RHG21_HUMAN
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RHG21_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 35.7143 | 4 | no |
GO:0019901 | protein kinase binding | 35.7143 | 5 | no |
GO:0017076 | purine nucleotide binding | 27.5510 | 4 | no |
GO:0045296 | cadherin binding | 26.5306 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 25.5102 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.5102 | 4 | no |
GO:0003779 | actin binding | 24.4898 | 4 | no |
GO:0046872 | metal ion binding | 21.4286 | 4 | no |
GO:0003723 | RNA binding | 21.4286 | 4 | no |
GO:0030695 | GTPase regulator activity | 14.2857 | 4 | yes |
GO:0005096 | GTPase activator activity | 9.1837 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RHG21_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 65.3061 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 56.1224 | 4 | no |
GO:0051128 | regulation of cellular component organization | 54.0816 | 4 | no |
GO:0048523 | negative regulation of cellular process | 53.0612 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 53.0612 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.0204 | 4 | no |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0006996 | organelle organization | 45.9184 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 43.8776 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.8571 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 42.8571 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 41.8367 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.7959 | 5 | no |
GO:0008104 | protein localization | 38.7755 | 4 | no |
GO:0010468 | regulation of gene expression | 38.7755 | 5 | no |
GO:0022607 | cellular component assembly | 38.7755 | 4 | no |
GO:0051049 | regulation of transport | 37.7551 | 4 | no |
GO:0033043 | regulation of organelle organization | 34.6939 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 33.6735 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 32.6531 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 32.6531 | 6 | no |
GO:0007010 | cytoskeleton organization | 32.6531 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 31.6327 | 4 | no |
GO:0031399 | regulation of protein modification process | 31.6327 | 6 | no |
GO:0030030 | cell projection organization | 31.6327 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 30.6122 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 30.6122 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 29.5918 | 4 | no |
GO:0071702 | organic substance transport | 28.5714 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 28.5714 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 28.5714 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.5510 | 5 | no |
GO:0042325 | regulation of phosphorylation | 27.5510 | 7 | no |
GO:0010647 | positive regulation of cell communication | 27.5510 | 5 | no |
GO:0023056 | positive regulation of signaling | 27.5510 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 26.5306 | 7 | no |
GO:0071705 | nitrogen compound transport | 26.5306 | 4 | no |
GO:0060341 | regulation of cellular localization | 26.5306 | 4 | no |
GO:0045595 | regulation of cell differentiation | 26.5306 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.5102 | 5 | no |
GO:0051050 | positive regulation of transport | 25.5102 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 25.5102 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.5102 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.5102 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 25.5102 | 5 | no |
GO:0010941 | regulation of cell death | 25.5102 | 4 | no |
GO:0097435 | supramolecular fiber organization | 25.5102 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.4898 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 24.4898 | 5 | no |
GO:0032880 | regulation of protein localization | 24.4898 | 5 | no |
GO:0031344 | regulation of cell projection organization | 24.4898 | 5 | no |
GO:0051094 | positive regulation of developmental process | 24.4898 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.4898 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.4694 | 5 | no |
GO:0007015 | actin filament organization | 23.4694 | 5 | no |
GO:0042981 | regulation of apoptotic process | 23.4694 | 6 | no |
GO:0043067 | regulation of programmed cell death | 23.4694 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 22.4490 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 22.4490 | 7 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 22.4490 | 7 | no |
GO:0051252 | regulation of RNA metabolic process | 22.4490 | 5 | no |
GO:2000145 | regulation of cell motility | 22.4490 | 4 | no |
GO:0016192 | vesicle-mediated transport | 22.4490 | 4 | no |
GO:0042327 | positive regulation of phosphorylation | 21.4286 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 21.4286 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 21.4286 | 6 | no |
GO:0030334 | regulation of cell migration | 21.4286 | 5 | no |
GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 20.4082 | 8 | no |
GO:0051336 | regulation of hydrolase activity | 20.4082 | 4 | no |
GO:0051726 | regulation of cell cycle | 20.4082 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 20.4082 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 20.4082 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 20.4082 | 6 | no |
GO:0032970 | regulation of actin filament-based process | 20.4082 | 4 | no |
GO:0051056 | regulation of small GTPase mediated signal transduction | 13.2653 | 6 | yes |
GO:0007030 | Golgi organization | 7.1429 | 5 | yes |
GO:0030705 | cytoskeleton-dependent intracellular transport | 5.1020 | 4 | yes |
GO:0051683 | establishment of Golgi localization | 3.0612 | 4 | yes |
GO:0099111 | microtubule-based transport | 3.0612 | 4 | yes |
GO:0010970 | transport along microtubule | 2.0408 | 4 | yes |
GO:0072384 | organelle transport along microtubule | 2.0408 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in RHG21_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 3.0612 | 3 | no |
DOID:0050700 | cardiomyopathy | 2.0408 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 2.0408 | 5 | no |
DOID:2843 | long QT syndrome | 2.0408 | 6 | no |
DOID:331 | central nervous system disease | 2.0408 | 3 | no |
DOID:0111962 | combined immunodeficiency | 2.0408 | 4 | no |
DOID:612 | primary immunodeficiency disease | 2.0408 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HAKAI_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
CAVN1_HUMAN | [view interactions] | High throughput | no | no |
PP1RA_HUMAN | [view interactions] | High throughput | no | yes |
PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
K1107_HUMAN | [view interactions] | High throughput | no | yes |
PRR36_HUMAN | [view interactions] | High throughput | no | no |
CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK16_HUMAN | [view interactions] | High throughput | no | yes |
ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
SP1_HUMAN | [view interactions] | High throughput | no | yes |
DRC5_HUMAN | [view interactions] | High throughput | no | no |
CE128_HUMAN | [view interactions] | High throughput | no | yes |
CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
NINL_HUMAN | [view interactions] | High throughput | no | yes |
CE152_HUMAN | [view interactions] | High throughput | no | yes |
ODFP2_HUMAN | [view interactions] | High throughput | no | no |
CP135_HUMAN | [view interactions] | High throughput | no | no |
SPICE_HUMAN | [view interactions] | High throughput | no | yes |
CE120_HUMAN | [view interactions] | High throughput | no | no |
ZN177_HUMAN | [view interactions] | High throughput | no | no |
SAPC1_HUMAN | [view interactions] | High throughput | no | no |
CENPE_HUMAN | [view interactions] | High throughput | no | no |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACK1_HUMAN | [view interactions] | High throughput | no | yes |
ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX42_HUMAN | [view interactions] | High throughput | no | yes |
FIP1_HUMAN | [view interactions] | High throughput | no | yes |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
HMGN1_HUMAN | [view interactions] | High throughput | no | yes |
LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LG3BP_HUMAN | [view interactions] | High throughput | no | no |
METK2_HUMAN | [view interactions] | High throughput | no | no |
MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
PABP2_HUMAN | [view interactions] | High throughput | no | yes |
PHF6_HUMAN | [view interactions] | High throughput | no | yes |
PLMN_HUMAN | [view interactions] | High throughput | no | no |
PPIL4_HUMAN | [view interactions] | High throughput | no | yes |
PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBLN5_HUMAN | [view interactions] | High throughput | no | no |
S10A2_HUMAN | [view interactions] | High throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S100P_HUMAN | [view interactions] | High throughput | no | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M4K4_HUMAN | [view interactions] | High throughput | no | yes |
MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
NECP1_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG15_HUMAN | [view interactions] | High throughput | no | no |
RHG19_HUMAN | [view interactions] | High throughput | no | yes |
RHG40_HUMAN | [view interactions] | High throughput | no | no |
RHG42_HUMAN | [view interactions] | High throughput | no | yes |
ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIAS3_HUMAN | [view interactions] | High throughput | no | yes |
PRIC1_HUMAN | [view interactions] | High throughput | no | yes |
RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTR2_HUMAN | [view interactions] | High throughput | no | no |
SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIM44_HUMAN | [view interactions] | High throughput | no | yes |
CEGT_HUMAN | [view interactions] | High throughput | no | yes |
VAV_HUMAN | [view interactions] | High throughput | no | no |
RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG35_HUMAN | [view interactions] | High throughput | no | yes |
ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD2AP_HUMAN | [view interactions] | High throughput | no | no |
CHIO_HUMAN | [view interactions] | High throughput | no | yes |
DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LPXN_HUMAN | [view interactions] | High throughput | no | yes |
PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RGF1B_HUMAN | [view interactions] | High throughput | no | no |
VINEX_HUMAN | [view interactions] | High throughput | no | no |
SRGP1_HUMAN | [view interactions] | High throughput | no | no |
SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STA13_HUMAN | [view interactions] | High throughput | no | yes |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
DYLT1_HUMAN | [view interactions] | High throughput | no | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NIN_HUMAN | [view interactions] | High throughput | no | no |
ENTR1_HUMAN | [view interactions] | High throughput | no | no |
ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
K2C8_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFAD_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PARD3_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNE3_HUMAN | [view interactions] | High throughput | no | no |
ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI36_HUMAN | [view interactions] | High throughput | no | no |
VASP_HUMAN | [view interactions] | High throughput | no | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
RAB28_HUMAN | [view interactions] | Computational | no | yes |
ARRB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |