Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CPT1A_HUMAN

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed, PubMed, PubMed). Plays an important role in hepatic triglyceride metabolism . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
123 Arg Cys Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
304 Cys Trp Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
314 Thr Ile Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
357 Arg Trp Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
360 Glu Gly Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
414 Ala Val Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
454 Asp Gly Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
479 Pro Leu Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
484 Leu Pro Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
498 Tyr Cys Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
709 Gly Glu Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
710 Gly Glu Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
316 Arg Gly Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
343 Phe Val Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -
465 Gly Trp Carnitinepalmitoyltransferase1Adeficiency(CPT1AD) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CPT1A_HUMAN
GO:0017076 purine nucleotide binding 31.6667 4 no
GO:0032555 purine ribonucleotide binding 31.6667 4 no
GO:0046872 metal ion binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0030554 adenyl nucleotide binding 23.3333 5 no
GO:0032559 adenyl ribonucleotide binding 23.3333 5 no
GO:0015399 primary active transmembrane transporter activity 23.3333 4 no
GO:0005524 ATP binding 21.6667 5 no
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 10.0000 4 yes
GO:0004095 carnitine O-palmitoyltransferase activity 5.0000 7 yes
GO:0008374 O-acyltransferase activity 5.0000 5 yes
GO:0016406 carnitine O-acyltransferase activity 5.0000 6 yes
GO:0016409 palmitoyltransferase activity 5.0000 5 yes
GO:0016416 O-palmitoyltransferase activity 5.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CPT1A_HUMAN
GO:0048522 positive regulation of cellular process 48.3333 4 yes
GO:0031323 regulation of cellular metabolic process 43.3333 4 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 yes
GO:0080090 regulation of primary metabolic process 40.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 36.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 36.6667 4 no
GO:0048523 negative regulation of cellular process 35.0000 4 no
GO:0010646 regulation of cell communication 35.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 yes
GO:0071310 cellular response to organic substance 31.6667 4 yes
GO:0051246 regulation of protein metabolic process 30.0000 5 no
GO:0022607 cellular component assembly 30.0000 4 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0010243 response to organonitrogen compound 30.0000 4 yes
GO:0051247 positive regulation of protein metabolic process 28.3333 6 no
GO:0009966 regulation of signal transduction 28.3333 4 no
GO:0010468 regulation of gene expression 28.3333 5 no
GO:0006996 organelle organization 28.3333 4 no
GO:0051049 regulation of transport 28.3333 4 yes
GO:0006796 phosphate-containing compound metabolic process 26.6667 4 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0071702 organic substance transport 25.0000 4 yes
GO:0031399 regulation of protein modification process 23.3333 6 no
GO:0048584 positive regulation of response to stimulus 23.3333 4 no
GO:1902531 regulation of intracellular signal transduction 23.3333 5 no
GO:0042325 regulation of phosphorylation 21.6667 7 no
GO:0045937 positive regulation of phosphate metabolic process 21.6667 7 no
GO:0009967 positive regulation of signal transduction 21.6667 5 no
GO:1901701 cellular response to oxygen-containing compound 21.6667 4 yes
GO:0006811 ion transport 21.6667 4 no
GO:0008104 protein localization 21.6667 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.6667 6 no
GO:0019752 carboxylic acid metabolic process 20.0000 5 yes
GO:0043436 oxoacid metabolic process 20.0000 4 yes
GO:0032787 monocarboxylic acid metabolic process 18.3333 6 yes
GO:0060341 regulation of cellular localization 18.3333 4 yes
GO:0014070 response to organic cyclic compound 16.6667 4 yes
GO:0009894 regulation of catabolic process 15.0000 4 yes
GO:0032880 regulation of protein localization 15.0000 5 yes
GO:0006631 fatty acid metabolic process 13.3333 4 yes
GO:0033993 response to lipid 11.6667 4 yes
GO:0051046 regulation of secretion 11.6667 5 yes
GO:0051223 regulation of protein transport 11.6667 5 yes
GO:0070201 regulation of establishment of protein localization 11.6667 6 yes
GO:0071396 cellular response to lipid 11.6667 5 yes
GO:0016042 lipid catabolic process 10.0000 4 yes
GO:0019216 regulation of lipid metabolic process 10.0000 5 yes
GO:0031329 regulation of cellular catabolic process 10.0000 5 yes
GO:1903530 regulation of secretion by cell 10.0000 4 yes
GO:0006635 fatty acid beta-oxidation 8.3333 6 yes
GO:0009062 fatty acid catabolic process 8.3333 5 yes
GO:0009896 positive regulation of catabolic process 8.3333 5 yes
GO:0015849 organic acid transport 8.3333 5 yes
GO:0016054 organic acid catabolic process 8.3333 4 yes
GO:0019395 fatty acid oxidation 8.3333 5 yes
GO:0030258 lipid modification 8.3333 4 yes
GO:0031667 response to nutrient levels 8.3333 4 yes
GO:0034440 lipid oxidation 8.3333 5 yes
GO:0044242 cellular lipid catabolic process 8.3333 4 yes
GO:0046395 carboxylic acid catabolic process 8.3333 5 yes
GO:0072329 monocarboxylic acid catabolic process 8.3333 6 yes
GO:0001676 long-chain fatty acid metabolic process 6.6667 5 yes
GO:0006839 mitochondrial transport 6.6667 4 yes
GO:0006869 lipid transport 6.6667 5 yes
GO:0015908 fatty acid transport 6.6667 6 yes
GO:0015909 long-chain fatty acid transport 6.6667 7 yes
GO:0031331 positive regulation of cellular catabolic process 6.6667 6 yes
GO:0043279 response to alkaloid 6.6667 5 yes
GO:0045834 positive regulation of lipid metabolic process 6.6667 5 yes
GO:0048732 gland development 6.6667 4 yes
GO:0062012 regulation of small molecule metabolic process 6.6667 4 yes
GO:1905039 carboxylic acid transmembrane transport 6.6667 4 yes
GO:0002791 regulation of peptide secretion 5.0000 6 yes
GO:0006006 glucose metabolic process 5.0000 5 yes
GO:0006577 amino-acid betaine metabolic process 5.0000 4 yes
GO:0009437 carnitine metabolic process 5.0000 5 yes
GO:0019318 hexose metabolic process 5.0000 4 yes
GO:0030855 epithelial cell differentiation 5.0000 4 yes
GO:0046883 regulation of hormone secretion 5.0000 4 yes
GO:0050708 regulation of protein secretion 5.0000 5 yes
GO:0050796 regulation of insulin secretion 5.0000 6 yes
GO:0090087 regulation of peptide transport 5.0000 5 yes
GO:0090276 regulation of peptide hormone secretion 5.0000 5 yes
GO:1902001 fatty acid transmembrane transport 5.0000 5 yes
GO:0001889 liver development 3.3333 5 yes
GO:0006853 carnitine shuttle 3.3333 4 yes
GO:0010565 regulation of cellular ketone metabolic process 3.3333 5 yes
GO:0019217 regulation of fatty acid metabolic process 3.3333 6 yes
GO:0032365 intracellular lipid transport 3.3333 4 yes
GO:0045471 response to ethanol 3.3333 5 yes
GO:0046486 glycerolipid metabolic process 3.3333 4 yes
GO:0062013 positive regulation of small molecule metabolic process 3.3333 5 yes
GO:0097305 response to alcohol 3.3333 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in CPT1A_HUMAN
DOID:3146 lipid metabolism disorder 3.3333 3 yes
DOID:0060038 specific developmental disorder 3.3333 3 no
DOID:1059 intellectual disability 3.3333 4 no
DOID:331 central nervous system disease 3.3333 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BCL2_HUMAN [view interactions] Low throughput no no
LDHA_HUMAN [view entry] [view interactions] Low throughput yes yes
VSIG4_HUMAN [view interactions] High throughput no no
KLRD1_HUMAN [view interactions] High throughput no no
ADAM7_HUMAN [view interactions] High throughput no no
T184A_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
THB_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOC_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
CPSM_HUMAN [view interactions] High throughput no no
LPP_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
U520_HUMAN [view interactions] High throughput no yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
EMC4_HUMAN [view interactions] High throughput no yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
ODBA_HUMAN [view interactions] High throughput no yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
EMC2_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
YIPF3_HUMAN [view interactions] High throughput no yes
PLOD3_HUMAN [view interactions] High throughput no yes
EMC3_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
COX7C_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB9_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
TOM5_HUMAN [view interactions] High throughput no yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS5_HUMAN [view interactions] High throughput no yes
NDUS8_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
NR4A1_HUMAN [view interactions] High throughput no yes
CY24A_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
NPDC1_HUMAN [view interactions] High throughput no yes
HDA11_HUMAN [view interactions] High throughput no no
TOIP1_HUMAN [view interactions] High throughput no yes
PP4C_HUMAN [view interactions] High throughput no yes
KCNK1_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
COQ9_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
ELK1_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
E2F3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
MYPC3_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CLIC1_HUMAN [view interactions] High throughput no no
KBTB7_HUMAN [view interactions] High throughput no yes
TIFAB_HUMAN [view interactions] High throughput no no
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
CLN3_HUMAN [view interactions] High throughput no no
PCKGC_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
LGR4_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
TBCD9_HUMAN [view interactions] High throughput no yes
GBRG2_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
EMC1_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
INS_HUMAN [view interactions] High throughput no no
RMC1_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
F16P1_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
CD1A_HUMAN [view interactions] High throughput no no
CKLF5_HUMAN [view interactions] High throughput no yes
DQB1_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
S39A9_HUMAN [view interactions] High throughput no yes
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
INLR1_HUMAN [view interactions] High throughput no no
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
TMM59_HUMAN [view interactions] High throughput no yes
MAGA8_HUMAN [view interactions] High throughput no no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
RAMP2_HUMAN [view interactions] High throughput no no
PCDGM_HUMAN [view interactions] High throughput no yes
TSN8_HUMAN [view interactions] High throughput no no
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
AQP3_HUMAN [view interactions] High throughput no no
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
DOXA2_HUMAN [view interactions] High throughput no no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
ITLN1_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
HLAC_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
MFD4A_HUMAN [view interactions] High throughput no yes
GPIX_HUMAN [view interactions] High throughput no no
CPT1B_HUMAN [view interactions] Computational no no
PPARA_HUMAN [view interactions] Computational no yes
FAS_HUMAN [view entry] [view interactions] Computational yes no
EP300_HUMAN [view interactions] Computational no yes
ECHP_HUMAN [view interactions] Computational no no
NCOA2_HUMAN [view interactions] Computational no no
JUN_HUMAN [view interactions] Computational no yes
SRA1_HUMAN [view interactions] Computational no yes
CBP_HUMAN [view interactions] Computational no yes
APOA1_HUMAN [view interactions] Computational no no
RORA_HUMAN [view interactions] Computational no yes
CARM1_HUMAN [view interactions] Computational no yes
TF65_HUMAN [view entry] [view interactions] Computational yes yes
MAOX_HUMAN [view interactions] Computational no yes
MCAT_HUMAN [view interactions] Computational no yes
ACSL3_HUMAN [view entry] [view interactions] Computational yes yes
ACSL5_HUMAN [view interactions] Computational no yes
SP1_HUMAN [view interactions] Computational no yes
TGS1_HUMAN [view interactions] Computational no yes
TBL1R_HUMAN [view interactions] Computational no yes
CPT2_HUMAN [view entry] [view interactions] Computational yes yes
NCOA1_HUMAN [view interactions] Computational no yes
PRGC1_HUMAN [view interactions] Computational no no
ACSL1_HUMAN [view interactions] Computational no no
ACOX1_HUMAN [view interactions] Computational no yes
SRBP1_HUMAN [view interactions] Computational no yes
ACSL4_HUMAN [view entry] [view interactions] Computational yes yes
NCOA6_HUMAN [view interactions] Computational no yes
CPT1C_HUMAN [view entry] [view interactions] Computational yes yes
SMRD3_HUMAN [view interactions] Computational no no
CHD9_HUMAN [view interactions] Computational no yes
MED1_HUMAN [view interactions] Computational no no
RXRA_HUMAN [view interactions] Computational no yes
APOA2_HUMAN [view interactions] Computational no no
ACACB_HUMAN [view interactions] Computational no no
RAB28_HUMAN [view interactions] Computational no yes
HELZ2_HUMAN [view interactions] Computational no no
NRIP1_HUMAN [view interactions] Computational no yes
FABPL_HUMAN [view interactions] Computational no no