Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WASF3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in WASF3_HUMAN
GO:0000166 nucleotide binding 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no
GO:0003779 actin binding 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0019901 protein kinase binding 21.4286 5 no
GO:0034237 protein kinase A regulatory subunit binding 10.7143 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WASF3_HUMAN
GO:0051128 regulation of cellular component organization 78.5714 4 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0022607 cellular component assembly 64.2857 4 yes
GO:0048523 negative regulation of cellular process 64.2857 4 no
GO:0030030 cell projection organization 60.7143 4 yes
GO:0060255 regulation of macromolecule metabolic process 60.7143 4 no
GO:0010646 regulation of cell communication 53.5714 4 no
GO:0031323 regulation of cellular metabolic process 53.5714 4 no
GO:0080090 regulation of primary metabolic process 53.5714 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0033043 regulation of organelle organization 46.4286 5 yes
GO:0044087 regulation of cellular component biogenesis 46.4286 4 no
GO:0032956 regulation of actin cytoskeleton organization 42.8571 5 yes
GO:0032970 regulation of actin filament-based process 42.8571 4 yes
GO:0051493 regulation of cytoskeleton organization 42.8571 6 yes
GO:0110053 regulation of actin filament organization 42.8571 6 yes
GO:1902903 regulation of supramolecular fiber organization 42.8571 5 yes
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0010468 regulation of gene expression 42.8571 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0051130 positive regulation of cellular component organization 39.2857 5 yes
GO:0048584 positive regulation of response to stimulus 39.2857 4 no
GO:0031344 regulation of cell projection organization 39.2857 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 39.2857 6 no
GO:0007015 actin filament organization 35.7143 5 yes
GO:0030031 cell projection assembly 35.7143 5 yes
GO:0097435 supramolecular fiber organization 35.7143 4 yes
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0141124 intracellular signaling cassette 35.7143 4 no
GO:0007010 cytoskeleton organization 32.1429 5 yes
GO:0034330 cell junction organization 32.1429 4 yes
GO:1902531 regulation of intracellular signal transduction 32.1429 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 32.1429 4 no
GO:0010638 positive regulation of organelle organization 28.5714 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 yes
GO:0051495 positive regulation of cytoskeleton organization 28.5714 7 yes
GO:0097581 lamellipodium organization 28.5714 6 yes
GO:1902905 positive regulation of supramolecular fiber organization 28.5714 6 yes
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0043254 regulation of protein-containing complex assembly 28.5714 5 no
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0060491 regulation of cell projection assembly 28.5714 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 28.5714 6 no
GO:0008154 actin polymerization or depolymerization 25.0000 6 yes
GO:0043933 protein-containing complex organization 25.0000 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 25.0000 6 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0032271 regulation of protein polymerization 25.0000 6 no
GO:0032535 regulation of cellular component size 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0007264 small GTPase-mediated signal transduction 25.0000 5 no
GO:0008104 protein localization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0048812 neuron projection morphogenesis 25.0000 5 no
GO:0010591 regulation of lamellipodium assembly 25.0000 7 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 25.0000 6 no
GO:1902743 regulation of lamellipodium organization 25.0000 7 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0030032 lamellipodium assembly 21.4286 7 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 21.4286 8 yes
GO:0051125 regulation of actin nucleation 21.4286 7 yes
GO:0051127 positive regulation of actin nucleation 21.4286 7 yes
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 yes
GO:0065003 protein-containing complex assembly 21.4286 5 yes
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 21.4286 8 yes
GO:0008064 regulation of actin polymerization or depolymerization 21.4286 6 no
GO:0030832 regulation of actin filament length 21.4286 5 no
GO:0030833 regulation of actin filament polymerization 21.4286 7 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0010592 positive regulation of lamellipodium assembly 21.4286 7 no
GO:0016601 Rac protein signal transduction 21.4286 6 no
GO:0030334 regulation of cell migration 21.4286 5 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:1902745 positive regulation of lamellipodium organization 21.4286 7 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:0016310 phosphorylation 21.4286 5 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0050808 synapse organization 17.8571 5 yes
GO:0022604 regulation of cell morphogenesis 14.2857 5 yes
GO:0030041 actin filament polymerization 14.2857 7 yes
GO:0044057 regulation of system process 14.2857 4 yes
GO:0051258 protein polymerization 14.2857 6 yes
GO:0051960 regulation of nervous system development 14.2857 5 yes
GO:0099563 modification of synaptic structure 10.7143 6 yes
GO:0031641 regulation of myelination 7.1429 4 yes
GO:0098885 modification of postsynaptic actin cytoskeleton 7.1429 8 yes
GO:0099010 modification of postsynaptic structure 7.1429 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BIP_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40A_HUMAN [view interactions] Low throughput no no
ARP3_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
WASC3_HUMAN [view interactions] High throughput no yes
HXB9_HUMAN [view interactions] High throughput no no
CENPF_HUMAN [view interactions] High throughput no no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
SUV3_HUMAN [view interactions] High throughput no yes
CMTR1_HUMAN [view interactions] High throughput no yes
LPP_HUMAN [view interactions] High throughput no yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
RASL3_HUMAN [view interactions] High throughput no no
BYST_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
KIFC3_HUMAN [view interactions] High throughput no no
CKS1_HUMAN [view interactions] High throughput no yes
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
GT2D1_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view interactions] High throughput no no
CD47_HUMAN [view interactions] High throughput no no
F10C1_HUMAN [view interactions] High throughput no yes
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
AMZ1_HUMAN [view interactions] High throughput no no
RHG12_HUMAN [view entry] [view interactions] High throughput yes yes
NHSL3_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
OGFR_HUMAN [view interactions] High throughput no yes
WDR33_HUMAN [view interactions] High throughput no yes
CPNE7_HUMAN [view interactions] High throughput no no
ES8L2_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no