | 5 | no |
GO:0030030 | cell projection organization | 34.7826 | 4 | no |
GO:0031175 | neuron projection development | 34.7826 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 34.7826 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 34.7826 | 4 | no |
GO:0010468 | regulation of gene expression | 34.7826 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 34.7826 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 34.7826 | 5 | no |
GO:0031344 | regulation of cell projection organization | 34.7826 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.7826 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.7826 | 6 | no |
GO:0007010 | cytoskeleton organization | 34.7826 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 34.7826 | 4 | no |
GO:0033043 | regulation of organelle organization | 34.7826 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 30.4348 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.4348 | 5 | no |
GO:0045595 | regulation of cell differentiation | 30.4348 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 30.4348 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 30.4348 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 30.4348 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 30.4348 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 30.4348 | 6 | no |
GO:0022607 | cellular component assembly | 30.4348 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 30.4348 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 26.0870 | 5 | no |
GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 26.0870 | 4 | yes |
GO:0043066 | negative regulation of apoptotic process | 26.0870 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 26.0870 | 6 | no |
GO:0060548 | negative regulation of cell death | 26.0870 | 5 | no |
GO:0042325 | regulation of phosphorylation | 26.0870 | 7 | no |
GO:0050804 | modulation of chemical synaptic transmission | 26.0870 | 5 | no |
GO:0071310 | cellular response to organic substance | 26.0870 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 26.0870 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 6 | no |
GO:0009891 | positive regulation of biosynthetic process | 26.0870 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 26.0870 | 5 | no |
GO:0030335 | positive regulation of cell migration | 26.0870 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 26.0870 | 6 | no |
GO:0031346 | positive regulation of cell projection organization | 26.0870 | 6 | no |
GO:0040017 | positive regulation of locomotion | 26.0870 | 4 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.0870 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 26.0870 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 26.0870 | 7 | no |
GO:2000147 | positive regulation of cell motility | 26.0870 | 5 | no |
GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
GO:0007015 | actin filament organization | 26.0870 | 5 | no |
GO:0097435 | supramolecular fiber organization | 26.0870 | 4 | no |
GO:0030155 | regulation of cell adhesion | 26.0870 | 4 | no |
GO:0032880 | regulation of protein localization | 26.0870 | 5 | no |
GO:0051050 | positive regulation of transport | 26.0870 | 4 | no |
GO:0060341 | regulation of cellular localization | 26.0870 | 4 | no |
GO:0060491 | regulation of cell projection assembly | 26.0870 | 5 | no |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 26.0870 | 6 | no |
GO:1903829 | positive regulation of protein localization | 26.0870 | 5 | no |
GO:1904951 | positive regulation of establishment of protein localization | 21.7391 | 6 | no |
GO:0060284 | regulation of cell development | 21.7391 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 21.7391 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 21.7391 | 7 | no |
GO:0006605 | protein targeting | 21.7391 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.7391 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.7391 | 5 | no |
GO:0016192 | vesicle-mediated transport | 21.7391 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.7391 | 6 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 21.7391 | 7 | no |
GO:0051254 | positive regulation of RNA metabolic process | 21.7391 | 6 | no |
GO:1902680 | positive regulation of RNA biosynthetic process | 21.7391 | 7 | no |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 21.7391 | 8 | no |
GO:0008360 | regulation of cell shape | 21.7391 | 6 | no |
GO:0030865 | cortical cytoskeleton organization | 21.7391 | 6 | no |
GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
GO:0051726 | regulation of cell cycle | 21.7391 | 4 | no |
GO:0006911 | phagocytosis, engulfment | 21.7391 | 7 | no |
GO:0008284 | positive regulation of cell population proliferation | 21.7391 | 5 | no |
GO:0010324 | membrane invagination | 21.7391 | 5 | no |
GO:0010810 | regulation of cell-substrate adhesion | 21.7391 | 5 | no |
GO:0030031 | cell projection assembly | 21.7391 | 5 | no |
GO:0032386 | regulation of intracellular transport | 21.7391 | 5 | no |
GO:0032388 | positive regulation of intracellular transport | 21.7391 | 5 | no |
GO:0033157 | regulation of intracellular protein transport | 21.7391 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 21.7391 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 21.7391 | 5 | no |
GO:0051222 | positive regulation of protein transport | 21.7391 | 5 | no |
GO:0051223 | regulation of protein transport | 21.7391 | 5 | no |
GO:0061024 | membrane organization | 21.7391 | 4 | no |
GO:0070201 | regulation of establishment of protein localization | 21.7391 | 6 | no |
GO:0090316 | positive regulation of intracellular protein transport | 21.7391 | 6 | no |
GO:0099024 | plasma membrane invagination | 21.7391 | 6 | no |
GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 21.7391 | 6 | no |
GO:0043087 | regulation of GTPase activity | 17.3913 | 5 | yes |
GO:0043547 | positive regulation of GTPase activity | 17.3913 | 6 | yes |
GO:0051345 | positive regulation of hydrolase activity | 17.3913 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DOC11_HUMAN | [view interactions] | High throughput | no | yes |
DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNBP_HUMAN | [view interactions] | High throughput | no | no |
CHD1_HUMAN | [view interactions] | High throughput | no | yes |
CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
ATG12_HUMAN | [view interactions] | High throughput | no | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
FHL1_HUMAN | [view interactions] | High throughput | no | no |
MYOTI_HUMAN | [view interactions] | High throughput | no | no |
NEBU_HUMAN | [view interactions] | High throughput | no | no |
CASL_HUMAN | [view interactions] | High throughput | no | yes |
NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
2A5E_HUMAN | [view interactions] | High throughput | no | yes |
SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
TAF1_HUMAN | [view interactions] | High throughput | no | yes |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
DOC10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAAT_HUMAN | [view interactions] | High throughput | no | yes |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAMP3_HUMAN | [view interactions] | High throughput | no | no |
CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
CIRBP_HUMAN | [view interactions] | High throughput | no | no |
LBR_HUMAN | [view interactions] | High throughput | no | yes |
NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHX8_HUMAN | [view interactions] | Computational | no | yes |