Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NUCG_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NUCG_HUMAN
GO:0017076 purine nucleotide binding 41.6667 4 no
GO:0030554 adenyl nucleotide binding 41.6667 5 no
GO:0005524 ATP binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0032559 adenyl ribonucleotide binding 37.5000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0046872 metal ion binding 29.1667 4 yes
GO:0042803 protein homodimerization activity 25.0000 4 yes
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0016462 pyrophosphatase activity 20.8333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.8333 4 no
GO:0016887 ATP hydrolysis activity 20.8333 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.8333 6 no
GO:0000287 magnesium ion binding 12.5000 5 yes
GO:0000014 single-stranded DNA endodeoxyribonuclease activity 8.3333 6 yes
GO:0004518 nuclease activity 8.3333 4 yes
GO:0004519 endonuclease activity 8.3333 5 yes
GO:0004520 endodeoxyribonuclease activity 8.3333 5 yes
GO:0004521 endoribonuclease activity 8.3333 5 yes
GO:0004536 deoxyribonuclease activity 8.3333 4 yes
GO:0004540 ribonuclease activity 8.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NUCG_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 yes
GO:0080090 regulation of primary metabolic process 62.5000 4 yes
GO:0009893 positive regulation of metabolic process 58.3333 4 yes
GO:0048523 negative regulation of cellular process 58.3333 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 58.3333 5 yes
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 54.1667 5 yes
GO:0031323 regulation of cellular metabolic process 54.1667 4 yes
GO:0031325 positive regulation of cellular metabolic process 45.8333 5 yes
GO:0051128 regulation of cellular component organization 41.6667 4 yes
GO:0071310 cellular response to organic substance 41.6667 4 yes
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0009966 regulation of signal transduction 37.5000 4 yes
GO:0010646 regulation of cell communication 37.5000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 yes
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0009894 regulation of catabolic process 33.3333 4 yes
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0010941 regulation of cell death 33.3333 4 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0033993 response to lipid 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 6 yes
GO:0043067 regulation of programmed cell death 33.3333 5 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0014070 response to organic cyclic compound 29.1667 4 yes
GO:0051130 positive regulation of cellular component organization 29.1667 5 yes
GO:1902531 regulation of intracellular signal transduction 29.1667 5 yes
GO:0071702 organic substance transport 29.1667 4 no
GO:0006996 organelle organization 29.1667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.1667 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0030162 regulation of proteolysis 29.1667 6 no
GO:0009057 macromolecule catabolic process 25.0000 4 yes
GO:0009896 positive regulation of catabolic process 25.0000 5 yes
GO:0010638 positive regulation of organelle organization 25.0000 6 yes
GO:0031329 regulation of cellular catabolic process 25.0000 5 yes
GO:0033043 regulation of organelle organization 25.0000 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 yes
GO:0090304 nucleic acid metabolic process 25.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 yes
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0071396 cellular response to lipid 25.0000 5 no
GO:0006986 response to unfolded protein 25.0000 4 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0010942 positive regulation of cell death 20.8333 5 yes
GO:0031331 positive regulation of cellular catabolic process 20.8333 6 yes
GO:0036293 response to decreased oxygen levels 20.8333 4 yes
GO:0036294 cellular response to decreased oxygen levels 20.8333 5 yes
GO:0043065 positive regulation of apoptotic process 20.8333 7 yes
GO:0043068 positive regulation of programmed cell death 20.8333 6 yes
GO:0044265 cellular macromolecule catabolic process 20.8333 4 yes
GO:0048584 positive regulation of response to stimulus 20.8333 4 yes
GO:0071453 cellular response to oxygen levels 20.8333 4 yes
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0006355 regulation of DNA-templated transcription 20.8333 6 no
GO:0008285 negative regulation of cell population proliferation 20.8333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 20.8333 5 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:0071407 cellular response to organic cyclic compound 20.8333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 20.8333 7 no
GO:2000026 regulation of multicellular organismal development 20.8333 4 no
GO:2001141 regulation of RNA biosynthetic process 20.8333 6 no
GO:0010628 positive regulation of gene expression 20.8333 6 no
GO:0033365 protein localization to organelle 20.8333 5 no
GO:0035967 cellular response to topologically incorrect protein 20.8333 4 no
GO:0043254 regulation of protein-containing complex assembly 20.8333 5 no
GO:1902903 regulation of supramolecular fiber organization 20.8333 5 no
GO:0019220 regulation of phosphate metabolic process 20.8333 6 no
GO:0051174 regulation of phosphorus metabolic process 20.8333 5 no
GO:0031396 regulation of protein ubiquitination 20.8333 8 no
GO:0051338 regulation of transferase activity 20.8333 4 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 20.8333 7 no
GO:0022607 cellular component assembly 20.8333 4 no
GO:0044089 positive regulation of cellular component biogenesis 20.8333 5 no
GO:0065003 protein-containing complex assembly 20.8333 5 no
GO:0051336 regulation of hydrolase activity 20.8333 4 no
GO:0019439 aromatic compound catabolic process 16.6667 4 yes
GO:0032355 response to estradiol 16.6667 4 yes
GO:0034655 nucleobase-containing compound catabolic process 16.6667 4 yes
GO:0044270 cellular nitrogen compound catabolic process 16.6667 4 yes
GO:0046700 heterocycle catabolic process 16.6667 4 yes
GO:0071456 cellular response to hypoxia 16.6667 4 yes
GO:0080134 regulation of response to stress 16.6667 4 yes
GO:0080135 regulation of cellular response to stress 16.6667 4 yes
GO:1901361 organic cyclic compound catabolic process 16.6667 4 yes
GO:1902532 negative regulation of intracellular signal transduction 16.6667 6 yes
GO:0001701 in utero embryonic development 12.5000 6 yes
GO:0006259 DNA metabolic process 12.5000 4 yes
GO:0009792 embryo development ending in birth or egg hatching 12.5000 4 yes
GO:0010038 response to metal ion 12.5000 4 yes
GO:0010821 regulation of mitochondrion organization 12.5000 6 yes
GO:0033500 carbohydrate homeostasis 12.5000 5 yes
GO:0042593 glucose homeostasis 12.5000 6 yes
GO:0043009 chordate embryonic development 12.5000 5 yes
GO:0048878 chemical homeostasis 12.5000 4 yes
GO:0051052 regulation of DNA metabolic process 12.5000 5 yes
GO:0051592 response to calcium ion 12.5000 5 yes
GO:0071241 cellular response to inorganic substance 12.5000 4 yes
GO:1902510 regulation of apoptotic DNA fragmentation 12.5000 7 yes
GO:1903624 regulation of DNA catabolic process 12.5000 6 yes
GO:0000737 DNA catabolic process, endonucleolytic 8.3333 6 yes
GO:0001678 cellular glucose homeostasis 8.3333 4 yes
GO:0006275 regulation of DNA replication 8.3333 6 yes
GO:0006308 DNA catabolic process 8.3333 5 yes
GO:0006309 apoptotic DNA fragmentation 8.3333 7 yes
GO:0006310 DNA recombination 8.3333 5 yes
GO:0009743 response to carbohydrate 8.3333 4 yes
GO:0009746 response to hexose 8.3333 6 yes
GO:0009749 response to glucose 8.3333 7 yes
GO:0010506 regulation of autophagy 8.3333 6 yes
GO:0010508 positive regulation of autophagy 8.3333 7 yes
GO:0010822 positive regulation of mitochondrion organization 8.3333 7 yes
GO:0032006 regulation of TOR signaling 8.3333 6 yes
GO:0032007 negative regulation of TOR signaling 8.3333 7 yes
GO:0032042 mitochondrial DNA metabolic process 8.3333 5 yes
GO:0032043 mitochondrial DNA catabolic process 8.3333 6 yes
GO:0034097 response to cytokine 8.3333 4 yes
GO:0034284 response to monosaccharide 8.3333 5 yes
GO:0034612 response to tumor necrosis factor 8.3333 5 yes
GO:0036475 neuron death in response to oxidative stress 8.3333 4 yes
GO:0045740 positive regulation of DNA replication 8.3333 7 yes
GO:0051054 positive regulation of DNA metabolic process 8.3333 6 yes
GO:0071248 cellular response to metal ion 8.3333 5 yes
GO:0071277 cellular response to calcium ion 8.3333 6 yes
GO:0071322 cellular response to carbohydrate stimulus 8.3333 5 yes
GO:0071326 cellular response to monosaccharide stimulus 8.3333 6 yes
GO:0071331 cellular response to hexose stimulus 8.3333 7 yes
