Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NUCG_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NUCG_HUMAN
GO:0000166 nucleotide binding 44.0000 4 no
GO:0017076 purine nucleotide binding 40.0000 5 no
GO:0030554 adenyl nucleotide binding 40.0000 6 no
GO:0043168 anion binding 40.0000 4 no
GO:0005524 ATP binding 36.0000 5 no
GO:0032555 purine ribonucleotide binding 36.0000 4 no
GO:0032559 adenyl ribonucleotide binding 36.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 36.0000 4 no
GO:0042803 protein homodimerization activity 32.0000 4 yes
GO:0043169 cation binding 32.0000 4 yes
GO:0046872 metal ion binding 28.0000 5 yes
GO:0031625 ubiquitin protein ligase binding 28.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 28.0000 4 no
GO:0001664 G protein-coupled receptor binding 24.0000 4 no
GO:0000287 magnesium ion binding 12.0000 6 yes
GO:0000014 single-stranded DNA endodeoxyribonuclease activity 8.0000 6 yes
GO:0004518 nuclease activity 8.0000 4 yes
GO:0004519 endonuclease activity 8.0000 5 yes
GO:0004520 DNA endonuclease activity 8.0000 5 yes
GO:0004521 RNA endonuclease activity 8.0000 5 yes
GO:0004536 DNA nuclease activity 8.0000 4 yes
GO:0004540 RNA nuclease activity 8.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NUCG_HUMAN
GO:0048522 positive regulation of cellular process 64.0000 4 yes
GO:0048523 negative regulation of cellular process 56.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.0000 4 yes
GO:0080090 regulation of primary metabolic process 56.0000 4 yes
GO:0031323 regulation of cellular metabolic process 52.0000 4 yes
GO:0009893 positive regulation of metabolic process 48.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.0000 5 yes
GO:0009966 regulation of signal transduction 44.0000 4 yes
GO:0010646 regulation of cell communication 44.0000 4 yes
GO:0051128 regulation of cellular component organization 44.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 yes
GO:0051246 regulation of protein metabolic process 36.0000 5 no
GO:0009968 negative regulation of signal transduction 36.0000 5 yes
GO:0010648 negative regulation of cell communication 36.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.0000 5 yes
GO:0023057 negative regulation of signaling 36.0000 4 yes
GO:0042981 regulation of apoptotic process 36.0000 5 yes
GO:0043067 regulation of programmed cell death 36.0000 4 yes
GO:0048585 negative regulation of response to stimulus 36.0000 4 yes
GO:0006996 organelle organization 32.0000 4 no
GO:0009892 negative regulation of metabolic process 32.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.0000 5 no
GO:0071310 cellular response to organic substance 32.0000 4 no
GO:0031399 regulation of protein modification process 32.0000 6 no
GO:0044087 regulation of cellular component biogenesis 32.0000 4 no
GO:0051247 positive regulation of protein metabolic process 32.0000 6 no
GO:0090304 nucleic acid metabolic process 28.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 28.0000 5 yes
GO:0071702 organic substance transport 28.0000 4 no
GO:0008104 protein localization 28.0000 4 no
GO:0009889 regulation of biosynthetic process 28.0000 4 no
GO:0010468 regulation of gene expression 28.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 28.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 28.0000 5 no
GO:0033993 response to lipid 28.0000 4 no
GO:0051129 negative regulation of cellular component organization 28.0000 5 no
GO:0043933 protein-containing complex organization 28.0000 4 no
GO:0009894 regulation of catabolic process 28.0000 4 yes
GO:0033043 regulation of organelle organization 28.0000 5 yes
GO:0051130 positive regulation of cellular component organization 28.0000 5 yes
GO:0042127 regulation of cell population proliferation 24.0000 4 no
GO:0006355 regulation of DNA-templated transcription 24.0000 7 no
GO:0009890 negative regulation of biosynthetic process 24.0000 5 no
GO:0009891 positive regulation of biosynthetic process 24.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.0000 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 24.0000 6 no
GO:0014070 response to organic cyclic compound 24.0000 4 no
GO:0031327 negative regulation of cellular biosynthetic process 24.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.0000 6 no
GO:0051252 regulation of RNA metabolic process 24.0000 5 no
GO:0071396 cellular response to lipid 24.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 24.0000 6 no
GO:0006796 phosphate-containing compound metabolic process 24.0000 4 no
GO:0030162 regulation of proteolysis 24.0000 6 no
GO:0080134 regulation of response to stress 24.0000 4 no
GO:0033365 protein localization to organelle 24.0000 5 no
GO:0071705 nitrogen compound transport 24.0000 4 no
GO:0022607 cellular component assembly 24.0000 4 no
GO:0065003 protein-containing complex assembly 24.0000 5 no
GO:0009057 macromolecule catabolic process 24.0000 4 yes
