Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RHG21_HUMAN

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RHG21_HUMAN
GO:0019900 kinase binding 35.7143 4 no
GO:0019901 protein kinase binding 35.7143 5 no
GO:0017076 purine nucleotide binding 27.5510 4 no
GO:0045296 cadherin binding 26.5306 4 no
GO:0032555 purine ribonucleotide binding 25.5102 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.5102 4 no
GO:0003779 actin binding 24.4898 4 no
GO:0046872 metal ion binding 21.4286 4 no
GO:0003723 RNA binding 21.4286 4 no
GO:0030695 GTPase regulator activity 14.2857 4 yes
GO:0005096 GTPase activator activity 9.1837 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RHG21_HUMAN
GO:0048522 positive regulation of cellular process 65.3061 4 no
GO:0060255 regulation of macromolecule metabolic process 56.1224 4 no
GO:0051128 regulation of cellular component organization 54.0816 4 no
GO:0048523 negative regulation of cellular process 53.0612 4 no
GO:0080090 regulation of primary metabolic process 53.0612 4 no
GO:0051171 regulation of nitrogen compound metabolic process 51.0204 4 no
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0006996 organelle organization 45.9184 4 yes
GO:0009893 positive regulation of metabolic process 43.8776 4 no
GO:0009966 regulation of signal transduction 42.8571 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0051246 regulation of protein metabolic process 41.8367 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.7959 5 no
GO:0008104 protein localization 38.7755 4 no
GO:0010468 regulation of gene expression 38.7755 5 no
GO:0022607 cellular component assembly 38.7755 4 no
GO:0051049 regulation of transport 37.7551 4 no
GO:0033043 regulation of organelle organization 34.6939 5 no
GO:1902531 regulation of intracellular signal transduction 33.6735 5 yes
GO:0031325 positive regulation of cellular metabolic process 32.6531 5 no
GO:0051247 positive regulation of protein metabolic process 32.6531 6 no
GO:0007010 cytoskeleton organization 32.6531 5 no
GO:0009892 negative regulation of metabolic process 31.6327 4 no
GO:0031399 regulation of protein modification process 31.6327 6 no
GO:0030030 cell projection organization 31.6327 4 no
GO:0019220 regulation of phosphate metabolic process 30.6122 6 no
GO:0051174 regulation of phosphorus metabolic process 30.6122 5 no
GO:0048584 positive regulation of response to stimulus 29.5918 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051493 regulation of cytoskeleton organization 28.5714 6 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.5510 5 no
GO:0042325 regulation of phosphorylation 27.5510 7 no
GO:0010647 positive regulation of cell communication 27.5510 5 no
GO:0023056 positive regulation of signaling 27.5510 4 no
GO:0001932 regulation of protein phosphorylation 26.5306 7 no
GO:0071705 nitrogen compound transport 26.5306 4 no
GO:0060341 regulation of cellular localization 26.5306 4 no
GO:0045595 regulation of cell differentiation 26.5306 4 no
GO:0031324 negative regulation of cellular metabolic process 25.5102 5 no
GO:0051050 positive regulation of transport 25.5102 4 no
GO:0009889 regulation of biosynthetic process 25.5102 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.5102 5 no
GO:0031326 regulation of cellular biosynthetic process 25.5102 5 no
GO:0009967 positive regulation of signal transduction 25.5102 5 no
GO:0010941 regulation of cell death 25.5102 4 no
GO:0097435 supramolecular fiber organization 25.5102 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 24.4898 5 no
GO:0120036 plasma membrane bounded cell projection organization 24.4898 5 no
GO:0032880 regulation of protein localization 24.4898 5 no
GO:0031344 regulation of cell projection organization 24.4898 5 no
GO:0051094 positive regulation of developmental process 24.4898 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.4898 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.4694 5 no
GO:0007015 actin filament organization 23.4694 5 no
GO:0042981 regulation of apoptotic process 23.4694 6 no
GO:0043067 regulation of programmed cell death 23.4694 5 no
GO:0010562 positive regulation of phosphorus metabolic process 22.4490 6 no
GO:0031401 positive regulation of protein modification process 22.4490 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.4490 7 no
GO:0051252 regulation of RNA metabolic process 22.4490 5 no
GO:2000145 regulation of cell motility 22.4490 4 no
GO:0016192 vesicle-mediated transport 22.4490 4 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0030334 regulation of cell migration 21.4286 5 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0001934 positive regulation of protein phosphorylation 20.4082 8 no
GO:0051336 regulation of hydrolase activity 20.4082 4 no
GO:0051726 regulation of cell cycle 20.4082 4 no
GO:0006355 regulation of DNA-templated transcription 20.4082 6 no
GO:1903506 regulation of nucleic acid-templated transcription 20.4082 7 no
GO:2001141 regulation of RNA biosynthetic process 20.4082 6 no
GO:0032970 regulation of actin filament-based process 20.4082 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 13.2653 6 yes
GO:0007030 Golgi organization 7.1429 5 yes
GO:0030705 cytoskeleton-dependent intracellular transport 5.1020 4 yes
GO:0051683 establishment of Golgi localization 3.0612 4 yes
GO:0099111 microtubule-based transport 3.0612 4 yes
GO:0010970 transport along microtubule 2.0408 4 yes
GO:0072384 organelle transport along microtubule 2.0408 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in RHG21_HUMAN
DOID:114 heart disease 3.0612 3 no
DOID:0050700 cardiomyopathy 2.0408 4 no
DOID:0060036 intrinsic cardiomyopathy 2.0408 5 no
DOID:2843 long QT syndrome 2.0408 6 no
DOID:331 central nervous system disease 2.0408 3 no
DOID:0111962 combined immunodeficiency 2.0408 4 no
DOID:612 primary immunodeficiency disease 2.0408 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
HAKAI_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
AXIN1_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CDC73_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
PP1RA_HUMAN [view interactions] High throughput no yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
MAT2B_HUMAN [view interactions] High throughput no yes
K1107_HUMAN [view interactions] High throughput no yes
PRR36_HUMAN [view interactions] High throughput no no
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK16_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
TULP3_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
DRC5_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
SPICE_HUMAN [view interactions] High throughput no yes
CE120_HUMAN [view interactions] High throughput no no
ZN177_HUMAN [view interactions] High throughput no no
SAPC1_HUMAN [view interactions] High throughput no no
CENPE_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
ACK1_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
CCNT1_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
DDX42_HUMAN [view interactions] High throughput no yes
FIP1_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
LANC1_HUMAN [view entry] [view interactions] High throughput yes yes
LG3BP_HUMAN [view interactions] High throughput no no
METK2_HUMAN [view interactions] High throughput no no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
NSRP1_HUMAN [view interactions] High throughput no yes
PABP2_HUMAN [view interactions] High throughput no yes
PHF6_HUMAN [view interactions] High throughput no yes
PLMN_HUMAN [view interactions] High throughput no no
PPIL4_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
PNMA2_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
FBLN5_HUMAN [view interactions] High throughput no no
S10A2_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
S100P_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
M4K4_HUMAN [view interactions] High throughput no yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
RHG15_HUMAN [view interactions] High throughput no no
RHG19_HUMAN [view interactions] High throughput no yes
RHG40_HUMAN [view interactions] High throughput no no
RHG42_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS3_HUMAN [view interactions] High throughput no yes
PRIC1_HUMAN [view interactions] High throughput no yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTR2_HUMAN [view interactions] High throughput no no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TIM44_HUMAN [view interactions] High throughput no yes
CEGT_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG35_HUMAN [view interactions] High throughput no yes
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
CD2AP_HUMAN [view interactions] High throughput no no
CHIO_HUMAN [view interactions] High throughput no yes
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RGF1B_HUMAN [view interactions] High throughput no no
VINEX_HUMAN [view interactions] High throughput no no
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STA13_HUMAN [view interactions] High throughput no yes
SYNE2_HUMAN [view interactions] High throughput no no
DYLT1_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NIN_HUMAN [view interactions] High throughput no no
ENTR1_HUMAN [view interactions] High throughput no no
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
DIRA3_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
K2C8_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI36_HUMAN [view interactions] High throughput no no
VASP_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
RNF43_HUMAN [view interactions] High throughput no yes
RAB28_HUMAN [view interactions] Computational no yes
ARRB1_HUMAN [view entry] [view interactions] Computational yes yes