WASF3_HUMAN
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in WASF3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 38.8889 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 38.8889 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 38.8889 | 4 | no |
GO:0003779 | actin binding | 27.7778 | 4 | yes |
GO:0019900 | kinase binding | 25.0000 | 4 | no |
GO:0005524 | ATP binding | 25.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
GO:0045296 | cadherin binding | 25.0000 | 4 | no |
GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
GO:0034237 | protein kinase A regulatory subunit binding | 8.3333 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in WASF3_HUMAN |
---|---|---|---|---|
GO:0051128 | regulation of cellular component organization | 77.7778 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 72.2222 | 4 | yes |
GO:0022607 | cellular component assembly | 63.8889 | 4 | yes |
GO:0033043 | regulation of organelle organization | 63.8889 | 5 | yes |
GO:0051493 | regulation of cytoskeleton organization | 61.1111 | 6 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 58.3333 | 4 | no |
GO:0006996 | organelle organization | 55.5556 | 4 | yes |
GO:0030030 | cell projection organization | 55.5556 | 4 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 55.5556 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 55.5556 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 55.5556 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 55.5556 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 55.5556 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 55.5556 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 55.5556 | 4 | no |
GO:0110053 | regulation of actin filament organization | 50.0000 | 6 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 50.0000 | 5 | yes |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 47.2222 | 5 | yes |
GO:0007015 | actin filament organization | 44.4444 | 5 | yes |
GO:0097435 | supramolecular fiber organization | 44.4444 | 4 | yes |
GO:0009966 | regulation of signal transduction | 44.4444 | 4 | no |
GO:0010468 | regulation of gene expression | 44.4444 | 5 | no |
GO:0010638 | positive regulation of organelle organization | 41.6667 | 6 | yes |
GO:0044089 | positive regulation of cellular component biogenesis | 41.6667 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 41.6667 | 4 | no |
GO:0051049 | regulation of transport | 41.6667 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 38.8889 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 38.8889 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.8889 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 38.8889 | 5 | no |
GO:0007010 | cytoskeleton organization | 38.8889 | 5 | yes |
GO:0030031 | cell projection assembly | 38.8889 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 38.8889 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | no |
GO:0031344 | regulation of cell projection organization | 38.8889 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.1111 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 36.1111 | 5 | no |
GO:0008104 | protein localization | 36.1111 | 4 | no |
GO:0051495 | positive regulation of cytoskeleton organization | 36.1111 | 7 | yes |
GO:1902905 | positive regulation of supramolecular fiber organization | 36.1111 | 6 | yes |
GO:0031346 | positive regulation of cell projection organization | 36.1111 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0043254 | regulation of protein-containing complex assembly | 33.3333 | 5 | no |
GO:0043412 | macromolecule modification | 30.5556 | 4 | no |
GO:0060491 | regulation of cell projection assembly | 30.5556 | 5 | no |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 30.5556 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 30.5556 | 6 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 30.5556 | 7 | no |
GO:0051252 | regulation of RNA metabolic process | 30.5556 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 30.5556 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 30.5556 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 30.5556 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 30.5556 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 30.5556 | 6 | no |
GO:0023056 | positive regulation of signaling | 30.5556 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 30.5556 | 5 | no |
GO:0036211 | protein modification process | 30.5556 | 4 | no |
GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 27.7778 | 6 | no |
GO:1902743 | regulation of lamellipodium organization | 27.7778 | 7 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 27.7778 | 6 | no |
GO:0016192 | vesicle-mediated transport | 27.7778 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 27.7778 | 5 | yes |
GO:0120031 | plasma membrane bounded cell projection assembly | 27.7778 | 6 | yes |
GO:0009967 | positive regulation of signal transduction | 27.7778 | 5 | no |
GO:0032271 | regulation of protein polymerization | 27.7778 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 27.7778 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 27.7778 | 4 | no |
GO:0010591 | regulation of lamellipodium assembly | 27.7778 | 7 | no |
GO:1902745 | positive regulation of lamellipodium organization | 25.0000 | 7 | no |
GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
GO:0043933 | protein-containing complex organization | 25.0000 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
GO:0032535 | regulation of cellular component size | 25.0000 | 4 | no |
GO:0032990 | cell part morphogenesis | 25.0000 | 4 | no |
GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