GO:0009896 positive regulation of catabolic process 24.0000 5 yes
GO:0010638 positive regulation of organelle organization 24.0000 6 yes
GO:0043068 positive regulation of programmed cell death 24.0000 5 yes
GO:0043065 positive regulation of apoptotic process 20.0000 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.0000 5 yes
GO:0141188 nucleic acid catabolic process 16.0000 5 yes
GO:1901361 organic cyclic compound catabolic process 16.0000 4 yes
GO:1902532 negative regulation of intracellular signal transduction 16.0000 6 yes
GO:0006259 DNA metabolic process 16.0000 5 yes
GO:0006974 DNA damage response 16.0000 4 yes
GO:0034655 nucleobase-containing compound catabolic process 16.0000 4 yes
GO:0051052 regulation of DNA metabolic process 16.0000 5 yes
GO:0001701 in utero embryonic development 12.0000 6 yes
GO:0009792 embryo development ending in birth or egg hatching 12.0000 4 yes
GO:0010821 regulation of mitochondrion organization 12.0000 6 yes
GO:0032042 mitochondrial DNA metabolic process 12.0000 6 yes
GO:0043009 chordate embryonic development 12.0000 5 yes
GO:0051054 positive regulation of DNA metabolic process 12.0000 6 yes
GO:0090297 positive regulation of mitochondrial DNA replication 8.0000 8 yes
GO:0090329 regulation of DNA-templated DNA replication 8.0000 7 yes
GO:1901858 regulation of mitochondrial DNA metabolic process 8.0000 6 yes
GO:1901860 positive regulation of mitochondrial DNA metabolic process 8.0000 7 yes
GO:2000105 positive regulation of DNA-templated DNA replication 8.0000 8 yes
GO:0006275 regulation of DNA replication 8.0000 6 yes
GO:0006308 DNA catabolic process 8.0000 5 yes
GO:0006309 apoptotic DNA fragmentation 8.0000 6 yes
GO:0006310 DNA recombination 8.0000 6 yes
GO:0010506 regulation of autophagy 8.0000 6 yes
GO:0010508 positive regulation of autophagy 8.0000 7 yes
GO:0031329 regulation of cellular catabolic process 8.0000 5 yes
GO:0031331 positive regulation of cellular catabolic process 8.0000 6 yes
GO:0032006 regulation of TOR signaling 8.0000 6 yes
GO:0032007 negative regulation of TOR signaling 8.0000 7 yes
GO:0032043 mitochondrial DNA catabolic process 8.0000 6 yes
GO:0034097 response to cytokine 8.0000 4 yes
GO:0034612 response to tumor necrosis factor 8.0000 5 yes
GO:0045740 positive regulation of DNA replication 8.0000 7 yes
GO:0090296 regulation of mitochondrial DNA replication 8.0000 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NUCG_HUMAN [view entry] [view interactions] Low throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] Low throughput yes no
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
FEN1_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
BIRC2_HUMAN [view interactions] Low throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
BAG1_HUMAN [view interactions] High throughput no yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
COPT1_HUMAN [view interactions] High throughput no no
CYTD_HUMAN [view interactions] High throughput no no
TUSC2_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
DKC1_HUMAN [view interactions] High throughput no yes
RNZ2_HUMAN [view interactions] High throughput no yes
NLE1_HUMAN [view interactions] High throughput no yes
ANM8_HUMAN [view entry] [view interactions] High throughput yes yes
PRPS2_HUMAN [view interactions] High throughput no no
RBM8A_HUMAN [view interactions] High throughput no yes
ELP2_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
TRM11_HUMAN [view interactions] High throughput no no
BCCIP_HUMAN [view interactions] High throughput no no
RL1D1_HUMAN [view interactions] High throughput no yes
WDR12_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
S2512_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
DNJC7_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNKS1_HUMAN [view interactions] High throughput no yes
DNJA4_HUMAN [view interactions] High throughput no yes
ZNRD2_HUMAN [view interactions] High throughput no yes
KAPCG_HUMAN [view interactions] High throughput no no
PCGF2_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BAG4_HUMAN [view interactions] High throughput no yes
ITLN1_HUMAN [view interactions] High throughput no no
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA8_HUMAN [view interactions] High throughput no no
ITLN2_HUMAN [view interactions] High throughput no no
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
PLRKT_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
CBPA4_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
NFYC_HUMAN [view interactions] High throughput no no
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
GRK6_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
PSME1_HUMAN [view interactions] High throughput no yes
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
EFNA2_HUMAN [view interactions] High throughput no no
NUBP1_HUMAN [view interactions] High throughput no yes