GO:0071333 cellular response to glucose stimulus 8.3333 5 yes
GO:0090296 regulation of mitochondrial DNA replication 8.3333 7 yes
GO:0090297 positive regulation of mitochondrial DNA replication 8.3333 8 yes
GO:0090329 regulation of DNA-templated DNA replication 8.3333 7 yes
GO:1900407 regulation of cellular response to oxidative stress 8.3333 5 yes
GO:1901031 regulation of response to reactive oxygen species 8.3333 6 yes
GO:1901033 positive regulation of response to reactive oxygen species 8.3333 6 yes
GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 8.3333 6 yes
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death 8.3333 7 yes
GO:1901858 regulation of mitochondrial DNA metabolic process 8.3333 6 yes
GO:1901860 positive regulation of mitochondrial DNA metabolic process 8.3333 7 yes
GO:1902512 positive regulation of apoptotic DNA fragmentation 8.3333 8 yes
GO:1902882 regulation of response to oxidative stress 8.3333 5 yes
GO:1902884 positive regulation of response to oxidative stress 8.3333 5 yes
GO:1903201 regulation of oxidative stress-induced cell death 8.3333 5 yes
GO:1903205 regulation of hydrogen peroxide-induced cell death 8.3333 6 yes
GO:1903209 positive regulation of oxidative stress-induced cell death 8.3333 6 yes
GO:1903626 positive regulation of DNA catabolic process 8.3333 7 yes
GO:1905206 positive regulation of hydrogen peroxide-induced cell death 8.3333 7 yes
GO:2000105 positive regulation of DNA-templated DNA replication 8.3333 8 yes
GO:2001020 regulation of response to DNA damage stimulus 8.3333 5 yes
GO:2001022 positive regulation of response to DNA damage stimulus 8.3333 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in NUCG_HUMAN
DOID:0050542 Charcot-Marie-Tooth disease type X 8.3333 7 no
DOID:10595 Charcot-Marie-Tooth disease 8.3333 6 no
DOID:440 neuromuscular disease 8.3333 5 no
DOID:574 peripheral nervous system disease 8.3333 3 no
DOID:870 neuropathy 8.3333 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AIFM1_HUMAN [view entry] [view interactions] Low throughput yes no
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
FEN1_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
BIRC2_HUMAN [view interactions] Low throughput no yes
NUCG_HUMAN [view entry] [view interactions] Low throughput yes yes
TNKS1_HUMAN [view interactions] High throughput no yes
DNJA4_HUMAN [view interactions] High throughput no yes
ZNRD2_HUMAN [view interactions] High throughput no yes
KAPCG_HUMAN [view interactions] High throughput no no
PCGF2_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BAG4_HUMAN [view interactions] High throughput no yes
ITLN1_HUMAN [view interactions] High throughput no no
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA8_HUMAN [view interactions] High throughput no no
ITLN2_HUMAN [view interactions] High throughput no no
COX14_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
CBPA4_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
NFYC_HUMAN [view interactions] High throughput no no
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
GRK6_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
PSME1_HUMAN [view interactions] High throughput no yes
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
EFNA2_HUMAN [view interactions] High throughput no no
NUBP1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
BAG1_HUMAN [view interactions] High throughput no yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
COPT1_HUMAN [view interactions] High throughput no no
CYTD_HUMAN [view interactions] High throughput no no
TUSC2_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
DKC1_HUMAN [view interactions] High throughput no yes
RNZ2_HUMAN [view interactions] High throughput no yes
NLE1_HUMAN [view interactions] High throughput no yes
ANM8_HUMAN [view interactions] High throughput no yes
PRPS2_HUMAN [view interactions] High throughput no no
RBM8A_HUMAN [view interactions] High throughput no yes
ELP2_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
TRM11_HUMAN [view interactions] High throughput no no
BCCIP_HUMAN [view interactions] High throughput no no
RL1D1_HUMAN [view interactions] High throughput no yes
WDR12_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
DNJC7_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
APAF_HUMAN [view interactions] Computational no no
CYC_HUMAN [view entry] [view interactions] Computational yes yes