GO:0048858 | cell projection morphogenesis | 25.0000 | 5 | no |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 25.0000 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
GO:0007264 | small GTPase mediated signal transduction | 25.0000 | 4 | no |
GO:0010592 | positive regulation of lamellipodium assembly | 25.0000 | 7 | no |
GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
GO:0080135 | regulation of cellular response to stress | 22.2222 | 4 | no |
GO:0006897 | endocytosis | 22.2222 | 5 | no |
GO:0010243 | response to organonitrogen compound | 22.2222 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 22.2222 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 22.2222 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 22.2222 | 4 | no |
GO:0008154 | actin polymerization or depolymerization | 22.2222 | 6 | yes |
GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation | 22.2222 | 8 | yes |
GO:0034330 | cell junction organization | 22.2222 | 4 | yes |
GO:0051125 | regulation of actin nucleation | 22.2222 | 7 | yes |
GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | yes |
GO:0097581 | lamellipodium organization | 22.2222 | 6 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 22.2222 | 6 | no |
GO:0010941 | regulation of cell death | 22.2222 | 4 | no |
GO:0030155 | regulation of cell adhesion | 22.2222 | 4 | no |
GO:0030335 | positive regulation of cell migration | 22.2222 | 6 | no |
GO:0030832 | regulation of actin filament length | 22.2222 | 5 | no |
GO:0030833 | regulation of actin filament polymerization | 22.2222 | 7 | no |
GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
GO:0040017 | positive regulation of locomotion | 22.2222 | 4 | no |
GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
GO:0045597 | positive regulation of cell differentiation | 22.2222 | 5 | no |
GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
GO:2000147 | positive regulation of cell motility | 22.2222 | 5 | no |
GO:0006468 | protein phosphorylation | 22.2222 | 5 | no |
GO:0007265 | Ras protein signal transduction | 22.2222 | 5 | no |
GO:0016310 | phosphorylation | 22.2222 | 5 | no |
GO:0051127 | positive regulation of actin nucleation | 19.4444 | 7 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 19.4444 | 4 | yes |
GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation | 19.4444 | 8 | yes |
GO:0008360 | regulation of cell shape | 16.6667 | 6 | yes |
GO:0030032 | lamellipodium assembly | 16.6667 | 7 | yes |
GO:2000026 | regulation of multicellular organismal development | 16.6667 | 4 | yes |
GO:0030041 | actin filament polymerization | 13.8889 | 7 | yes |
GO:0044057 | regulation of system process | 13.8889 | 4 | yes |
GO:0050808 | synapse organization | 13.8889 | 5 | yes |
GO:0051258 | protein polymerization | 13.8889 | 6 | yes |
GO:0099563 | modification of synaptic structure | 13.8889 | 6 | yes |
GO:0051960 | regulation of nervous system development | 11.1111 | 5 | yes |
GO:0031641 | regulation of myelination | 5.5556 | 4 | yes |
GO:0031644 | regulation of nervous system process | 5.5556 | 5 | yes |
GO:0098885 | modification of postsynaptic actin cytoskeleton | 5.5556 | 8 | yes |
GO:0099010 | modification of postsynaptic structure | 5.5556 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PR40A_HUMAN | [view interactions] | Low throughput | no | yes |
ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WASC3_HUMAN | [view interactions] | High throughput | no | yes |
LPP_HUMAN | [view interactions] | High throughput | no | yes |
CMTR1_HUMAN | [view interactions] | High throughput | no | yes |
SUV3_HUMAN | [view interactions] | High throughput | no | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CENPF_HUMAN | [view interactions] | High throughput | no | no |
HXB9_HUMAN | [view interactions] | High throughput | no | no |
CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN_HUMAN | [view interactions] | High throughput | no | no |
KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
RASL3_HUMAN | [view interactions] | High throughput | no | no |
BYST_HUMAN | [view interactions] | High throughput | no | yes |
ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIFC3_HUMAN | [view interactions] | High throughput | no | no |
CKS1_HUMAN | [view interactions] | High throughput | no | yes |
KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RYK_HUMAN | [view interactions] | High throughput | no | no |
TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
BRK1_HUMAN | [view interactions] | High throughput | no | no |
NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CD47_HUMAN | [view interactions] | High throughput | no | no |
F10C1_HUMAN | [view interactions] | High throughput | no | yes |
SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
AMZ1_HUMAN | [view interactions] | High throughput | no | no |
RHG12_HUMAN | [view interactions] | High throughput | no | yes |
K1522_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OGFR_HUMAN | [view interactions] | High throughput | no | yes |
WDR33_HUMAN | [view interactions] | High throughput | no | yes |
CPNE7_HUMAN | [view interactions] | High throughput | no | no |
ES8L2_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NCKPL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ABL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARPC3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
WIPF1_HUMAN | [view interactions] | Computational | no | no |
CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
WASP_HUMAN | [view interactions] | Computational | no | yes |
BAIP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NCK1_HUMAN | [view interactions] | Computational | no | yes |