Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RHG21_HUMAN

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RHG21_HUMAN
GO:0043168 anion binding 32.1101 4 no
GO:0019900 kinase binding 32.1101 4 no
GO:0019901 protein kinase binding 32.1101 5 no
GO:0000166 nucleotide binding 27.5229 4 no
GO:0017076 purine nucleotide binding 27.5229 5 no
GO:0032555 purine ribonucleotide binding 27.5229 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.5229 4 no
GO:0045296 cadherin binding 25.6881 4 no
GO:0003779 actin binding 24.7706 4 no
GO:0043169 cation binding 22.9358 4 no
GO:0046872 metal ion binding 22.9358 5 no
GO:0030695 GTPase regulator activity 12.8440 4 yes
GO:0005096 GTPase activator activity 7.3394 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RHG21_HUMAN
GO:0048522 positive regulation of cellular process 66.0550 4 no
GO:0060255 regulation of macromolecule metabolic process 56.8807 4 no
GO:0031323 regulation of cellular metabolic process 55.9633 4 no
GO:0051128 regulation of cellular component organization 54.1284 4 no
GO:0048523 negative regulation of cellular process 53.2110 4 no
GO:0080090 regulation of primary metabolic process 50.4587 4 no
GO:0010646 regulation of cell communication 47.7064 4 yes
GO:0009893 positive regulation of metabolic process 44.0367 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.0367 5 no
GO:0009889 regulation of biosynthetic process 43.1193 4 no
GO:0010556 regulation of macromolecule biosynthetic process 43.1193 5 no
GO:0031326 regulation of cellular biosynthetic process 43.1193 5 no
GO:0006996 organelle organization 42.2018 4 yes
GO:0010468 regulation of gene expression 42.2018 6 no
GO:0051246 regulation of protein metabolic process 41.2844 5 no
GO:0009966 regulation of signal transduction 40.3670 4 yes
GO:0008104 protein localization 39.4495 4 no
GO:0022607 cellular component assembly 38.5321 4 no
GO:0031325 positive regulation of cellular metabolic process 36.6972 5 no
GO:0051049 regulation of transport 34.8624 4 no
GO:0051247 positive regulation of protein metabolic process 33.0275 6 no
GO:0031399 regulation of protein modification process 32.1101 6 no
GO:1902531 regulation of intracellular signal transduction 31.1927 5 yes
GO:0033043 regulation of organelle organization 31.1927 5 no
GO:0044087 regulation of cellular component biogenesis 30.2752 4 no
GO:0051130 positive regulation of cellular component organization 30.2752 5 no
GO:0009892 negative regulation of metabolic process 30.2752 4 no
GO:0030030 cell projection organization 29.3578 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.4404 5 no
GO:0031324 negative regulation of cellular metabolic process 28.4404 5 no
GO:0060341 regulation of cellular localization 28.4404 4 no
GO:0007010 cytoskeleton organization 27.5229 5 no
GO:0019220 regulation of phosphate metabolic process 27.5229 6 no
GO:0048584 positive regulation of response to stimulus 27.5229 4 no
GO:0051174 regulation of phosphorus metabolic process 27.5229 5 no
GO:0051493 regulation of cytoskeleton organization 25.6881 6 no
GO:0009891 positive regulation of biosynthetic process 25.6881 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.6881 6 no
GO:0032880 regulation of protein localization 25.6881 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.6881 5 no
GO:0031344 regulation of cell projection organization 24.7706 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.7706 6 no
GO:0001932 regulation of protein phosphorylation 24.7706 7 no
GO:0010647 positive regulation of cell communication 24.7706 5 no
GO:0023056 positive regulation of signaling 24.7706 4 no
GO:0042325 regulation of phosphorylation 24.7706 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.7706 6 no
GO:0051252 regulation of RNA metabolic process 24.7706 5 no
GO:0120036 plasma membrane bounded cell projection organization 23.8532 5 no
GO:0097435 supramolecular fiber organization 22.9358 4 no
GO:0141124 intracellular signaling cassette 22.9358 4 no
GO:0031401 positive regulation of protein modification process 22.9358 7 no
GO:0045595 regulation of cell differentiation 22.9358 4 no
GO:0051050 positive regulation of transport 22.9358 4 no
GO:0006355 regulation of DNA-templated transcription 22.9358 7 no
GO:2001141 regulation of RNA biosynthetic process 22.9358 6 no
GO:2000145 regulation of cell motility 22.9358 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.0183 4 no
GO:0009967 positive regulation of signal transduction 22.0183 5 no
GO:0071702 organic substance transport 22.0183 4 no
GO:0071705 nitrogen compound transport 22.0183 4 no
GO:0034330 cell junction organization 22.0183 4 no
GO:0030334 regulation of cell migration 22.0183 5 no
GO:0042981 regulation of apoptotic process 21.1009 5 no
GO:0043067 regulation of programmed cell death 21.1009 4 no
GO:0051248 negative regulation of protein metabolic process 21.1009 6 no
GO:0007015 actin filament organization 20.1835 5 no
GO:0010648 negative regulation of cell communication 20.1835 5 no
GO:0023057 negative regulation of signaling 20.1835 4 no
GO:0051094 positive regulation of developmental process 20.1835 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 11.9266 6 yes
GO:0007030 Golgi organization 6.4220 5 yes
GO:0030705 cytoskeleton-dependent intracellular transport 5.5046 4 yes
GO:0051683 establishment of Golgi localization 2.7523 4 yes
GO:0099111 microtubule-based transport 2.7523 4 yes
GO:0010970 transport along microtubule 1.8349 4 yes
GO:0072384 organelle transport along microtubule 1.8349 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
HAKAI_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
AXIN1_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CDC73_HUMAN [view interactions] High throughput no yes
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
CDK16_HUMAN [view interactions] High throughput no yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
PRR36_HUMAN [view interactions] High throughput no no
BTBD8_HUMAN [view interactions] High throughput no yes
MAT2B_HUMAN [view interactions] High throughput no yes
PDIA4_HUMAN [view interactions] High throughput no yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
PP1RA_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
TULP3_HUMAN [view interactions] High throughput no yes
VP26C_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
DRC5_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
SPICE_HUMAN [view interactions] High throughput no yes
CE120_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
ZN177_HUMAN [view interactions] High throughput no no
SAPC1_HUMAN [view interactions] High throughput no no
CENPE_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
ATIF1_HUMAN [view interactions] High throughput no yes
CCNT1_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
DDX42_HUMAN [view interactions] High throughput no yes
FIP1_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
LANC1_HUMAN [view entry] [view interactions] High throughput yes yes
LG3BP_HUMAN [view interactions] High throughput no no
METK2_HUMAN [view interactions] High throughput no no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
NSRP1_HUMAN [view interactions] High throughput no yes
PABP2_HUMAN [view interactions] High throughput no yes
PHF6_HUMAN [view interactions] High throughput no yes
PLMN_HUMAN [view interactions] High throughput no no
PPIL4_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
S2512_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
PNMA2_HUMAN [view interactions] High throughput no yes
FBLN5_HUMAN [view interactions] High throughput no no
S10A2_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
S100P_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
M4K4_HUMAN [view interactions] High throughput no yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
FER_HUMAN [view interactions] High throughput no yes
GCSP_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG19_HUMAN [view interactions] High throughput no yes
RHG40_HUMAN [view interactions] High throughput no no
RHG42_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS3_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC1_HUMAN [view entry] [view interactions] High throughput yes yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTR2_HUMAN [view interactions] High throughput no no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
TIM44_HUMAN [view interactions] High throughput no yes
CEGT_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG35_HUMAN [view interactions] High throughput no yes
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
CD2AP_HUMAN [view interactions] High throughput no no
CHIO_HUMAN [view interactions] High throughput no yes
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RGF1B_HUMAN [view interactions] High throughput no no
VINEX_HUMAN [view interactions] High throughput no no
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STA13_HUMAN [view interactions] High throughput no yes
SYNE2_HUMAN [view interactions] High throughput no no
DYLT1_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NIN_HUMAN [view interactions] High throughput no no
ENTR1_HUMAN [view interactions] High throughput no no
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
DIRA3_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
K2C8_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI36_HUMAN [view interactions] High throughput no no
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
RNF43_HUMAN [view interactions] High throughput no yes
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
GSK3A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes