CPT1A_HUMAN
Evidence for PS localization
Functions
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed, PubMed, PubMed). Plays an important role in hepatic triglyceride metabolism . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPT1A_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 31.7460 | 4 | no |
| GO:0043168 | anion binding | 31.7460 | 4 | no |
| GO:0043169 | cation binding | 31.7460 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.1587 | 5 | no |
| GO:0046872 | metal ion binding | 30.1587 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 28.5714 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 28.5714 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.9841 | 4 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 25.3968 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 22.2222 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.6349 | 6 | no |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4.7619 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPT1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.6190 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.2698 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 38.0952 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 38.0952 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.9206 | 4 | yes |
| GO:0010646 | regulation of cell communication | 34.9206 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 34.9206 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.7460 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 31.7460 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.1587 | 4 | yes |
| GO:0022607 | cellular component assembly | 30.1587 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.5714 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.9841 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.9841 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.3968 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.8095 | 6 | no |
| GO:0008104 | protein localization | 23.8095 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 22.2222 | 4 | yes |
| GO:0051049 | regulation of transport | 22.2222 | 4 | yes |
| GO:0071702 | organic substance transport | 22.2222 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.6349 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 20.6349 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 14.2857 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 14.2857 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 12.6984 | 4 | yes |
| GO:0033993 | response to lipid | 12.6984 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 11.1111 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 11.1111 | 4 | yes |
| GO:0071396 | cellular response to lipid | 11.1111 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 9.5238 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 9.5238 | 6 | yes |
| GO:0032880 | regulation of protein localization | 9.5238 | 5 | yes |
| GO:0036293 | response to decreased oxygen levels | 9.5238 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 7.9365 | 5 | yes |
| GO:0051046 | regulation of secretion | 7.9365 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 7.9365 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 7.9365 | 4 | yes |
| GO:0006839 | mitochondrial transport | 6.3492 | 4 | yes |
| GO:0016042 | lipid catabolic process | 6.3492 | 4 | yes |
| GO:0030855 | epithelial cell differentiation | 6.3492 | 4 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 6.3492 | 6 | yes |
| GO:0051223 | regulation of protein transport | 6.3492 | 5 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 6.3492 | 4 | yes |
| GO:0006006 | glucose metabolic process | 4.7619 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 4.7619 | 4 | yes |
| GO:0006635 | fatty acid beta-oxidation | 4.7619 | 6 | yes |
| GO:0009062 | fatty acid catabolic process | 4.7619 | 5 | yes |
| GO:0015711 | organic anion transport | 4.7619 | 5 | yes |
| GO:0015849 | organic acid transport | 4.7619 | 5 | yes |
| GO:0016054 | organic acid catabolic process | 4.7619 | 4 | yes |
| GO:0019216 | regulation of lipid metabolic process | 4.7619 | 5 | yes |
| GO:0019318 | hexose metabolic process | 4.7619 | 4 | yes |
| GO:0019395 | fatty acid oxidation | 4.7619 | 5 | yes |
| GO:0030258 | lipid modification | 4.7619 | 4 | yes |
| GO:0034440 | lipid oxidation | 4.7619 | 5 | yes |
| GO:0043279 | response to alkaloid | 4.7619 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 4.7619 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 4.7619 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 4.7619 | 6 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 4.7619 | 6 | yes |
| GO:1905039 | carboxylic acid transmembrane transport | 4.7619 | 4 | yes |
| GO:0002791 | regulation of peptide secretion | 3.1746 | 6 | yes |
| GO:0006869 | lipid transport | 3.1746 | 5 | yes |
| GO:0010565 | regulation of cellular ketone metabolic process | 3.1746 | 5 | yes |
| GO:0015718 | monocarboxylic acid transport | 3.1746 | 7 | yes |
| GO:0015908 | fatty acid transport | 3.1746 | 6 | yes |
| GO:0015909 | long-chain fatty acid transport | 3.1746 | 7 | yes |
| GO:0019217 | regulation of fatty acid metabolic process | 3.1746 | 6 | yes |
| GO:0046486 | glycerolipid metabolic process | 3.1746 | 4 | yes |
| GO:0046883 | regulation of hormone secretion | 3.1746 | 4 | yes |
| GO:0048732 | gland development | 3.1746 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 3.1746 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 3.1746 | 6 | yes |
| GO:0062013 | positive regulation of small molecule metabolic process | 3.1746 | 5 | yes |
| GO:0090087 | regulation of peptide transport | 3.1746 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 3.1746 | 5 | yes |
| GO:1902001 | fatty acid transmembrane transport | 3.1746 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| LDHA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP50_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELK1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPC3_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| PCKGC_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD9_HUMAN | [view interactions] | High throughput | no | yes |
| GBRG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD1A_HUMAN | [view interactions] | High throughput | no | no |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| DQB1_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INLR1_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAMP2_HUMAN | [view interactions] | High throughput | no | no |
| PCDGM_HUMAN | [view interactions] | High throughput | no | yes |
| TSN8_HUMAN | [view interactions] | High throughput | no | no |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITLN1_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| KLRD1_HUMAN | [view interactions] | High throughput | no | no |
| ADAM7_HUMAN | [view interactions] | High throughput | no | no |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSM_HUMAN | [view interactions] | High throughput | no | no |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| EMC3_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| COX7C_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| CY24A_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPDC1_HUMAN | [view interactions] | High throughput | no | yes |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |